{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T09:33:03Z","timestamp":1793439183614,"version":"4.5.0"},"reference-count":74,"publisher":"Radiation Research Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2021,7,29]]},"abstract":"<jats:p>Signal transduction at sensory neurons occurs via transmembrane flux of cations, which is largely governed by the transient receptor potential (TRP) family of ion channels. It is unknown whether TRP channel activation contributes to the pain that accompanies radiation-induced oral mucositis. This study sought to characterize changes in TRP channel expression and function that occur in the locally irradiated tissues and afferent neurons of mice. Female CD-1 mice received single high-dose (27 Gy) tongue irradiation, or sham irradiation. Animals were euthanized either before overt glossitis developed (days 1 and 5 postirradiation), when glossitis was severe (day 11), or after mice had recovered (days 21 and 45). Tongue irradiation caused upregulation of the Trpv1 gene in trigeminal ganglia (TG) neurons. Other TRP genes (Trpv2, Trpv4, Trpa1, Trpm8) and Gfr\u03b13 (which acts upstream of several TRP channels) were also upregulated in TGs and\/or tongue tissue, in response to radiation. Ex vivo calcium imaging experiments demonstrated that the proportions of TG neurons responding to histamine (an activator of TRPV1, TRPV4 and TRPA1), TNF-\u03b1 (an activator of TRPV1, TRPV2 and TRPV4), and capsaicin (a TRPV1 agonist), were increased as early as one day after tongue irradiation; these changes persisted for at least 21 days. In a subsequent experiment, we found that genetic deletion of TRPV1 mitigated weight loss (a surrogate marker of pain severity) in mice with severe glossitis. The results intimate that various TRP channels, and TRPV1 in particular, should be explored as analgesic targets for patients experiencing pain after oral irradiation.<\/jats:p>","DOI":"10.1667\/rade-21-000103.1","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T04:43:38Z","timestamp":1632804218000},"page":"331-344","source":"Crossref","is-referenced-by-count":4,"title":["Irradiation of the Normal Murine Tongue Causes Upregulation and Activation of Transient Receptor Potential (TRP) Ion Channels"],"prefix":"10.1667","volume":"196","author":[{"given":"Yen","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"B\u00e4umer","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Meneses","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Roback","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Rex Cancer Center, Raleigh, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Robertson","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh K.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Comparative Medicine Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Duncan X.","family":"Lascelles","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"LS Elting, DM Keefe, ST Sonis, et al.  \"Cancer.\"  113, \"Patient-reported measurements of oral mucositis in head and neck cancer patients treated with radiotherapy with or without chemotherapy: demonstration of increased frequency, severity, resistance to palliation, and impact on quality of life.\" 2704 (2008)","DOI":"10.1002\/cncr.23898"},{"key":"2","doi-asserted-by":"crossref","unstructured":"E McNicol, N Horowicz-Mehler, RA Fisk, et al.  \"J Pain.\"  4, \"Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review.\" 231 (2003)","DOI":"10.1016\/S1526-5900(03)00556-X"},{"key":"3","doi-asserted-by":"crossref","unstructured":"DD McKemy, WM Neuhausser, D Julius,  \"Nature.\"  416, \"Identification of a cold receptor reveals a general role for TRP channels in thermosensation.