{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:34:54Z","timestamp":1793428494394,"version":"4.5.0"},"reference-count":48,"publisher":"American Association of Avian Pathologists (AAAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Avian Diseases"],"published-print":{"date-parts":[[2022,12,20]]},"abstract":"<jats:p>Estudio recapitulativo- Evaluaci\u00f3n de patogenicidad y antigenicidad de reovirus aviares y control de enfermedades mediante vacunaci\u00f3n Los reovirus aviares son ubicuos en la producci\u00f3n av\u00edcola en todo el mundo y pueden transmitirse por v\u00edas vertical u horizontal entre los pollos. La patogenicidad de los reovirus puede variar desde virus muy pat\u00f3genos que afectan m\u00faltiples tejidos y \u00f3rganos hasta virus apat\u00f3genos. Los reovirus aviares se han asociado con muchas presentaciones de enfermedades, y dos de las enfermedades m\u00e1s significativas desde el punto de vista econ\u00f3mico son la artritis\/tenosinovitis viral y la enteritis viral. La artritis\/tenosinovitis viral se ha reconocido desde la d\u00e9cada de 1950 y esencialmente desapareci\u00f3 despu\u00e9s del desarrollo de vacunas vivas atenuadas e inactivadas en la d\u00e9cada de 1980, pero resurgi\u00f3 en 2011 debido a la aparici\u00f3n de variantes antig\u00e9nicas. La enteritis viral se reconoci\u00f3 por primera vez en la d\u00e9cada de 1970 y se convirti\u00f3 en la enfermedad predominante asociada a reovirus entre 2006 y 2011 debido a la aparici\u00f3n de reovirus enterotr\u00f3picos pat\u00f3genos. La patogenicidad de los aislados de reovirus se puede evaluar de varias maneras, incluida la inoculaci\u00f3n de pollos de engorde de un d\u00eda con t\u00edtulos bajos de anticuerpos maternos contra el reovirus a trav\u00e9s de la v\u00eda del cojinete almohadilla plantar o la v\u00eda oral e intratraqueal. Los reovirus pat\u00f3genos inducen la inflamaci\u00f3n de las almohadillas de las patas dentro de los tres d\u00edas posteriores a la inoculaci\u00f3n, y m\u00e1s reovirus pat\u00f3genos pueden diseminarse y da\u00f1ar los \u00f3rganos viscerales. Solo las infecciones por reovirus en pollos j\u00f3venes resultan en enfermedades debido a la resistencia relacionada con la edad al desarrollo de la enfermedad. Los reovirus existen como muchos serotipos y subtipos con varios grados de interrelaci\u00f3n. Las primeras cepas de reovirus en los Estados Unidos estaban relacionadas antig\u00e9nicamente entre s\u00ed y se conocen como virus relacionados a la cepa S1133, pero en la d\u00e9cada de 2000 surgieron reovirus que eran antig\u00e9nicamente diferentes de los virus relacionados con S1133. Se ha utilizado el ensayo de neutralizaci\u00f3n de virus con antisueros policlonales para clasificar las variantes de reovirus emergentes en serogrupos. Las primeras vacunas contra el reovirus se desarrollaron en la d\u00e9cada de 1970, y en la d\u00e9cada de 1980 se establecieron programas de vacunaci\u00f3n para reproductores que proteg\u00edan a los reproductores, preven\u00edan la transmisi\u00f3n vertical de reovirus y proporcionaban inmunidad materna a la progenie durante las cruciales primeras tres semanas de vida. Con la aparici\u00f3n de variantes antig\u00e9nicas de reovirus en la d\u00e9cada de 2000, los programas de vacunaci\u00f3n con vacunas relacionadas con la cepa S1133 se volvieron ineficaces. La industria av\u00edcola se ha basado en la vacunaci\u00f3n con vacunas aut\u00f3genas de reovirus inactivado para aliviar las p\u00e9rdidas debidas a artritis\/tenosinovitis viral y enteritis viral. Los aislados de virus utilizados para las vacunas aut\u00f3genas deben actualizarse con regularidad y se seleccionan seg\u00fan el patotipo, el serotipo o el genotipo Sigma C (\u03c3C). Las vacunas vivas atenuadas S1133 todav\u00eda se usan en pollos reproductores para el efecto de preparaci\u00f3n, seguidas de una o m\u00e1s inyecciones de las vacunas inactivadas autorizadas y\/o aut\u00f3genas. La v\u00eda de vacunaci\u00f3n y el n\u00famero de dosis recibidas por los pollos reproductores son muy importantes