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L. Afonso, E. R. Tulman, Z. Lu, et al. \"J. Virol.\" 75, \"The genome of turkey herpesvirus.\" 971 (2001)","DOI":"10.1128\/JVI.75.2.971-978.2001"},{"key":"1","doi-asserted-by":"crossref","unstructured":"A. P. Avakian, R. M. Poston, F. K. Kong, et al. \"Expert Rev. Vaccines.\" 6, \"Automated mass immunization of poultry: the prospect for nonreplicating human adenovirus-vectored in ovo vaccines.\" 457 (2007)","DOI":"10.1586\/14760584.6.3.457"},{"key":"1","doi-asserted-by":"crossref","unstructured":"L. D. Bacon, H. D. Hunt, H. H. Cheng, \"Poult. Sci.\" 79, \"A review of the development of chicken lines to resolve genes determining resistance to diseases.\" 1082 (2000)","DOI":"10.1093\/ps\/79.8.1082"},{"key":"1","unstructured":"M. Bublot, E. Laplace, J. C. Audonnet, \"Acta Virol.\" 43, \"Non-essential loci in the BamHI-I and -F fragments of the HVT FC126 genome.\" 181 (1999)"},{"key":"1","doi-asserted-by":"crossref","unstructured":"M. Bublot, N. Pritchard, F. X. Le Gros, et al. \"J. Comp. Pathol.\" 137, \"Use of a vectored vaccine against infectious bursal disease of chickens in the face of high-titred maternally derived antibody.\" S81 (2007)","DOI":"10.1016\/j.jcpa.2007.04.017"},{"key":"1","doi-asserted-by":"crossref","unstructured":"M. Bublot and J. Sharma \"Marek's disease, an evolving problem.\" , \"Vaccination against Marek's disease.\" 168 (2004)","DOI":"10.1016\/B978-012088379-0\/50017-7"},{"key":"1","doi-asserted-by":"crossref","unstructured":"S. A. Callison, S. M. Riblet, I. Oldoni, et al. \"J. Virol. Methods.\" 139, \"Development and validation of a real-time Taqman PCR assay for the detection and quantitation of infectious laryngotracheitis virus in poultry.\" 31 (2007)","DOI":"10.1016\/j.jviromet.2006.09.001"},{"key":"1","doi-asserted-by":"crossref","unstructured":"B. R. Cho, \"IV. Viral maturation in the feather follicle epithelium. Avian Dis.\" 19, \"Horizontal transmission of turkey herpesvirus to chickens.\" 136 (1975)","DOI":"10.2307\/1588964"},{"key":"1","doi-asserted-by":"crossref","unstructured":"Y. Cho and S. A. Edgar \"Poult. Sci.\" 48, \"Characterization of the infectious bursal agent.\" 2102 (1969)","DOI":"10.3382\/ps.0482102"},{"key":"1","doi-asserted-by":"crossref","unstructured":"A. E. Churchill, W. Baxendale, G. Carrington, \"Vet. Rec.\" 92, \"Viraemia and antibody development in chicks following the administration of turkey herpesvirus.\" 327 (1973)","DOI":"10.1136\/vr.92.13.327"},{"key":"1","unstructured":"J. Cruz-Coy, S. Cook, L. Gergen, et al. \"Double recombinant herpesvirus of turkey for protection against diseases caused by Newcastle disease virus, infectious bursal disease virus and Marek's disease virus. Abstract.\" , (2017)"},{"key":"1","unstructured":"L. F. da Silva, \"Stability, safety and efficacy of a multivalent HVT-vectored vaccine against Marek's disease, Newcastle disease and infectious bursal disease. Abstract.\" , (2018)"},{"key":"1","doi-asserted-by":"crossref","unstructured":"R. Darteil, M. Bublot, E. Laplace, et al. \"Virology.\" 211, \"Herpesvirus of turkey recombinant viruses expressing infectious bursal disease virus (IBDV) VP2 immunogen induce protection against an IBDV virulent challenge in chickens.\" 481 (1995)","DOI":"10.1006\/viro.1995.1430"},{"key":"1","unstructured":"K. M. Dimitrov, A. Clavijo, L. Sneed, \"Rev. Med. Vet.\" 165, \"RNA extraction for molecular detection of Newcastle disease virus\u2014comparative study of three methods.