{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T17:50:40Z","timestamp":1772560240324,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472254"],"award-info":[{"award-number":["81472254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2016A020215064"],"award-info":[{"award-number":["2016A020215064"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The predictive model of postsurgical recurrence for solitary early hepatocellular carcinoma (SE-HCC) is not well established. The aim of this study was to develop a novel model for prediction of postsurgical recurrence and survival for patients with hepatitis B virus (HBV)-related SE-HCC \u226410 cm.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and Methods<\/jats:title>\n                  <jats:p>Data from 1,081 patients with HBV-related SE-HCC \u226410 cm who underwent curative liver resection from 2003 to 2016 in our center were collected retrospectively and randomly divided into the derivation cohort (n =\u2009811) and the internal validation cohort (n =\u2009270). Eight hundred twenty-three patients selected from another four tertiary hospitals served as the external validation cohort. Postsurgical recurrence-free survival (RFS) and overall survival (OS) predictive nomograms were generated. The discriminatory accuracies of the nomograms were compared with six conventional hepatocellular carcinoma (HCC) staging systems.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Tumor size, differentiation, microscopic vascular invasion, preoperative \u03b1-fetoprotein, neutrophil-to-lymphocyte ratio, albumin-to-bilirubin ratio, and blood transfusion were identified as the risk factors associated with RFS and OS. RFS and OS predictive nomograms based on these seven variables were generated. The C-index was 0.83 (95% confidence interval [CI], 0.79\u20130.87) for the RFS-nomogram and 0.87 (95% CI, 0.83\u20130.91) for the OS-nomogram. Calibration curves showed good agreement between actual observation and nomogram prediction. Both C-indices of the two nomograms were substantially higher than those of the six conventional HCC staging systems (0.54\u20130.74 for RFS; 0.58\u20130.76 for OS) and those of HCC nomograms reported in literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The novel nomograms were shown to be accurate at predicting postoperative recurrence and OS for patients with HBV-related SE-HCC \u226410 cm after curative liver resection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1634\/theoncologist.2019-0766","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T16:59:56Z","timestamp":1594745996000},"page":"e1552-e1561","source":"Crossref","is-referenced-by-count":15,"title":["Novel Models Predict Postsurgical Recurrence and Overall Survival for Patients with Hepatitis B Virus-Related Solitary Hepatocellular Carcinoma \u226410 cm and Without Portal Venous Tumor Thrombus"],"prefix":"10.1093","volume":"25","author":[{"given":"Xiao-Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Liver Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China"},{"name":"Department of Hepatobiliary Surgery, The Tumor Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Jie","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of 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Provincial People's Hospital, Changsha, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ming","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Gansu People's Hospital, Lanzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Gansu People's Hospital, Lanzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, The First Affiliated Hospital of Sun Yat-sen University, 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