{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:56:30Z","timestamp":1791248190282,"version":"4.1.0"},"reference-count":46,"publisher":"American Association of Zoo Veterinarians","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Zoo and Wildlife Medicine"],"published-print":{"date-parts":[[2024,6,13]]},"abstract":"<jats:p>Megachiroptera is a mammalian suborder that includes old world fruit bats. Common clinical problems among captive Megachiroptera, such as liver disease (e.g., iron storage disease), kidney disease (e.g., protein-losing nephropathy), and heart disease (e.g., dilated cardiomyopathy), carry elevated risk for hemostatic derangements. The assessment of viscoelastic coagulation assays, however, has not yet been reported in bats. The main objective of the study was to describe viscoelastography data using the Viscoelastic Coagulation Monitor (VCM) Vet in captive large flying foxes (Pteropus vampyrus) (n = 20) and variable flying foxes (Pteropus hypomelanus) (n = 10). Additional objectives were to compare viscoelastic and clotting parameters (1) between healthy P. vampyrus and P. hypomelanus bats and (2) between untreated bats and those treated with meloxicam or aspirin, and (3) to examine relationships between activated partial thromboplastin time (aPTT) and potentially homologous viscoelastic parameters clotting time (CT) and clot formation time (CFT). The results showed marked variability among clinically normal bats. The intrinsic pathway, as measured by aPTT, had prolonged times compared with most terrestrial mammals, but similar times to birds, marine mammals, and sea turtles. A search of P. vampyrus genome found stop codons present in two exons of the factor XI gene; alterations in factor XI expression would be expected to alter intrinsic coagulation. Because of the high variability, no statistically significant findings were noted in the secondary objectives. Correlation between aPTT and CT or CFT was not strong (rs = 0.406 or 0.192, respectively). The results from this study suggest that clot kinetics vary widely among Megachiroptera when using the VCM Vet with untreated blood. A prolonged intrinsic coagulation pathway, as has been found in other megachiropteran species, and activation of the extrinsic coagulation pathway during venipuncture may be responsible for the inconsistent results.<\/jats:p>","DOI":"10.1638\/2023-0037","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T09:49:30Z","timestamp":1718272170000},"page":"393-403","source":"Crossref","is-referenced-by-count":2,"title":["USE OF VISCOELASTIC COAGULATION TESTING IN MEGACHIROPTERA (PTEROPUS HYPOMELANUS AND PTEROPUS VAMPYRUS) REVEALS HIGH VARIABILITY IN CLOT KINETICS"],"prefix":"10.1638","volume":"55","author":[{"given":"Emily E.","family":"Brenner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy B.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonel A.","family":"Londo\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole I.","family":"Stacy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Crevasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.X.","family":"Wellehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1213","reference":[{"key":"24","doi-asserted-by":"crossref","unstructured":"AM Leone, GJ Crawshaw, MM Garner, et al.  \"J Zoo Wildl Med.\"  47, \"A retrospective study of the lesions associated with iron storage disease in captive Egyptian fruit bats (Rousettus aegyptiacus).\" 45 (2016)","DOI":"10.1638\/2015-0224.1"},{"key":"4","doi-asserted-by":"crossref","unstructured":"BM Brainard, CP Meredith, MB Callan, et al.  \"Am J Vet Res.\"  68, \"Changes in platelet function, hemostasis, and prostaglandin expression after treatment with nonsteroidal anti-inflammatory drugs with various cyclooxygenase selectivities in dogs.\" 251 (2007)","DOI":"10.2460\/ajvr.68.3.251"},{"key":"1","doi-asserted-by":"crossref","unstructured":"A Barratclough, RF Floyd, RL Reep, et al.  \"Vet Clin Pathol.\"  47, \"Thromboelastography in wild Florida manatees (Trichechus manatus latirostris).\" 227 (2018)","DOI":"10.1111\/vcp.12599"},{"key":"31","doi-asserted-by":"crossref","unstructured":"KL Perrin, AK Krogh, M Kjelgaard-Hansen, et al.  \"J Zoo Wildl Med.\"  49, \"Thromboelastography in the healthy Asian elephant (Elephas maximus): reference intervals and effects of storage.\" 54 (2018)","DOI":"10.1638\/2017-0179R.1"},{"key":"2","doi-asserted-by":"crossref","unstructured":"A Barratclough, K Tuxbury, R Hanel, et al.  \"J Zoo Wildl Med.\"  50, \"Baseline plasma thromboelastography in Kemp's ridley (Lepidochelys kempii), green (Chelonia mydas), and loggerhead (Caretta caretta) sea turtles and its use to diagnose coagulopathies in cold-stunned Kemp's ridley and green sea turtles.\" 62 (2019)","DOI":"10.1638\/2018-0142"},{"key":"3","doi-asserted-by":"crossref","unstructured":"J Benes, J Zatloukal, J Kletecka,  \"Front Med.\"  2, \"Viscoelastic methods of blood clotting assessment\u2014a multidisciplinary review.\" 1 (2015)","DOI":"10.3389\/fmed.2015.00062"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Y Buriko, K Drobatz, DC. 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