\" 52 (2002)","DOI":"10.1038\/nature719"},{"key":"4","doi-asserted-by":"crossref","unstructured":"C. Montell,  \"Sci STKE.\"  2005, \"The TRP superfamily of cation channels.\" re3 (2005)","DOI":"10.1126\/stke.2722005re3"},{"key":"5","doi-asserted-by":"crossref","unstructured":"GG Duncan, JB Epstein, D Tu, et al.  \"Head Neck.\"  27, \"Quality of life, mucositis, and xerostomia from radiotherapy for head and neck cancers: a report from the NCIC CTG HN2 randomized trial of an antimicrobial lozenge to prevent mucositis.\" 421 (2005)","DOI":"10.1002\/hed.20162"},{"key":"6","doi-asserted-by":"crossref","unstructured":"L De Petrocellis  and V Di Marzo  \"Life Sci.\"  77, \"Lipids as regulators of the activity of transient receptor potential type V1 (TRPV1) channels.\" 1651 (2005)","DOI":"10.1016\/j.lfs.2005.05.021"},{"key":"7","doi-asserted-by":"crossref","unstructured":"MJ Caterina, MA Schumacher, M Tominaga, et al.  \"Nature.\"  389, \"The capsaicin receptor: a heat-activated ion channel in the pain pathway.\" 816 (1997)","DOI":"10.1038\/39807"},{"key":"8","doi-asserted-by":"crossref","unstructured":"M Tominaga, MJ Caterina, AB Malmberg, et al.  \"Neuron.\"  21, \"The cloned capsaicin receptor integrates multiple pain-producing stimuli.\" 531 (1998)","DOI":"10.1016\/S0896-6273(00)80564-4"},{"key":"9","doi-asserted-by":"crossref","unstructured":"MJ Gunthorpe, MH Harries, RK Prinjha, et al.  \"J Physiol.\"  525, \"Voltage- and time-dependent properties of the recombinant rat vanilloid receptor (rVR1).\" 747 (2000)","DOI":"10.1111\/j.1469-7793.2000.t01-1-00747.x"},{"key":"10","doi-asserted-by":"crossref","unstructured":"M Quartu, MP Serra, M Boi, et al.  \"J Anat.\"  229, \"TRPV1 receptor in the human trigeminal ganglion and spinal nucleus: immunohistochemical localization and comparison with the neuropeptides CGRP and SP.\" 755 (2016)","DOI":"10.1111\/joa.12529"},{"key":"11","doi-asserted-by":"crossref","unstructured":"S Wang, M Kim, Z Ali, et al.  \"Front Physiol.\"  10, \"TRPV1 and TRPV1-expressing nociceptors mediate orofacial pain behaviors in a mouse model of orthodontic tooth movement.\" 1207 (2019)","DOI":"10.3389\/fphys.2019.01353"},{"key":"12","doi-asserted-by":"crossref","unstructured":"S Wang, B Brigoli, J Lim, et al.  \"Neuroscience.\"  384, \"Roles of TRPV1 and TRPA1 in spontaneous pain from inflamed masseter muscle.\" 290 (2018)","DOI":"10.1016\/j.neuroscience.2018.05.048"},{"key":"13","doi-asserted-by":"crossref","unstructured":"K Urata, M Shinoda, K Honda, et al.  \"J Dent Res.\"  94, \"Involvement of TRPV1 and TRPA1 in incisional intraoral and extraoral pain.\" 446 (2015)","DOI":"10.1177\/0022034514565645"},{"key":"15","doi-asserted-by":"crossref","unstructured":"A. Trotti,  \"Int J Radiat Oncol Biol Phys.\"  47, \"Toxicity in head and neck cancer: a review of trends and issues.\" 1 (2000)","DOI":"10.1016\/S0360-3016(99)00558-1"},{"key":"16","doi-asserted-by":"crossref","unstructured":"G Sunavala-Dossabhoy, F Abreo, PS Timiri Shanmugam, et al.  \"Oral Dis.\"  21, \"Histopathologic grading of oral mucositis.\" 355 (2015)","DOI":"10.1111\/odi.12287"},{"key":"17","doi-asserted-by":"crossref","unstructured":"RM. Deacon,  \"Nat Protoc.\"  1, \"Burrowing in rodents: a sensitive method for detecting behavioral dysfunction.\" 118 (2006)","DOI":"10.1038\/nprot.2006.19"},{"key":"18","doi-asserted-by":"crossref","unstructured":"P. Jirkof,  \"J Neurosci Methods.\"  234, \"Burrowing and nest building behavior as indicators of well-being in mice.\" 139 (2014)","DOI":"10.1016\/j.jneumeth.2014.02.001"},{"key":"20","doi-asserted-by":"crossref","unstructured":"ML Price, YE Lai, KL Marcus, et al.  \"Vet Radiol Ultrasound.