{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:55:18Z","timestamp":1791240918110,"version":"4.1.0"},"reference-count":16,"publisher":"American Association of Zoo Veterinarians","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Zoo and Wildlife Medicine"],"published-print":{"date-parts":[[2025,6,5]]},"abstract":"<jats:p>Protein electrophoresis and acute phase proteins are valuable clinical diagnostic tools to identify inflammation. This study evaluated capillary zone electrophoresis (CZE) for clinically normal giant pandas (Ailuropoda melanoleuca) against individuals that were clinically ill. Assay validation for C-reactive protein (CRP), serum amyloid A (SAA), and haptoglobin (HP) was also attempted. Using CZE, total protein, alpha-1 and -2, beta globulins, beta-2 globulins, and gamma globulins were observed to be significantly higher, and albumin:globulin, pre-albumin, and albumin were significantly lower in clinically abnormal giant pandas (p &lt; 0.05). Among the tested APPs, reactivity was only found for CRP reagents and was significantly higher in abnormal giant panda (p = 0.045).<\/jats:p>","DOI":"10.1638\/2024-0070","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T04:33:46Z","timestamp":1749098026000},"page":"402-409","source":"Crossref","is-referenced-by-count":2,"title":["ACUTE PHASE PROTEINS AND CAPILLARY ZONE ELECTROPHORESIS IN CLINICALLY NORMAL GIANT PANDA (AILUROPODA MELANOLEUCA) AND COMPARISON TO CLINICALLY ILL GIANT PANDA"],"prefix":"10.1638","volume":"56","author":[{"given":"Megan","family":"Partyka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Cray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano","family":"Montiani-Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchao","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1213","reference":[{"key":"8","doi-asserted-by":"crossref","unstructured":"Y Gao, C Yu, G Liu, et al.  \"Animals.\"  13, \"Comparison between hematology and serum biochemistry of Qinling and Sichuan giant panda (Ailuropoda melanoleuca qinlingensis and sichuanensis).\" 3149 (2023)","DOI":"10.3390\/ani13193149"},{"key":"1","doi-asserted-by":"crossref","unstructured":"MF Bertelsen, M Kjelgaard-Hansen, C Gr\u00f8ndahl, et al.  \"J Zoo Wild Med.\"  40, \"Identification of acute phase proteins and assays applicable in nondomesticated mammals.\" 199 (2009)","DOI":"10.1638\/2007-0125.1"},{"key":"2","doi-asserted-by":"crossref","unstructured":"C Burrell, H Zhang, D Li, et al.  \"J Zoo Wild Med.\"  48, \"Hematology, serum biochemistry, and urinalysis values in the adult giant panda (Ailuropoda melanoleuca).\" 1072 (2017)","DOI":"10.1638\/2016-0215.1"},{"key":"3","doi-asserted-by":"crossref","unstructured":"JR Comolli, S Rivera, C Wang, et al.  \"J Zoo Wild Med.\"  53, \"Analysis of serum proteins in healthy giant pandas (Ailuropoda melanoleuca) under managed care.\" 442 (2022)","DOI":"10.1638\/2020-0211"},{"key":"4","doi-asserted-by":"crossref","unstructured":"C. Cray,  \"Prog Molec Biol Translational Sci.\"  105, \"Acute phase proteins in animals.\" 113 (2012)","DOI":"10.1016\/B978-0-12-394596-9.00005-6"},{"key":"5","doi-asserted-by":"crossref","unstructured":"C. Cray,  \"Vet Clin Path.\"  50, \"Protein electrophoresis of non-traditional species: a review.\" 478 (2021)","DOI":"10.1111\/vcp.13067"},{"key":"6","doi-asserted-by":"crossref","unstructured":"G Efthymiou, E Dardiotis, C Liaskos, et al.  \"J Neuroimmuno.\"  298, \"Antihsp60 antibody responses based on Helicobacter pylori in patients with multiple sclerosis:(ir) Relevance to disease pathogenesis.\" 19 (2016)","DOI":"10.1016\/j.jneuroim.2016.06.009"},{"key":"7","doi-asserted-by":"crossref","unstructured":"G F\u00fcst, K Uray, L Bene, et al.  \"Cell Stress and Chaperones.\"  17, \"Comparison of epitope specificity of anti-heat shock protein 60\/65 IgG type antibodies in the sera of healthy subjects, patients with coronary heart disease and inflammatory bowel disease.\" 215 (2012)","DOI":"10.1007\/s12192-011-0301-7"},{"key":"9","doi-asserted-by":"crossref","unstructured":"EH Hooijberg  and C Cray  \"Vet Clin Path.\"  52, \"Acute phase reactants in nondomesticated mammals - a veterinary clinical pathology perspective.\" 19 (2023)","DOI":"10.1111\/vcp.13189"},{"key":"10","doi-asserted-by":"crossref","unstructured":"C Hu, J Yang, Z Qi, et al.  \"MedComm.\"  3, \"Heat shock proteins: biological functions, pathological roles, and therapeutic opportunities.\" e161 (2022)","DOI":"10.1002\/mco2.161"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Q Huang, Y Fei, H Yang, et al.  \"Glob Ecol Conserv.\"  22, \"Giant Panda National Park, a step towards streamlining protected areas and cohesive conservation management in China.\" e00947 (2020)","DOI":"10.1016\/j.gecco.2020.e00947"},{"key":"12","doi-asserted-by":"crossref","unstructured":"R Jiang, X Zhang, M Xia, et al.  \"Animals.\"  13, \"Effects of age and season on blood parameters of captive giant pandas: a pilot study.\" 3023 (2023)","DOI":"10.3390\/ani13193023"},{"key":"13","unstructured":"SA Mainka, T He, M Chen, et al.  \"J Zoo Wild Med.\"  26, \"Hematologic and serum biochemical values for healthy captive giant pandas (Ailuropoda melanoleuca) at the Wolong Reserve, Sichuan, China.\" 377 (1995)"},{"key":"14","doi-asserted-by":"crossref","unstructured":"A Meyer, JA Emerson, KL Rainwater, et al.  \"J Zoo Wild Med.\"  53, \"Assessment of capillary zone electrophoresis and serum amyloid: a quantitation in clinically normal and abnormal southern white rhinoceros (Ceratotherium simum simum) and southern black rhinoceros (Diceros bicornis minor).\" 319 (2022)","DOI":"10.1638\/2021-0072"},{"key":"15","unstructured":"X Qiu  and SA Mainka  \"J Zoo Wild Med.\"  24, \"Review of mortality of the giant panda (Ailuropoda melanoleuca).\" 425 (1993)"},{"key":"16","unstructured":"R Swaisgood, D Wang, F Wei,  \"The International Union for Conservation of Nature Red List of Threatened Species 2016.\"  \"Ailuropoda melanoleuca (errata version published in 2017\" e.T712A121745669"}],"container-title":["Journal of Zoo and Wildlife Medicine"],"original-title":[],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:29:15Z","timestamp":1791239355000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/journal-of-zoo-and-wildlife-medicine\/volume-56\/issue-2\/2024-0070\/ACUTE-PHASE-PROTEINS-AND-CAPILLARY-ZONE-ELECTROPHORESIS-IN-CLINICALLY-NORMAL\/10.1638\/2024-0070.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6,1]]}},"URL":"https:\/\/doi.org\/10.1638\/2024-0070","relation":{},"ISSN":["1042-7260","1937-2825"],"issn-type":[{"value":"1042-7260","type":"print"},{"value":"1937-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]}}}