{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:56:46Z","timestamp":1791237406314,"version":"4.1.0"},"reference-count":46,"publisher":"American Association of Avian Pathologists (AAAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Avian Diseases"],"published-print":{"date-parts":[[2026,3,5]]},"abstract":"<jats:p>Evaluaci\u00f3n del efecto del \u00e1cido acetilsalic\u00edlico en pavipollos infectados experimentalmente con coccidios. El \u00e1cido acetilsalic\u00edlico, originalmente conocido como aspirina, es un antiinflamatorio no esteroideo com\u00fan, utilizado en medicina humana y veterinaria para aliviar el dolor y la pirexia causados por procesos inflamatorios. Existe informaci\u00f3n limitada sobre la eficacia del \u00e1cido acetilsalic\u00edlico en la producci\u00f3n de pavos. El objetivo de este estudio fue investigar el efecto del \u00e1cido acetilsalic\u00edlico en pavitos con enteritis por coccidia inducida. Se realizaron dos ensayos experimentales. En ambos, los pavos se dividieron en cuatro grupos: sin coccidios + sin \u00e1cido acetilsalic\u00edlico; sin coccidios + \u00e1cido acetilsalic\u00edlico (NA); coccidios + sin \u00e1cido acetilsalic\u00edlico (CN); y coccidios + \u00e1cido acetilsalic\u00edlico (CA). En ambos ensayos, a los pavos de los grupos CN y CA se les administr\u00f3 una dosis 100 veces superior a la de una vacuna comercial contra coccidios en pavos. A partir de las 48 h posteriores a la inoculaci\u00f3n y durante 7 d\u00edas, los pavos de los grupos NA y CA recibieron \u00e1cido acetilsalic\u00edlico (50 mg\/kg por d\u00eda). Para el Ensayo 1, el \u00e1cido acetilsalic\u00edlico se administr\u00f3 por sonda oral dos veces al d\u00eda, mientras que en el Ensayo 2 (T2), el \u00e1cido acetilsalic\u00edlico estaba en el agua de bebida. Se registraron diariamente los pesos de los pavitos y las temperaturas cloacales. Se recolect\u00f3 sangre diariamente de dos aves seleccionadas al azar de cada grupo para el an\u00e1lisis bioqu\u00edmico y para evaluar los niveles s\u00e9ricos de \u00e1cido salic\u00edlico y \u00f3xido n\u00edtrico (NO). Al final de los ensayos, se examinaron histol\u00f3gicamente los tejidos y se evalu\u00f3 la expresi\u00f3n de genes inmunes. La infecci\u00f3n por coccidios fue el factor que tuvo la influencia m\u00e1s significativa en la mayor\u00eda de los par\u00e1metros medidos. El \u00e1cido acetilsalic\u00edlico tuvo un efecto m\u00ednimo o nulo en la reducci\u00f3n de los signos cl\u00ednicos, la minimizaci\u00f3n de la p\u00e9rdida de peso o el control de la temperatura corporal. Estos hallazgos pueden deberse a la r\u00e1pida eliminaci\u00f3n del f\u00e1rmaco o a que las aves enfermas no consumieron suficiente \u00e1cido acetilsalic\u00edlico. En el Ensayo 2, se estim\u00f3 que los pavitos del grupo CA consumieron 31 mg\/kg de \u00e1cido acetilsalic\u00edlico o menos por d\u00eda. Aunque la concentraci\u00f3n en el agua de bebida se calcul\u00f3 para que coincidiera con la ingesta diaria total (50 mg\/kg al d\u00eda), el r\u00e1pido metabolismo del \u00e1cido acetilsalic\u00edlico implic\u00f3 que la ingesti\u00f3n continua de niveles bajos podr\u00eda no haber alcanzado el umbral plasm\u00e1tico terap\u00e9utico alcanzado con dos o tres dosis diarias en bolo. Dado que el AAS se metaboliza r\u00e1pidamente, podr\u00eda requerirse una dosis diaria total mayor cuando se administra