{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:30:11Z","timestamp":1793446211896,"version":"4.5.0"},"reference-count":65,"publisher":"Radiation Research Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2020,10,12]]},"abstract":"<jats:p>Radiation-induced skin injury remains a serious concern for cancer radiotherapy, radiation accidents and occupational exposure, and the damage mainly occurs due to apoptosis and reactive oxygen species (ROS) generation. There is currently no effective treatment for this disorder. The \u03b2-catenin signaling pathway is involved in the repair and regeneration of injured tissues. However, the role of the \u03b2-catenin signaling pathway in radiation-induced skin injury has not been reported. In this study, we demonstrated that the \u03b2-catenin signaling pathway was activated in response to radiation and that its activation by Wnt3a, a ligand-protein involved in the \u03b2-catenin signaling pathway, inhibited apoptosis and the production of ROS in irradiated human keratinocyte HaCaT cells and skin fibroblast WS1 cells. Additionally, Wnt3a promoted cell migration after irradiation. In a mouse model of full-thickness skin wounds combined with total-body irradiation, Wnt3a was shown to facilitate skin wound healing. The results from RNA-Seq revealed that 24 genes were upregulated and 154 were downregulated in Wnt3a-treated irradiated skin cells, and these dysregulated genes were mainly enriched in the tight junction pathway. Among them, Marvel D3 showed the most obvious difference. We further found that the activated \u03b2-catenin signaling pathway stimulated the phosphorylation of JNK by silencing Marvel D3. Treatment of irradiated cells with SP600125, a JNK inhibitor, augmented ROS production and impeded cell migration. Furthermore, treatment with Wnt3a or transfection with Marvel D3-specific siRNAs could reverse the above effects. Taken together, these findings illustrate that activated \u03b2-catenin signaling stimulates the activation of JNK by negatively regulating Marvel D3 to ameliorate radiation-induced skin injury.<\/jats:p>","DOI":"10.1667\/rade-20-00050.1","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T09:01:06Z","timestamp":1612170066000},"page":"173-190","source":"Crossref","is-referenced-by-count":1,"title":["Activated Beta-Catenin Signaling Ameliorates Radiation-Induced Skin Injury by Suppressing Marvel D3 Expression"],"prefix":"10.1667","volume":"195","author":[{"given":"Jinming","family":"Cao","sequence":"first","affiliation":[{"name":"School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Qian","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoren","family":"Wang","sequence":"additional","affiliation":[{"name":"Nantong Tumor Hospital, Nantong University, Nantong 226000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu 610051 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yue","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jiao","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"46","doi-asserted-by":"crossref","unstructured":"F Ginhoux  and S Jung  \"Nat Rev Immunol.\"  14, \"Monocytes and macrophages: developmental pathways and tissue homeostasis.\" 392 (2014)","DOI":"10.1038\/nri3671"},{"key":"44","doi-asserted-by":"crossref","unstructured":"T Lammermann, PV Afonso, BR Angermann, et al.  \"Nature.\"  498, \"Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo.\" 371 (2013)","DOI":"10.1038\/nature12175"},{"key":"5","doi-asserted-by":"crossref","unstructured":"JC Chamcheu, IA Siddiqui, DN Syed, et al.  \"Arch Biochem Biophys.\"  508, \"Keratin gene mutations in disorders of human skin and its appendages.\" 123 (2011)","DOI":"10.1016\/j.abb.2010.12.019"},{"key":"52","doi-asserted-by":"crossref","unstructured":"G Tajima, AJ Delisle, K Hoang, et al.  \"Radiat Res.\"  179, \"Immune system phenotyping of radiation and radiation combined injury in outbred mice.\" 101 (2013)","DOI":"10.1667\/RR3120.1"},{"key":"7","doi-asserted-by":"crossref","unstructured":"JG Kiang  and AO Olabisi  \"Cell Biosci.\"  9, \"Radiation: a poly-traumatic hit leading to multi-organ injury.\" 25 (2019)","DOI":"10.1186\/s13578-019-0286-y"},{"key":"33","doi-asserted-by":"crossref","unstructured":"JL Palmer, CR Deburghgraeve, MD Bird, et al.  \"J Burn Care Res.\"  32, \"Development of a combined radiation and burn injury model.\" 317 (2011)","DOI":"10.1097\/BCR.0b013e31820aafa9"},{"key":"1","doi-asserted-by":"crossref","unstructured":"FN Brey, BJ Simmons, AH Wolfson, et al.  \"Dermatol Ther (Heidelb).\"  6, \"Acute and chronic cutaneous reactions to ionizing radiation therapy.\" 185 (2016)","DOI":"10.1007\/s13555-016-0120-y"},{"key":"2","doi-asserted-by":"crossref","unstructured":"RM Brand, MW Epperly, JM Stottlemyer, et al.  \"J Invest Dermatol.\"  137, \"A topical mitochondria-targeted redox-cycling nitroxide mitigates oxidative stress\u2013induced skin damage.\" 576 (2017)","DOI":"10.1016\/j.jid.2016.09.033"},{"key":"3","unstructured":"TC Pellmar  and GD Ledney  \"NATO RTG.\"  099, \"Combined injury: radiation in combination with trauma, infectious disease, or chemical exposures.\" 1 (2017)"},{"key":"4","unstructured":"AM. Johnson,  \"J R Army Med Corps.\"  150, \"Pulmonary effects of combined the blast injury and radiation poisoning.\" 22 (2004)"},{"key":"6","doi-asserted-by":"crossref","unstructured":"G Atturu, S Homer-Vanniasinkam, DA Russell,  \"Semin Intervent Radiol.\"  31, \"Pharmacology in peripheral arterial disease: what the interventional radiologist needs to know.\" 330 (2014)","DOI":"10.1055\/s-0034-1393969"},{"key":"8","doi-asserted-by":"crossref","unstructured":"SA Eming, P Martin, M Tomic-Canic,  \"Sci Trans Med.\"  6, \"Wound repair and regeneration: mechanisms, signaling, and translation.\" 265sr6 (2014)","DOI":"10.1126\/scitranslmed.3009337"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Y Li  and J Jiao  \"J Cell Biol.\"  216, \"Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via beta-catenin.\" 1975 (2017)","DOI":"10.1083\/jcb.201610014"},{"key":"10","doi-asserted-by":"crossref","unstructured":"SP. Monga,  \"Gene Expr.\"  16, \"Role and regulation of beta-catenin signaling during physiological liver growth.\" 51 (2014)","DOI":"10.3727\/105221614X13919976902138"},{"key":"11","doi-asserted-by":"crossref","unstructured":"S Amini-Nik, E Cambridge, W Yu, et al.  \"J Clin Invest.\"  124, \"Beta-catenin-regulated myeloid cell adhesion and migration determine wound healing.\" 2599 (2014)","DOI":"10.1172\/JCI62059"},{"key":"12","doi-asserted-by":"crossref","unstructured":"W Lento, T Ito, C Zhao, et al.  \"Genes Dev.\"  28, \"Loss of beta-catenin triggers oxidative stress and impairs hematopoietic regeneration.\" 995 (2014)","DOI":"10.1101\/gad.231944.113"},{"key":"13","doi-asserted-by":"crossref","unstructured":"B Hai, Z Yang, L Shangguan, et al.  \"Int J Radiat Oncol Biol Phys.\"  83, \"Concurrent transient activation of Wnt\/beta-catenin pathway prevents radiation damage to salivary glands.\" e109 (2012)","DOI":"10.1016\/j.ijrobp.2011.11.062"},{"key":"14","doi-asserted-by":"crossref","unstructured":"JL Whyte, AA Smith, L Bo, et al.  \"PLoS One.\"  8, \"Augmenting endogenous Wnt signaling improves skin wound healing.\" e76883 (2013)","DOI":"10.1371\/journal.pone.0076883"},{"key":"15","doi-asserted-by":"crossref","unstructured":"M Ito, Z Yang, T Andl, et al.  \"Nature.\"  447, \"Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding.\" 316 (2007)","DOI":"10.1038\/nature05766"},{"key":"16","doi-asserted-by":"crossref","unstructured":"CL Stoick-Cooper, G Weidinger, KJ Riehle, et al.  \"Development.\"  134, \"Distinct Wnt signaling pathways have opposing roles in appendage regeneration.\" 479 (2007)","DOI":"10.1242\/dev.001123"},{"key":"17","doi-asserted-by":"crossref","unstructured":"WJ Wang, JD Luo, WJ Sheng, et al.  \"Int J Radiat Oncol Biol Phys.\"  95, \"Proteomic profiling of radiation-induced skin fibrosis in rats: targeting the ubiquitin-proteasome system.\" 751 (2016)","DOI":"10.1016\/j.ijrobp.2016.01.021"},{"key":"18","doi-asserted-by":"crossref","unstructured":"SY Zhang, WJ Wang, Q Gu, et al.  \"Free Radic Biol Med.\"  69, \"Protein and miRNA profiling of radiation-induced skin injury in rats: the protective role of peroxiredoxin-6 against ionizing radiation.\" 96 (2014)","DOI":"10.1016\/j.freeradbiomed.2014.01.019"},{"key":"19","doi-asserted-by":"crossref","unstructured":"MT Veeman, DC Slusarski, A Kaykas, et al.  \"Curr Biol.\"  13, \"Zebrafish prickle, a modulator of noncanonical Wnt\/Fz signaling, regulates gastrulation movements.\" 680 (2003)","DOI":"10.1016\/S0960-9822(03)00240-9"},{"key":"20","doi-asserted-by":"crossref","unstructured":"JM Cao, W Zhu, DJ Yu, et al.  \"Radiat Res.\"  192, \"The involvement of SDF-1alpha\/CXCR4 axis in radiation-induced acute injury and fibrosis of skin.\" 410 (2019)","DOI":"10.1667\/RR15384.1"},{"key":"21","doi-asserted-by":"crossref","unstructured":"E Steed, NT Rodrigues, MS Balda, et al.  \"BMC Cell Biol.\"  10, \"Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family.\" 1 (2009)","DOI":"10.1186\/1471-2121-10-95"},{"key":"22","doi-asserted-by":"crossref","unstructured":"P Aurelien, L Jeongeun, R Gennadiy, et al.  \"PLoS One.\"  9, \"Collective epithelial migration drives kidney repair after acute injury.\" e101304 (2014)","DOI":"10.1371\/journal.pone.0101304"},{"key":"23","doi-asserted-by":"crossref","unstructured":"E Lang, A Polec, A Lang, et al.  \"Nat Commun.\"  9, \"Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding.\" 3665 (2018)","DOI":"10.1038\/s41467-018-05578-7"},{"key":"24","doi-asserted-by":"crossref","unstructured":"B Vacca, E Sanchez-Heras, E Steed, et al.  \"Sci Rep.\"  8, \"Control of neural crest induction by MarvelD3-mediated attenuation of JNK signaling.