{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:54:08Z","timestamp":1791240848282,"version":"4.1.0"},"reference-count":29,"publisher":"American Association of Zoo Veterinarians","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Zoo and Wildlife Medicine"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p>The naked mole-rat (Heterocephalus glaber) has become a subject of interest in cardiovascular research due to its unique biological properties. However, the ECG of this species has not been thoroughly described. The objective of this study was to characterize the ECG of ten clinically healthy naked mole-rats. Each animal was anesthetized with ketamine and alfaxalone, and ECGs were recorded in sternal recumbency using a hexaxial lead system. ECG resembled those of other rodents with a median heart rate of 174 beats\/min (range: 131\u2013202 beats\/min), positive Q wave, R wave, and S wave (QRS) complexes in lead II, and absence of an isoelectric ST segment. All P waves were low amplitude (range: 0\u20130.05 millivolts (mV)) and &lt;40 milliseconds (ms) in duration (26\u201333 ms) while the median PR interval was 85 ms (76\u2013100 ms). Peak R wave amplitudes ranged from 0.26\u20131.15 mV depending on filter settings and QRS complex durations were 26\u201344 ms. The QT intervals ranged from 168\u2013254 ms. An arrhythmia characterized by sinus rhythm with first- and second-degree atrioventricular block was noted in one animal. Collectively, these results provide baseline values in clinically healthy naked mole-rats, which will be relevant to clinical and research situations.<\/jats:p>","DOI":"10.1638\/2024-0116","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T09:01:51Z","timestamp":1759309311000},"page":"621-627","source":"Crossref","is-referenced-by-count":0,"title":["THE STATIC ELECTROCARDIOGRAM OF ZOO-KEPT NAKED MOLE-RATS (HETEROCEPHALUS GLABER) UNDER ALFAXALONE\u2013KETAMINE ANESTHESIA"],"prefix":"10.1638","volume":"56","author":[{"given":"Nathan","family":"Boyd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Thomason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neta","family":"Ambar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trenton","family":"Shrader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Eshar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1213","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"PD Arini, S Liberczuk, JG Mendieta, et al.  \"Comput Math Methods Med.\"  2185378, \"Electrocardiogram delineation in a wistar rat experimental model.\" 1 (2018)","DOI":"10.1155\/2018\/2185378"},{"key":"2","doi-asserted-by":"crossref","unstructured":"C Baillard, P Mansier, PV Ennezat, et al.  \"Hypertension.\"  36, \"Converting enzyme inhibition normalizes QT interval in spontaneously hypertensive rats.\" 350 (2000)","DOI":"10.1161\/01.HYP.36.3.350"},{"key":"3","unstructured":"HC. 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\"Electrocardiography of the Dog and Cat: Diagnosis of Arrhythmias.\"  \"Formation and Interpretation of the Electrocardiographic Waves.\" 52 (2018)"},{"key":"24","unstructured":"R Santilli, NS Mo\u03case, R Pariaut, et al.  \"Electrocardiography of the Dog and Cat: Diagnosis of Arrhythmias.\"  \"Conduction disorders.\" 270 (2018)"},{"key":"25","doi-asserted-by":"crossref","unstructured":"A Sugiyama, A Takahar, S Honsho, et al.  \"J Pharmacol Sci.\"  98, \"A simple in vivo atrial fibrillation model of rat induced by transesophageal atrial burst pacing.\" 315 (2005)","DOI":"10.1254\/jphs.SCJ05002X"},{"key":"26","doi-asserted-by":"crossref","unstructured":"M Viltard, S Durand, M P\u00e9rez-Lanz\u00f3n, et al.  \"Aging.\"  11, \"The metabolomic signature of extreme longevity: naked mole rats versus mice.\" 4783 (2019)","DOI":"10.18632\/aging.102116"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Z Yang, Y Zhang, L Chen,  \"BMC Syst Biol.\"  7, \"Investigation of anticancer mechanisms by comparative analysis of naked mole rat and rat.\" S5 (2013)","DOI":"10.1186\/1752-0509-7-S2-S5"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Z Yang, Y Zhang, L Chen,  \"Gene.\"  572, \"Single amino acid changes in naked mole rat may reveal new anti-cancer mechanisms in mammals.\" 101 (2015)","DOI":"10.1016\/j.gene.2015.07.004"},{"key":"29","doi-asserted-by":"crossref","unstructured":"C Yu, Y Li, A Holmes, et al.  \"PLoS One.\"  6, \"RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice.\" 26729 (2011)","DOI":"10.1371\/journal.pone.0026729"}],"container-title":["Journal of Zoo and Wildlife Medicine"],"original-title":[],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:16:28Z","timestamp":1791238588000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/journal-of-zoo-and-wildlife-medicine\/volume-56\/issue-3\/2024-0116\/THE-STATIC-ELECTROCARDIOGRAM-OF-ZOO-KEPT-NAKED-MOLE-RATS-HETEROCEPHALUS\/10.1638\/2024-0116.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.1638\/2024-0116","relation":{},"ISSN":["1042-7260","1937-2825"],"issn-type":[{"value":"1042-7260","type":"print"},{"value":"1937-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]}}}