{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:53:34Z","timestamp":1791298414913,"version":"4.1.0"},"reference-count":92,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Care at the Catholic University Leuven"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Positron emission tomography (PET) is now an important cancer imaging tool, both for diagnosis and staging, as well as offering prognostic information based on response. This report attempts to comprehensively review the value of PET in the locoregional and distant staging of non-small cell lung cancer (NSCLC), illustrate the potential effects on patient management, and give a short overview of newer applications. PET sets the gold standard in the evaluation of an indeterminate solitary pulmonary nodule or mass, where PET has proven to be significantly more accurate than computed tomography (CT) in the distinction between benign and malignant lesions. In the evaluation of metastatic spread to locoregional lymph nodes, PET is significantly more accurate than CT, so that invasive surgical staging may be omitted in many patients with negative mediastinal PET images. In patients with positive mediastinal PET mages, invasive surgical staging remains mandatory because of the possibility of false-positive findings due to inflammatory nodes or granulomatous disorders. In the search for metastatic spread, PET is a useful adjunct to conventional imaging. This may be due to the finding of unexpected metastatic lesions or due to exclusion of malignancy in lesions that are equivocal on standard imaging. However, at this time, PET does not replace conventional imaging. Large-scale randomized studies are currently examining whether PET staging will actually improve the appearance of lung cancer outcome.<\/jats:p>","DOI":"10.1634\/theoncologist.9-6-633","type":"journal-article","created":{"date-parts":[[2004,11,23]],"date-time":"2004-11-23T14:29:11Z","timestamp":1101220151000},"page":"633-643","source":"Crossref","is-referenced-by-count":199,"title":["The Role of PET Scan in Diagnosis, Staging, and Management of Non-Small Cell Lung Cancer"],"prefix":"10.1093","volume":"9","author":[{"given":"Liesbet","family":"Schrevens","sequence":"first","affiliation":[{"name":"Respiratory Oncology Unit (Pulmonology) and Leuven Lung Cancer Group, University Hospital, Catholic University, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Lorent","sequence":"additional","affiliation":[{"name":"Respiratory Oncology Unit (Pulmonology) and Leuven Lung Cancer Group, University Hospital, Catholic University, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Dooms","sequence":"additional","affiliation":[{"name":"Respiratory Oncology Unit (Pulmonology) and Leuven Lung Cancer Group, University Hospital, Catholic University, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Vansteenkiste","sequence":"additional","affiliation":[{"name":"Respiratory Oncology Unit (Pulmonology) and Leuven Lung Cancer Group, University Hospital, Catholic University, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,11,1]]},"reference":[{"key":"2021122209332345400_R1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1148\/radiology.160.2.3726107","article-title":"CT of the pulmonary nodule: a cooperative study","volume":"160","author":"Zerhouni","year":"1986","journal-title":"Radiology"},{"key":"2021122209332345400_R2","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1378\/chest.70.3.332","article-title":"The coin lesion story: update 1976. Twenty years' experience with thoracotomy for 179 suspected malignant coin lesions","volume":"70","author":"Ray","year":"1976","journal-title":"Chest"},{"key":"2021122209332345400_R3","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/1097-0142(19830201)51:3<534::AID-CNCR2820510328>3.0.CO;2-B","article-title":"The coin lesion of the lung. A review of 955 resected coin lesions","volume":"51","author":"Toomes","year":"1983","journal-title":"Cancer"},{"key":"2021122209332345400_R4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2214\/ajr.168.2.9016198","article-title":"Does 2-year stability imply that pulmonary nodules are benign?","volume":"168","author":"Yankelevitz","year":"1997","journal-title":"AJR Am J Roentgenol"},{"key":"2021122209332345400_R5","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1164\/ajrccm.162.3.9812152","article-title":"Evaluation and management of the solitary pulmonary nodule","volume":"162","author":"Ost","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"2021122209332345400_R6","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1378\/chest.81.6.665","article-title":"Flexible fiberoptic bronchoscopy