{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T11:05:59Z","timestamp":1794049559740,"version":"4.8.0"},"reference-count":35,"publisher":"American Association of Avian Pathologists (AAAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Avian Diseases"],"published-print":{"date-parts":[[2023,1,11]]},"abstract":"<jats:p>Estudio recapitulativo- Reovirus aviares de casos cl\u00ednicos de tenosinovitis: una descripci\u00f3n general de los enfoques de diagn\u00f3stico y una revisi\u00f3n de 10 a\u00f1os de aislamientos y caracterizaci\u00f3n gen\u00e9tica. La tenosinovitis\/artritis viral inducida por reovirus es una enfermedad econ\u00f3micamente significativa de la avicultura. Las aves afectadas presentan cojera, articulaciones de corvejones o patas inflamadas unilateral o bilateralmente y\/o renuencia a moverse. En casos severos, puede ocurrir la ruptura de los tendones del gastrocnemio o del flexor digital, y puede ser necesario una eliminaci\u00f3n de aves afectadas significativa. Hist\u00f3ricamente, la vacunaci\u00f3n con una combinaci\u00f3n de vacunas vivas modificadas e inactivadas ha controlado con \u00e9xito la enfermedad. La vacunaci\u00f3n adecuada redujo la transmisi\u00f3n vertical y proporcion\u00f3 anticuerpos derivados de las reproductoras a la progenie para protegerlos contra la enfermedad, a una edad en la que eran m\u00e1s susceptibles. A partir de los a\u00f1os 2011-2012, se observ\u00f3 una mayor incidencia de tenosinovitis\/artritis viral en pollos y pavos. En los pollos, la progenie de reproductores vacunados con reovirus se vio afectada, lo que sugiere que las vacunas comerciales no brindaron una protecci\u00f3n adecuada contra la enfermedad. En pavos, la enfermedad cl\u00ednica fue principalmente en machos, aunque las hembras tambi\u00e9n pueden verse afectadas. Los signos m\u00e1s significativos se observaron alrededor de las 14 a 16 semanas de edad e incluyen renuencia a moverse y cojera en una o ambas piernas. La incidencia de tenosinovitis\/artritis viral actualmente sigue siendo alta. Los reovirus aislados de casos cl\u00ednicos se caracterizan gen\u00e9tica y antig\u00e9nicamente como variantes, lo que significa que son diferentes de las cepas vacunales. La caracterizaci\u00f3n de los aislamientos de campo revela m\u00faltiples genotipos y serotipos nuevos que son significativamente diferentes de las vacunas comerciales y entre s\u00ed. En 2012, se aisl\u00f3 un solo virus prevalente de la mayor\u00eda de los casos presentados al Centro de Investigaci\u00f3n y Diagn\u00f3stico Av\u00edcola de la Universidad de Georgia. La caracterizaci\u00f3n gen\u00e9tica de la prote\u00edna sigma C revel\u00f3 que los primeros aislamientos pertenec\u00edan al grupo gen\u00e9tico 5 (GC5). Poco despu\u00e9s de la identificaci\u00f3n inicial de la variante GC5 del reovirus, muchas empresas de pollos de engorde incorporaron estos aislamientos de sus granjas en sus vacunas aut\u00f3genas y contin\u00faan haci\u00e9ndolo en la actualidad. La incidencia de aislamientos de campo de GC5 ha disminuido significativamente, probablemente debido al uso generalizado de los aislamientos en vacunas aut\u00f3genas. Desafortunadamente, han surgido variantes de reovirus que pertenecen a m\u00faltiples grupos gen\u00e9ticos, a pesar de la inclusi\u00f3n de estos aislados en vacunas aut\u00f3genas. En esta revisi\u00f3n, se cubrir\u00e1 una descripci\u00f3n general de la nomenclatura, la recolecci\u00f3n de muestras y las pruebas de diagn\u00f3stico, y se brindar\u00e1 un resumen de las variantes de reovirus aisladas de casos cl\u00ednicos de tenosinovitis\/artritis viral durante los \u00faltimos 10 a\u00f1os.