{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T08:31:51Z","timestamp":1793435511231,"version":"4.5.0"},"reference-count":49,"publisher":"American Society of Parasitologists","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Parasitology"],"published-print":{"date-parts":[[2022,2,4]]},"abstract":"<jats:p>Cystic echinococcosis is a zoonotic disease caused by the larval stage of Echinococcus granulosus. This affliction is an endemic worldwide condition that represents a neglected parasitic disease with important socioeconomic repercussions. Proteomic characterization of larval and adult stages of E. granulosus, as well as the association between expression profiles and host interactions, is relevant for a better understanding of parasite biology, and eventually for drug design and vaccine development. This study aimed to develop a synthesis of the evidence available related to proteomics of E. granulosus. A systematic review was carried out to collect data concerning the proteomics of E. granulosus, without language or host restriction, published between 1980 and 2019. A systematic search was carried out in the Trip Database, BIREME-BVS, SciELO, Web of Science, PubMed, EMBASE, SCOPUS, EBSCO host, and LILACS, using MeSH terms, free words, and Boolean connectors, and adapting strategies to each source of information. Additionally, a manual cross-reference search was performed. Variables studied were the year of publication, geographic origin of the study, number of samples, hosts, parasitic organs, proteomic techniques, and parasite proteins verified. Nine-hundred and thirty-six related articles were identified: 17 fulfilled selection criteria, including slightly more than 188 samples. Most articles were published between 2014 and 2019 (64.7%) and were from Brazil and China (35.3% each). In reference to confirmed hosts in the primary articles, cattle (41.2%) and humans (23.5%) were the most frequently reported. Concerning proteomic techniques applied in the primary articles, LC-MS\/MS was the most used (41.1%), and 890 proteins were reported by the primary articles. As the results of our search suggest, the information related to E. granulosus proteomics is scarce, heterogeneous, and scattered throughout several articles that include a diversity of tissues, samples, intermediate hosts, and proteomic techniques. Consequently, the level of evidence generated by our search is type 4.<\/jats:p>","DOI":"10.1645\/20-86","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T01:39:21Z","timestamp":1643852361000},"page":"64-69","source":"Crossref","is-referenced-by-count":5,"title":["Proteomic Profile of Echinococcus granulosus: A Systematic Review"],"prefix":"10.1645","volume":"108","author":[{"given":"Nayely","family":"Garc\u00eda-M\u00e9ndez","sequence":"first","affiliation":[{"name":"Ph.D. Program in Medical Sciences, Universidad de La Frontera, 4811230, Temuco, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Manterola","sequence":"additional","affiliation":[{"name":"Ph.D. Program in Medical Sciences, Universidad de La Frontera, 4811230, Temuco, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Totomoch-Serra","sequence":"additional","affiliation":[{"name":"Ph.D. Program in Medical Sciences, Universidad de La Frontera, 4811230, Temuco, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela L.","family":"Riffo-Campos","sequence":"additional","affiliation":[{"name":"Ph.D. Program in Medical Sciences, Universidad de La Frontera, 4811230, Temuco, Chile."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar A.","family":"Brito-Carre\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Biology, Center for Research and Advanced Studies, National Polytechnic Institute, 36824, M\u00e9xico City, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1220","reference":[{"key":"11","doi-asserted-by":"crossref","unstructured":"P. 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Rezaie-Tavirani, N. A. Ahmadi, et al.  \"Gastroenterology and Hepatology from Bed to Bench.\"  11, \"Proteome evaluation of human cystic echinococcosis sera using two dimensional gel electrophoresis.\" 75 (2018)"},{"key":"35","doi-asserted-by":"crossref","unstructured":"G. B. Santos, K. M. Monteiro, E. D. Da Silva, et al.  \"International Journal for Parasitology.\"  46, \"Excretory\/secretory products in the Echinococcus granulosus metacestode: Is the intermediate host complacent with infection caused by the larval form of the parasite?