{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:31:59Z","timestamp":1793446319201,"version":"4.5.0"},"reference-count":170,"publisher":"Radiation Research Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2020,8,28]]},"abstract":"<jats:p>Many cases of human exposures to high-dose radiation have been documented, including individuals exposed during the detonation of atomic bombs in Hiroshima and Nagasaki, nuclear power plant disasters (e.g., Chernobyl), as well as industrial and medical accidents. For many of these exposures, injuries to the skin have been present and have played a significant role in the progression of the injuries and survivability from the radiation exposure. There are also instances of radiation-induced skin complications in routine clinical radiotherapy and radiation diagnostic imaging procedures. In response to the threat of a radiological or nuclear mass casualty incident, the U.S. Department of Health and Human Services tasked the National Institute of Allergy and Infectious Diseases (NIAID) with identifying and funding early- to mid-stage medical countermeasure (MCM) development to treat radiation-induced injuries, including those to the skin. To appropriately assess the severity of radiation-induced skin injuries and determine efficacy of different approaches to mitigate\/treat them, it is necessary to develop animal models that appropriately simulate what is seen in humans who have been exposed. In addition, it is important to understand the techniques that are used in other clinical indications (e.g., thermal burns, diabetic ulcers, etc.) to accurately assess the extent of skin injury and progression of healing. For these reasons, the NIAID partnered with two other U.S. Government funding and regulatory agencies, the Biomedical Advanced Research and Development Authority (BARDA) and the Food and Drug Administration (FDA), to identify state-of-the-art methods in assessment of skin injuries, explore animal models to better understand radiation-induced cutaneous damage and investigate treatment approaches. A two-day workshop was convened in May 2019 highlighting talks from 28 subject matter experts across five scientific sessions. This report provides an overview of information that was presented and the subsequent guided discussions.<\/jats:p>","DOI":"10.1667\/rade-20-00120.1","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T11:09:37Z","timestamp":1600081777000},"page":"315-344","source":"Crossref","is-referenced-by-count":83,"title":["Cutaneous Radiation Injuries: Models, Assessment and Treatments"],"prefix":"10.1667","volume":"194","author":[{"given":"Andrea L.","family":"DiCarlo","sequence":"first","affiliation":[{"name":"Radiation and Nuclear Countermeasures Program (RNCP), Division of Allergy, Immunology and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron C.","family":"Bandremer","sequence":"additional","affiliation":[{"name":"Biomedical Advanced Research and Development Authority (BARDA), Department of Health and Human Services (HHS), Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brynn A.","family":"Hollingsworth","sequence":"additional","affiliation":[{"name":"Radiation and Nuclear Countermeasures Program (RNCP), Division of Allergy, Immunology and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhail","family":"Kasim","sequence":"additional","affiliation":[{"name":"U.S. Food and Drug Administration (FDA), White Oak, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adebayo","family":"Laniyonu","sequence":"additional","affiliation":[{"name":"U.S. Food and Drug Administration (FDA), White Oak, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nushin F.","family":"Todd","sequence":"additional","affiliation":[{"name":"U.S. Food and Drug Administration (FDA), White Oak, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue-Jane","family":"Wang","sequence":"additional","affiliation":[{"name":"U.S. Food and Drug Administration (FDA), White Oak, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen R.","family":"Wertheimer","sequence":"additional","affiliation":[{"name":"DRT Strategies, Arlington, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen I.","family":"Rios","sequence":"additional","affiliation":[{"name":"Radiation and Nuclear Countermeasures Program (RNCP), Division of Allergy, Immunology and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"55","doi-asserted-by":"crossref","unstructured":"JM Straub, J New, CD Hamilton, et al.  \"J Cancer Res Clin Oncol.\"  141, \"Radiation-induced fibrosis: mechanisms and implications for therapy.\" 1985 (2015)","DOI":"10.1007\/s00432-015-1974-6"},{"key":"22","doi-asserted-by":"crossref","unstructured":"LK Jacobson, MB Johnson, RD Dedhia, et al.  \"JPRAS Open.\"  13, \"Impaired wound healing after radiation therapy: A systematic review of pathogenesis and treatment.\" 92 (2017)","DOI":"10.1016\/j.jpra.2017.04.001"},{"key":"128","doi-asserted-by":"crossref","unstructured":"JK Waselenko, TJ MacVittie, WF Blakely, et al.  \"Ann Intern Med.\"  140, \"Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group.\" 1037 (2004)","DOI":"10.7326\/0003-4819-140-12-200406150-00015"},{"key":"146","doi-asserted-by":"crossref","unstructured":"S Flamant  and R Tamarat  \"Radiat Res.\"  186, \"Extracellular vesicles and vascular injury: new insights for radiation exposure.\" 203 (2016)","DOI":"10.1667\/RR14482.1"},{"key":"101","doi-asserted-by":"crossref","unstructured":"MS. 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