{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T18:50:12Z","timestamp":1793472612043,"version":"4.5.0"},"reference-count":117,"publisher":"Radiation Research Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2021,8,3]]},"abstract":"<jats:p>Research and development of medical countermeasures (MCMs) for radiation-induced lung injury relies on the availability of animal models with well-characterized pathophysiology, allowing effective bridging to humans. To develop useful animal models, it is important to understand the clinical condition, advantages and limitations of individual models, and how to properly apply these models to demonstrate MCM efficacy. On March 20, 2019, a meeting sponsored by the Radiation and Nuclear Countermeasures Program (RNCP) within the National Institute of Allergy and Infectious Diseases (NIAID) brought together medical, scientific and regulatory communities, including academic and industry subject matter experts, and government stakeholders from the Food and Drug Administration (FDA) and the Biomedical Advanced Research and Development Authority (BARDA), to identify critical research gaps, discuss current clinical practices for various forms of pulmonary damage, and consider available animal models for radiation-induced lung injury.<\/jats:p>","DOI":"10.1667\/rade-21-00127.1","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T13:46:41Z","timestamp":1648820801000},"page":"415-433","source":"Crossref","is-referenced-by-count":2,"title":["A Trans-Agency Workshop on the Pathophysiology of Radiation-Induced Lung Injury"],"prefix":"10.1667","volume":"197","author":[{"given":"David R.","family":"Cassatt","sequence":"first","affiliation":[{"name":"Radiation and Nuclear Countermeasures Program (RNCP)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Gorovets","sequence":"additional","affiliation":[{"name":"Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"Karimi-Shah","sequence":"additional","affiliation":[{"name":"Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Roberts","sequence":"additional","affiliation":[{"name":"Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Price","sequence":"additional","affiliation":[{"name":"Office of Regulatory Affairs, Division of Allergy, Immunology and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merriline M.","family":"Satyamitra","sequence":"additional","affiliation":[{"name":"Radiation and Nuclear Countermeasures Program (RNCP)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nushin","family":"Todd","sequence":"additional","affiliation":[{"name":"Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue-Jane","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libero","family":"Marzella","sequence":"additional","affiliation":[{"name":"Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"65","doi-asserted-by":"crossref","unstructured":"C Prado, A Kazi, A Bennett, et al.  \"Health Phys.\"  109, \"Mean organ doses resulting from non-human primate whole thorax lung irradiation prescribed to mid-line tissue.\" 367 (2015)","DOI":"10.1097\/HP.0000000000000336"},{"key":"17","doi-asserted-by":"publisher","unstructured":"GA Parker, N Li, K Takayama, et al.  \"Health Phys.\"  116, \"Lung and heart injury in a nonhuman primate model of partial-body irradiation with minimal bone marrow sparing: Histopathological evidence of lung and heart injury.\" 383 (2019)","DOI":"10.1097\/HP.0000000000000936"},{"key":"2","doi-asserted-by":"crossref","unstructured":"NJ. Gross,  \"Ann Intern Med.\"  86, \"Pulmonary effects of radiation therapy.\" 81 (1977)","DOI":"10.7326\/0003-4819-86-1-81"},{"key":"3","doi-asserted-by":"crossref","unstructured":"J Van Dyk, TJ Keane, S Kan, et al.  \"Int J Radiat Oncol Biol Phys.\"  7, \"Radiation pneumonitis following large single dose irradiation: A reevaluation based on absolute dose to lung.