en el agua de bebida para mantener concentraciones s\u00e9ricas efectivas en comparaci\u00f3n con la administraci\u00f3n en bolo. Si bien el an\u00e1lisis de NO s\u00e9rico y de expresi\u00f3n g\u00e9nica tisular mostr\u00f3 que la infecci\u00f3n por coccidios induce predominantemente una respuesta inflamatoria, el efecto antiinflamatorio del \u00e1cido acetilsalic\u00edlico administrado a las aves de los grupos NA o CA fue nulo o m\u00ednimo. Este estudio destaca la complejidad de los efectos del \u00e1cido acetilsalic\u00edlico en los pavos.<\/jats:p>","DOI":"10.1637\/aviandiseases-d-25-00029","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:34:21Z","timestamp":1775194461000},"page":"99-111","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Effect of Acetylsalicylic Acid in Turkey Poults Experimentally Infected with Coccidia"],"prefix":"10.1637","volume":"70","author":[{"given":"Aaliyah","family":"Gore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pok Man","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Yeatts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Baynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raveendra R.","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-1004","authenticated-orcid":false,"given":"Rocio","family":"Crespo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1212","reference":[{"key":"35","doi-asserted-by":"crossref","unstructured":"PC. Allen,  \"Poult Sci.\"  76, \"Nitric oxide production during Eimeria tenella infections in chickens.\" 810 (1997)","DOI":"10.1093\/ps\/76.6.810"},{"key":"22","doi-asserted-by":"publisher","unstructured":"V Vrba  and M Pakandl  \"Int J Parasitol.\"  44, \"Coccidia of turkey: from isolation, characterisation and comparison to molecular phylogeny and molecular diagnostics.\" 985 (2014)","DOI":"10.1016\/j.ijpara.2014.06.004"},{"key":"38","doi-asserted-by":"publisher","unstructured":"MFA Baxter, JD Latorre, S Dridi, et al.  \"Front Vet Sci.\"  6, \"Identification of serum biomarkers for intestinal integrity in a broiler chicken malabsorption model.\" 144 (2019)","DOI":"10.3389\/fvets.2019.00144"},{"key":"1","doi-asserted-by":"crossref","unstructured":"S Calatayud  and JV Esplugues  \"NSAIDs and aspirin: recent advances and implications for clinical management.\"  \"Chemistry, pharmacodynamics, and pharmacokinetics of NSAIDs.\" 3 (2016)","DOI":"10.1007\/978-3-319-33889-7_1"},{"key":"2","doi-asserted-by":"crossref","unstructured":"K. Schr\u00f6r,  \"Acetylsalicylic acid.\"  \"Pharmacology.\" (2016)","DOI":"10.1002\/9783527685059"},{"key":"3","unstructured":"H Arif  and S Aggarwal  \"Salicylic acid (aspirin).\"  (2024)"},{"key":"4","doi-asserted-by":"publisher","unstructured":"M Kopcha, JB Kaneene, ME Shea, et al.  \"J Am Vet Med Assoc.\"  201, \"Use of nonsteroidal anti-inflammatory drugs in food animal practice.\" 1868 (1992)","DOI":"10.2460\/javma.1992.201.12.1868"},{"key":"5","doi-asserted-by":"publisher","unstructured":"GW Smith, JL Davis, LA Tell, et al.  \"J Am Vet Med Assoc.\"  232, \"Extralabel use of nonsteroidal anti-inflammatory drugs in cattle.\" 697 (2008)","DOI":"10.2460\/javma.232.5.697"},{"key":"6","doi-asserted-by":"publisher","unstructured":"M Alagawany, MR Farag, ME Abd El-Hack, et al.  \"World Poult Sci J.\"  73, \"Use of acetylsalicylic acid as a feed additive in poultry nutrition.