\"  62, \"Early radiation-induced oral pain signaling responses are reduced with pentoxifylline treatment.\" 255 (2021)","DOI":"10.1111\/vru.12943"},{"key":"21","doi-asserted-by":"crossref","unstructured":"C Grienberger  and A Konnerth  \"Neuron.\"  73, \"Imaging calcium in neurons.\" 862 (2012)","DOI":"10.1016\/j.neuron.2012.02.011"},{"key":"23","doi-asserted-by":"crossref","unstructured":"JD Levine  and N Alessandri-Haber  \"Biochim Biophys Acta Mol Basis Dis.\"  1772, \"TRP channels: Targets for the relief of pain.\" 989 (2007)","DOI":"10.1016\/j.bbadis.2007.01.008"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Y Chen, SH Williams, AL McNulty, et al.  \"Pain.\"  154, \"Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.\" 1295 (2013)","DOI":"10.1016\/j.pain.2013.04.004"},{"key":"25","doi-asserted-by":"crossref","unstructured":"KM Hargreaves  and S Ruparel  \"J Dent Res.\"  95, \"Role of oxidized lipids and TRP channels in orofacial pain and inflammation.\" 1117 (2016)","DOI":"10.1177\/0022034516653751"},{"key":"26","doi-asserted-by":"crossref","unstructured":"M Tominaga  and MJ Caterina  \"J Neurobiol.\"  61, \"Thermosensation and pain.\" 3 (2004)","DOI":"10.1002\/neu.20079"},{"key":"27","doi-asserted-by":"crossref","unstructured":"AD Guler, H Lee, T Iida, et al.  \"J Neurosci.\"  22, \"Heat-evoked activation of the ion channel, TRPV4.\" 6408 (2002)","DOI":"10.1523\/JNEUROSCI.22-15-06408.2002"},{"key":"28","doi-asserted-by":"crossref","unstructured":"GM Story, AM Peier, AJ Reeve, et al.  \"Cell.\"  112, \"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.\" 819 (2003)","DOI":"10.1016\/S0092-8674(03)00158-2"},{"key":"30","doi-asserted-by":"crossref","unstructured":"JJ DeBerry, JL Saloman, BK Dragoo, et al.  \"J Pain.\"  16, \"Artemin immunotherapy is effective in preventing and reversing cystitis-induced bladder hyperalgesia via TRPA1 regulation.\" 628 (2015)","DOI":"10.1016\/j.jpain.2015.03.014"},{"key":"31","doi-asserted-by":"crossref","unstructured":"P Thornton, JP Hatcher, I Robinson, et al.  \"Neurosci Lett.\"  545, \"Artemin-GFRalpha3 interactions partially contribute to acute inflammatory hypersensitivity.\" 23 (2013)","DOI":"10.1016\/j.neulet.2013.04.007"},{"key":"32","doi-asserted-by":"crossref","unstructured":"AM Peier, A Moqrich, AC Hergarden, et al.  \"Cell.\"  108, \"A TRP channel that senses cold stimuli and menthol.\" 705 (2002)","DOI":"10.1016\/S0092-8674(02)00652-9"},{"key":"34","doi-asserted-by":"crossref","unstructured":"C Wang, L Gu, Y Ruan, et al.  \"FASEB J.\"  33, \"Facilitation of MrgprD by TRP-A1 promotes neuropathic pain.\" 1360 (2019)","DOI":"10.1096\/fj.201800615RR"},{"key":"36","doi-asserted-by":"crossref","unstructured":"MJ Caterina, A Leffler, AB Malmberg, et al.  \"Science.\"  288, \"Impaired nociception and pain sensation in mice lacking the capsaicin receptor.\" 306 (2000)","DOI":"10.1126\/science.288.5464.306"},{"key":"37","doi-asserted-by":"crossref","unstructured":"H Kittaka, J DeBrecht, SK Mishra,  \"Mol Pain.\"  16, \"Differential contribution of sensory transient receptor potential channels in response to the bioactive lipid sphingosine-1-phosphate.\" 1744806920903515 (2020)","DOI":"10.1177\/1744806920903515"},{"key":"38","doi-asserted-by":"crossref","unstructured":"LA Pogorzala, SK Mishra, MA Hoon,  \"J Neurosci.\"  33, \"The cellular code for mammalian thermosensation.\" 5533 (2013)","DOI":"10.1523\/JNEUROSCI.5788-12.2013"},{"key":"41","doi-asserted-by":"crossref","unstructured":"EC Rouchka, RM Flight, BH Fasciotto, et al.  \"Genom Data.\"  7, \"Transcriptional profile of immediate response to ionizing radiation exposure.\" 82 (2016)","DOI":"10.1016\/j.gdata.2015.11.027"},{"key":"43","doi-asserted-by":"crossref","unstructured":"MC Marrone, A Morabito, M Giustizieri, et al.  \"Nat Commun.\"  8, \"TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice.\" 15292 (2017)","DOI":"10.1038\/ncomms15292"},{"key":"44","doi-asserted-by":"crossref","unstructured":"Q Zhou, L Yang, S Larson, et al.  \"Gut.\"  65, \"Decreased miR-199 augments visceral pain in patients with IBS through translational upregulation of TRPV1.\" 797 (2016)","DOI":"10.1136\/gutjnl-2013-306464"},{"key":"45","doi-asserted-by":"crossref","unstructured":"J Zhang, Z Zhou, N Zhang, et al.  \"Saudi J Biol Sci.\"  24, \"Establishment of preliminary regulatory network of TRPV1 and related cytokines.\" 582 (2017)","DOI":"10.1016\/j.sjbs.2017.01.029"},{"key":"46","doi-asserted-by":"crossref","unstructured":"SS Acharya, W Fendler, J Watson, et al.  \"Sci Transl Med.\"  7, \"Serum microRNAs are early indicators of survival after radiation-induced hematopoietic injury.\" 287ra69 (2015)","DOI":"10.1126\/scitranslmed.aaa6593"},{"key":"47","doi-asserted-by":"crossref","unstructured":"MJ Caterina, TA Rosen, M Tominaga, et al.  \"Nature.\"  398, \"A capsaicin-receptor homologue with a high threshold for noxious heat.\" 436 (1999)","DOI":"10.1038\/18906"},{"key":"48","doi-asserted-by":"crossref","unstructured":"MW Nolan, KL Kelsey, M Enomoto, et al.  \"Radiat Res.\"  193, \"Pet dogs with subclinical acute radiodermatitis experience widespread somatosensory sensitization.\" 241 (2020)","DOI":"10.1667\/RR15468.1"},{"key":"50","unstructured":"RE. Meyn,  \"Oncology (Williston Park).\"  11, \"Apoptosis and response to radiation: implications for radiation therapy.\" 349 (1997)"},{"key":"51","doi-asserted-by":"crossref","unstructured":"F Amaya, Y Izumi, M Matsuda, et al.  \"Curr Neuropharmacol.\"  11, \"Tissue injury and related mediators of pain exacerbation.\" 592 (2013)","DOI":"10.2174\/1570159X11311060003"},{"key":"52","doi-asserted-by":"crossref","unstructured":"AI Basbaum, DM Bautista, G Scherrer, et al.  \"Cell.\"  139, \"Cellular and molecular mechanisms of pain.\" 267 (2009)","DOI":"10.1016\/j.cell.2009.09.028"},{"key":"53","doi-asserted-by":"crossref","unstructured":"SP Cook  and EW McCleskey  \"Pain.\"  95, \"Cell damage excites nociceptors through release of cytosolic ATP.\" 41 (2002)","DOI":"10.1016\/S0304-3959(01)00372-4"},{"key":"54","doi-asserted-by":"crossref","unstructured":"L Zhang, T Berta, Z-Z Xu, et al.  \"Pain.\"  152, \"TNF-a contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2.\" 419 (2011)","DOI":"10.1016\/j.pain.2010.11.014"},{"key":"55","doi-asserted-by":"crossref","unstructured":"D Spicarova  and J Palecek  \"J Neuroinflammation.\"  7, \"Tumor necrosis factor alpha sensitizes spinal cord TRPV1 receptors to the endogenous agonist N-oleoyldopamine.\" 49 (2010)","DOI":"10.1186\/1742-2094-7-49"},{"key":"56","doi-asserted-by":"crossref","unstructured":"MY Kochukov, TA McNearney, H Yin, et al.  \"Mol Pain.\"  5, \"Tumor necrosis factor-alpha (TNF-alpha) enhances functional thermal and chemical responses of TRP cation channels in human synoviocytes.\" 49 (2009)","DOI":"10.1186\/1744-8069-5-49"},{"key":"57","doi-asserted-by":"crossref","unstructured":"J Liu, Z Zhao, J Wen, et al.  \"Int Endod J.\"  52, \"TNF-a differently regulates TRPV2 and TRPV4 channels in human dental pulp cells.\" 1617 (2019)","DOI":"10.1111\/iej.13174"},{"key":"58","doi-asserted-by":"crossref","unstructured":"D Balemans, J Aguilera-Lizarraga, MV Florens, et al.  \"Am J Physiol Gastrointest Liver Physiol.\"  316, \"Histamine-mediated potentiation of transient receptor potential (TRP) ankyrin 1 and TRP vanilloid 4 signaling in submucosal neurons in patients with irritable bowel syndrome.