and percutaneous needle lung aspiration for evaluating the solitary pulmonary nodule","volume":"81","author":"Wallace","year":"1982","journal-title":"Chest"},{"key":"2021122209332345400_R7","first-page":"475","article-title":"Transthoracic needle biopsy: accuracy and complications in relation to location and type of lesion","volume":"55","author":"Berquist","year":"1980","journal-title":"Mayo Clin Proc"},{"key":"2021122209332345400_R8","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1378\/chest.93.6.1152","article-title":"Transthoracic needle aspiration biopsy following negative fiberoptic bronchoscopy in solitary pulmonary nodules","volume":"93","author":"Levine","year":"1988","journal-title":"Chest"},{"key":"2021122209332345400_R9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1148\/radiology.137.1.7422857","article-title":"Direct percutaneous needle aspiration of localized pulmonary lesions: result in 422 patients","volume":"137","author":"Westcott","year":"1980","journal-title":"Radiology"},{"issue":"suppl 1","key":"2021122209332345400_R10","doi-asserted-by":"crossref","first-page":"89S","DOI":"10.1378\/chest.123.1_suppl.89S","article-title":"The solitary pulmonary nodule","volume":"123","author":"Tan","year":"2003","journal-title":"Chest"},{"key":"2021122209332345400_R11","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1148\/radiol.2232011131","article-title":"T1 lung cancers: sensitivity of diagnosis with fluorodeoxyglucose PET","volume":"223","author":"Marom","year":"2002","journal-title":"Radiology"},{"key":"2021122209332345400_R12","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1183\/09031936.01.17408020","article-title":"The role of positron emission tomography with 18F-fluoro-2-deoxy-D-glucose in respiratory oncology","volume":"17","author":"Vansteenkiste","year":"2001","journal-title":"Eur Respir J"},{"key":"2021122209332345400_R13","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jama.285.7.914","article-title":"Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions: a meta-analysis","volume":"285","author":"Gould","year":"2001","journal-title":"JAMA"},{"key":"2021122209332345400_R14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S1470-2045(01)00555-1","article-title":"Positron emission tomography in the diagnosis and staging of lung cancer: a systematic, quantitative review","volume":"2","author":"Fischer","year":"2001","journal-title":"Lancet Oncol"},{"key":"2021122209332345400_R15","first-page":"1412","article-title":"Dual time point 18F-FDG PET imaging for differentiating malignant from inflammatory processes","volume":"42","author":"Zhuang","year":"2001","journal-title":"J Nucl Med"},{"key":"2021122209332345400_R16","first-page":"540","article-title":"18F-FDG accumulation with PET for differentiation between benign and malignant lesions in the thorax","volume":"44","author":"Demura","year":"2003","journal-title":"J Nucl Med"},{"key":"2021122209332345400_R17","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1200\/JCO.1998.16.3.1075","article-title":"Prospective investigation of positron emission tomography in lung nodules","volume":"16","author":"Lowe","year":"1998","journal-title":"J Clin Oncol"},{"key":"2021122209332345400_R18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.lungcan.2004.01.009","article-title":"Evaluation of F-18 fluorodeoxyglucose (FDG) PET scanning for pulmonary nodules less than 3 cm in diameter, with special reference to the CT images","volume":"45","author":"Nomori","year":"2004","journal-title":"Lung Cancer"},{"key":"2021122209332345400_R19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.lungcan.2004.02.012","article-title":"Nodules, CT-scans and PET-scans: a good partnership [editorial]","volume":"45","author":"Vansteenkiste","year":"2004","journal-title":"Lung Cancer"},{"key":"2021122209332345400_R20","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1183\/09031936.98.11061392","article-title":"Magnetic resonance (MR) imaging of the chest: state-of-the-art","volume":"11","author":"Bittner","year":"1998","journal-title":"Eur Respir J"},{"key":"2021122209332345400_R21","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1001\/archinte.1973.03650120060011","article-title":"Cells in pleural fluid. Their value in differential diagnosis","volume":"132","author":"Light","year":"1973","journal-title":"Arch Intern Med"},{"key":"2021122209332345400_R22","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1378\/chest.122.6.1918","article-title":"Clinical role of F-18 fluorodeoxyglucose positron emission tomography imaging in patients with lung cancer and suspected malignant pleural