\" 633 (2017)","DOI":"10.1017\/S0043933917000253"},{"key":"7","doi-asserted-by":"publisher","unstructured":"ERM Almeida, SL G\u00f3rniak, MC Di Gregorio, et al.  \"Animal.\"  1, \"Safety and growth-promoting potential of repeated administration of sodium salicylate to broilers.\" 100026 (2022)","DOI":"10.1016\/j.anopes.2022.100026"},{"key":"8","doi-asserted-by":"publisher","unstructured":"P Konieczka, M Barszcz, P Kowalczyk, et al.  \"Vet Res.\"  50, \"The potential of acetylsalicylic acid and vitamin E in modulating inflammatory cascades in chickens under lipopolysaccharide-induced inflammation.\" 65 (2019)","DOI":"10.1186\/s13567-019-0685-4"},{"key":"9","doi-asserted-by":"publisher","unstructured":"P Damian, AL Craigmill, JE Riviere,  \"J Am Vet Med Assoc.\"  211, \"Extralabel use of nonsteroidal anti-inflammatory drugs.\" 860 (1997)","DOI":"10.2460\/javma.1997.211.07.860"},{"key":"11","doi-asserted-by":"publisher","unstructured":"HS Lillehoj  and G Li  \"Avian Dis.\"  48, \"Nitric oxide production by macrophages stimulated with coccidia sporozoites, lipopolysaccharide, or interferon-gamma, and its dynamic changes in SC and TK strains of chickens infected with Eimeria tenella.\" 244 (2004)","DOI":"10.1637\/7054"},{"key":"12","doi-asserted-by":"publisher","unstructured":"M Arendt, J Elissa, N Schmidt, et al.  \"Vet Immunol Immunopathol.\"  218, \"Investigating the role of interleukin 10 on Eimeria intestinal pathogenesis in broiler chickens.\" 109934 (2019)","DOI":"10.1016\/j.vetimm.2019.109934"},{"key":"13","doi-asserted-by":"publisher","unstructured":"Y Lee, M Lu, HS Lillehoj,  \"Vaccines.\"  10, \"Coccidiosis: recent progress in host immunity and alternatives to antibiotic strategies.\" 215 (2022)","DOI":"10.3390\/vaccines10020215"},{"key":"14","unstructured":"\"Poultry industry manual.\"  (2013)"},{"key":"15","unstructured":"\"Poultry coccidiosis diagnostic and testing procedures.\"  (2007)"},{"key":"16","doi-asserted-by":"publisher","unstructured":"WO Wilson  and A Woodard  \"Poult Sci.\"  34, \"Some factors affecting body temperature of turkeys.\" 369 (1955)","DOI":"10.3382\/ps.0340369"},{"key":"17","doi-asserted-by":"publisher","unstructured":"D Adams, E Gruber, H Sather, et al.  \"Poultry.\"  1, \"Evaluation of growing turkey blood biochemistry panel measured using the VetScan VS2.\" 138 (2022)","DOI":"10.3390\/poultry1020012"},{"key":"18","doi-asserted-by":"publisher","unstructured":"B Po'zniak, \u015a Marcin, K Jaworski, et al.  \"Br Poult Sci.\"  54, \"Comparative pharmacokinetics of acetylsalicylic acid and sodium salicylate in chickens and turkeys.\" 538 (2013)","DOI":"10.1080\/00071668.2013.809403"},{"key":"19","doi-asserted-by":"publisher","unstructured":"B Po'zniak, M \u015awita\u0142a, K Bobrek, et al.  \"Br Poult Sci.\"  53, \"Adverse effects associated with high-dose acetylsalicylic acid and sodium salicylate treatment in broilers.\" 777 (2012)","DOI":"10.1080\/00071668.2012.745929"},{"key":"21","doi-asserted-by":"publisher","unstructured":"AC Voeten, WW Braunius, FW Orthel, et al.  \"Vet Q.\"  10, \"Influence of coccidiosis on growth rate and feed conversion in broilers after experimental infections with Eimeria acervulina and Eimeria maxima.\" 256 (1988)","DOI":"10.1080\/01652176.1988.9694182"},{"key":"23","doi-asserted-by":"publisher","unstructured":"HS Nakaue, CW Weber, BL Reid,  \"Exp Biol Med.\"  125, \"The influence of acetyl-salicylic acid on growth and some respiratory enzymes in broiler chicks.