\" G338 (2019)","DOI":"10.1152\/ajpgi.00116.2018"},{"key":"59","doi-asserted-by":"crossref","unstructured":"WS Shim, MH Tak, MH Lee, et al.  \"J Neurosci.\"  27, \"TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase.\" 2331 (2007)","DOI":"10.1523\/JNEUROSCI.4643-06.2007"},{"key":"60","doi-asserted-by":"crossref","unstructured":"Y Chen, Q Fang, Z Wang, et al.  \"J Biol Chem.\"  291, \"Transient receptor potential vanilloid 4 ion channel functions as a pruriceptor in epidermal keratinocytes to evoke histaminergic itch.\" 10252 (2016)","DOI":"10.1074\/jbc.M116.716464"},{"key":"61","doi-asserted-by":"crossref","unstructured":"GL Astrup, T Rustoen, C Miaskowski, et al.  \"Pain.\"  156, \"Changes in and predictors of pain characteristics in patients with head and neck cancer undergoing radiotherapy.\" 967 (2015)","DOI":"10.1097\/j.pain.0000000000000142"},{"key":"62","doi-asserted-by":"crossref","unstructured":"E Fathers, D Thrush, SM Huson, et al.  \"Clin Rehabil.\"  16, \"Radiation-induced brachial plexopathy in women treated for carcinoma of the breast.\" 160 (2002)","DOI":"10.1191\/0269215502cr470oa"},{"key":"63","doi-asserted-by":"crossref","unstructured":"GM Hermann, AJ Iovoli, AJ Platek, et al.  \"Cancer.\"  126, \"A single-institution, randomized, pilot study evaluating the efficacy of gabapentin and methadone for patients undergoing chemoradiation for head and neck squamous cell cancer.\" 1480 (2020)","DOI":"10.1002\/cncr.32676"},{"key":"64","doi-asserted-by":"crossref","unstructured":"T Kataoka, N Kiyota, T Shimada, et al.  \"Auris Nasus Larynx.\"  43, \"Randomized trial of standard pain control with or without gabapentin for pain related to radiation-induced mucositis in head and neck cancer.\" 677 (2016)","DOI":"10.1016\/j.anl.2016.02.012"},{"key":"65","doi-asserted-by":"crossref","unstructured":"CA Milazzo-Kiedaisch, J Itano, PR Dutta,  \"Clin J Oncol Nurs.\"  20, \"Role of Gabapentin in managing mucositis pain in patients undergoing radiation therapy to the head and neck.\" 623 (2016)","DOI":"10.1188\/16.CJON.623-628"},{"key":"66","doi-asserted-by":"crossref","unstructured":"H Knotkova, M Pappagallo, A Szallasi,  \"Clin J Pain.\"  24, \"Capsaicin (TRPV1 agonist) therapy for pain relief: farewell or revival?\" 142 (2008)","DOI":"10.1097\/AJP.0b013e318158ed9e"},{"key":"67","doi-asserted-by":"crossref","unstructured":"L De Petrocellis  and AS Moriello  \"Recent Pat CNS Drug Discov.\"  8, \"Modulation of the TRPV1 channel: current clinical trials and recent patents with focus on neurological conditions.\" 180 (2013)","DOI":"10.2174\/1574889808666131209124012"},{"key":"68","doi-asserted-by":"crossref","unstructured":"GY Wong  and NR Gavva  \"Brain Res Rev.\"  60, \"Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks.\" 267 (2009)","DOI":"10.1016\/j.brainresrev.2008.12.006"},{"key":"69","doi-asserted-by":"crossref","unstructured":"SK Mishra  and MA Hoon  \"Mol Cell Neurosci.\"  43, \"Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation.\" 157 (2010)","DOI":"10.1016\/j.mcn.2009.10.006"},{"key":"70","doi-asserted-by":"crossref","unstructured":"LS Premkumar  and P Sikand  \"Curr Neuropharmacol.\"  6, \"TRPV1: a target for next generation analgesics.\" 151 (2008)","DOI":"10.2174\/157015908784533888"},{"key":"71","doi-asserted-by":"crossref","unstructured":"A Berger, M Henderson, W Nadoolman, et al.  \"J Pain Symptom Manage.\"  10, \"Oral capsaicin provides temporary relief for oral mucositis pain secondary to chemotherapy\/radiation therapy.\" 243 (1995)","DOI":"10.1016\/0885-3924(94)00130-D"},{"key":"72","doi-asserted-by":"crossref","unstructured":"CM Elitt, SA Malin, HR Koerber, et al.  \"Brain Res.\"  1230, \"Overexpression of artemin in the tongue increases expression of TRPV1 and TRPA1 in trigeminal afferents and causes oral sensitivity to capsaicin and mustard oil.