{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:57:39Z","timestamp":1791237459078,"version":"4.1.0"},"reference-count":30,"publisher":"American Association of Zoo Veterinarians","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Zoo and Wildlife Medicine"],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:p>Five of a cohort of 13 aye-ayes (Daubentonia madagascariensis) at the Duke Lemur Center (DLC) exhibited acute, nonspecific signs of lethargy and ataxia within 24 h of ingesting a meal containing avocado fruit (Persea americana) that included the skin and pit. Deaths rapidly ensued in four of the five animals within 13 h of initial symptoms. All animals that died had pericardial effusion on postmortem examination and microscopic findings of acute myocardial degeneration. After ruling out other causes, all evidence points to avocado toxicity as the cause of death. Following an analysis of the DLC deaths in 2016, all deaths in aye-ayes from 1985 to 2022 occurring at the DLC or on loan to other institutions were reviewed. An additional six cases of acute death and pericardial effusion associated with cardiomyopathy and acute myocardial degeneration were identified for a total of 10 of 27 deaths (37%) over 37 yr. This analysis led the authors to conclude that aye-ayes may be acutely sensitive to toxins present in avocado and that mortality due to avocado toxicosis in this species is more common than previously recognized. Prior stress on animals in advance of avocado consumption may have contributed to the acute myocardial degeneration and death following avocado fruit ingestion, as noted in this report. Avocado toxicosis has been reported in various avian and mammalian species, but adverse effects have not been previously noted in other lemur or primate species. This case series is of particular interest because all affected animals had regularly been fed avocado previously and some zoologic institutions routinely use avocado in diets for primates.<\/jats:p>","DOI":"10.1638\/2025-0069","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:51:03Z","timestamp":1770087063000},"page":"140-147","source":"Crossref","is-referenced-by-count":1,"title":["ACUTE MYOCARDIAL DEGENERATION AND DEATH IN AYE-AYES (DAUBENTONIA MADAGASCARIENSIS) FOLLOWING INGESTION OF AVOCADO (PERSEA AMERICANA)"],"prefix":"10.1638","volume":"57","author":[{"given":"Cathy V.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Schopler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohannes G.","family":"Asfaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Cullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"Proia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey I.","family":"Everitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1213","reference":[{"key":"13","doi-asserted-by":"publisher","unstructured":"KN Morgan  and CT Tromborg  \"Appl Anim Behav Sci.\"  102, \"Sources of stress in captivity.\" 262 (2007)","DOI":"10.1016\/j.applanim.2006.05.032"},{"key":"10","doi-asserted-by":"publisher","unstructured":"AM Hargis, E Stauber, S Casteel, et al.  \"J Am Vet Med Assoc.\"  194, \"Avocado (Persea americana) intoxication in caged birds.\" 64 (1989)","DOI":"10.2460\/javma.1989.194.01.64"},{"key":"1","doi-asserted-by":"publisher","unstructured":"A Adameova, Y Abdellatif, NS Dhalla,  \"Can J Physiol Pharmacol.\"  87, \"Role of the excessive amounts of circulating catecholamines and glucocorticoids in stress-induced heart disease.\" 493 (2009)","DOI":"10.1139\/y09-042"},{"key":"2","doi-asserted-by":"publisher","unstructured":"LS Aguirre, GV Sandoval, DM Medina, et al.  \"Toxicon.\"  164, \"Acute heart failure in rabbits by avocado leaf poisoning.\" 16 (2019)","DOI":"10.1016\/j.toxicon.2019.03.024"},{"key":"3","unstructured":"IB Buoro, SB Nyamwange, D Chai, et al.  \"Onderstepoort J Vet Res.\"  61, \"Putative avocado toxicity in two dogs.\" 107 (1994)"},{"key":"4","unstructured":"WP Burger, TW Naude, IB Van Rensburg, et al.  \"J S Afr Vet Assoc.\"  65, \"Cardiomyopathy in ostriches (Struthio camelus) due to avocado (Persea americana var. guatemalensis) intoxication.\" 113 (1994)"},{"key":"5","doi-asserted-by":"crossref","unstructured":"AL Craigmill, AA Seawright, T Mattila, et al.  \"Aust Vet J.