\" 461 (1981)","DOI":"10.1016\/0360-3016(81)90131-0"},{"key":"4","doi-asserted-by":"crossref","unstructured":"H Jin, Y Yoo, Y Kim, et al.  \"Cancers.\"  2020, \"Radiation-induced lung fibrosis: Preclinical animal models and therapeutic strategies.\"","DOI":"10.3390\/cancers12061561"},{"key":"5","doi-asserted-by":"crossref","unstructured":"M Ghita, V Dunne, GG Hanna, et al.  \"Br J Radiol.\"  92, \"Preclinical models of radiation-induced lung damage: Challenges and opportunities for small animal radiotherapy.\" 20180473 (2019)","DOI":"10.1259\/bjr.20180473"},{"key":"6","doi-asserted-by":"crossref","unstructured":"N Ueki, Y Matsuo, Y Togashi, et al.  \"J Thorac Oncol.\"  10, \"Impact of pretreatment interstitial lung disease on radiation pneumonitis and survival after stereotactic body radiation therapy for lung cancer.\" 116 (2015)","DOI":"10.1097\/JTO.0000000000000359"},{"key":"7","doi-asserted-by":"crossref","unstructured":"R Rajan Radha  and G Chandrasekharan  \"Biomed Pharmacother.\"  89, \"Pulmonary injury associated with radiation therapy \u2013 assessment, complications and therapeutic targets.\" 1092 (2017)","DOI":"10.1016\/j.biopha.2017.02.106"},{"key":"8","doi-asserted-by":"crossref","unstructured":"FM Kong, R Ten Haken, A Eisbruch, et al.  \"Semin Oncol.\"  32, \"Non-small cell lung cancer therapy-related pulmonary toxicity: An update on radiation pneumonitis and fibrosis.\" S42 (2005)","DOI":"10.1053\/j.seminoncol.2005.03.009"},{"key":"10","doi-asserted-by":"crossref","unstructured":"H Uozaki, M Fukayama, K Nakagawa, et al.  \"Br J Radiol.\"  78, \"The pathology of multi-organ involvement: Two autopsy cases from the Tokai-mura criticality accident.\" 13 (2005)","DOI":"10.1259\/bjr\/70312032"},{"key":"11","doi-asserted-by":"crossref","unstructured":"JP Williams, IL Jackson, JR Shah, et al.  \"Radiat Res.\"  177, \"Animal models and medical countermeasures development for radiation-induced lung damage: Report from an NIAID workshop.\" e0025 (2012)","DOI":"10.1667\/RROL04.1"},{"key":"12","unstructured":"\"Guidance for industry: Product development under the Animal Rule. Docket No. FDA-2009-D-0007.\"  (2015)"},{"key":"15","doi-asserted-by":"crossref","unstructured":"TJ MacVittie, AM Farese, GA Parker, et al.  \"Health Phys.\"  119, \"Acute radiation-induced lung injury in the non-human primate: A review and comparison of mortality and comorbidities using models of partial-body irradiation with marginal bone marrow sparing and whole thorax lung irradiation.\" 559 (2020)","DOI":"10.1097\/HP.0000000000001346"},{"key":"19","doi-asserted-by":"crossref","unstructured":"AL DiCarlo, IL Jackson, JR Shah, et al.  \"Radiat Res.\"  177, \"Development and licensure of medical countermeasures to treat lung damage resulting from a radiological or nuclear incident.\" 717 (2012)","DOI":"10.1667\/RR2881.1"},{"key":"20","doi-asserted-by":"crossref","unstructured":"W. Checkley,  \"Eur Respir J.\"  41, \"Neuregulin-1 as a potentially novel biomarker in acute respiratory distress syndrome.\" 259 (2013)","DOI":"10.1183\/09031936.00110412"},{"key":"21","doi-asserted-by":"crossref","unstructured":"BT Thompson, RC Chambers, KD Liu,  \"N Engl J Med.\"  377, \"Acute respiratory distress syndrome.\" 562 (2017)","DOI":"10.1056\/NEJMra1608077"},{"key":"22","doi-asserted-by":"crossref","unstructured":"F Wirsdorfer  and V Jendrossek  \"Front Immunol.\"  7, \"The role of lymphocytes in radiotherapy-induced adverse late effects in the lung.\" 591 (2016)","DOI":"10.3389\/fimmu.2016.00591"},{"key":"23","doi-asserted-by":"crossref","unstructured":"TE King, A Pardo, M Selman,  \"Lancet.\"  378, \"Idiopathic pulmonary fibrosis.\" 1949 (2011)","DOI":"10.1016\/S0140-6736(11)60052-4"},{"key":"24","doi-asserted-by":"crossref","unstructured":"DJ Lederer  and FJ Martinez  \"N Engl J Med.\"  378, \"Idiopathic pulmonary fibrosis.\" 1811 (2018)","DOI":"10.1056\/NEJMra1705751"},{"key":"28","doi-asserted-by":"crossref","unstructured":"JG Garcia, F Liu, AD Verin, et al.  \"J Clin Invest.\"  108, \"Sphingosine 1-phosphate promotes endothelial cell barrier integrity by edg-dependent cytoskeletal rearrangement.\" 689 (2001)","DOI":"10.1172\/JCI12450"},{"key":"29","doi-asserted-by":"crossref","unstructured":"NJ Meyer, Y Huang, PA Singleton, et al.  \"FASEB J.\"  23, \"GADD45a is a novel candidate gene in inflammatory lung injury via influences on Akt signaling.\" 1325 (2009)","DOI":"10.1096\/fj.08-119073"},{"key":"30","doi-asserted-by":"crossref","unstructured":"S Mitra, S Sammani, T Wang, et al.  \"Am J Respir Crit Care Med.\"  184, \"Role of growth arrest and DNA damage-inducible alpha in Akt phosphorylation and ubiquitination after mechanical stress-induced vascular injury.\" 1030 (2011)","DOI":"10.1164\/rccm.201103-0447OC"},{"key":"31","doi-asserted-by":"crossref","unstructured":"S Mitra, MS Wade, X Sun, et al.  \"PLoS 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223 (2014)","DOI":"10.1165\/rcmb.2012-0519OC"},{"key":"35","doi-asserted-by":"crossref","unstructured":"YW Choi, RF Munden, JJ Erasmus, et al.  \"Radiographics.\"  24, \"Effects of radiation therapy on the lung: Radiologic appearances and differential diagnosis.\" 985 (2004)","DOI":"10.1148\/rg.244035160"},{"key":"36","unstructured":"G Karpathiou, A Giatromanolaki, MI Koukourakis, et al.  \"Anticancer Res.\"  34, \"Histological changes after radiation therapy in patients with lung cancer: A prospective study.\" 3119 (2014)"},{"key":"37","doi-asserted-by":"crossref","unstructured":"T Hayashi, Y Morishita, Y Kubo, et al.  \"Am J Med.\"  118, \"Long-term effects of radiation dose on inflammatory markers in atomic bomb survivors.\" 83 (2005)","DOI":"10.1016\/j.amjmed.2004.06.045"},{"key":"39","doi-asserted-by":"crossref","unstructured":"AE Baranov, GD Selidovkin, A Butturini, et al.  \"Blood.\"  83, \"Hematopoietic recovery after 10-Gy acute total body radiation.\" 596 (1994)","DOI":"10.1182\/blood.V83.2.596.596"},{"key":"40","doi-asserted-by":"crossref","unstructured":"J Jacob, BJ Bartholmai, S Rajagopalan, et al.  \"J Thorac Imaging.\"  31, \"Automated quantitative computed tomography versus visual computed tomography scoring in idiopathic pulmonary fibrosis: Validation against pulmonary function.\" 304 (2016)","DOI":"10.1097\/RTI.0000000000000220"},{"key":"41","doi-asserted-by":"crossref","unstructured":"R Werner, C Hofmann, E M\u00fccke, et al.  \"Radiat Oncol.\"  12, \"Reduction of breathing irregularity-related motion artifacts in low-pitch spiral 4D CT by optimized projection binning.\" 100 (2017)","DOI":"10.1186\/s13014-017-0835-7"},{"key":"42","doi-asserted-by":"crossref","unstructured":"C Plathow, M Li, P Gong, et al.  \"Invest Radiol.\"  39, \"Computed tomography monitoring of radiation-induced lung fibrosis in mice.\" 600 (2004)","DOI":"10.1097\/01.rli.0000138134.89050.a5"},{"key":"43","doi-asserted-by":"crossref","unstructured":"HJ Kim, MS Brown, D Chong, et al.  \"Acad Radiol.\"  22, \"Comparison of the quantitative CT imaging biomarkers of idiopathic pulmonary fibrosis at baseline and early change with an interval of 7 months.\" 70 (2015)","DOI":"10.1016\/j.acra.2014.08.004"},{"key":"44","doi-asserted-by":"crossref","unstructured":"D Brennan, L Schubert, Q Diot, et al.  \"Int J Radiat Oncol Biol Phys.\"  92, \"Clinical validation of 4-dimensional computed tomography ventilation with pulmonary function test data.\" 423 (2015)","DOI":"10.1016\/j.ijrobp.2015.01.019"},{"key":"45","doi-asserted-by":"crossref","unstructured":"Y Vinogradskiy, PJ Koo, R Castillo, et al.  \"Int J Radiat Oncol Biol Phys.\"  89, \"Comparison of 4-dimensional computed tomography ventilation with nuclear medicine ventilation-perfusion imaging: A clinical validation study.\" 199 (2014)","DOI":"10.1016\/j.ijrobp.2014.01.009"},{"key":"46","unstructured":"K. Tsipis,  \"Understanding nuclear weapons.\"  (1985)"},{"key":"48","doi-asserted-by":"crossref","unstructured":"RD Foster, MP Speiser, TD Solberg,  \"J Appl Clin Med Phys.