\" 80 (2008)","DOI":"10.1016\/j.brainres.2008.06.119"},{"key":"73","doi-asserted-by":"crossref","unstructured":"JM Terner, LM Lomas, MJ Picker,  \"J Pain.\"  6, \"Influence of estrous cycle and gonadal hormone depletion on nociception and opioid antinociception in female rats of four strains.\" 372 (2005)","DOI":"10.1016\/j.jpain.2005.01.354"},{"key":"74","doi-asserted-by":"crossref","unstructured":"S Cun-Jin, X Jian-Hao, L Xu, et al.  \"Mol Pain.\"  15, \"X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation.\" 1744806919849201 (2019)","DOI":"10.1177\/1744806919849201"},{"key":"22","doi-asserted-by":"crossref","unstructured":"RA McCloy, S Rogers, CE Caldon, et al.  \"Cell Cycle.\"  13, \"Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events.\" 1400 (2014)","DOI":"10.4161\/cc.28401"},{"key":"49","doi-asserted-by":"crossref","unstructured":"GT Gobbel, M Bellinzona, AR Vogt, et al.  \"J Neurosci.\"  18, \"Response of postmitotic neurons to X-irradiation: implications for the role of DNA damage in neuronal apoptosis.\" 147 (1998)","DOI":"10.1523\/JNEUROSCI.18-01-00147.1998"},{"key":"42","doi-asserted-by":"crossref","unstructured":"E Yin, DO Nelson, MA Coleman, et al.  \"Int J Radiat Biol.\"  79, \"Gene expression changes in mouse brain after exposure to low-dose ionizing radiation.\" 759 (2003)","DOI":"10.1080\/09553000310001610961"},{"key":"35","doi-asserted-by":"crossref","unstructured":"KJ Livak  and TD Schmittgen  \"Methods.\"  25, \"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.\" 402 (2001)","DOI":"10.1006\/meth.2001.1262"},{"key":"40","doi-asserted-by":"crossref","unstructured":"E Macaeva, Y Saeys, K Tabury, et al.  \"Sci Rep.\"  6, \"Radiation-induced alternative transcription and splicing events and their applicability to practical biodosimetry.\" 19251 (2016)","DOI":"10.1038\/srep19251"},{"key":"39","doi-asserted-by":"crossref","unstructured":"MW Nolan, CT Long, KL Marcus, et al.  \"Radiat Res.\"  187, \"Nocifensive behaviors in mice with radiation-induced oral mucositis.\" 397 (2017)","DOI":"10.1667\/RR14669.1"},{"key":"14","doi-asserted-by":"crossref","unstructured":"MW Nolan, CT Long, KL Marcus, et al.  \"Radiat Res.\"  187, \"Nocifensive behaviors in mice with radiation-induced oral mucositis.\" 397 (2017)","DOI":"10.1667\/RR14669.1"},{"key":"19","doi-asserted-by":"crossref","unstructured":"N Percie du Sert  and AS Rice  \"Br J Pharmacol.\"  171, \"Improving the translation of analgesic drugs to the clinic: animal models of neuropathic pain.\" 2951 (2014)","DOI":"10.1111\/bph.12645"},{"key":"29","doi-asserted-by":"crossref","unstructured":"S Malin, D Molliver, JA Christianson, et al.  \"J Neurosci.\"  31, \"TRPV1 and TRPA1 function and modulation are target tissue dependent.\" 10516 (2011)","DOI":"10.1523\/JNEUROSCI.2992-10.2011"},{"key":"33","doi-asserted-by":"crossref","unstructured":"DJ Cavanaugh, H Lee, L Lo, et al.  \"Proc Natl Acad Sci U S A.\"  106, \"Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli.\" 9075 (2009)","DOI":"10.1073\/pnas.0901507106"}],"container-title":["Radiation Research"],"original-title":[],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T08:50:39Z","timestamp":1793436639000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-196\/issue-4\/RADE-21-000103.1\/Irradiation-of-the-Normal-Murine-Tongue-Causes-Upregulation-and-Activation\/10.1667\/RADE-21-000103.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":74,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,10,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rade-21-000103.1","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,29]]}}}