{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:54:31Z","timestamp":1791240871871,"version":"4.1.0"},"reference-count":27,"publisher":"American Association of Zoo Veterinarians","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Zoo and Wildlife Medicine"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p>This case series describes the presentation, diagnostic, and pathologic findings for mesothelioma in ten Panthera felids at two sanctuaries. Over ten years, seven African lions (Panthera leo) and three tigers (Panthera tigris) were diagnosed with mesothelioma, with a median age of 18 years. The most common clinical signs were nonspecific (lethargy, hyporexia, weight loss) and respiratory (coughing, wheezing, dyspnea), linked to cavitary effusions. Hematology and biochemistry values did not show consistent abnormalities although elevated creatinine (4\/10), neutrophilia (4\/10), monocytosis (3\/10), and hyperglobulinemia (4\/10) were most common. Radiographs, echocardiograms, and fluid cytology identified effusion, but did not diagnose mesothelioma specifically. All pericardial fluid samples (collected from 3\/10 cases) were hemorrhagic, one of which had mesothelial cells but were not definitively neoplastic and one had neoplastic cells but were not definitively mesothelial. Treatments were only palliative; therapeutic pericardiocentesis provided short-term relief for three animals. Median survival time from the onset of clinical signs was 50 (range 0\u2013176) days. If not euthanized on presentation, cases were managed with a combination of antibiotics, antifungals, immunosuppressives, diuretics, cardiac medications, and supportive care. Cavitary effusions were identified in 8\/10 of cases at necropsy, including pericardial (7\/10), pleural (5\/10), and peritoneal (1\/10), and diagnoses were confirmed with cytokeratin and vimentin immunohistochemistry. Further research is necessary to determine true prevalence and causes of this disease in domestic and nondomestic felids and to improve antemortem diagnostic testing and treatments.<\/jats:p>","DOI":"10.1638\/2024-0110","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:00:55Z","timestamp":1759309255000},"page":"708-716","source":"Crossref","is-referenced-by-count":1,"title":["MESOTHELIOMA IN LIONS (PANTHERA LEO) AND TIGERS (PANTHERA TIGRIS): AN ANTEMORTEM CHALLENGE"],"prefix":"10.1638","volume":"56","author":[{"given":"Julie D.","family":"Sheldon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Gai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"McDaniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Lowenstine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Cushing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linden","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1213","reference":[{"key":"2","doi-asserted-by":"crossref","unstructured":"E Bollo, FE Scaglione, M Tursi, et al.  \"Res Vet Sci.\"  91, \"Malignant pleural mesothelioma in a female lion (Panthera leo).\" 116 (2011)","DOI":"10.1016\/j.rvsc.2010.08.005"},{"key":"5","doi-asserted-by":"crossref","unstructured":"I d'Aquino, G Piegari, SM Casciaro, et al.  \"Front Vet Sci.\"  9, \"An overview of neoplasia in captive wild felids in southern Italy zoos.\" 899481 (2022)","DOI":"10.3389\/fvets.2022.899481"},{"key":"7","unstructured":"LW Geib, F DeNarvaez, CH Eby,  \"J Am Vet Med Assoc.\"  140, \"Pleural mesothelioma in a dog.\" 1317 (1962)"},{"key":"9","doi-asserted-by":"crossref","unstructured":"DW Henderson, KB Shilkin, D Whitaker,  \"Am J Clin Pathol.\"  110, \"Reactive mesothelial hyperplasia vs mesothelioma, including mesothelioma in situ: a brief review.\" 397 (1998)","DOI":"10.1093\/ajcp\/110.3.397"},{"key":"10","doi-asserted-by":"crossref","unstructured":"AN Husain, TV Colby, NG Ord\u00f3\u00f1ez, et al.  \"Arch Pathol Lab Med.\"  142, \"Guidelines for pathologic diagnosis of malignant mesothelioma: 2017 update of the consensus statement from the International Mesothelioma Interest Group.\" 89 (2018)","DOI":"10.5858\/arpa.2017-0124-RA"},{"key":"11","unstructured":"\"Idexx Interpretive Criteria for the Feline Cardiopet\u00ae proBNP Test.\"  (2013)"},{"key":"13","doi-asserted-by":"crossref","unstructured":"A Kawashima  and HI Libshitz  \"AJR. 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