{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:36:28Z","timestamp":1790516188252,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The likelihood that health-related quality of life (HRQoL) could depend on factors other than clinical data increases with the duration of follow-up since diagnosis. The aim of this study was to identify determinants of long-term HRQoL in women with cervical, endometrial, and ovarian cancer. Secondary objectives were to describe their living conditions (sexual function, psychological distress, social and professional reinsertion).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>In a cross-sectional survey, women diagnosed with cervical, endometrial, and ovarian cancers from 2006 to 2013 were selected through the French gynecological cancers registry of C\u00f4te d'Or. Validated questionnaires exploring HRQoL (short-form health survey; SF-12), anxiety and depression (Hospital Anxiety and Depression Scale), social support (Sarason's Social Support Questionnaire), sexual function (Female Sexual Function Index), and living conditions (EPICES questionnaire) were used to assess HRQoL and its determinants. Social and professional reinsertion were also investigated using study-specific questionnaires. Determinants of HRQoL were identified using a multivariable mixed-regression model for each composite score of the SF-12.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 195 gynecological cancer survivors participated in the survey. HRQoL was deteriorated for almost all the SF-12 dimensions. The main determinants of poor HRQoL were comorbidities, deprivation, lack of availability and satisfaction with social support, and psychological outcomes. Thirty-four percent of survivors of gynecological cancer reported a negative impact of cancer on their work, and 73% reported an impaired ability to work after treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Long-term HRQoL of survivors of gynecological cancer is not impacted by stage of disease. Specific interventions should focus on issues that promote social and professional reintegration and improve HRQoL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1634\/theoncologist.2018-0347","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T20:15:20Z","timestamp":1545423320000},"page":"e490-e500","source":"Crossref","is-referenced-by-count":22,"title":["Long-Term Gynecological Cancer Survivors in C\u00f4te d'Or: Health-Related Quality of Life and Living Conditions"],"prefix":"10.1093","volume":"24","author":[{"given":"Ariane","family":"Mamguem Kamga","sequence":"first","affiliation":[{"name":"Breast and Gynecologic Cancer Registry of C\u00f4te d'Or, Georges-Fran\u00e7ois Leclerc Cancer Centre-UNICANCER, Dijon, France"},{"name":"Lipids, Nutrition, Cancer Research Center, INSERM U1231, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Dumas","sequence":"additional","affiliation":[{"name":"Centre for Research in Epidemiology and Population Health (CESP), INSERM U1018, Universit\u00e9 Paris-Sud, University of Paris-Saclay, Villejuif, France and Department of Clinical Research, Gustave Roussy, INSERM U1018, B2M, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Joly","sequence":"additional","affiliation":[{"name":"University Hospital C\u00f4te de Nacre, Fran\u00e7ois Baclesse Comprehensive Cancer Centre, Medical Oncology Department, INSERM U1086, Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oumar","family":"Billa","sequence":"additional","affiliation":[{"name":"Breast and Gynecologic Cancer Registry of C\u00f4te d'Or, Georges-Fran\u00e7ois Leclerc Cancer Centre-UNICANCER, Dijon, France"},{"name":"Lipids, Nutrition, Cancer Research Center, INSERM U1231, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Simon","sequence":"additional","affiliation":[{"name":"Breast and Gynecologic Cancer Registry of C\u00f4te d'Or, Georges-Fran\u00e7ois Leclerc Cancer Centre-UNICANCER, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Poillot","sequence":"additional","affiliation":[{"name":"Breast and Gynecologic Cancer Registry of C\u00f4te d'Or, Georges-Fran\u00e7ois Leclerc Cancer Centre-UNICANCER, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Darut-Jouve","sequence":"additional","affiliation":[{"name":"Centre Radioth\u00e9rapie du Parc, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Coutant","sequence":"additional","affiliation":[{"name":"Medical Oncology, Georges-Fran\u00e7ois Leclerc Cancer Centre-UNICANCER, Dijon, France"},{"name":"Burgundy Franche-Comt\u00e9 University, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Fumoleau","sequence":"additional","affiliation":[{"name":"Burgundy Franche-Comt\u00e9 University, Dijon, France"},{"name":"Curie Institute, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Arveux","sequence":"additional","affiliation":[{"name":"Breast and Gynecologic Cancer Registry of C\u00f4te d'Or, Georges-Fran\u00e7ois Leclerc Cancer Centre-UNICANCER, Dijon, France"},{"name":"Lipids, Nutrition, Cancer Research Center, INSERM U1231, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tienhan Sandrine","family":"Dabakuyo-Yonli","sequence":"additional","affiliation":[{"name":"Breast and Gynecologic Cancer Registry of C\u00f4te d'Or, Georges-Fran\u00e7ois Leclerc Cancer Centre-UNICANCER, Dijon, France"},{"name":"Lipids, Nutrition, Cancer Research Center, INSERM U1231, Dijon, France"},{"name":"National Quality of Life and Cancer Clinical Research Platform, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"2021122507240428500_R1","article-title":"Survival of people with cancer in France, 1989-2007. 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