{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:31:40Z","timestamp":1793449900450,"version":"4.5.0"},"reference-count":58,"publisher":"American Association of Avian Pathologists (AAAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Avian Diseases"],"published-print":{"date-parts":[[2020,5,18]]},"abstract":"<jats:p>Newcastle disease virus (NDV) vectors expressing avian influenza virus (AIV) hemagglutinin of subtype H5 protect specific pathogen\u2013free chickens from Newcastle disease and avian influenza. However, maternal AIV antibodies (AIV-MDA+) are known to interfere with active immunization by influencing vaccine virus replication and gene expression, resulting in inefficient protection. To overcome this disadvantage, we inserted a transgene encoding a truncated soluble hemagglutinin (HA) in addition to the gene encoding membrane-bound HA from highly pathogenic avian influenza virus (HPAIV) H5N1 into lentogenic NDV Clone 30 genome (rNDVsolH5_H5) to overexpress H5 antigen. Vaccination of 3-wk-old AIV-MDA+ chickens with rNDVsolH5_H5 and subsequent challenge infection with HPAIV H5N1 3 wk later resulted in 100% protection. Vaccination of younger chickens with higher AIV-MDA levels 1 and 2 wk after hatch resulted in protection rates of 40% and 85%, respectively. However, all vaccinated chickens showed strongly reduced shedding of challenge virus compared with age-matched, nonvaccinated control chickens. All control chickens succumbed to the HPAIV infection with a grading in disease progression between the three groups, indicating the influence of AIV-MDAs even at a low level. Furthermore, the shedding and serologic data gathered after immunization indicate sufficient replication of the vaccine virus, which leads to the assumption that lower protection rates in younger AIV-MDA+ chickens are caused by an H5 antigen\u2013specific block and not by the interference of the AIV-MDA and the vaccine virus itself. In summary, solid protective efficacy and reduced virus transmission were achieved in 3-wk-old AIV-MDA+ chickens, which is relevant especially in regions endemically infected with HPAIV H5N1.<\/jats:p>","DOI":"10.1637\/aviandiseases-d-20-00014","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T06:58:29Z","timestamp":1608101909000},"page":"427-436","source":"Crossref","is-referenced-by-count":10,"title":["Protection of Chickens with Maternal Immunity Against Avian Influenza Virus (AIV) by Vaccination with a Novel Recombinant Newcastle Disease Virus Vector"],"prefix":"10.1637","volume":"64","author":[{"given":"Magdalena","family":"Murr","sequence":"first","affiliation":[{"name":"Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, S\u00fcdufer 10, 17493 Greifswald\u2013Insel Riems, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Grund","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic Virology, Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, S\u00fcdufer 10, 17493 Greifswald\u2013Insel Riems, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angele","family":"Breithaupt","sequence":"additional","affiliation":[{"name":"Department of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, S\u00fcdufer 10, 17493 Greifswald\u2013Insel Riems, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Mettenleiter","sequence":"additional","affiliation":[{"name":"Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, S\u00fcdufer 10, 17493 Greifswald\u2013Insel Riems, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"R\u00f6mer-Oberd\u00f6rfer","sequence":"additional","affiliation":[{"name":"Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institute, Federal Research Institute for Animal Health, S\u00fcdufer 10, 17493 Greifswald\u2013Insel Riems, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1212","reference":[{"key":"41","unstructured":"et al.  ,  (2018)"},{"key":"36","doi-asserted-by":"crossref","unstructured":"E Spackman, DA Senne, TJ Myers, et al.  \"J Clin Microbiol.\"  40, \"Development of a real-time reverse transcriptase PCR assay for type A influenza virus and the avian H5 and H7 hemagglutinin subtypes.\" 3256 (2002)","DOI":"10.1128\/JCM.40.9.3256-3260.2002"},{"key":"44","doi-asserted-by":"crossref","unstructured":"DR Kapczynski, M Esaki, KM Dorsey, et al.  \"Vaccine.\"  33, \"Vaccine protection of chickens against antigenically diverse H5 highly pathogenic avian influenza isolates with a live HVT vector vaccine expressing the influenza hemagglutinin gene derived from a clade 2.2 avian influenza virus.\" 1197 (2015)","DOI":"10.1016\/j.vaccine.2014.12.028"},{"key":"49","doi-asserted-by":"crossref","unstructured":"J Mast  and BM Goddeeris  \"Vet Immunol Immunopathol.\"  70, \"Development of immunocompetence of broiler chickens.\" 245 (1999)","DOI":"10.1016\/S0165-2427(99)00079-3"},{"key":"38","doi-asserted-by":"crossref","unstructured":"B Hoffmann, K Depner, H Schirrmeier, et al.  \"J Virol Methods.\"  136, \"A universal heterologous internal control system for duplex real-time RT-PCR assays used in a detection system for pestiviruses.\" 200 (2006)","DOI":"10.1016\/j.jviromet.2006.05.020"},{"key":"47","doi-asserted-by":"crossref","unstructured":"WH Kilany, MK Hassan, M Safwat, et al.  \"Avian Pathol.\"  44, \"Comparison of the effectiveness of rHVT-H5, inactivated H5 and rHVT-H5 with inactivated H5 prime\/boost vaccination regimes in commercial broiler chickens carrying MDAs against HPAI H5N1 clade 2.2.1 virus.\" 333 (2015)","DOI":"10.1080\/03079457.2015.1053840"},{"key":"11","doi-asserted-by":"crossref","unstructured":"JK Kim, G Kayali, D Walker, et al.  \"Proc Natl Acad Sci U. 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De Wit,  \"Pol Vet J.\"  3, \"Gumboro disease: estimation of optimal time of vaccination by the Deventer formula.\" 19 (1998)"}],"container-title":["Avian Diseases"],"original-title":[],"link":[{"URL":"https:\/\/bioone.org\/journals\/avian-diseases\/volume-64\/issue-4\/aviandiseases-D-20-00014\/Protection-of-Chickens-with-Maternal-Immunity-Against-Avian-Influenza-Virus\/10.1637\/aviandiseases-D-20-00014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:46:41Z","timestamp":1793447201000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/avian-diseases\/volume-64\/issue-4\/aviandiseases-D-20-00014\/Protection-of-Chickens-with-Maternal-Immunity-Against-Avian-Influenza-Virus\/10.1637\/aviandiseases-D-20-00014.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,18]]},"references-count":58,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1637\/aviandiseases-d-20-00014","relation":{},"ISSN":["0005-2086","1938-4351"],"issn-type":[{"value":"0005-2086","type":"print"},{"value":"1938-4351","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,18]]}}}