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Vane, \"Nat New Biol.\" 231, \"Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.\" 232 (1971)","DOI":"10.1038\/newbio231232a0"},{"key":"7","unstructured":"DR. Robinson, \"Clin Exp Rheumatol.\" 7, \"Eicosanoids, inflammation, and anti-inflammatory drugs.\" 155 (1989)"},{"key":"8","doi-asserted-by":"crossref","unstructured":"EV Hersh, PA Moore, GL Ross, \"Clin Ther.\" 22, \"Over-the-counter analgesics and antipyretics: a critical assessment.\" 500 (2000)","DOI":"10.1016\/S0149-2918(00)80043-0"},{"key":"9","doi-asserted-by":"crossref","unstructured":"NV Chandrasekharan, H Dai, KL Roos, \"Proc Natl Acad Sci U S A.\" 99, \"COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic\/antipyretic drugs: cloning, structure and expression.\" 13926 (2002)","DOI":"10.1073\/pnas.162468699"},{"key":"10","doi-asserted-by":"crossref","unstructured":"DB Hales, Y Zunge, JA Lagman, \"Endocrine.\" 33, \"Cyclooxygenase expression and distribution in the normal ovary and their role in ovarian cancer in the domestic hen (Gallus domesticus).\" 235 (2008)","DOI":"10.1007\/s12020-008-9080-z"},{"key":"11","doi-asserted-by":"crossref","unstructured":"D Rodler and F Sinowatz \"Acta Histochem.\" 117, \"Expression of prostaglandin synthesizing enzymes (cyclooxygenase 1 and cyclooxygenase 2) in the ovary of the ostrich (Struthio camelus).\" 69 (2015)","DOI":"10.1016\/j.acthis.2014.11.005"},{"key":"12","doi-asserted-by":"crossref","unstructured":"D Rodler and F Sinowatz \"Folia Biol (Praha).\" 61, \"Expression of prostaglandin-synthesizing enzymes (cyclooxygenase 1 and cyclooxygenase 2) in the ovary of the quail (Coturnix japonica).\" 125 (2015)","DOI":"10.1016\/j.acthis.2014.11.005"},{"key":"13","doi-asserted-by":"crossref","unstructured":"M Del Tacca, R Colucci, M Fornai, \"Clin Drug Invest.\" 22, \"Efficacy and tolerability of meloxicam, a COX-2 preferential nonsteroidal anti-inflammatory drug.\" 799 (2002)","DOI":"10.2165\/00044011-200222120-00001"},{"key":"14","unstructured":"DC. 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Kluger, \"Fever. Its Biology, Evolution and Function.\" , (1979)"},{"key":"37","doi-asserted-by":"crossref","unstructured":"CA Jones, FW Edens, DM Denbow, \"Poult Sci.\" 62, \"Influence of age on the temperature response of chickens to Escherichia coli and Salmonella typhimurium endotoxins.\" 1553 (1983)","DOI":"10.3382\/ps.0621553"},{"key":"38","doi-asserted-by":"crossref","unstructured":"S. Nomoto, \"Jpn J Physiol.\" 53, \"Role of prostaglandin E2 and indomethacin in the febrile response of pigeons.\" 253 (2003)","DOI":"10.2170\/jjphysiol.53.253"},{"key":"39","doi-asserted-by":"crossref","unstructured":"SK Maloney and DA Gray \"J Comp Physiol B.\" 168, \"Characteristics of the febrile response in Pekin ducks.\" 177 (1998)","DOI":"10.1007\/s003600050134"},{"key":"40","doi-asserted-by":"crossref","unstructured":"EA Koutsos and KC Klasing \"Comp Biochem Physiol C Toxicol Pharmacol.\" 128, \"The acute phase response in Japanese quail (Cotunix cotunix japonica).\" 255 (2001)","DOI":"10.1016\/S1532-0456(00)00199-X"},{"key":"41","doi-asserted-by":"crossref","unstructured":"JE. 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