effusion","volume":"122","author":"Gupta","year":"2002","journal-title":"Chest"},{"key":"2021122209332345400_R23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2214\/ajr.175.1.1750245","article-title":"FDG PET of pleural effusions in patients with non-small cell lung cancer","volume":"175","author":"Erasmus","year":"2000","journal-title":"AJR Am J Roentgenol"},{"key":"2021122209332345400_R24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1010-7940(97)00267-4","article-title":"Leuven Lung Cancer Group. Present status of induction treatment for N2 non-small cell lung cancer: a review","volume":"13","author":"Vansteenkiste","year":"1998","journal-title":"Eur J Cardiothorac Surg"},{"key":"2021122209332345400_R25","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1055-3207(18)30303-X","article-title":"The role of multimodality therapy in locoregional non-small cell lung cancer","volume":"6","author":"Martini","year":"1997","journal-title":"Surg Oncol Clin N Am"},{"key":"2021122209332345400_R26","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1148\/radiology.178.3.1847239","article-title":"CT and MR imaging in staging non-small cell bronchogenic carcinoma: report of the Radiology Diagnostic Oncology Group","volume":"178","author":"Webb","year":"1991","journal-title":"Radiology"},{"key":"2021122209332345400_R27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/1010-7940(94)90131-7","article-title":"Value of computed tomography and mediastinoscopy in preoperative evaluation of mediastinal nodes in non-small cell lung cancer","volume":"8","author":"Dillemans","year":"1994","journal-title":"Eur J Cardiothorac Surg"},{"key":"2021122209332345400_R28","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1183\/09031936.96.09122560","article-title":"Staging of the mediastinum: value of positron emission tomography imaging in non-small cell lung cancer","volume":"9","author":"Bury","year":"1996","journal-title":"Eur Respir J"},{"key":"2021122209332345400_R29","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0003-4975(03)00888-9","article-title":"The role of FDG-PET scan in staging patients with non-small cell carcinoma","volume":"76","author":"Cerfolio","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"2021122209332345400_R30","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1164\/rccm.200301-050OC","article-title":"Endoscopic ultrasound, positron emission tomography, and computerized tomography for lung cancer","volume":"168","author":"Fritscher-Ravens","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"2021122209332345400_R31","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S0003-4975(99)00788-2","article-title":"PET, CT, and MRI with Combidex for mediastinal staging in non-small cell lung carcinoma","volume":"68","author":"Kernstine","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"2021122209332345400_R32","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.jtcvs.2003.07.030","article-title":"Results of the American College of Surgeons Oncology Group Z0050 trial: the utility of positron emission tomography in staging potentially operable non-small cell lung cancer","volume":"126","author":"Reed","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021122209332345400_R33","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0003-4975(98)01257-0","article-title":"Evaluation of fluorine-18-fluorodeoxyglucose whole body positron emission tomography imaging in the staging of lung cancer","volume":"67","author":"Saunders","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"2021122209332345400_R34","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/0003-4975(95)00752-0","article-title":"Staging non-small cell lung cancer by whole-body positron emission tomographic imaging","volume":"60","author":"Valk","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"2021122209332345400_R35","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1200\/JCO.1998.16.6.2142","article-title":"Lymph node staging in non-small cell lung cancer with FDG-PET scan: a prospective study on 690 lymph node stations from 68 patients","volume":"16","author":"Vansteenkiste","year":"1998","journal-title":"J Clin Oncol"},{"key":"2021122209332345400_R36","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s002590050327","article-title":"Leuven Lung Cancer Group. FDG-PET scan in potentially operable non-small cell lung cancer: do anatometabolic PET-CT fusion images improve the localisation of regional lymph node metastases?","volume":"25","author":"Vansteenkiste","year":"1998","journal-title":"Eur J Nucl Med"},{"key":"2021122209332345400_R37","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1378\/chest.112.6.1480","article-title":"Leuven