{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:30:02Z","timestamp":1792197002567,"version":"4.4.0"},"reference-count":20,"publisher":"American Association of Zoo Veterinarians","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Zoo and Wildlife Medicine"],"published-print":{"date-parts":[[2025,3,10]]},"abstract":"<jats:p>Squamous cell carcinoma (SCC) is a malignant epidermal tumor. Biologic behavior and metastasis rate vary according to species and tumor location. The goal of this study was to report the occurrence and behavior of an oral SCC in a Tapirus terrestris treated with electrochemotherapy. The tapir was anesthetized for two electrochemotherapy sessions, six months apart, with intralesional cisplatin (0.25 mL\/cm3) and VetCP 125TM electroporator. Side effects were minimal. Because of tumor relapse, onset of joint disorders, and poor prognosis, the animal was euthanized and submitted to necropsy, followed by histopathological and immunohistochemical analyses. Electrochemotherapy significantly improved the tapi\u0155s life quality. Tumor bleeding resolved, and food uptake was improved. Necropsy demonstrated tumor invasion in adjacent soft tissues and bones and submandibular lymph nodes with multiple areas of metastasis. Overall survival time of 35 months was achieved, with good life quality. Histopathologic characteristics were more aggressive in the relapsed tumor.<\/jats:p>","DOI":"10.1638\/2023-0132","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T04:22:51Z","timestamp":1741580571000},"page":"193-198","source":"Crossref","is-referenced-by-count":1,"title":["ELECTROCHEMOTHERAPY WITH CISPLATIN FOR THE TREATMENT OF A NON-OPERABLE ORAL SQUAMOUS CELL CARCINOMA IN A LOWLAND TAPIR (TAPIRUS TERRESTRIS)"],"prefix":"10.1638","volume":"56","author":[{"given":"R\u00fabia M. C.","family":"Cunha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleidice E.","family":"Lavalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto B.","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herlandes P.","family":"Tinoco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlyle M.","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fab\u00edola de Oliveira","family":"Paes Leme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anelise C.","family":"Nepomuceno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz A.","family":"Lago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel O.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato L.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo P. N.","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1213","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"IK Barker  and AA Dreumel  \"Pathology of Domestic Animals.\"  2, \"The alimentary system.\" 1 (1985)","DOI":"10.1016\/B978-0-12-391602-0.50007-4"},{"key":"2","doi-asserted-by":"crossref","unstructured":"CH Brunner, G Dutra, CB Silva, et al.  \"J Zoo Wildl Med.\"  45, \"Electrochemotherapy for the treatment of fibropapillomas in Chelonia mydas.\" 213 (2014)","DOI":"10.1638\/2010-0125.1"},{"key":"3","doi-asserted-by":"crossref","unstructured":"RMC Cunha, GE Lavalle, FC Nunes, et al.  \"Veterinary and Comparative Oncology.\"  21, \"Canine squamous cell carcinoma: Electrochemotherapy association with surgery and correlation with overall survival.\" 1 (2023)","DOI":"10.1111\/vco.12882"},{"key":"4","doi-asserted-by":"crossref","unstructured":"J. Gehl,  \"Acta Physiol Scand.\"  177, \"Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research.\" 437 (2003)","DOI":"10.1046\/j.1365-201X.2003.01093.x"},{"key":"5","unstructured":"MH Goldschmidt  and FS Shofer  \"Skin Tumors of the Dog and Cat.\"  \"Squamous cell carcinoma.