{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:34:25Z","timestamp":1793442865590,"version":"4.5.0"},"reference-count":49,"publisher":"Radiation Research Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2020,11,12]]},"abstract":"<jats:p>Administration of diethylenetriaminepentaacetic acid (DTPA) is the treatment approach used to promote the decorporation of internalized plutonium. Here we evaluated the efficacy of PEGylated liposomes coated with DTPA, primarily designed to prevent enhanced plutonium accumulation in bones, compared to marketed nonliposomal DTPA and liposomes encapsulating DTPA. The comparative effects were examined in terms of reduction of activity in tissues of plutonium-injected rats. The prompt treatment with DTPA-coated liposomes elicited an even greater efficacy than that with liposome-encapsulated DTPA in limiting skeletal plutonium. This advantage, undoubtedly due to the anchorage of DTPA to the outer layer of liposomes, is discussed, as well as the reason for the loss of this superiority at delayed times after contamination. Plutonium complexed with DTPA-coated liposomes in extracellular compartments was partly diverted into the liver and the spleen. These complexes and those directly formed inside hepatic and splenic cells appeared to be degraded, then released from cells at extremely slow rates. This transitory accumulation of activity, which could not be counteracted by combining both liposomal forms, entailed an underestimation of the efficacy of DTPA-coated liposomes on soft tissue plutonium until total elimination probably more than one month after treatment. DTPA-coated liposomes may provide the best delivery vehicle of DTPA for preventing plutonium deposition in tissues, especially in bone where nuclides become nearly impossible to remove once fixed. Additional development efforts are needed to limit the diversion or to accelerate cell release of plutonium bound to DTPA-coated liposomes, using a labile bond for DTPA attachment.<\/jats:p>","DOI":"10.1667\/rade-20-00142.1","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T11:39:37Z","timestamp":1609414777000},"page":"77-92","source":"Crossref","is-referenced-by-count":1,"title":["DTPA-Coated Liposomes as a New Delivery Vehicle for Plutonium Decorporation"],"prefix":"10.1667","volume":"195","author":[{"given":"Olivier","family":"Gr\u00e9my","sequence":"first","affiliation":[{"name":"Laboratoire de RadioToxicologie, CEA, Universit\u00e9 de Paris-Saclay, Bruy\u00e8res-le-Ch\u00e2tel, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Mougin-Degraef","sequence":"additional","affiliation":[{"name":"CRCINA, INSERM, CNRS, Universit\u00e9 d'Angers, Universit\u00e9 de Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Devilliers","sequence":"additional","affiliation":[{"name":"Laboratoire de RadioToxicologie, CEA, Universit\u00e9 de Paris-Saclay, Bruy\u00e8res-le-Ch\u00e2tel, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Berdal","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, University Hospital, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Laroche","sequence":"additional","affiliation":[{"name":"Direction of Health, Security, Environment and Radioprotection, ORANO, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Miccoli","sequence":"additional","affiliation":[{"name":"Laboratoire de RadioToxicologie, CEA, Universit\u00e9 de Paris-Saclay, Bruy\u00e8res-le-Ch\u00e2tel, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"22","doi-asserted-by":"crossref","unstructured":"J Schubert, JF Fried, MW Rosenthal, et al.  \"Radiat Res.\"  15, \"Tissue distribution of monomeric and polymeric plutonium as modified by a chelating agent.\" 220 (1961)","DOI":"10.2307\/3571253"},{"key":"44","doi-asserted-by":"crossref","unstructured":"P Fritsch, AL Serandour, O Gr\u00e9my, et al.  \"Health Phys.\"  99, \"Structure of a single model to describe plutonium and americium decorporation by DTPA treatments.\" 553 (2010)","DOI":"10.1097\/HP.0b013e3181c1cccd"},{"key":"29","doi-asserted-by":"crossref","unstructured":"O Gr\u00e9my, L Miccoli, F Lelan, et al.  \"Radiat Res.\"  189, \"Delivery of DTPA through liposomes as a good strategy for enhancing plutonium decorporation regardless of treatment regimen.\" 477 (2018)","DOI":"10.1667\/RR14968.1"},{"key":"11","doi-asserted-by":"crossref","unstructured":"O Gr\u00e9my, D Laurent, S Coudert, et al.  \"Radiat Res.\"  185, \"Decorporation of Pu\/Am actinides by chelation therapy: New arguments in favor of an intracellular component of DTPA action.\" 568 (2016)","DOI":"10.1667\/RR14193.1"},{"key":"32","doi-asserted-by":"crossref","unstructured":"BJ Grube, W Stevens, DR Atherton,  \"Radiat Res.\"  73, \"The retention of plutonium in hepatocytes and sinusoidal lining cells isolated from rat liver.\" 168 (1978)","DOI":"10.2307\/3574581"},{"key":"8","doi-asserted-by":"crossref","unstructured":"JW Stather, H Smith, MR Bailey, et al.  \"Health Phys.\"  44, \"The retention of 14C-DTPA in human volunteers after inhalation or intravenous injection.\" 45 (1983)","DOI":"10.1097\/00004032-198301000-00006"},{"key":"7","doi-asserted-by":"crossref","unstructured":"W Stevens, FW Bruenger, DR Atherton, et al.  \"Radiat Res.\"  75, \"The retention and distribution of 241Am and 65Zn, given as DTPA chelates in rats and of [14C]DTPA in rats and beagles.\" 397 (1978)","DOI":"10.2307\/3574913"},{"key":"10","doi-asserted-by":"crossref","unstructured":"HD Roedler, D Nosske, L Ohlenschlager, et al.  \"Radiat Prot Dosim.\"  26, \"Incorporation of 241Am: effectiveness of late DTPA chelation therapy.\" 377 (1989)","DOI":"10.1093\/oxfordjournals.rpd.a080433"},{"key":"31","doi-asserted-by":"crossref","unstructured":"MH Bhattacharyya  and A Lindenbaum  \"Radiat Res.\"  66, \"Association of plutonium with isolated liver parenchymal cells following injection of monomeric plutonium into mice.\" 552 (1976)","DOI":"10.2307\/3574459"},{"key":"33","doi-asserted-by":"crossref","unstructured":"M Fouillit, G Grillon, P Fritsch, et al.  \"Int J Radiat Biol.\"  80, \"Comparative tissue uptake and cellular deposition of three different plutonium chemical forms in rats.\" 683 (2004)","DOI":"10.1080\/09553000400005486"},{"key":"39","doi-asserted-by":"crossref","unstructured":"W. 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