{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T14:03:47Z","timestamp":1712757827333},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title \/>\n                  <jats:p>Colorectal cancer (CRC) is rare in young patients without a confirmed family history of cancer. Reports of an increased prevalence of POLD1\/POLE mutations in young patients with colorectal cancer have raised awareness and support routine genetic testing for patients with early-onset tumors. In cases of CRC without proven MMR-germline mutation, molecular analyses are warranted to confirm or rule out other familial CRC syndromes. This article describes the cases of two young male patients, who presented with locally advanced and metastatic CRC, and reports the results of the germline mutational analyses done for both patients. These cases demonstrate the importance of special care and molecular diagnostic procedures for young patients with CRC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Key Points<\/jats:title>\n                  <jats:p>Patients with colorectal cancer who are younger than 50 years at initial diagnosis (early onset) should routinely undergo genetic testing. Early- and very-early-onset patients (younger than 40 years) with absence of microsatellite instability should be considered for tumor mutation burden testing and\/or DNA polymerase proofreading mutation. The mutational signature of HSP110 within mismatch repair deficiency-related tumors may help to identify patients likely to benefit from 5-fluorouracil-based chemotherapy. Intensified, maintained, and specific surveillance may help to reduce secondary tumor progression.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1634\/theoncologist.2018-0614","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T20:24:17Z","timestamp":1548447857000},"page":"877-882","source":"Crossref","is-referenced-by-count":2,"title":["Suspected Hereditary Cancer Syndromes in Young Patients: Heterogeneous Clinical and Genetic Presentation of Colorectal Cancers"],"prefix":"10.1093","volume":"24","author":[{"given":"Claudia","family":"Maletzki","sequence":"first","affiliation":[{"name":"Medical Clinic III\u2014Hematology, Oncology, Palliative Medicine, Department\u2009of Internal Medicine, Rostock University Medical Center, University of Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"H\u00fchns","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Rostock University Medical Center, University of Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Bauer","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics, Rostock University Medical Center, University of Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Prall","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Rostock University Medical Center, University of Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Junghanss","sequence":"additional","affiliation":[{"name":"Medical Clinic III\u2014Hematology, Oncology, Palliative Medicine, Department\u2009of Internal Medicine, Rostock University Medical Center, University of Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Henze","sequence":"additional","affiliation":[{"name":"Medical Clinic III\u2014Hematology, Oncology, Palliative Medicine, Department\u2009of Internal Medicine, Rostock University Medical Center, University of Rostock, Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"2021122507123961700_R1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/path.5129","article-title":"Consensus molecular subtype classification of colorectal adenomas","volume":"246","author":"Komor","year":"2018","journal-title":"J Pathol"},{"key":"2021122507123961700_R2","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1093\/annonc\/mdy337","article-title":"Colorectal premalignancy is associated with consensus molecular subtypes 1 and 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