para una respuesta de anticuerpos suficiente. La vacunaci\u00f3n intramuscular con vacunas inactivadas provoca la mayor respuesta de anticuerpos, mientras que la vacunaci\u00f3n subcut\u00e1nea con vacunas inactivadas provoca una baja respuesta de anticuerpos. M\u00e1s recientemente, la investigaci\u00f3n se ha centrado en el desarrollo de vacunas alternativas y estrategias de vacunaci\u00f3n. Se desarroll\u00f3 una vacuna de reovirus variante inactivada que provoca protecci\u00f3n contra m\u00faltiples serotipos variantes, y se han descrito vacunas experimentales recombinantes y de subunidades que muestran potencial. Se necesita m\u00e1s investigaci\u00f3n para desarrollar mejores vacunas, programas de vacunaci\u00f3n y otras medidas de control para prevenir la infecci\u00f3n, transmisi\u00f3n y p\u00e9rdidas por reovirus debido a la enfermedad.<\/jats:p>","DOI":"10.1637\/aviandiseases-d-22-99994","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T01:08:05Z","timestamp":1671584885000},"page":"435-442","source":"Crossref","is-referenced-by-count":27,"title":["Evaluation of Pathogenicity and Antigenicity of Avian Reoviruses and Disease Control Through Vaccination"],"prefix":"10.1637","volume":"66","author":[{"given":"Milos","family":"Markis","sequence":"first","affiliation":[{"name":"AviServe LLC, 1 Innovation Way, STE 100, Newark, DE 19711"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1212","reference":[{"key":"6","doi-asserted-by":"crossref","unstructured":"L. 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Sellers,  \"Vet Microbiol.\"  206, \"Current limitations in control of viral arthritis and tenosynovitis caused by avian reoviruses in commercial poultry.\" 152 (2017)","DOI":"10.1016\/j.vetmic.2016.12.014"},{"key":"10","doi-asserted-by":"crossref","unstructured":"FJ Sterner, JK Rosenberger, A Margolin, et al.  \"Avian Dis.\"  33, \"In vitro and in vivo characterization of avian reoviruses. II. Clinical evaluation of chickens infected with two avian reovirus pathotypes.\" 545 (1989)","DOI":"10.2307\/1591119"},{"key":"3","doi-asserted-by":"crossref","unstructured":"DE Roessler  and JK Rosenberger  \"Avian Dis.\"  33, \"In vitro and in vivo characterization of avian reoviruses. III. Host factors affecting virulence and persistence.\" 555 (1989)","DOI":"10.2307\/1591120"},{"key":"35","doi-asserted-by":"crossref","unstructured":"L Van der Heide, M Kalbac, M Brustolon,  \"Avian Dis.\"  27, \"Development of an attenuated apathogenic reovirus vaccine against viral arthritis\/tenosynovitis.\" 698 (1983)","DOI":"10.2307\/1590312"},{"key":"4","doi-asserted-by":"crossref","unstructured":"JK Rosenberger, FJ Sterner, S Botts, et al.  \"Avian Dis.\"  33, \"In vitro and in vivo characterization of avian reoviruses. I. Pathogenicity and antigenic relatedness of several avian reovirus isolates.\" 535 (1989)","DOI":"10.2307\/1591118"},{"key":"19","doi-asserted-by":"crossref","unstructured":"KM Kerr  and NO Olson  \"Avian Dis.\"  13, \"Pathology of chickens experimentally inoculated or contact-infected with an arthritis-producing virus.\" 729 (1969)","DOI":"10.2307\/1588581"}],"container-title":["Avian Diseases"],"original-title":[],"link":[{"URL":"https:\/\/bioone.org\/journals\/avian-diseases\/volume-66\/issue-4\/aviandiseases-D-22-99994\/Evaluation-of-Pathogenicity-and-Antigenicity-of-Avian-Reoviruses-and-Disease\/10.1637\/aviandiseases-D-22-99994.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:28:54Z","timestamp":1793428134000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/avian-diseases\/volume-66\/issue-4\/aviandiseases-D-22-99994\/Evaluation-of-Pathogenicity-and-Antigenicity-of-Avian-Reoviruses-and-Disease\/10.1637\/aviandiseases-D-22-99994.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":48,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12,1]]}},"URL":"https:\/\/doi.org\/10.1637\/aviandiseases-d-22-99994","relation":{},"ISSN":["0005-2086","1938-4351"],"issn-type":[{"value":"0005-2086","type":"print"},{"value":"1938-4351","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,20]]}}}