\" 172 (2014)"},{"key":"1","doi-asserted-by":"crossref","unstructured":"J. R. Dunn, S. M. Reddy, M. Niikura, et al. \"Avian Dis.\" 61, \"Evaluation and identification of Marek's disease virus BAC clones as standardized reagents for research.\" 107 (2017)","DOI":"10.1637\/0005-2086-61.1.107"},{"key":"1","doi-asserted-by":"crossref","unstructured":"J. R. Dunn and R. F. Silva \"Avian Dis.\" 56, \"Ability of MEQ-deleted MDV vaccine candidates to adversely affect lymphoid organs and chicken weight gain.\" 494 (2012)","DOI":"10.1637\/10062-011812-Reg.1"},{"key":"1","doi-asserted-by":"crossref","unstructured":"J. R. Dunn, R. F. Silva, L. F. Lee, et al. \"Avian Pathol.\" 41, \"Competition between two virulent Marek's disease virus strains in vivo.\" 267 (2012)","DOI":"10.1080\/03079457.2012.677804"},{"key":"1","doi-asserted-by":"crossref","unstructured":"M. Esaki, A. Godoy, J. K. Rosenberger, et al. \"Avian Dis.\" 57, \"Protection and antibody response caused by turkey herpesvirus vector Newcastle disease vaccine.\" 750 (2013)","DOI":"10.1637\/10540-032613-Reg.1"},{"key":"1","doi-asserted-by":"crossref","unstructured":"M. Esaki, L. Noland, T. Eddins, et al. \"Avian Dis.\" 57, \"Safety and efficacy of a turkey herpesvirus vector laryngotracheitis vaccine for chickens.\" 192 (2013)","DOI":"10.1637\/10383-092412-Reg.1"},{"key":"1","doi-asserted-by":"crossref","unstructured":"J. Fabricant, B. W. Calnek, K. A. Schat, \"Avian Dis.\" 26, \"The early pathogenesis of turkey herpesvirus infection in chickens and turkeys.\" 257 (1982)","DOI":"10.2307\/1590094"},{"key":"1","doi-asserted-by":"crossref","unstructured":"H. Gao, H. Cui, X. Cui, et al. \"PLOS One.\" 6, \"Expression of HA of HPAI H5N1 virus at US2 gene insertion site of turkey herpesvirus induced better protection than that at US10 gene insertion site.\" e22549 (2011)","DOI":"10.1371\/journal.pone.0022549"},{"key":"1","doi-asserted-by":"crossref","unstructured":"Y. Gardin, V. Palya, K. M. Dorsey, et al. \"Avian Dis.\" 60, \"Experimental and field results regarding immunity induced by a recombinant turkey herpesvirus H5 vector vaccine against H5N1 and other H5 highly pathogenic avian influenza virus challenges.\" 232 (2016)","DOI":"10.1637\/11144-050815-ResNote"},{"key":"1","doi-asserted-by":"crossref","unstructured":"J. Gelb, D. J. Jackwood, E. M. Brannick, et al. \"Avian Dis.\" 60, \"Efficacy of recombinant HVT-IBD vaccines administered to broiler chicks from a single breeder flock at 30 and 60 weeks of age.\" 603 (2016)","DOI":"10.1637\/11344-120815-Reg.1"},{"key":"1","doi-asserted-by":"crossref","unstructured":"I. M. Gimeno, A. L. Cortes, N. M. Faiz, et al. \"Avian Dis.\" 59, \"Evaluation of the protection efficacy of a serotype 1 Marek's disease virus-vectored bivalent vaccine against infectious laryngotracheitis and Marek's disease.\" 255 (2015)","DOI":"10.1637\/10966-103014-Reg"},{"key":"1","unstructured":"R. G. Hein, \"6th International Symposium on Avian Corona- and Pneumoviruses and Complicating Pathogens.\" , \"Novel HVT\/ILT recombinant vaccine to simultaneously control infectious laryngotracheitis and Marek's disease in chickens.\" (2009)"},{"key":"1","unstructured":"R. G. Hein, J. F. Rios, A. Aguilera, et al. \"57th Western Poultry Disease Conference. Puerto Vallarta, Mexico.\" , \"Newcastle disease (ND) efficacy in broilers vaccinated at one day of age with the recombinant HVT\/F(ND): INNOVAX-ND-SB challenged with the Mexican vND virus isolate Chimalhuacan.\" 32 (2008)"},{"key":"1","unstructured":"R. G. Hein, G. Slacum, P. Lynch, et al. \"43rd National Meeting on Poultry Health and Processing. 