{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:05:13Z","timestamp":1793135113260,"version":"4.5.0"},"reference-count":31,"publisher":"American Association of Avian Pathologists (AAAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Avian Diseases"],"published-print":{"date-parts":[[2025,8,26]]},"abstract":"<jats:p>Patogenia de un aislamiento de reovirus aviar con tropismo ent\u00e9rico y articular. Los reovirus aviares (ARV) del grupo gen\u00e9tico 2 representan un grupo amplio y heterog\u00e9neo de reovirus aviares circulantes actualmente aislados de casos cl\u00ednicos de tenosinovitis y de malabsorci\u00f3n intestinal. En este estudio, se investig\u00f3 la patog\u00e9nesis de un aislado de reovirus aviar del grupo gen\u00e9tico 2 mediante PCR cuantitativa con transcriptasa inversa (RT-qPCR), hibridaci\u00f3n in situ (ISH) e histopatolog\u00eda, tras inoculaci\u00f3n oral o en el cojinete plantar. La RT-qPCR detect\u00f3 al reovirus aviar en el tend\u00f3n flexor digital, coraz\u00f3n, pulm\u00f3n, h\u00edgado, bazo, ri\u00f1\u00f3n, duodeno, ciego, bolsa cloacal y timo. La mayor carga viral del reovirus aviar se observ\u00f3 en el tracto intestinal entre las 36 y 72 horas postinoculaci\u00f3n (hpi). La hibridaci\u00f3n in situ demostr\u00f3 la presencia del reovirus aviar en enterocitos de las vellosidades a lo largo del intestino, c\u00e9lulas epiteliales asociadas a fol\u00edculos (FAE) de la bursa y la membrana sinovial del tend\u00f3n. La histopatolog\u00eda intestinal consisti\u00f3 en sincitios raros con inflamaci\u00f3n insignificante, mientras que en los tejidos sinoviales se observ\u00f3 una inflamaci\u00f3n marcada. No se pudo determinar histol\u00f3gicamente la identidad de los enterocitos infectados como \u201cc\u00e9lulas M\u201d aviares ni la de las c\u00e9lulas del revestimiento sinovial infectadas como sinoviocitos similares a macr\u00f3fagos (MLS). Sin embargo, la susceptibilidad de estos diversos tipos celulares a la infecci\u00f3n con un reovirus aviar del grupo gen\u00e9tico 2 demuestra posibles funciones ent\u00e9ricas y artr\u00edticas simult\u00e1neas en la patog\u00e9nesis de estos reovirus.<\/jats:p>","DOI":"10.1637\/aviandiseases-d-25-00007","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T08:30:04Z","timestamp":1758184204000},"page":"275-280","source":"Crossref","is-referenced-by-count":3,"title":["Pathogenesis of an Avian Reovirus Isolate Displaying Enteric and Arthritic Tropisms"],"prefix":"10.1637","volume":"69","author":[{"given":"Kathryn","family":"McCullough","sequence":"first","affiliation":[{"name":"Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Linnemann","sequence":"additional","affiliation":[{"name":"Poultry Diagnostic and Research Center, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Gauthiersloan","sequence":"additional","affiliation":[{"name":"Poultry Diagnostic and Research Center, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6151-4377","authenticated-orcid":false,"given":"Holly S.","family":"Sellers","sequence":"additional","affiliation":[{"name":"Poultry Diagnostic and Research Center, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1212","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"D. 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Jones,  \"Diseases of poultry.\"  \"Reovirus infections.\" 351 (2013)","DOI":"10.1002\/9781119421481.ch11"},{"key":"3","doi-asserted-by":"crossref","unstructured":"J Benavente  and J Mart\u00ednez-Costas  \"Virus Res.\"  123, \"Avian reovirus: Structure and biology.\" 105 (2007)","DOI":"10.1016\/j.virusres.2006.09.005"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Y Ni  and MC Kemp  \"Avian Dis.\"  39, \"A comparative study of avian reovirus pathogenicity: virus spread and replication and induction of lesions.\" 554 (1995)","DOI":"10.2307\/1591809"},{"key":"25","doi-asserted-by":"crossref","unstructured":"D O'Hara, M Patrick, D Cepica, et al.  \"J Virol.\"  75, \"Avian reovirus major \u00b5-class outer capsid protein influences efficiency of productive macrophage infection in a virus strain-specific manner.\" 5027 (2001)","DOI":"10.1128\/JVI.75.11.5027-5035.2001"},{"key":"24","doi-asserted-by":"crossref","unstructured":"JN Mills  and GE Wilcox  \"Avian Pathol.\"  22, \"Replication of four antigenic types of avian reovirus in subpopulations of chicken leukocytes.\" 353 (1993)","DOI":"10.1080\/03079459308418926"},{"key":"10","doi-asserted-by":"crossref","unstructured":"KI Kang, M El-Gazzar, HS Sellers, et al.  \"Avian Pathol.\"  41, \"Investigation into the aetiology of runting and stunting syndrome in chickens.\" 41 (2012)","DOI":"10.1080\/03079457.2011.632402"}],"container-title":["Avian Diseases"],"original-title":[],"link":[{"URL":"https:\/\/bioone.org\/journals\/avian-diseases\/volume-69\/issue-3\/aviandiseases-D-25-00007\/Pathogenesis-of-an-Avian-Reovirus-Isolate-Displaying-Enteric-and-Arthritic\/10.1637\/aviandiseases-D-25-00007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:54:04Z","timestamp":1791240844000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/avian-diseases\/volume-69\/issue-3\/aviandiseases-D-25-00007\/Pathogenesis-of-an-Avian-Reovirus-Isolate-Displaying-Enteric-and-Arthritic\/10.1637\/aviandiseases-D-25-00007.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.1637\/aviandiseases-d-25-00007","relation":{},"ISSN":["0005-2086","1938-4351"],"issn-type":[{"value":"0005-2086","type":"print"},{"value":"1938-4351","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]}}}