{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T03:40:50Z","timestamp":1768707650757,"version":"3.49.0"},"reference-count":35,"publisher":"Radiation Research Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2021,3,23]]},"DOI":"10.1667\/rade-20-00239.1","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T05:28:42Z","timestamp":1620019722000},"source":"Crossref","is-referenced-by-count":9,"title":["Curcumin Enhances the Radiosensitivity of Human Urethral Scar Fibroblasts by Apoptosis, Cell Cycle Arrest and Downregulation of Smad4 via Autophagy"],"prefix":"10.1667","volume":"195","author":[{"given":"Chun","family":"Du","sequence":"first","affiliation":[{"name":"Departments of Urology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfeng","family":"Tian","sequence":"additional","affiliation":[{"name":"Xi'an Medical University, Xi'an 710068, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanli","family":"Duan","sequence":"additional","affiliation":[{"name":"Departments of Urology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Departments of Radiotherapy, Shaanxi Provincial People's Hospital, Xi'an 710068, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Ren","sequence":"additional","affiliation":[{"name":"Departments of Urology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Deng","sequence":"additional","affiliation":[{"name":"Departments of Urology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1243","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"YH Sun, CL Xu, X Gao, et al.  \"J Endourol.\"  15, \"Intraurethral brachytherapy for prevention of recurrent urethral stricture after internal urethrotomy or transurethral resection of scar.\" 859 (2001)","DOI":"10.1089\/089277901753205906"},{"key":"2","doi-asserted-by":"crossref","unstructured":"TA Mustoe, RD Cooter, MH Gold, et al.  \"Plast Reconstr Surg.\"  110, \"International clinical recommendations on scar management.\" 560 (2002)","DOI":"10.1097\/00006534-200208000-00031"},{"key":"3","doi-asserted-by":"crossref","unstructured":"K Song, S Peng, Z Sun, et al.  \"Biochem Biophys Res Commun.\"  411, \"Curcumin suppresses TGFbeta signaling by inhibition of TGIF degradation in scleroderma fibroblasts.\" 821 (2011)","DOI":"10.1016\/j.bbrc.2011.07.044"},{"key":"4","doi-asserted-by":"crossref","unstructured":"H Shanlong, Y Chuance, L Min, et al.  \"Biomed Pharmacother.\"  106, \"Effect of dual mTOR inhibitor on TGFbeta1-induced fibrosis in primary human urethral scar fibroblasts.\" 1182 (2018)","DOI":"10.1016\/j.biopha.2018.07.070"},{"key":"5","doi-asserted-by":"crossref","unstructured":"D Chendil, A Das, S Dey, et al.  \"Cancer Biol Ther.\"  1, \"Par-4, a pro-apoptotic gene, inhibits radiation-induced NF kappa B activity and Bcl-2 expression leading to induction of radiosensitivity in human prostate cancer cells PC-3.\" 152 (2002)","DOI":"10.4161\/cbt.61"},{"key":"6","doi-asserted-by":"crossref","unstructured":"HL Andersen, BU Duch, JB Nielsen, et al.  \"Urol Res.\"  31, \"An experimental model for stricture studies in the anterior urethra of the male rabbit.\" 363 (2003)","DOI":"10.1007\/s00240-003-0333-2"},{"key":"7","doi-asserted-by":"crossref","unstructured":"DS Levy, MM Salter, RE Roth,  \"AJR Am J Roentgenol.\"  127, \"Postoperative irradiation in the prevention of keloids.\" 509 (1976)","DOI":"10.2214\/ajr.127.3.509"},{"key":"8","unstructured":"S Malhotra  and PS Teirstein  \"J Invasive Cardiol.\"  12, \"The SCRIPPS trial\u2013catheter-based radiotherapy to inhibit coronary restenosis.\" 330 (2000)"},{"key":"9","doi-asserted-by":"crossref","unstructured":"T Olschewski, D Kropfl, MH Seegenschmiedt,  \"Int J Radiat Oncol Biol Phys.