\" 843 (2016)","DOI":"10.1016\/j.ijpara.2016.07.009"},{"key":"36","unstructured":"S. Sarkar, H. Roy, P. Saha, et al.  \"Tropical Parasitology.\"  7, \"Cystic echinococcosis: A neglected disease at usual and unusual locations.\" 51 (2017)"},{"key":"37","doi-asserted-by":"crossref","unstructured":"R. Shafiei, S. H. Teshnizi, K. Kalantar, et al.  \"Journal of Parasitology Research.\"  2016, \"The seroprevalence of human cystic echinococcosis in Iran: A systematic review and meta-analysis study.\" 1425147 (2016)","DOI":"10.1155\/2016\/1425147"},{"key":"38","doi-asserted-by":"crossref","unstructured":"B.J. Shea, B. C. Reeves, G. Wells, et al.  \"British Medical Journal.\"  358, \"AMSTAR 2: A critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both.\" j4008 (2017)","DOI":"10.1136\/bmj.j4008"},{"key":"39","doi-asserted-by":"crossref","unstructured":"M. Siles-Lucas  and C. Cuesta-Bandera  \"Journal of Helminthology.\"  70, \"Echinococcus granulosus in Spain: Strain differentiation by SDS-PAGE of somatic and excretory\/secretory proteins.\" 253 (1996)","DOI":"10.1017\/S0022149X00015492"},{"key":"40","doi-asserted-by":"crossref","unstructured":"M. Siles-Lucas  and B. Gottstein  \"Trends in Parasitology.\"  19, \"The 14-3-3 protein: A key molecule in parasites as in other organisms.\" 575 (2003)","DOI":"10.1016\/j.pt.2003.10.003"},{"key":"41","doi-asserted-by":"crossref","unstructured":"M. Siles-Lucas, C. S\u00e1nchez-Ovejero, M. Gonz\u00e1lez-S\u00e1nchez, et al.  \"Veterinary Parasitology.\"  236, \"Isolation and characterization of exosomes derived from fertile sheep hydatid cysts.\" 22 (2017)","DOI":"10.1016\/j.vetpar.2017.01.022"},{"key":"42","doi-asserted-by":"crossref","unstructured":"V. Silva-\u00c1lvarez, A. M. Folle, A. L. Ramos, et al.  \"Parasites & Vectors.\"  9, \"Echinococcus granulosus antigen B binds to monocytes and macrophages modulating cell response to inflammation.\" 69 (2016)","DOI":"10.1186\/s13071-016-1350-7"},{"key":"43","doi-asserted-by":"crossref","unstructured":"A. Siyadatpanah, D. Anvari, A. E. Zeydi, et al.  \"Epidemiology and Health.\"  41, \"A systematic review and meta-analysis of the genetic characterization of human echinococcosis in Iran, an endemic country.\" e2019024 (2019)","DOI":"10.4178\/epih.e2019024"},{"key":"44","unstructured":"\"UniProt Consortium, 2019.\"  (2019)"},{"key":"45","doi-asserted-by":"crossref","unstructured":"V. Velasco-Tirado, M. Alonso-Sard\u00f3n, A. Lopez-Bernus, et al.  \"BMC Infectious Disease.\"  18, \"Medical treatment of cystic echinococcosis: Systematic review and meta-analysis.\" 306 (2018)","DOI":"10.1186\/s12879-018-3201-y"},{"key":"46","doi-asserted-by":"crossref","unstructured":"V. G. Virginio, K. M. Monteiro, F. Drumond, et al.  \"Molecular and Biochemical Parasitology.\"  183, \"Excretory\/secretory products from in vitro\u2013cultured Echinococcus granulosus protoscoleces.\" 15 (2012)","DOI":"10.1016\/j.molbiopara.2012.01.001"},{"key":"47","doi-asserted-by":"crossref","unstructured":"Y. Wang, D. Xiao, Y. Shen, et al.  \"BMC Veterinary Research.\"  11, \"Proteomic analysis of the excretory\/secretory products and antigenic proteins of Echinococcus granulosus adult worms from infected dogs.\" 119 (2015)","DOI":"10.1186\/s12917-015-0423-8"},{"key":"48","doi-asserted-by":"crossref","unstructured":"R. Zeghir-Bouteldja, A. Polom\u00e9, S. Bousbata, et al.  \"Acta Tropica.\"  171, \"Comparative proteome profiling of hydatid fluid from Algerian patients reveals cyst location\u2013related variation in Echinococcus granulosus.\" 199 (2017)","DOI":"10.1016\/j.actatropica.2017.03.034"},{"key":"49","doi-asserted-by":"crossref","unstructured":"H. Zheng, W. Zhang, L. Zhang, et al.  \"Nature Genetics.\"  45, \"The genome of the hydatid tapeworm Echinococcus granulosus.\" 1168 (2013)","DOI":"10.1038\/ng.2757"}],"container-title":["Journal of Parasitology"],"original-title":[],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T07:48:13Z","timestamp":1793432893000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/journal-of-parasitology\/volume-108\/issue-1\/20-86\/Proteomic-Profile-of-Echinococcus-granulosus-A-Systematic-Review\/10.1645\/20-86.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,4]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,2,1]]}},"URL":"https:\/\/doi.org\/10.1645\/20-86","relation":{},"ISSN":["0022-3395","1937-2345"],"issn-type":[{"value":"0022-3395","type":"print"},{"value":"1937-2345","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,4]]}}}