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Saitoh, et al. \"Avian Dis.\" 60, \"Combination of two Marek's disease virus vectors shows effective vaccination against Marek's disease, infectious bursal disease, and Newcastle disease.\" 473 (2016)","DOI":"10.1637\/11359-122615-RegR"},{"key":"1","unstructured":"F. Jirjis, E. Szewczyk, I. Alvarado Ortiz, et al. \"Field safety studies of a novel laryngotracheitis-Newcastle disease-turkey herpesvirus recombinant vaccine in commercial broilers. Abstract.\" , (2017)"},{"key":"1","doi-asserted-by":"crossref","unstructured":"B. F. Kingham, V. Zelnik, J. Kopacek, et al. \"J. Gen. Virol.\" 82, \"The genome of herpesvirus of turkeys: comparative analysis with Marek's disease viruses.\" 1123 (2001)","DOI":"10.1099\/0022-1317-82-5-1123"},{"key":"1","doi-asserted-by":"crossref","unstructured":"S. Lemiere, R. Fernandez, N. Pritchard, et al. \"Avian Dis.\" 55, \"Concomitant turkey herpesvirus-infectious bursal disease vector vaccine and oil-adjuvanted inactivated Newcastle disease vaccine administration: consequences for vaccine intake and protection.\" 642 (2011)","DOI":"10.1637\/9751-040511-ResNote.1"},{"key":"1","doi-asserted-by":"crossref","unstructured":"S. Lemiere, S. Y. Wong, A. L. Saint-Gerand, et al. \"Avian Dis.\" 55, \"Compatibility of turkey herpesvirus-infectious bursal disease vector vaccine with Marek's disease rispens vaccine injected into day-old pullets.\" 113 (2011)","DOI":"10.1637\/9507-081810-ResNote.1"},{"key":"1","doi-asserted-by":"crossref","unstructured":"Y. Li, K. Reddy, S. M. Reid, et al. \"Vaccine.\" 29, \"Recombinant herpesvirus of turkeys as a vector-based vaccine against highly pathogenic H7N1 avian influenza and Marek's disease.\" 8257 (2011)","DOI":"10.1016\/j.vaccine.2011.08.115"},{"key":"1","doi-asserted-by":"crossref","unstructured":"P. J. Miller, D. J. King, C. L. Afonso, et al. \"Vaccine.\" 25, \"Antigenic differences among Newcastle disease virus strains of different genotypes used in vaccine formulation affect viral shedding after a virulent challenge.\" 7238 (2007)","DOI":"10.1016\/j.vaccine.2007.07.017"},{"key":"1","unstructured":"R. W. Morgan, \"42nd National Meeting on Poultry Health and Processing. Ocean City, MD.\" , \"HVT-vectored vaccines: Marek's disease protection and insert efficacy.\" 67 (2007)"},{"key":"1","unstructured":"et al. \"Biological Standards Commission, Manual of diagnostic tests and vaccines for terrestrial animals: mammals, birds and bees, 7th ed.\" , \"Newcastle disease.\" 555 (2012)"},{"key":"1","doi-asserted-by":"crossref","unstructured":"V. Palya, I. Kiss, T. Tatar-Kis, et al. \"Avian Dis.\" 56, \"Advancement in vaccination against Newcastle disease: recombinant HVT NDV provides high clinical protection and reduces challenge virus shedding with the absence of vaccine reactions.\" 282 (2012)","DOI":"10.1637\/9935-091511-Reg.1"},{"key":"1","unstructured":"V. J. Palya, T. Tatar-Kis, T. Mato, et al. \"Interference between different HVT-vectored vaccines applied subcutaneously at day-old in commercial broilers. Abstract.\" , (2010)"},{"key":"1","doi-asserted-by":"crossref","unstructured":"F. Perozo, A. P. Villegas, R. Fernandez, et al. \"Avian Dis.\" 53, \"Efficacy of single dose recombinant herpesvirus of turkey infectious bursal disease virus (IBDV) vaccination against a variant IBDV strain.\" 624 (2009)","DOI":"10.1637\/8687-31009RESNOTE.1"},{"key":"1","doi-asserted-by":"crossref","unstructured":"L. M. B. Prasad and P. B. Spradbrow \"J. Comp. Pathol.