\"  57, \"Endourethral brachytherapy for prevention of recurrent urethral stricture following internal urethrotomy\u2013first clinical experiences and results.\" 1400 (2003)","DOI":"10.1016\/S0360-3016(03)00779-X"},{"key":"10","unstructured":"D Kropfl, T Olschewski, MH Seegenschmiedt,  \"Urologe A.\"  43, \"Endourethral brachytherapy for the prevention of recurrent strictures following internal urethrotomy. (Article in German).\" 1254 (2004)"},{"key":"11","doi-asserted-by":"crossref","unstructured":"A Enhamre  and H Hammar  \"Dermatologica.\"  167, \"Treatment of keloids with excision and postoperative X-ray irradiation.\" 90 (1983)","DOI":"10.1159\/000249754"},{"key":"12","unstructured":"MD Hofer  and CM Gonzalez  \"Transl Androl Urol.\"  4, \"Management of radiation-induced urethral strictures.\" 66 (2015)"},{"key":"13","doi-asserted-by":"crossref","unstructured":"DD Shapiro, DC Goodspeed, W Bushman,  \"Urology.\"  114, \"Urosymphyseal fistulas resulting from endoscopic treatment of radiation-induced posterior urethral strictures.\" 207 (2018)","DOI":"10.1016\/j.urology.2017.12.020"},{"key":"14","doi-asserted-by":"crossref","unstructured":"F Ghasemi, M Shafiee, Z Banikazemi, et al.  \"Pathol Res Pract.\"  215, \"Curcumin inhibits NF-kB and Wnt\/beta-catenin pathways in cervical cancer cells.\" 152556 (2019)","DOI":"10.1016\/j.prp.2019.152556"},{"key":"15","doi-asserted-by":"crossref","unstructured":"A Noorafshan  and S Ashkani-Esfahani  \"Curr Pharm Des.\"  19, \"A review of therapeutic effects of curcumin.\" 2032 (2013)","DOI":"10.2174\/138161213805289273"},{"key":"16","doi-asserted-by":"crossref","unstructured":"R Mardani, MR Hamblin, M Taghizadeh, et al.  \"Pathol Res Pract.\"  216, \"Nanomicellar-curcumin exerts its therapeutic effects via affecting angiogenesis, apoptosis, and T cells in a mouse model of melanoma lung metastasis.\" 153082 (2020)","DOI":"10.1016\/j.prp.2020.153082"},{"key":"17","unstructured":"HC Wu  and B Zhang  \"Zhongguo Zhong Xi Yi Jie He Za Zhi.\"  33, \"The mechanism progress of anti-fibrosis by curcumin. (Article in Chinese).\" 135 (2013)"},{"key":"18","doi-asserted-by":"crossref","unstructured":"V. Verma,  \"World J Clin Oncol.\"  7, \"Relationship and interactions of curcumin with radiation therapy.\" 275 (2016)","DOI":"10.5306\/wjco.v7.i3.275"},{"key":"19","doi-asserted-by":"crossref","unstructured":"L Minafra, N Porcino, V Bravata, et al.  \"Sci Rep.\"  9, \"Radiosensitizing effect of curcumin-loaded lipid nanoparticles in breast cancer cells.\" 11134 (2019)","DOI":"10.1038\/s41598-019-47553-2"},{"key":"20","doi-asserted-by":"crossref","unstructured":"G Yang, J Qiu, D Wang, et al.  \"Anticancer Res.\"  38, \"Traditional Chinese medicine curcumin sensitizes human colon cancer to radiation by altering the expression of DNA repair-related genes.\" 131 (2018)","DOI":"10.21873\/anticanres.12200"},{"key":"21","doi-asserted-by":"crossref","unstructured":"FT Hsu, YC Liu, TT Liu, et al.  \"Biomed Res Int.\"  2015, \"Curcumin sensitizes hepatocellular carcinoma cells to radiation via suppression of radiation-induced NF-kappaB activity.\" 363671 (2015)","DOI":"10.1155\/2015\/363671"},{"key":"22","doi-asserted-by":"crossref","unstructured":"IT Chiang, YC Liu, FT Hsu, et al.  \"Oncol Rep.\"  31, \"Curcumin synergistically enhances the radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-kappaB activity.\" 1729 (2014)","DOI":"10.3892\/or.2014.3009"},{"key":"23","doi-asserted-by":"crossref","unstructured":"N Sebastia, A Montoro, D Hervas, et al.  \"Mutat Res.\"  766\u20137, \"Curcumin and trans-resveratrol exert cell cycle-dependent radioprotective or radiosensitizing effects as elucidated by the PCC and G2-assay.