{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:42:02Z","timestamp":1771656122147,"version":"3.50.1"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Fondo de Investigaciones Sanitarias","award":["FIS\/FEDER 02\/0010"],"award-info":[{"award-number":["FIS\/FEDER 02\/0010"]}]},{"name":"Fondo de Investigaciones Sanitarias","award":["RETICC RD06\/0020\/0035"],"award-info":[{"award-number":["RETICC RD06\/0020\/0035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The female predominance of meningiomas has been established, but how this is affected by hormones is still under discussion. We analyzed the characteristics of meningiomas from male (n = 53) and female (n = 111) patients by interphase fluorescence in situ hybridization (iFISH). In addition, in a subgroup of 45 (12 male and 33 female) patients, tumors were hybridized with the Affymetrix U133A chip. We show a higher frequency of larger tumors (p = .01) and intracranial meningiomas (p = .04) together with a higher relapse rate (p = .03) in male than in female patients. Male patients had a higher percentage of del(1p36) (p &amp;lt; .001), while loss of an X chromosome was restricted to tumors from female patients (p = .008). In turn, iFISH studies showed a higher frequency of chromosome losses, other than monosomy 22 alone, in meningiomas from male patients (p = .002), while female patients displayed a higher frequency of chromosome gains (p = .04) or monosomy 22 alone (p = .03) in the ancestral tumor clone. Interestingly, individual chromosomal abnormalities had a distinct impact on the recurrence-free survival rate of male versus female patients. In turn, gene expression showed that eight genes (RPS4Y1, DDX3Y, JARID1D, DDX3X, EIF1AY, XIST, USP9Y, and CYorf15B) had significantly different expression patterns (R2 &amp;gt; 0.80; p &amp;lt; .05) in tumors from male and female patients. In summary, we show the existence of different patterns of chromosome abnormalities and gene-expression profiles associated with patient gender, which could help to explain the slightly different clinical behavior of these two patient groups.<\/jats:p>","DOI":"10.1634\/theoncologist.12-10-1225","type":"journal-article","created":{"date-parts":[[2007,10,25]],"date-time":"2007-10-25T19:34:47Z","timestamp":1193340887000},"page":"1225-1236","source":"Crossref","is-referenced-by-count":33,"title":["Patient Gender Is Associated with Distinct Patterns of Chromosomal Abnormalities and Sex Chromosome\u2013Linked Gene-Expression Profiles in Meningiomas"],"prefix":"10.1093","volume":"12","author":[{"given":"Mar\u00eda Dolores","family":"Tabernero","sequence":"first","affiliation":[{"name":"a Unidad de Investigaci\u00f3n, IECSCYL-Hospital Universitario de Salamanca, Salamanca, Spain"}]},{"given":"Ana Bel\u00e9n","family":"Espinosa","sequence":"additional","affiliation":[{"name":"a Unidad de Investigaci\u00f3n, IECSCYL-Hospital Universitario de Salamanca, Salamanca, Spain"}]},{"given":"Angel","family":"Maillo","sequence":"additional","affiliation":[{"name":"b Neurosurgery Service, Hospital Universitario de Salamanca, Salamanca, Spain"}]},{"given":"Olinda","family":"Rebelo","sequence":"additional","affiliation":[{"name":"c Neuropathology Service, Hospital da Universidade de Coimbra, Coimbra, Portugal"}]},{"given":"Jaime Fernandez","family":"Vera","sequence":"additional","affiliation":[{"name":"a Unidad de Investigaci\u00f3n, IECSCYL-Hospital Universitario de Salamanca, Salamanca, Spain"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Sayagues","sequence":"additional","affiliation":[{"name":"d Centro de Investigaci\u00f3n del C\u00e1ncer, Cytometry General Service and Department of Medicine, University of Salamanca, Salamanca, Spain"}]},{"given":"Marta","family":"Merino","sequence":"additional","affiliation":[{"name":"b Neurosurgery Service, Hospital Universitario de Salamanca, Salamanca, Spain"}]},{"given":"Pedro","family":"Diaz","sequence":"additional","affiliation":[{"name":"b Neurosurgery Service, Hospital Universitario de Salamanca, Salamanca, Spain"}]},{"given":"Pablo","family":"Sousa","sequence":"additional","affiliation":[{"name":"b Neurosurgery Service, Hospital Universitario de Salamanca, Salamanca, Spain"}]},{"given":"Alberto","family":"Orfao","sequence":"additional","affiliation":[{"name":"d Centro de Investigaci\u00f3n del C\u00e1ncer, Cytometry General Service and Department of Medicine, University of Salamanca, Salamanca, Spain"}]}],"member":"286","published-online":{"date-parts":[[2007,10,1]]},"reference":[{"key":"2021122208425128200_R1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF00165649","article-title":"Epidemiology and etiology of intracranial meningiomas: A review","volume":"29","author":"Bondy","year":"1996","journal-title":"J Neurooncol"},{"key":"2021122208425128200_R2","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/1097-0142(19930801)72:3<639::AID-CNCR2820720304>3.0.CO;2-P","article-title":"Epidemiology of intracranial meningioma","volume":"72","author":"Longstreth","year":"1993","journal-title":"Cancer"},{"key":"2021122208425128200_R3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/jnen\/63.4.275","article-title":"Meningioma pathology, genetics, and biology","volume":"63","author":"Lamszus","year":"2004","journal-title":"J Neuropathol Exp Neurol"},{"key":"2021122208425128200_R4","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3171\/jns.1982.57.6.0804","article-title":"Spinal cord meningioma","volume":"57","author":"Levy","year":"1982","journal-title":"J Neurosurg"},{"key":"2021122208425128200_R5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1227\/00006123-198908000-00001","article-title":"Spinal meningiomas: Review of 174 operated cases","volume":"25","author":"Solero","year":"1989","journal-title":"Neurosurgery"},{"key":"2021122208425128200_R6","first-page":"164","article-title":"Contribution of cytogenetics and FISH in the diagnosis of meningiomas. 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