Lung Cancer Group. Mediastinal lymph node staging with FDG-PET scan in patients with potentially operable non-small cell lung cancer: a prospective analysis of 50 cases","volume":"112","author":"Vansteenkiste","year":"1997","journal-title":"Chest"},{"key":"2021122209332345400_R38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00000421-200002000-00014","article-title":"Accuracy and clinical impact of mediastinal lymph node staging with FDG-PET imaging in potentially resectable lung cancer","volume":"23","author":"Weng","year":"2000","journal-title":"Am J Clin Oncol"},{"key":"2021122209332345400_R39","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1148\/radiology.213.2.r99nv46530","article-title":"Metastases from non-small cell lung cancer: mediastinal staging in the 1990s. Meta-analytic comparison of PET and CT","volume":"213","author":"Dwamena","year":"1999","journal-title":"Radiology"},{"key":"2021122209332345400_R40","doi-asserted-by":"crossref","first-page":"879","DOI":"10.7326\/0003-4819-139-11-200311180-00013","article-title":"Test performance of positron emission tomography and computed tomography for mediastinal staging in patients with non-small cell lung cancer: a meta-analysis","volume":"139","author":"Gould","year":"2003","journal-title":"Ann Intern Med"},{"issue":"suppl 1","key":"2021122209332345400_R41","doi-asserted-by":"crossref","first-page":"137S","DOI":"10.1378\/chest.123.1_suppl.137S","article-title":"Noninvasive staging of non-small cell lung cancer: a review of the current evidence","volume":"123","author":"Toloza","year":"2003","journal-title":"Chest"},{"key":"2021122209332345400_R42","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0003-4975(02)04350-3","article-title":"Mediastinal lymph node staging in suspected lung cancer: comparison of positron emission tomography with F-18-fluorodeoxyglucose and mediastinoscopy","volume":"75","author":"Graeter","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"2021122209332345400_R43","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/S0003-4975(97)00314-7","article-title":"Survival and prognostic factors in resected N2 non-small cell lung cancer: a study of 140 cases. The Leuven Lung Cancer Group","volume":"63","author":"Vansteenkiste","year":"1997","journal-title":"Ann Thorac Surg"},{"key":"2021122209332345400_R44","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1007\/s002590000376","article-title":"Cost-effectiveness of FDG-PET for the management of potentially operable non-small cell lung cancer: priority for a PET-based strategy after nodal-negative CT results","volume":"27","author":"Dietlein","year":"2000","journal-title":"Eur J Nucl Med"},{"key":"2021122209332345400_R45","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0003-4975(96)00220-2","article-title":"Distribution of distant metastases from newly diagnosed non-small cell lung cancer","volume":"62","author":"Quint","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"2021122209332345400_R46","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0140-6736(96)91203-9","article-title":"Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small cell lung cancer without overt metastases","volume":"347","author":"Pantel","year":"1996","journal-title":"Lancet"},{"key":"2021122209332345400_R47","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1148\/radiology.153.1.6473783","article-title":"Isolated adrenal masses in non-small cell bronchogenic carcinoma","volume":"153","author":"Oliver","year":"1984","journal-title":"Radiology"},{"key":"2021122209332345400_R48","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1200\/JCO.1991.9.8.1462","article-title":"Prospective evaluation of unilateral adrenal masses in patients with operable non-small cell lung cancer","volume":"9","author":"Ettinghausen","year":"1991","journal-title":"J Clin Oncol"},{"key":"2021122209332345400_R49","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.2214\/ajr.168.5.9129444","article-title":"Evaluation of adrenal masses in patients with bronchogenic carcinoma using 18F-fluorodeoxyglucose positron emission tomography","volume":"168","author":"Erasmus","year":"1997","journal-title":"AJR Am J Roentgenol"},{"key":"2021122209332345400_R50","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1148\/radiology.212.3.r99se21803","article-title":"Staging non-small cell lung cancer with whole-body PET","volume":"212","author":"Marom","year":"1999","journal-title":"Radiology"},{"key":"2021122209332345400_R51","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1007\/s002590050291","article-title":"Fluorine-18 deoxyglucose positron emission