{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T08:34:04Z","timestamp":1793435644738,"version":"4.5.0"},"reference-count":64,"publisher":"Radiation Research Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2021,12,8]]},"abstract":"<jats:p>The present study evaluated the effects of proton and gamma-ray ionizing radiation on the mouse eye. The aim of this work was to analyze radiation-mediated retinoid oxidation in the retina and retinal pigment epithelium (RPE). The findings from this analysis can be used to develop a noninvasive method for rapid assessment of the effects of ionizing radiation. Comparative fluorescence and chromatographic analyses of retinoids before and after irradiations were performed. The fluorescent properties of chloroform extracts from irradiated mouse retina and RPE exhibited an increase in fluorescence intensity in the short-wave region of the spectrum (\u03bb &lt; 550 nm). This change is due to increased retinal and RPE retinoid oxidation and degradation products after radiation exposure. Comparative analyses of radiation effects demonstrated that the effect of proton exposure on the retina and RPE was higher than that of gamma-ray exposure. The present study revealed a new approach to assessing the level of radiation exposure in ocular tissues.<\/jats:p>","DOI":"10.1667\/rade-21-00069.1","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T12:47:27Z","timestamp":1638967647000},"page":"270-279","source":"Crossref","is-referenced-by-count":1,"title":["Ionized Radiation-Mediated Retinoid Oxidation in the Retina and Retinal Pigment Epithelium of the Murine Eye"],"prefix":"10.1667","volume":"197","author":[{"given":"Marina A.","family":"Yakovleva","sequence":"first","affiliation":[{"name":"Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana B.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina N.","family":"Lyakhova","sequence":"additional","affiliation":[{"name":"Laboratory of Radiation Biology, Joint Institute for Nuclear Research, Dubna, Moscow region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina M.","family":"Utina","sequence":"additional","affiliation":[{"name":"Laboratory of Radiation Biology, Joint Institute for Nuclear Research, Dubna, Moscow region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna A.","family":"Kolesnikova","sequence":"additional","affiliation":[{"name":"Laboratory of Radiation Biology, Joint Institute for Nuclear Research, Dubna, Moscow region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya V.","family":"Vinogradova","sequence":"additional","affiliation":[{"name":"Laboratory of Radiation Biology, Joint Institute for Nuclear Research, Dubna, Moscow region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G.","family":"Molokanov","sequence":"additional","affiliation":[{"name":"Laboratory of Radiation Biology, Joint Institute for Nuclear Research, Dubna, Moscow region, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail A.","family":"Ostrovsky","sequence":"additional","affiliation":[{"name":"Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"15","doi-asserted-by":"crossref","unstructured":"S Kobashigawa, K Suzuki, S Yamashita,  \"Biochem Biophys Res Commun.\"  414, \"Ionizing radiation accelerates Drp1-dependent mitochondrial fission, which involves delayed mitochondrial reactive oxygen species production in normal human fibroblast-like cells.\" 795 (2011)","DOI":"10.1016\/j.bbrc.2011.10.006"},{"key":"4","doi-asserted-by":"crossref","unstructured":"XW Mao, M Boerma, D Rodriguez, et al.  \"Radiat Res.\"  190, \"Acute effect of low-dose space radiation on mouse retina and retinal endothelial cells.\" 45 (2018)","DOI":"10.1667\/RR14977.1"},{"key":"56","doi-asserted-by":"crossref","unstructured":"J Folch, M Lees, GHS Stanley,  \"J Biol Chem.\"  226, \"A simple method for the isolation and purification of total lipides from animal tissues.\" 497 (1957)","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"59","doi-asserted-by":"crossref","unstructured":"EI Azzam, JP Jay-Gerin, D Pain,  \"Cancer Lett.\"  327, \"Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury.\" 48 (2012)","DOI":"10.1016\/j.canlet.2011.12.012"},{"key":"1","doi-asserted-by":"crossref","unstructured":"AR. 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(1984)","DOI":"10.1016\/0273-1177(84)90244-8"},{"key":"43","doi-asserted-by":"crossref","unstructured":"FA Cucinotta  and M Durante  \"Lancet Oncol.\"  7, \"Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings.\" (2006)","DOI":"10.1016\/S1470-2045(06)70695-7"},{"key":"44","doi-asserted-by":"crossref","unstructured":"S Furukawa, A Nagamatsu, M Nenoi, et al.  \"Biomed Res Int.\"  2020, \"Space Radiation Biology for \u201cLiving in Space\u201d.\" 4703286","DOI":"10.1155\/2020\/4703286"},{"key":"45","doi-asserted-by":"crossref","unstructured":"XS Wan, P Bloch, JH Ware, et al.  \"Radiat Res.\"  163, \"Detection of oxidative stress induced by low and high linear energy transfer radiation in cultured human epithelial cells.\" (2005)","DOI":"10.1667\/0033-7587(2005)163[0364:DOOSIB]2.0.CO;2"},{"key":"46","doi-asserted-by":"crossref","unstructured":"C Wambi, J Sanzari, M Nuth, et al.  \"Radiat Res.\"  169, \"Dietary antioxidants protect 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Sanzari, AR Kennedy,  \"Int J Radiat Biol.\"  88, \"The effects of proton radiation on the prothrombin and partial thromboplastin times of irradiated ferrets.\" (2012)","DOI":"10.3109\/09553002.2012.652727"},{"key":"51","doi-asserted-by":"crossref","unstructured":"H Ni, K Balint, Y Zhou, et al.  \"Radiat Res.\"  175, \"Effect of solar particle event radiation on gastrointestinal tract bacterial translocation and immune activation.\" (2011)","DOI":"10.1667\/RR2373.1"},{"key":"52","doi-asserted-by":"crossref","unstructured":"JM York, NA Blevins, DD Meling, et al.  \"Brain Behav Immun.\"  26, \"The biobehavioral and neuroimmune impact of low-dose ionizing radiation.\" (2012)","DOI":"10.1016\/j.bbi.2011.09.006"},{"key":"53","doi-asserted-by":"crossref","unstructured":"SK Mehta, DC Bloom, I Plante, et al.  \"Radiat Int J Mol Sci.\"  19, \"Reactivation of latent Epstein-Barr virus: A comparison after exposure to gamma, proton, carbon, and iron.\" 2961 (2018)","DOI":"10.3390\/ijms19102961"},{"key":"54","unstructured":"J Kuban\u010d\u00e1k  and AG Molokanov  \"Problems of atomic science and technology (PAST).\"  \"Measurements of LET spectra of the JINR phasotron radiotherapy proton beam.\" (2013)"},{"key":"55","doi-asserted-by":"crossref","unstructured":"NL Mata, J Weng, GH Travis,  \"Proc Natl Acad Sci USA.\"  97, \"Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration.\" (2000)","DOI":"10.1073\/pnas.130110497"},{"key":"57","doi-asserted-by":"crossref","unstructured":"CA Parish, M Hashimoto, K Nakanishi, et al.  \"Proc Natl Acad Sci USA.\"  95, \"Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium.\" (1998)","DOI":"10.1073\/pnas.95.25.14609"},{"key":"58","doi-asserted-by":"crossref","unstructured":"SR Kim, YP Jang, JR Sparrow,  \"Vis Res.\"  50, \"Photooxidation of RPE lipofuscin bisretinoids enhances fluorescence 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