\"  66, \"Pathological changes in the mammary gland and biochemical changes in milk of the goat following oral dosing with the leaf of the avocado (Persea americana).\" 206 (1989)","DOI":"10.1111\/j.1751-0813.1989.tb09809.x"},{"key":"6","doi-asserted-by":"publisher","unstructured":"A Daiber, S Kr\u00f6ller-Schon, K Freis, et al.  \"Biofactors.\"  45, \"Environmental noise induces the release of stress hormones and inflammatory signaling molecules leading to oxidative stress and vascular dysfunction\u2014signatures of the internal exposome.\" 495 (2019)","DOI":"10.1002\/biof.1506"},{"key":"7","doi-asserted-by":"publisher","unstructured":"MS Freitas, AHB Pereira, G Pereira, et al.  \"Toxicon.\"  219, \"Acetogenin-induced fibrotic heart disease from avocado (Persea americana, Lauraceae) poisoning in horses.\" 106921 (2022)","DOI":"10.1016\/j.toxicon.2022.09.007"},{"key":"8","doi-asserted-by":"crossref","unstructured":"R Grant, PA Basson, HH Booker, et al.  \"J S Afr Vet Assoc.\"  62, \"Cardiomyopathy caused by avocado (Persea americana Mill) leaves.\" 21 (1991)","DOI":"10.4102\/jsava.v62i1.1578"},{"key":"9","unstructured":"R Grant, HH Booker, PA Basson, et al.  \"J S Afr Vet Assoc.\"  59, \"Cardyomyopathies caused by januariebos (Gnidia polycephala) and avocado (Persea americana) leaves.\" 101 (1988)"},{"key":"11","doi-asserted-by":"publisher","unstructured":"EE Louis, TM Sefczek, DR Randimbiharinirina, et al.  \"The IUCN Red List of Threatened Species.\"  \"Daubentonia madagascariensis.\" 2020","DOI":"10.2305\/IUCN.UK.2020-2.RLTS.T6302A115560793.en"},{"key":"12","doi-asserted-by":"crossref","unstructured":"RA McKenzie  and OP Brown  \"Aust Vet J.\"  68, \"Avocado (Persea americana) poisoning of horses.\" 77 (1991)","DOI":"10.1111\/j.1751-0813.1991.tb03147.x"},{"key":"14","doi-asserted-by":"publisher","unstructured":"H Nakayama, X Chen, CP Baines, et al.  \"J Clin Invest.\"  117, \"Ca2+\u2013 and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure.\" 2431 (2007)","DOI":"10.1172\/JCI31060"},{"key":"15","doi-asserted-by":"crossref","unstructured":"PB Oelrichs, JC Ng, AA Seawright, et al.  \"Nat Toxins.\"  3, \"Isolation and identification of a compound from avocado (Persea americana) leaves which causes necrosis of the acinar epithelium of the lactating mammary gland and the myocardium.\" 344 (1995)","DOI":"10.1002\/nt.2620030504"},{"key":"16","doi-asserted-by":"publisher","unstructured":"MA Ramsier, AJ Cunningham, JJ Finneran, et al.  \"Philos Trans R Soc Lond B Biol Sci.\"  367, \"Social drive and the evolution of primate hearing.\" 1860 (2012)","DOI":"10.1098\/rstb.2011.0219"},{"key":"17","doi-asserted-by":"publisher","unstructured":"Y Sani, RB Atwell, AA Seawright,  \"Aust Vet J.\"  68, \"The cardiotoxicity of avocado leaves.\" 150 (1991)","DOI":"10.1111\/j.1751-0813.1991.tb03161.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"CM Shropshire, E Stauber, M Arai,  \"J Am Vet Med Assoc.\"  200, \"Evaluation of selected plants for acute toxicosis in budgerigars.\" 936 (1992)","DOI":"10.2460\/javma.1992.200.07.936"},{"key":"20","doi-asserted-by":"publisher","unstructured":"C Silva-Platas, N Garcia, C Fern\u00e1ndez-Sada, et al.  \"J Bioenerg Biomembr.\"  44, \"Cardiotoxicity of acetogenins from Persea americana occurs through the mitochondrial permeability transition pore and caspase-dependent apoptosis pathways.\" 461 (2012)","DOI":"10.1007\/s10863-012-9452-1"},{"key":"21","unstructured":"WR Singh, TK Rajkhowa, KV Chanu, et al.  \"Int J Res Pharm Sci.\"  1, \"Histopathological changes caused by accidental avocado leaves toxicity in rabbits.\" 517 (2010)"},{"key":"22","unstructured":"\"Necropsy\/Biopsy Advanced Search, date range January 01.\""},{"key":"23","doi-asserted-by":"publisher","unstructured":"P Stadler, IBJ Van Rensburg, TW Naude,  \"J S Afr Vet Assoc.\"  62, \"Suspected avocado (Persea americana) poisoning in goats.\" 186 (1991)","DOI":"10.4102\/jsava.v62i1.1578"},{"key":"24","doi-asserted-by":"crossref","unstructured":"EJ Sterling  and AF Richard  \"Creatures of the dark: nocturnal prosimians.\"  \"Social organization in the aye-aye (Daubentonia madagascariensis) and the perceived distinctiveness of nocturnal primates.\" 439 (1995)","DOI":"10.1007\/978-1-4757-2405-9_26"},{"key":"25","doi-asserted-by":"crossref","unstructured":"MK. 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