tomography for the detection of bone metastases in patients with non-small cell lung cancer","volume":"25","author":"Bury","year":"1998","journal-title":"Eur J Nucl Med"},{"key":"2021122209332345400_R52","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1200\/JCO.1998.16.10.3375","article-title":"Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions","volume":"16","author":"Cook","year":"1998","journal-title":"J Clin Oncol"},{"key":"2021122209332345400_R53","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1023\/A:1008290027419","article-title":"Clinical evaluation of whole-body 18F-fluorodeoxyglucose positron emission tomography in the detection of liver metastases","volume":"9","author":"Hustinx","year":"1998","journal-title":"Ann Oncol"},{"key":"2021122209332345400_R54","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1001\/archsurg.133.5.510","article-title":"Evaluation of benign vs malignant hepatic lesions with positron emission tomography","volume":"133","author":"Delbeke","year":"1998","journal-title":"Arch Surg"},{"key":"2021122209332345400_R55","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1183\/09031936.97.10112529","article-title":"Whole-body 18FDG positron emission tomography in the staging of non-small cell lung cancer","volume":"10","author":"Bury","year":"1997","journal-title":"Eur Respir J"},{"key":"2021122209332345400_R56","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0140-6736(94)90753-6","article-title":"Whole-body 18F-fluorodeoxyglucose positron emission tomography in preoperative evaluation of lung cancer","volume":"344","author":"Lewis","year":"1994","journal-title":"Lancet"},{"key":"2021122209332345400_R57","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0360-3016(01)01477-8","article-title":"High rate of detection of unsuspected distant metastases by PET in apparent stage III non-small cell lung cancer: implications for radical radiation therapy","volume":"50","author":"MacManus","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2021122209332345400_R58","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJM200007273430404","article-title":"Preoperative staging of non-small cell lung cancer with positron emission tomography","volume":"343","author":"Pieterman","year":"2000","journal-title":"N Engl J Med"},{"key":"2021122209332345400_R59","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3816\/CLC.2003.n.005","article-title":"Additional value of whole-body fluorodeoxyglucose positron emission tomography in the detection of distant metastases of non-small cell lung cancer","volume":"4","author":"Stroobants","year":"2003","journal-title":"Clin Lung Cancer"},{"key":"2021122209332345400_R60","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0003-4975(98)00675-4","article-title":"Detection of extrathoracic metastases by positron emission tomography in lung cancer","volume":"66","author":"Weder","year":"1998","journal-title":"Ann Thorac Surg"},{"key":"2021122209332345400_R61","first-page":"1596","article-title":"18F-FDG PET provides high-impact and powerful prognostic stratification in staging newly diagnosed non-small cell lung cancer","volume":"42","author":"Hicks","year":"2001","journal-title":"J Nucl Med"},{"key":"2021122209332345400_R62","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0169-5002(02)00446-4","article-title":"The value of [18F]fluoro-2-deoxy-D-glucose positron emission tomography in the selection of patients with stage IIIA-N2 non-small cell lung cancer for combined modality treatment","volume":"39","author":"Hoekstra","year":"2003","journal-title":"Lung Cancer"},{"key":"2021122209332345400_R63","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-3-642-59349-9_19","article-title":"Molecular whole-body cancer staging using positron emission tomography: consequences for therapeutic management and metabolic radiation treatment planning","volume":"162","author":"Schmucking","year":"2003","journal-title":"Recent Results Cancer Res"},{"key":"2021122209332345400_R64","first-page":"752","article-title":"The impact of PET on the management of lung cancer: the referring physician's perspective","volume":"43","author":"Seltzer","year":"2002","journal-title":"J Nucl Med"},{"issue":"suppl 1","key":"2021122209332345400_R65","first-page":"96S","article-title":"Implementing biologic target volumes in radiation treatment planning for non-small cell lung cancer","volume":"45","author":"Bradley","year":"2004","journal-title":"J Nucl Med"},{"key":"2021122209332345400_R66","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF03165392","article-title":"A clinical evaluation of FDG-PET to assess the response in radiation therapy