\" 316p (1998)"},{"key":"7","doi-asserted-by":"crossref","unstructured":"PJ. Johnson,  \"Veterinary Clinic of North America Equine Practice.\"  14, \"Dermatologic tumors (excluding sarcoids).\" 625 (1998)","DOI":"10.1016\/S0749-0739(17)30190-6"},{"key":"8","doi-asserted-by":"crossref","unstructured":"A. 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Mangini,  \"Tratado de animais selvagens: medicina veterin\u00e1ria.\"  \"Perissodactyla\u2013Tapiridae (Antas).\" 1025 (1963)"},{"key":"12","doi-asserted-by":"crossref","unstructured":"M Marty, G Sersa, JR Garbay, et al.  \"European Journal of Cancer.\"  4, \"Electrochemotherapy\u2014An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study.\" 3 (2006)","DOI":"10.1016\/j.ejcsup.2006.08.002"},{"key":"13","doi-asserted-by":"crossref","unstructured":"CL Miller, RS Templeton, L Karpinski,  \"Journal of Zoo and Wildlife Medicine.\"  31, \"Successful treatment of oral squamous cell carcinoma with intralesional fluorouracil in a Malayan tapir (Tapirus indicus).\" 262 (2000)","DOI":"10.1638\/1042-7260(2000)031[0262:STOOSC]2.0.CO;2"},{"key":"14","doi-asserted-by":"crossref","unstructured":"LM Mir, P Devauchelle, F Quintin-Colonna, et al.  \"British Journal of Cancer.\"  76, \"First clinical trial of cat soft tissue sarcomas treatment by electrochemotherapy.\" 1617 (1997)","DOI":"10.1038\/bjc.1997.606"},{"key":"16","unstructured":"G K Ogilvie  and AS Moore  \"Managing the Veterinary Cancer Patient: a practice manual.\"  473 (1995)"},{"key":"17","doi-asserted-by":"crossref","unstructured":"S Price  and O Bininda-Emonds  \"Zoosystematics and Evolution.\"  85, \"A comprehensive phylogeny of extant horses, rhinos and tapirs (Perissodactyla) through data combination.\" 277 (2009)","DOI":"10.1002\/zoos.200900005"},{"key":"18","doi-asserted-by":"crossref","unstructured":"P Quaglino, C Mortera, S Osella-Abate, et al.  \"Annals of Surgical Oncology.\"  15, \"Electrochemotherapy with intravenous bleomycin in the local treatment of skin melanoma metastases.\" 2215 (2008)","DOI":"10.1245\/s10434-008-9976-0"},{"key":"19","doi-asserted-by":"crossref","unstructured":"J Racnik, T Svara, M Zadravec, et al.  \"New Zealand Veterinary Journal.\"  67, \"Electrochemotherapy with cisplatin for the treatment of a non-operable cutaneous fibroma in a cockatiel (Nymphicus hollandicus).\" 55 (2019)","DOI":"10.1080\/00480169.2018.1564393"},{"key":"20","unstructured":"G Sersa, M Cemazar, D Miklavcic, et al.  \"Radiology and Oncology.\"  40, \"Electrochemotherapy of tumours.\" 163 (2006)"},{"key":"15","doi-asserted-by":"crossref","unstructured":"JS Munday, CV L\u00f6hr, M Kiupel,  \"Tumors in Domestic Animals.\"  \"Tumors of the alimentary tract.\" 499 (2017)","DOI":"10.1002\/9781119181200.ch13"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Kw Head, Rw Else, Rr Dubielzig,  \"Tumors in domestic animals.\"  \"Tumors of the alimentary tract.\" 401 (2002)","DOI":"10.1002\/9780470376928.ch8"}],"container-title":["Journal of Zoo and Wildlife Medicine"],"original-title":[],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:29:14Z","timestamp":1791242954000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/journal-of-zoo-and-wildlife-medicine\/volume-56\/issue-1\/2023-0132\/ELECTROCHEMOTHERAPY-WITH-CISPLATIN-FOR-THE-TREATMENT-OF-A-NON-OPERABLE\/10.1638\/2023-0132.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,10]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,3,1]]}},"URL":"https:\/\/doi.org\/10.1638\/2023-0132","relation":{},"ISSN":["1042-7260","1937-2825"],"issn-type":[{"value":"1042-7260","type":"print"},{"value":"1937-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,10]]}}}