{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:00:12Z","timestamp":1791237612268,"version":"4.1.0"},"reference-count":20,"publisher":"American Association of Zoo Veterinarians","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Zoo and Wildlife Medicine"],"published-print":{"date-parts":[[2026,1,19]]},"abstract":"<jats:p>Atrial septal defects represent one of the most common congenital heart diseases in humans as well as in dogs and cats. However, reports in wildlife animals are limited. Additionally, ensuring treatment compliance and regular follow-ups in these species are often challenging. The aim of the present clinical brief is to describe the first successful long-term medical management of a nonrestrictive atrial septal defect in a crab-eating macaque (Macaca fascicularis). A seven-year-old castrated male crab-eating macaque was diagnosed with a severe left-to-right shunting, 7.5 mm atrial septal defect with altered general condition, right heart enlargement, and vena cava dilation. Medical treatment (spironolactone and taurine) was initiated and was associated with progressive improvement of the clinical status over time. Serial echocardiographic examinations confirmed substantial reduction of both defect size (0.9 mm) and right-sided volume overload. Two years after the initial diagnosis, the animal is doing well without any treatment.<\/jats:p>","DOI":"10.1638\/2025-0032","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:48:18Z","timestamp":1768808898000},"page":"133-139","source":"Crossref","is-referenced-by-count":0,"title":["MEDICAL MANAGEMENT OF A LARGE NONRESTRICTIVE ATRIAL SEPTAL DEFECT IN A CRAB-EATING MACAQUE (MACACA FASCICULARIS)"],"prefix":"10.1638","volume":"57","author":[{"given":"Antonin","family":"Boutibou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norin","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Bureau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Chetboul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1213","reference":[{"key":"5","unstructured":"MJ Greenberg, DL Janssen, SW Jamieson, et al.  \"J Zoo Wildl Med.\"  30, \"Surgical repair of an atrial septal defect in a juvenile Sumatran orangutan (Pongo pygmaeus sumatraensis).\" 256 (1999)"},{"key":"1","doi-asserted-by":"crossref","unstructured":"F Bernay, JM Bland, J H\u00e4ggstr\u00f6m, et al.  \"J Vet Intern Med.\"  24, \"Efficacy of spironolactone on survival in dogs with naturally occurring mitral regurgitation caused by myxomatous mitral valve disease.\" 331 (2010)","DOI":"10.1111\/j.1939-1676.2009.0467.x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"V Chetboul, V Charles, A Nicolle, et al.  \"J Vet Med A Physiol Pathol Clin Med.\"  53, \"Retrospective study of 156 atrial septal defects in dogs and cats (2001-2005).\" 179 (2006)","DOI":"10.1111\/j.1439-0442.2006.00813.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"B Fox, MA Owston, S Kumar, et al.  \"J Med Primatol.\"  40, \"Congenital anomalies in the baboon (Papio spp.).\" 357 (2011)","DOI":"10.1111\/j.1600-0684.2011.00472.x"},{"key":"4","doi-asserted-by":"publisher","unstructured":"MR Frager, WH Frishman, WS Aronow,  \"Cardiol Rev.\"  \"Advances in Atrial Septal Defect Closure: Managing Pulmonary Hypertension and Expanding Treatment Criteria Applicability.\" 2025","DOI":"10.1097\/CRD.0000000000000896"},{"key":"6","doi-asserted-by":"publisher","unstructured":"AG Hendrickx  and PE Binkerd  \"Nonhuman primates I. 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Randomized Aldactone Evaluation Study Investigators.\" 709 (1999)","DOI":"10.1056\/NEJM199909023411001"},{"key":"17","doi-asserted-by":"crossref","unstructured":"F Serres, V Chetboul, R Tissier, et al.  \"J Vet Cardiol.\"  11, \"Quantification of pulmonary to systemic flow ratio by a Doppler echocardiographic method in the normal dog: Repeatability, reproducibility, and reference ranges.\" 23 (2009)","DOI":"10.1016\/j.jvc.2009.04.001"},{"key":"18","doi-asserted-by":"crossref","unstructured":"AJ. Torres,  \"J Thorac Dis.\"  10, \"Hemodynamic assessment of atrial septal defects.\" S2882 (2018)","DOI":"10.21037\/jtd.2018.02.17"},{"key":"19","doi-asserted-by":"publisher","unstructured":"CC Tzang, WC Lin, LH Lin, et al.  \"Nutr J.\"  23, \"Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis.\" 93 (2024)","DOI":"10.1186\/s12937-024-00995-5"},{"key":"20","unstructured":"YJ Xu, AS Arneja, PS Tappia, et al.  \"Exp Clin Cardiol.\"  13, \"The potential health benefits of taurine in cardiovascular disease.\" 57 (2008)"}],"container-title":["Journal of Zoo and Wildlife Medicine"],"original-title":[],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:26:23Z","timestamp":1791235583000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/journal-of-zoo-and-wildlife-medicine\/volume-57\/issue-1\/2025-0032\/MEDICAL-MANAGEMENT-OF-A-LARGE-NONRESTRICTIVE-ATRIAL-SEPTAL-DEFECT-IN\/10.1638\/2025-0032.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3,1]]}},"URL":"https:\/\/doi.org\/10.1638\/2025-0032","relation":{},"ISSN":["1042-7260","1937-2825"],"issn-type":[{"value":"1042-7260","type":"print"},{"value":"1937-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]}}}