for bronchogenic carcinoma","volume":"10","author":"Ichiya","year":"1996","journal-title":"Ann Nucl Med"},{"key":"2021122209332345400_R67","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/00000421-199608000-00020","article-title":"Positron emission tomography in the pretreatment evaluation and follow-up of non-small cell lung cancer patients treated with radiotherapy: preliminary findings","volume":"19","author":"Hebert","year":"1996","journal-title":"Am J Clin Oncol"},{"key":"2021122209332345400_R68","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1200\/JCO.2003.07.054","article-title":"Positron emission tomography is superior to computed tomography scanning for response-assessment after radical radiotherapy or chemoradiotherapy in patients with non-small cell lung cancer","volume":"21","author":"MacManus","year":"2003","journal-title":"J Clin Oncol"},{"key":"2021122209332345400_R69","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1200\/JCO.2003.12.004","article-title":"Positron emission tomography in non-small cell lung cancer: prediction of response to chemotherapy by quantitative assessment of glucose use","volume":"21","author":"Weber","year":"2003","journal-title":"J Clin Oncol"},{"key":"2021122209332345400_R70","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1023\/A:1008437915860","article-title":"Leuven Lung Cancer Group. Potential use of FDG-PET scan after induction chemotherapy in surgically staged IIIA-N2 non-small cell lung cancer: a prospective pilot study","volume":"9","author":"Vansteenkiste","year":"1998","journal-title":"Ann Oncol"},{"key":"2021122209332345400_R71","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0003-4975(01)03257-X","article-title":"An initial experience with FDG-PET in the imaging of residual disease after induction therapy for lung cancer","volume":"73","author":"Akhurst","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"2021122209332345400_R72","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0169-5002(01)00332-4","article-title":"FDG-PET in staging and restaging non-small cell lung cancer after neoadjuvant chemoradiotherapy: correlation with histopathology","volume":"35","author":"Ryu","year":"2002","journal-title":"Lung Cancer"},{"key":"2021122209332345400_R73","first-page":"313A","article-title":"18Fluoro-2-deoxyglucose positron emission tomography (PET) in the assessment of induction chemotherapy (IC) in stage IIIA-N2 NSCLC: a multi-center prospective study","volume":"20","author":"Vansteenkiste","year":"2001","journal-title":"Proc Am Soc Clin Oncol"},{"key":"2021122209332345400_R74","first-page":"1605","article-title":"The utility of (18)F-FDG PET for suspected recurrent non-small cell lung cancer after potentially curative therapy: impact on management and prognostic stratification","volume":"42","author":"Hicks","year":"2001","journal-title":"J Nucl Med"},{"key":"2021122209332345400_R75","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1183\/09031936.99.14613769","article-title":"Value of FDG-PET in detecting residual or recurrent non-small cell lung cancer","volume":"14","author":"Bury","year":"1999","journal-title":"Eur Respir J"},{"key":"2021122209332345400_R76","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/0003-4975(95)00754-9","article-title":"Lung tumor growth correlates with glucose metabolism measured by fluoride-18 fluorodeoxyglucose positron emission tomography","volume":"60","author":"Duhaylongsod","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"2021122209332345400_R77","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/(SICI)1097-0142(19980901)83:5<918::AID-CNCR17>3.0.CO;2-Y","article-title":"The prognostic significance of fluorodeoxyglucose positron emission tomography imaging for patients with nonsmall cell lung carcinoma","volume":"83","author":"Ahuja","year":"1998","journal-title":"Cancer"},{"key":"2021122209332345400_R78","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1200\/JCO.1999.17.10.3201","article-title":"Leuven Lung Cancer Group. Prognostic importance of the standardized uptake value on FDG-PET-scan in non-small cell lung cancer: an analysis of 125 cases","volume":"17","author":"Vansteenkiste","year":"1999","journal-title":"J Clin Oncol"},{"key":"2021122209332345400_R79","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1010-7940(00)00535-2","article-title":"[(18)F]Fluorodeoxyglucose positron emission tomography and its prognostic value in lung cancer","volume":"18","author":"Dhital","year":"2000","journal-title":"Eur J Cardiothorac Surg"},{"key":"2021122209332345400_R80","first-page":"39","article-title":"18F-FDG uptake as a biologic prognostic factor for