\" 49 (2014)","DOI":"10.1016\/j.mrfmmm.2014.05.006"},{"key":"24","doi-asserted-by":"crossref","unstructured":"G Li, Z Wang, T Chong, et al.  \"Biomed Pharmacother.\"  94, \"Curcumin enhances the radiosensitivity of renal cancer cells by suppressing NF-kappaB signaling pathway.\" 974 (2017)","DOI":"10.1016\/j.biopha.2017.07.148"},{"key":"25","unstructured":"MA Shah  and GK Schwartz  \"Clin Cancer Res.\"  7, \"Cell cycle-mediated drug resistance: an emerging concept in cancer therapy.\" 2168 (2001)"},{"key":"26","doi-asserted-by":"crossref","unstructured":"X Zhang, L Peng, A Liu, et al.  \"J Pharm Pharmacol.\"  70, \"The enhanced effect of tetrahydrocurcumin on radiosensitivity of glioma cells.\" 749 (2018)","DOI":"10.1111\/jphp.12891"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Y Tian, R Wazir, X Yue, et al.  \"J Endourol.\"  28, \"Prevention of stricture recurrence following urethral endoscopic management: what do we have?\" 502 (2014)","DOI":"10.1089\/end.2013.0538"},{"key":"28","doi-asserted-by":"crossref","unstructured":"KK Kim, D Sheppard, HA Chapman,  \"Cold Spring Harb Perspect Biol.\"  10, \"TGF-beta1 signaling and tissue fibrosis.\" a022293 (2018)","DOI":"10.1101\/cshperspect.a022293"},{"key":"29","doi-asserted-by":"crossref","unstructured":"B Wang, J Wei, L Meng, et al.  \"Biomed Pharmacother.\"  121, \"Advances in pathogenic mechanisms and management of radiation-induced fibrosis.\" 109560 (2020)","DOI":"10.1016\/j.biopha.2019.109560"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Z Li, F Wang, S Zha, et al.  \"J Cell Physiol.\"  233, \"SIRT1 inhibits TGF-beta-induced endothelial-mesenchymal transition in human endothelial cells with Smad4 deacetylation.\" 9007 (2018)","DOI":"10.1002\/jcp.26846"},{"key":"31","doi-asserted-by":"crossref","unstructured":"K Kawaoka, S Doi, A Nakashima, et al.  \"Clin Exp Nephrol.\"  21, \"Valproic acid attenuates renal fibrosis through the induction of autophagy.\" 771 (2017)","DOI":"10.1007\/s10157-016-1365-6"},{"key":"32","doi-asserted-by":"crossref","unstructured":"Y Ding, S Kim, SY Lee, et al.  \"J Am Soc Nephrol.\"  25, \"Autophagy regulates TGF-beta expression and suppresses kidney fibrosis induced by unilateral ureteral obstruction.\" 2835 (2014)","DOI":"10.1681\/ASN.2013101068"},{"key":"33","doi-asserted-by":"crossref","unstructured":"S Ghavami, B Yeganeh, AA Zeki, et al.  \"Am J Physiol Lung Cell Mol Physiol.\"  314, \"Autophagy and the unfolded protein response promote profibrotic effects of TGF-beta1 in human lung fibroblasts.\" L493 (2018)","DOI":"10.1152\/ajplung.00372.2017"},{"key":"34","doi-asserted-by":"crossref","unstructured":"C Liang, J Xu, Q Meng, et al.  \"Autophagy.\"  16, \"TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status.\" 486 (2020)","DOI":"10.1080\/15548627.2019.1628540"},{"key":"35","doi-asserted-by":"crossref","unstructured":"M Bertrand, V Petit, A Jain, et al.  \"Cell Cycle.\"  14, \"SQSTM1\/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors.\" 364 (2015)","DOI":"10.4161\/15384101.2014.987619"}],"container-title":["Radiation Research"],"original-title":[],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T05:29:37Z","timestamp":1620019777000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-195\/issue-5\/RADE-20-00239.1\/Curcumin-Enhances-the-Radiosensitivity-of-Human-Urethral-Scar-Fibroblasts-by\/10.1667\/RADE-20-00239.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rade-20-00239.1","relation":{},"ISSN":["0033-7587"],"issn-type":[{"value":"0033-7587","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3,23]]}}}