{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:58:45Z","timestamp":1791237525273,"version":"4.1.0"},"reference-count":18,"publisher":"American Association of Zoo Veterinarians","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Zoo and Wildlife Medicine"],"published-print":{"date-parts":[[2026,1,19]]},"abstract":"<jats:p>A white Bengal hybrid tiger (Panthera tigris cross) was presented for a tumor subjacent to the right inferior eyelid. Surgical excision under general anesthesia followed by photodynamic therapy (PDT) with infracyanine green (EmunDow) was performed. Two months after surgery, a new tumor involving the concave left pinna was noted, and surgical excision followed by PDT was again performed. Healing of both surgical sites was achieved by 37 d postoperatively. Histopathologic review of both masses was consistent with cutaneous melanocytic tumors with complete surgical margins. To the authors' knowledge, PDT is a novel surgical procedure in nondomestic species. Melanocytic tumors may be associated with the uncommon white hair phenotype of Bengal tigers. PDT removes the requirement for wound closure following surgery, provides adjunctive therapy for neoplastic lesions, appears well tolerated, and results in an excellent cosmetic outcome. This case highlights the potential use of this therapy for cutaneous melanoma in captive tigers.<\/jats:p>","DOI":"10.1638\/2025-0066","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T05:48:31Z","timestamp":1768801711000},"page":"119-124","source":"Crossref","is-referenced-by-count":0,"title":["PHOTODYNAMIC THERAPY WITH INFRACYANINE GREEN (EMUNDO\u00ae) FOLLOWING SURGICAL EXCISION OF MULTIPLE CUTANEOUS MELANOCYTIC TUMORS IN A WHITE BENGAL HYBRID TIGER (PANTHERA TIGRIS CROSS)"],"prefix":"10.1638","volume":"57","author":[{"given":"Lauren","family":"Charnock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3322-0355","authenticated-orcid":false,"given":"Jackie","family":"Gai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinson C.","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena K.","family":"Affolter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler J.M.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Good","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1213","reference":[{"key":"1","doi-asserted-by":"publisher","unstructured":"P Agostinis, K Berg, KA Cengel, et al.  \"CA Cancer J Clin.\"  61, \"Photodynamic therapy of cancer: an update.\" 250 (2011)","DOI":"10.3322\/caac.20114"},{"key":"2","doi-asserted-by":"publisher","unstructured":"G Chamel, J Abadie, O Albaric, et al.  \"J Feline Med Surg.\"  19, \"Non-ocular melanomas in cats: a retrospective study of 30 cases.\" 351 (2017)","DOI":"10.1177\/1098612X15625355"},{"key":"3","doi-asserted-by":"publisher","unstructured":"EA Giuliano, I MacDonald, DL McCaw, et al.  \"Vet Ophthalmol.\"  11, \"Photodynamic therapy for the treatment of periocular squamous cell carcinoma in horses: a pilot study.\" 27 (2008)","DOI":"10.1111\/j.1463-5224.2008.00643.x"},{"key":"4","doi-asserted-by":"publisher","unstructured":"EA Giuliano, J Ota, SA Tucker,  \"Vet Ophthalmol.\"  10, \"Photodynamic therapy: basic principles and potential uses for the veterinary ophthalmologist.\" 337 (2007)","DOI":"10.1111\/j.1463-5224.2007.00578.x"},{"key":"5","doi-asserted-by":"publisher","unstructured":"GA Gonz\u00e1lez-Gonz\u00e1lez  and V Centeno Aldana  \"Rev Med Vet.\"  1, \"Melanoma maligno cut\u00e1neo con met\u00e1stasis sist\u00e9mica en una hembra de tigre de bengala blanca (Panthera tigris tigris) [Cutaneous malignant melanoma with systemic metastasis in a female white Bengal tiger (Panthera tigris tigris)].\" 81 (2021)","DOI":"10.19052\/mv.vol1.iss43.8"},{"key":"6","doi-asserted-by":"publisher","unstructured":"TG Guimar\u00e3es, KM Cardoso, CM Marto, et al.  \"Appl Sci.\"  12, \"Oncological applications of photodynamic therapy in dogs and cats.\" 12276 (2022)","DOI":"10.3390\/app122312276"},{"key":"7","doi-asserted-by":"publisher","unstructured":"E Hefner  and RJ McMullen  \"Abstr 51st Ann Sci Meet Am Coll Vet Ophthalmol;.\"  23, \"Treatment of equine ocular and periocular squamous cell carcinoma with infracyanine green photodynamic therapy.\" e1 (2020)","DOI":"10.1111\/vop.12844"},{"key":"8","doi-asserted-by":"publisher","unstructured":"Y-Y Huang, D Vecchio, P Avci, et al.  \"Biol Chem.\"  394, \"Melanoma resistance to photodynamic therapy: new insights.\" 239 (2013)","DOI":"10.1515\/hsz-2012-0228"},{"key":"10","doi-asserted-by":"publisher","unstructured":"GV Long, SM Swetter, AM Menzies, et al.  \"Lancet.\"  402, \"Cutaneous melanoma.\" 485 (2023)","DOI":"10.1016\/S0140-6736(23)00821-8"},{"key":"11","doi-asserted-by":"publisher","unstructured":"ATJ Ng, RJ McMullen, GC Shaw, et al.  \"Case Rep Vet Med.\"  2023, \"Limbal squamous cell carcinoma in a Black Baldy cow: case report and surgical treatment.\" 2429241","DOI":"10.1155\/2023\/2429241"},{"key":"12","doi-asserted-by":"publisher","unstructured":"X Ning, G He, W Zeng, et al.  \"Front Med.\"  9, \"The photosensitizer-based therapies enhance the repairing of skin wounds.\" 915548 (2022)","DOI":"10.3389\/fmed.2022.915548"},{"key":"13","doi-asserted-by":"publisher","unstructured":"R Pittaway, MJ Dobromylskyj, K Erles, et al.  \"Vet Pathol.\"  56, \"Non-ocular melanocytic neoplasia in cats: characterization and proposal of a histologic classification scheme to more accurately predict clinical outcome.\" 868 (2019)","DOI":"10.1177\/0300985819854435"},{"key":"14","doi-asserted-by":"publisher","unstructured":"G Polton, JF Borrego, F Clemente-Vicario, et al.  \"Front Vet Sci.\"  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