recurrence in patients with surgically resected non-small cell lung cancer","volume":"43","author":"Higashi","year":"2002","journal-title":"J Nucl Med"},{"key":"2021122209332345400_R81","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/00006231-200209000-00010","article-title":"Determination of the prognostic value of [(18)F]fluorodeoxyglucose uptake by using positron emission tomography in patients with non-small cell lung cancer","volume":"23","author":"Jeong","year":"2002","journal-title":"Nucl Med Commun"},{"key":"2021122209332345400_R82","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2214\/ajr.174.3.1740769","article-title":"Prognostic value of thoracic FDG PET imaging after treatment for non-small cell lung cancer","volume":"174","author":"Patz","year":"2000","journal-title":"AJR Am J Roentgenol"},{"key":"2021122209332345400_R83","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0140-6736(99)06093-6","article-title":"Early Lung Cancer Action Project: overall design and findings from baseline screening","volume":"354","author":"Henschke","year":"1999","journal-title":"Lancet"},{"key":"2021122209332345400_R84","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0140-6736(03)14188-8","article-title":"Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results","volume":"362","author":"Pastorino","year":"2003","journal-title":"Lancet"},{"key":"2021122209332345400_R85","first-page":"1426","article-title":"Imaging proliferation in lung tumors with PET: 18F-FLT versus 18F-FDG","volume":"44","author":"Buck","year":"2003","journal-title":"J Nucl Med"},{"key":"2021122209332345400_R86","first-page":"741","article-title":"FDG\/PET and spiral CT image fusion for mediastinal lymph node assessment of non-small cell lung cancer patients","volume":"40","author":"Magnani","year":"1999","journal-title":"J Cardiovasc Surg Torino"},{"key":"2021122209332345400_R87","doi-asserted-by":"crossref","first-page":"939","DOI":"10.2214\/ajr.178.4.1780939","article-title":"Improved image interpretation with registered thoracic CT and positron emission tomography data sets","volume":"178","author":"Aquino","year":"2002","journal-title":"AJR Am J Roentgenol"},{"key":"2021122209332345400_R88","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1056\/NEJMoa022136","article-title":"Staging of non-small cell lung cancer with integrated positron-emission tomography and computed tomography","volume":"348","author":"Lardinois","year":"2003","journal-title":"N Engl J Med"},{"issue":"suppl 2","key":"2021122209332345400_R89","doi-asserted-by":"crossref","first-page":"414S","DOI":"10.1016\/S0360-3016(03)01356-7","article-title":"Effects of PET\/CT image registration on radiation treatment planning in lung cancer","volume":"57","author":"Jang","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2021122209332345400_R90","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0360-3016(03)00346-8","article-title":"Radiation treatment planning with an integrated positron emission and computer tomography (PET\/CT): a feasibility study","volume":"57","author":"Ciernik","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2021122209332345400_R91","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ijrobp.2003.10.044","article-title":"Impact of FDG-PET on radiation therapy volume delineation in non-small cell lung cancer","volume":"59","author":"Bradley","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"suppl 1","key":"2021122209332345400_R92","first-page":"15S","article-title":"PET\/CT: panacea, redundancy, or something in between?","volume":"45","author":"Vogel","year":"2004","journal-title":"J Nucl Med"}],"container-title":["The Oncologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1634\/theoncologist.9-6-633","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1634\/theoncologist.9-6-633","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/9\/6\/633\/41844345\/oncolo_9_6_633.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/9\/6\/633\/41844345\/oncolo_9_6_633.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T11:50:50Z","timestamp":1640173850000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/oncolo\/article\/9\/6\/633\/6388101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,1]]},"references-count":92,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2004,11,1]]},"published-print":{"date-parts":[[2004,11,1]]}},"URL":"https:\/\/doi.org\/10.1634\/theoncologist.9-6-633","relation":{},"ISSN":["1083-7159","1549-490X"],"issn-type":[{"value":"1083-7159","type":"print"},{"value":"1549-490X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,11,1]]},"published":{"date-parts":[[2004,11,1]]}}}