\" 663 (1967)","DOI":"10.3181\/00379727-125-32173"},{"key":"24","doi-asserted-by":"publisher","unstructured":"AA Romanovsky  and M Sz\u00e9kely  \"Med. Hypotheses.\"  50, \"Fever and hypothermia: two adaptive thermoregulatory responses to systemic inflammation.\" 219 (1980)","DOI":"10.1016\/S0306-9877(98)90022-6"},{"key":"25","doi-asserted-by":"publisher","unstructured":"HM. Hafez,  \"Eur Poult Sci.\"  71, \"Poultry coccidiosis: prevention and control approaches.\" 2 (2008)","DOI":"10.1016\/S0003-9098(25)00872-0"},{"key":"26","doi-asserted-by":"crossref","unstructured":"R. Crespo,  \"Diseases of poultry.\"  \"Developmental, metabolic, and other noninfectious disorders.\" 1286 (2020)","DOI":"10.1002\/9781119371199.ch30"},{"key":"27","doi-asserted-by":"publisher","unstructured":"LC Senay  and ML Christensen  \"J Appl Physiol.\"  20, \"Changes in blood plasma during progressive dehydration.\" 1107 (1965)","DOI":"10.1152\/jappl.1965.20.6.1136"},{"key":"28","doi-asserted-by":"publisher","unstructured":"MD Ruff, PC Allen, MB Chute,  \"Poult Sci.\"  60, \"Composition of heart, liver, and skeletal muscle from broilers with coccidiosis.\" 1807 (1981)","DOI":"10.3382\/ps.0601807"},{"key":"29","doi-asserted-by":"publisher","unstructured":"DJ Waters, LD Bowers, RJ Cipolle, et al.  \"J Vet Pharmacol Ther.\"  16, \"Plasma salicylate concentrations in immature dogs following aspirin administration: comparison with adult dogs.\" 275 (1993)","DOI":"10.1111\/j.1365-2885.1993.tb00174.x"},{"key":"30","doi-asserted-by":"publisher","unstructured":"HW Choi, M Tian, F Song, et al.  \"Mol Med.\"  21, \"Aspirin's active metabolite salicylic acid targets high mobility group box 1 to modulate inflammatory responses.\" 526 (2015)","DOI":"10.2119\/molmed.2015.00148"},{"key":"31","doi-asserted-by":"publisher","unstructured":"K Houben, P Delahaut, ML Scippo, et al.  \"Food Risk Assess Eur.\"  2, \"Salicylic acid residues in products of animal origin.\" 0015E (2024)","DOI":"10.2903\/fr.efsa.2024.FR-0015"},{"key":"32","doi-asserted-by":"publisher","unstructured":"V. D'Agati,  \"Am J Kidney Dis.\"  28, \"Does aspirin cause acute or chronic renal failure in experimental animals and in humans?\" S24 (1996)","DOI":"10.1016\/s0272-6386(96)90565-x"},{"key":"33","doi-asserted-by":"publisher","unstructured":"RM Clancy  and SB Abramson  \"Proc Soc Exp Biol Med.\"  210, \"Nitric oxide: a novel mediator of inflammation.\" 93 (1996)","DOI":"10.3181\/00379727-210-43927aa"},{"key":"34","doi-asserted-by":"publisher","unstructured":"PC. Allen,  \"Poult Sci.\"  76, \"Production of free radical species during Eimeria maxima infections in chickens.\" 814 (1997)","DOI":"10.1093\/ps\/76.6.814"},{"key":"36","doi-asserted-by":"publisher","unstructured":"M Carraro Di Gregorio, ER Motta de Almeida, C Momo, et al.  \"Animals.\"  13, \"Sodium salicylate as feed additive in broilers: absence of toxicopathological findings.\" 1430 (2023)","DOI":"10.3390\/ani13091430"},{"key":"37","doi-asserted-by":"publisher","unstructured":"K Mohan, K Jayakumar, HD Narayanaswamy, et al.  \"J Appl Anim Res.\"  40, \"Study of potential toxic effects of acetylsalicylic acid upon short-term repeated oral administration in chickens.\" 330 (2012)","DOI":"10.1080\/09712119.2012.692328"},{"key":"39","doi-asserted-by":"publisher","unstructured":"PP Singh, S Singh, BVS Kumar, et al.  \"Comp Immunol Microbiol Infect Dis.\"  69, \"Serum amyloid A (SAA) mRNA expression in chicken and quails in response to bacterial stress.\" 101421 (2020)","DOI":"10.1016\/j.cimid.2020.101421"},{"key":"40","doi-asserted-by":"publisher","unstructured":"SM Razavi, MS Soltan, K Abbasian, et al.  \"Vet Parasitol.\"  331, \"Acute phase response and oxidative stress in coccidiosis: a review in domestic animals.\" 110286 (2024)","DOI":"10.1016\/j.vetpar.2024.110286"},{"key":"41","doi-asserted-by":"publisher","unstructured":"SA Rizo-T\u00e9llez, M Sekheri, JG Filep,  \"Front Immunol.\"  14, \"C-reactive protein: a target for therapy to reduce inflammation.\" 1237729 (2023)","DOI":"10.3389\/fimmu.2023.1237729"},{"key":"42","doi-asserted-by":"publisher","unstructured":"MU Sohail, A Ijaz, MS Yousaf, et al.  \"Poult Sci.\"  89, \"Alleviation of cyclic heat stress in broilers by dietary supplementation of mannan-oligosaccharide and lactobacillus-based probiotic: dynamics of cortisol, thyroid hormones, cholesterol, C-reactive protein, and humoral immunity.\" 1934 (2010)","DOI":"10.3382\/ps.2010-00751"},{"key":"44","doi-asserted-by":"publisher","unstructured":"B Lassen, B Bangoura, T Lepik, et al.  \"Vet Parasitol.\"  212, \"Systemic acute phase proteins response in calves experimentally infected with Eimeria zuernii.\" 140 (2015)","DOI":"10.1016\/j.vetpar.2015.06.024"},{"key":"45","doi-asserted-by":"publisher","unstructured":"L Sepp\u00e4-Lassila, T Orro, B Lassen, et al.  \"Comp Immunol Microbiol Infect Dis.\"  41, \"Intestinal pathogens, diarrhoea and acute phase proteins in naturally infected dairy calves.\" 10 (2015)","DOI":"10.1016\/j.cimid.2015.05.004"},{"key":"20","doi-asserted-by":"crossref","unstructured":"HD. Chapman,  \"Avian Pathol.\"  37, \"Coccidiosis in the turkey.\" 205 (2008)","DOI":"10.1080\/03079450802050689"},{"key":"43","doi-asserted-by":"crossref","unstructured":"NR Sproston  and JJ Ashworth  \"Front Immunol.\"  9, \"Role of C-reactive protein at sites of inflammation and infection.\" 754 (2018)","DOI":"10.3389\/fimmu.2018.00754"},{"key":"10","unstructured":"HM Cervantes, LR McDougald, MC Jenkins,  \"Diseases of poultry.\"  \"Coccidiosis.\" 1193 (2020)"},{"key":"46","doi-asserted-by":"publisher","unstructured":"YH Hong, HS Lillehoj, EP Lillehoj, et al.  \"Vet Immunol Immunopathol.\"  114, \"Changes in immune-related gene expression and intestinal lymphocyte subpopulations following Eimeria maxima infection of chickens.\" 259 (2006)","DOI":"10.1016\/j.vetimm.2006.08.006"}],"container-title":["Avian Diseases"],"original-title":[],"link":[{"URL":"https:\/\/bioone.org\/journals\/avian-diseases\/volume-70\/issue-1\/aviandiseases-D-25-00029\/Evaluating-the-Effect-of-Acetylsalicylic-Acid-in-Turkey-Poults-Experimentally\/10.1637\/aviandiseases-D-25-00029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:15:41Z","timestamp":1791234941000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/avian-diseases\/volume-70\/issue-1\/aviandiseases-D-25-00029\/Evaluating-the-Effect-of-Acetylsalicylic-Acid-in-Turkey-Poults-Experimentally\/10.1637\/aviandiseases-D-25-00029.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3,1]]}},"URL":"https:\/\/doi.org\/10.1637\/aviandiseases-d-25-00029","relation":{},"ISSN":["0005-2086","1938-4351"],"issn-type":[{"value":"0005-2086","type":"print"},{"value":"1938-4351","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]}}}