\" 90, \"Ultrastructure and infectivity of tissue from normal and immunodepressed chickens inoculated with turkey herpesvirus.\" 47 (1980)","DOI":"10.1016\/0021-9975(80)90027-4"},{"key":"1","unstructured":"H. G. Purchase, \"Adv. Vet. Sci. Comp. Med.\" 16, \"Recent advances in the knowledge of Marek's disease.\" 223 (1972)"},{"key":"1","doi-asserted-by":"crossref","unstructured":"F. Rauw, V. Palya, Y. Gardin, et al. \"Avian Dis.\" 56, \"Efficacy of rHVT-AI vector vaccine in broilers with passive immunity against challenge with two antigenically divergent Egyptian clade 2.2.1 HPAI H5N1 strains.\" 913 (2012)","DOI":"10.1637\/10172-041012-Reg.1"},{"key":"1","doi-asserted-by":"crossref","unstructured":"S. M. Reddy, Y. Izumiya, B. Lupiani, \"Vet. Microbiol.\" 206, \"Marek's disease vaccines: current status, and strategies for improvement and development of vector vaccines.\" 113 (2017)","DOI":"10.1016\/j.vetmic.2016.11.024"},{"key":"1","doi-asserted-by":"crossref","unstructured":"Y. Sadigh, C. Powers, S. Spiro, et al. \"npj Vaccines.\" 3, \"Gallid herpesvirus 3 SB-1 strain as a recombinant viral vector for poultry vaccination.\" 21 (2018)","DOI":"10.1038\/s41541-018-0056-6"},{"key":"1","doi-asserted-by":"crossref","unstructured":"S. M. Singh, S. J. Baigent, L. J. Petherbridge, et al. \"Res. Vet. Sci.\" 89, \"Comparative efficacy of BAC-derived recombinant SB-1 vaccine and the parent wild type strain in preventing replication, shedding and disease induced by virulent Marek's disease virus.\" 140 (2010)","DOI":"10.1016\/j.rvsc.2010.01.010"},{"key":"1","doi-asserted-by":"crossref","unstructured":"A. Vagnozzi, G. Zavala, S. M. Riblet, et al. \"Avian Pathol.\" 41, \"Protection induced by commercially available live-attenuated and recombinant viral vector vaccines against infectious laryngotracheitis virus in broiler chickens.\" 21 (2012)","DOI":"10.1080\/03079457.2011.631983"},{"key":"1","doi-asserted-by":"crossref","unstructured":"S. C. Weli and M. Tryland \"Virol. J.\" 8, \"Avipoxviruses: infection biology and their use as vaccine vectors.\" 49 (2011)","DOI":"10.1186\/1743-422X-8-49"},{"key":"1","doi-asserted-by":"crossref","unstructured":"R. L. Witter, \"Avian Pathol.\" 21, \"Influence of serotype and virus strain on synergism between Marek's disease vaccine viruses.\" 601 (1992)","DOI":"10.1080\/03079459208418881"},{"key":"1","unstructured":"R. L. Witter, \"3rd International Symposium on Marek's Disease.\" , \"Protective synergism among Marek's disease vaccine viruses.\" 398 (1988)"},{"key":"1","doi-asserted-by":"crossref","unstructured":"R. L. Witter, L. D. Bacon, J. G. Calvert, \"Avian Dis.\" 38, \"Partial inhibition by turkey herpesvirus of serotype 2 Marek's disease virus plaque formation and in vivo infectivity.\" 800 (1994)","DOI":"10.2307\/1592117"},{"key":"1","doi-asserted-by":"crossref","unstructured":"R. L. Witter, J. M. Sharma, L. Offenbecker, \"Avian Dis.\" 20, \"Turkey herpesvirus infection in chickens: induction of lymphoproliferative lesions and characterization of vaccinal immunity against Marek's disease.\" 676 (1976)","DOI":"10.2307\/1589448"},{"key":"1","doi-asserted-by":"crossref","unstructured":"R. L. Witter and J. J. Solomon \"Infect. Immun.\" 4, \"Epidemiology of a herpesvirus of turkeys: possible sources and spread of infection in turkey flocks.\" 356 (1971)","DOI":"10.1128\/IAI.4.4.356-361.1971"},{"key":"1","doi-asserted-by":"crossref","unstructured":"M. G. Wise, D. L. Suarez, B. S. Seal, et al. \"J. Clin. 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