\" 1204 (2018)","DOI":"10.1038\/s41598-018-19579-5"},{"key":"25","doi-asserted-by":"crossref","unstructured":"CM Van Itallie, JM Anderson, D Biology,  \"Semin Cell Dev Biol.\"  36, \"Architecture of tight junctions and principles of molecular composition.\" 157 (2014)","DOI":"10.1016\/j.semcdb.2014.08.011"},{"key":"26","doi-asserted-by":"crossref","unstructured":"H Tanjore, AL Degryse, PF Crossno, et al.  \"Am J Respir Crit Care Med.\"  187, \"Beta-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycin.\" 630 (2013)","DOI":"10.1164\/rccm.201205-0972OC"},{"key":"27","doi-asserted-by":"crossref","unstructured":"P Bhanja, A Norris, P Gupta-Saraf, et al.  \"Stem Cell Res Ther.\"  9, \"BCN057 induces intestinal stem cell repair and mitigates radiation-induced intestinal injury.\" 26 (2018)","DOI":"10.1186\/s13287-017-0763-3"},{"key":"28","doi-asserted-by":"crossref","unstructured":"JP Gerlach, BL Emmink, H Nojima, et al.  \"Open Biol.\"  4, \"Wnt signaling induces accumulation of phosphorylated beta-catenin in two distinct cytosolic complexes.\" 140120 (2014)","DOI":"10.1098\/rsob.140120"},{"key":"29","doi-asserted-by":"crossref","unstructured":"T Valenta, G Hausmann, K Basler,  \"EMBO J.\"  31, \"The many faces and functions of beta-catenin.\" 2714 (2012)","DOI":"10.1038\/emboj.2012.150"},{"key":"30","doi-asserted-by":"crossref","unstructured":"SY Zhang, CJ Song, JD Zhou, et al.  \"Radiat Oncol.\"  7, \"Amelioration of radiation-induced skin injury by adenovirus-mediated heme oxygenase-1 (HO-1) overexpression in rats.\" 4 (2012)","DOI":"10.1186\/1748-717X-7-4"},{"key":"31","doi-asserted-by":"crossref","unstructured":"RR Kohl, A Kolozsvary, SL Brown, et al.  \"Radiat Res.\"  168, \"Differential radiation effect in tumor and normal tissue after treatment with ramipril, an angiotensin-converting enzyme inhibitor.\" 440 (2007)","DOI":"10.1667\/RR0707.1"},{"key":"32","doi-asserted-by":"crossref","unstructured":"J Xue, CX Yu, WJ Sheng, et al.  \"J Invest Dermatol.\"  137, \"The Nrf2\/GCH1\/BH4 axis ameliorates radiation-induced skin injury by modulating the ROS cascade.\" 2059 (2017)","DOI":"10.1016\/j.jid.2017.05.019"},{"key":"34","doi-asserted-by":"crossref","unstructured":"F Wang, X Wang, K Ma, et al.  \"Wound Repair Regen.\"  28, \"Akermanite bioceramic enhances wound healing with accelerated reepithelialization by promoting proliferation, migration, and stemness of epidermal cells.\" 16 (2020)","DOI":"10.1111\/wrr.12742"},{"key":"35","doi-asserted-by":"crossref","unstructured":"DP Wan, Y Fu, YY Li, et al.  \"Stem Cells Int.\"  2019, \"Luteolin-7-glucoside promotes human epidermal stem cell proliferation by upregulating beta-catenin, c-Myc and cyclin expression.\" 1575480 (2019)","DOI":"10.1155\/2019\/1575480"},{"key":"36","doi-asserted-by":"crossref","unstructured":"LW Jia, JX Zhou, S Peng, et al.  \"Biochem Biophys Res Commun.\"  368, \"Effects of Wnt3a on proliferation and differentiation of human epidermal stem cells.\" 483 (2008)","DOI":"10.1016\/j.bbrc.2008.01.097"},{"key":"37","doi-asserted-by":"crossref","unstructured":"SH Lee, SY Jin, JS Song, et al.  \"Ann Dermatol.\"  24, \"Paracrine effects of adipose-derived stem cells on keratinocytes and dermal fibroblasts.\" 136 (2012)","DOI":"10.5021\/ad.2012.24.2.136"},{"key":"38","doi-asserted-by":"crossref","unstructured":"S Schlosser, C Dennler, R Schweizer, et al.  \"Microvasc Res.\"  83, \"Paracrine effects of mesenchymal stem cells enhance vascular regeneration in ischemic murine skin.\" 267 (2012)","DOI":"10.1016\/j.mvr.2012.02.011"},{"key":"39","doi-asserted-by":"crossref","unstructured":"DE Lee, N Ayoub, DK Agrawal,  \"Stem Cell Res Ther.\"  7, \"Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy.\" 37 (2016)","DOI":"10.1186\/s13287-016-0303-6"},{"key":"40","doi-asserted-by":"crossref","unstructured":"JL Yan, GD Tie, SY Wang, et al.  \"Nat Commun.\"  9, \"Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.\" 33 (2018)","DOI":"10.1038\/s41467-017-02425-z"},{"key":"41","doi-asserted-by":"crossref","unstructured":"JL Whyte, AA Smith, JA Helms,  \"Cold Spring Harb Perspect Biol.\"  4, \"Wnt signaling and injury repair.\" a008078 (2012)","DOI":"10.1101\/cshperspect.a008078"},{"key":"42","doi-asserted-by":"crossref","unstructured":"J Schuijers  and H Clevers  \"EMBO J.\"  31, \"Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins.\" 2685 (2012)","DOI":"10.1038\/emboj.2012.149"},{"key":"43","doi-asserted-by":"crossref","unstructured":"AV Nguyen  and AM Soulika  \"Int J Mol Sci.\"  20, \"The dynamics of the skin's immune system.\" 1811 (2019)","DOI":"10.3390\/ijms20081811"},{"key":"45","doi-asserted-by":"crossref","unstructured":"S Oliveira, EE Rosowski, A Huttenlocher,  \"Nat Rev Immunol.\"  16, \"Neutrophil migration in infection and wound repair: Going forward in reverse.\" 378 (2016)","DOI":"10.1038\/nri.2016.49"},{"key":"47","doi-asserted-by":"crossref","unstructured":"S Willenborg, T Lucas, G Loo, et al.  \"Blood.\"  120, \"CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair.\" 613 (2012)","DOI":"10.1182\/blood-2012-01-403386"},{"key":"48","doi-asserted-by":"crossref","unstructured":"B Shook, E Xiao, Y Kumamoto, et al.  \"J Invest Dermatol.\"  136, \"CD301b+ macrophages are essential for effective skin wound healing.\" 1885 (2016)","DOI":"10.1016\/j.jid.2016.05.107"},{"key":"49","doi-asserted-by":"crossref","unstructured":"FM Menzies, FL Henriquez, J Alexander, et al.  \"Clin Exp Immunol.\"  160, \"Sequential expression of macrophage anti-microbial\/inflammatory and wound healing markers following innate, alternative and classical activation.\" 369 (2010)","DOI":"10.1111\/j.1365-2249.2009.04086.x"},{"key":"50","doi-asserted-by":"crossref","unstructured":"M Vinish, WH Cui, E Stafford, et al.  \"Wound Repair Regen.\"  24, \"Dendritic cells modulate burn wound healing by enhancing early proliferation.\" 6 (2016)","DOI":"10.1111\/wrr.12388"},{"key":"51","doi-asserted-by":"crossref","unstructured":"M Haseeb, RH Pirzada, QU Ain, et al.  \"Cells.\"  8, \"Wnt signaling in the regulation of immune cell and cancer therapeutics.\" 1380 (2019)","DOI":"10.3390\/cells8111380"},{"key":"53","doi-asserted-by":"crossref","unstructured":"MS Balda  and K Matter  \"Biochim Biophys Acta.\"  1788, \"Tight junctions and the regulation of gene expression.\" 761 (2009)","DOI":"10.1016\/j.bbamem.2008.11.024"},{"key":"54","doi-asserted-by":"crossref","unstructured":"MS Balda  and K Matter  \"J Cell Sci.\"  121, \"Tight junctions at a glance.\" 3677 (2008)","DOI":"10.1242\/jcs.023887"},{"key":"55","doi-asserted-by":"crossref","unstructured":"G Xie, X Ao, T Lin, et al.  \"J Invest Dermatol.\"  137, \"E-cadherin-mediated cell contact controls the epidermal damage response in radiation dermatitis.\" 1731 (2017)","DOI":"10.1016\/j.jid.2017.03.036"},{"key":"56","doi-asserted-by":"crossref","unstructured":"K Matter  and MS Balda  \"Cell.\"  157, \"SnapShot: Epithelial tight junctions.\" 992 (2014)","DOI":"10.1016\/j.cell.2014.04.027"},{"key":"57","doi-asserted-by":"crossref","unstructured":"C Zihni, C Mills, K Matter, et al.  \"Nat Rev Mol Cell Biol.\"  17, \"Tight junctions: from simple barriers to multifunctional molecular gates.\" 564 (2016)","DOI":"10.1038\/nrm.2016.80"},{"key":"58","doi-asserted-by":"crossref","unstructured":"E Steed, A Elbediwy, B Vacca, et al.  \"J Cell Biol.\"  204, \"MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival.\" 821 (2014)","DOI":"10.1083\/jcb.201304115"},{"key":"59","doi-asserted-by":"crossref","unstructured":"T Kojima, A Takasawa, D Kyuno, et al.  \"Exp Cell Res.\"  317, \"Downregulation of tight junction-associated MARVEL protein marvelD3 during epithelial\u2013mesenchymal transition in human pancreatic cancer cells.\" 2288 (2011)","DOI":"10.1016\/j.yexcr.2011.06.020"},{"key":"60","doi-asserted-by":"crossref","unstructured":"DR Raleigh, AM Marchiando, Y Zhang, et al.  \"Mol Biol Cell.\"  21, \"Tight junction-associated MARVEL proteins marvelD3, tricellulin, and occludin have distinct but overlapping functions.\" 1200 (2010)","DOI":"10.1091\/mbc.e09-08-0734"},{"key":"61","doi-asserted-by":"crossref","unstructured":"DN Dhanasekaran  and EP Reddy  \"Genes Cancer.\"  8, \"JNK-signaling: A multiplexing hub in programmed cell death.\" 682 (2017)","DOI":"10.18632\/genesandcancer.155"},{"key":"62","doi-asserted-by":"crossref","unstructured":"JC Chen, BB Lin, HW Hu, et al.  \"Biomed Res Int.\"  2014, \"NGF accelerates cutaneous wound healing by promoting the migration of dermal fibroblasts via the PI3K\/Akt-Rac1-JNK and ERK pathways.\" 547187 (2014)","DOI":"10.1155\/2014\/547187"},{"key":"63","doi-asserted-by":"crossref","unstructured":"BC Lee, J Song, A Lee, et al.  \"Int J Mol Sci.\"  19, \"Visfatin promotes wound healing through the activation of ERK1\/2 and JNK1\/2 pathway.\" 3642 (2018)","DOI":"10.3390\/ijms19113642"},{"key":"64","doi-asserted-by":"crossref","unstructured":"HR Willsey, X Zheng, JC Pastorpareja, et al.  \"Elife.\"  5, \"Localized JNK signaling regulates organ size during development.\" e11491 (2016)","DOI":"10.7554\/eLife.11491"},{"key":"65","doi-asserted-by":"crossref","unstructured":"A Zeke, M Misheva, A Remenyi, et al.  \"Microbiol Mol Biol Rev.\"  80, \"JNK Signaling: regulation and functions based on complex protein-protein partnerships.\" 793 (2016)","DOI":"10.1128\/MMBR.00043-14"}],"container-title":["Radiation Research"],"original-title":[],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:32:13Z","timestamp":1793442733000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-195\/issue-2\/RADE-20-00050.1\/Activated-Beta-Catenin-Signaling-Ameliorates-Radiation-Induced-Skin-Injury-by\/10.1667\/RADE-20-00050.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,12]]},"references-count":65,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rade-20-00050.1","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,12]]}}}