<\/jats:p>","DOI":"10.1637\/aviandiseases-d-22-99990","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T16:38:20Z","timestamp":1674491900000},"page":"420-426","source":"Crossref","is-referenced-by-count":22,"title":["Avian Reoviruses from Clinical Cases of Tenosynovitis: An Overview of Diagnostic Approaches and 10-Year Review of Isolations and Genetic Characterization"],"prefix":"10.1637","volume":"66","author":[{"given":"Holly S.","family":"Sellers","sequence":"first","affiliation":[{"name":"Poultry Diagnostic and Research Center, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1212","reference":[{"key":"34","doi-asserted-by":"crossref","unstructured":"K Tamura, G Stecher, S Kumar,  \"Mol Biol Evol.\"  38, \"MEGA11: Molecular Evolutionary Genetics Analysis Version 11.\" 3022 (2021)","DOI":"10.1093\/molbev\/msab120"},{"key":"27","doi-asserted-by":"crossref","unstructured":"M Mase, M Gotou, D Inoue, et al.  \"Avian Dis.\"  65, \"Genetic analysis of avian reovirus isolated from chickens in Japan.\" 346 (2021)","DOI":"10.1637\/0005-2086-65.3.346"},{"key":"24","doi-asserted-by":"crossref","unstructured":"L Ma, H Shi, M Zhang, et al.  \"Front Vet Sci.\"  7, \"Establishment of a real-time recombinase polymerase amplification assay for the detection of avian reovirus.\" 551350 (2020)","DOI":"10.3389\/fvets.2020.551350"},{"key":"29","doi-asserted-by":"crossref","unstructured":"SO Souza, S De Carli, VR Lunge, et al.  \"Poult Sci.\"  97, \"Pathological and molecular findings of avian reoviruses from clinical cases of tenosynovitis in poultry flocks from Brazil.\" 3550 (2018)","DOI":"10.3382\/ps\/pey239"},{"key":"30","doi-asserted-by":"crossref","unstructured":"T Yan, L Guo, X Jiang, et al.  \"Vet Microbiol.\"  260, \"Discovery of a novel recombinant Avian Orthoreovirus in China.\" 109094 (2021)","DOI":"10.1016\/j.vetmic.2021.109094"},{"key":"13","doi-asserted-by":"crossref","unstructured":"S Ega\u00f1a-Labrin, R Hauck, A Figueroa, et al.  \"Sci Rep.\"  9, \"Genotypic characterization of emerging avian reovirus genetic variants in California.\" 9351 (2019)","DOI":"10.1038\/s41598-019-45494-4"},{"key":"1","unstructured":"NO. 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Sellers,  \"Vet Microbiol.\"  206, \"Current limitations in control of viral arthritis and tenosynovitis caused by avian reoviruses in commercial poultry.\" 152 (2017)","DOI":"10.1016\/j.vetmic.2016.12.014"},{"key":"22","doi-asserted-by":"crossref","unstructured":"L Huang, Z Xie, L Xie, et al.  \"Virol J.\"  12, \"A duplex real-time PCR assay for the detection and quantification of avian reovirus and Mycoplasma synoviae.\" 22 (2015)","DOI":"10.1186\/s12985-015-0255-y"}],"container-title":["Avian Diseases"],"original-title":[],"link":[{"URL":"https:\/\/bioone.org\/journals\/avian-diseases\/volume-66\/issue-4\/aviandiseases-D-22-99990\/Avian-Reoviruses-from-Clinical-Cases-of-Tenosynovitis--An-Overview\/10.1637\/aviandiseases-D-22-99990.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:22:31Z","timestamp":1793427751000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/avian-diseases\/volume-66\/issue-4\/aviandiseases-D-22-99990\/Avian-Reoviruses-from-Clinical-Cases-of-Tenosynovitis--An-Overview\/10.1637\/aviandiseases-D-22-99990.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,11]]},"references-count":35,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12,1]]}},"URL":"https:\/\/doi.org\/10.1637\/aviandiseases-d-22-99990","relation":{},"ISSN":["0005-2086","1938-4351"],"issn-type":[{"value":"0005-2086","type":"print"},{"value":"1938-4351","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,11]]}}}