\"  15, \"Commissioning and verification of the collapsed cone convolution superposition algorithm for SBRT delivery using flattening filter-free beams.\" 4631 (2014)","DOI":"10.1120\/jacmp.v15i2.4631"},{"key":"51","doi-asserted-by":"crossref","unstructured":"T. Allio,  \"Ther Innov Regul Sci.\"  50, \"Product development under FDA's animal rule: Understanding FDA's expectations and potential implications for traditional development programs.\" 660 (2016)","DOI":"10.1177\/2168479016641717"},{"key":"53","doi-asserted-by":"crossref","unstructured":"IL Jackson, P Xu, C Hadley, et al.  \"Health Phys.\"  103, \"A preclinical rodent model of radiation-induced lung injury for medical countermeasure screening in accordance with the FDA animal rule.\" 463 (2012)","DOI":"10.1097\/HP.0b013e31826386ef"},{"key":"54","doi-asserted-by":"crossref","unstructured":"MB Dabjan, CM Buck, IL Jackson, et al.  \"Lab Invest.\"  96, \"A survey of changing trends in modelling radiation lung injury in mice: Bringing out the good, the bad, and the uncertain.\" 936 (2016)","DOI":"10.1038\/labinvest.2016.76"},{"key":"55","doi-asserted-by":"crossref","unstructured":"EL Travis, JD Down, SJ Holmes, et al.  \"Radiat Res.\"  84, \"Radiation pneumonitis and fibrosis in mouse lung assayed by respiratory frequency and histology.\" 133 (1980)","DOI":"10.2307\/3575224"},{"key":"56","doi-asserted-by":"crossref","unstructured":"EL Travis, CS Parkins, SJ Holmes, et al.  \"Int J Radiat Oncol Biol Phys.\"  10, \"WR-2721 protection of pneumonitis and fibrosis in mouse lung after single doses of x rays.\" 243 (1984)","DOI":"10.1016\/0360-3016(84)90010-5"},{"key":"58","doi-asserted-by":"crossref","unstructured":"IL Jackson, F Baye, CP Goswami, et al.  \"Dis Model Mech.\"  10, \"Gene expression profiles among murine strains segregate with distinct differences in the progression of radiation-induced lung disease.\" 425 (2017)","DOI":"10.1242\/dmm.028217"},{"key":"59","doi-asserted-by":"crossref","unstructured":"L Kma, F Gao, BL Fish, et al.  \"J Radiat Res.\"  53, \"Angiotensin converting enzyme inhibitors mitigate collagen synthesis induced by a single dose of radiation to the whole thorax.\" 10 (2012)","DOI":"10.1269\/jrr.11035"},{"key":"61","doi-asserted-by":"crossref","unstructured":"M Medhora, F Gao, C Glisch, et al.  \"J Radiat Res.\"  56, \"Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling.\" 248 (2015)","DOI":"10.1093\/jrr\/rru095"},{"key":"63","doi-asserted-by":"crossref","unstructured":"M Medhora, S Haworth, Y Liu, et al.  \"J Nucl Med.\"  57, \"Biomarkers for radiation pneumonitis using noninvasive molecular imaging.\" 1296 (2016)","DOI":"10.2967\/jnumed.115.160291"},{"key":"67","doi-asserted-by":"crossref","unstructured":"EB de Faria, KR Barrow, BT Ruehle, et al.  \"Health Phys.\"  109, \"The evolving Mcart multimodal imaging core: Establishing a protocol for computed tomography and echocardiography in the rhesus macaque to perform longitudinal analysis of radiation-induced organ injury.\" 479 (2015)","DOI":"10.1097\/HP.0000000000000344"},{"key":"69","doi-asserted-by":"crossref","unstructured":"FN Murigi, P Mohindra, C Hung, et al.  \"Radiat Res.\"  184, \"Dose optimization study of AEOL 10150 as a mitigator of radiation-induced lung injury in CBA\/J mice.\" 422 (2015)","DOI":"10.1667\/RR14110.1"},{"key":"71","doi-asserted-by":"crossref","unstructured":"I Jackson, Z Vujaskovic, J Down,  \"Radiat Res.\"  173, \"Revisiting strain-related differences in radiation sensitivity of the mouse lung: Recognizing and avoiding the confounding effects of pleural effusions.\" 10 (2010)","DOI":"10.1667\/RR1911.1"},{"key":"72","doi-asserted-by":"crossref","unstructured":"ZN Rabbani, I Batinic-Haberle, MS Anscher, et al.  \"Int J Radiat Oncol Biol Phys.\"  67, \"Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury.\" 573 (2007)","DOI":"10.1016\/j.ijrobp.2006.09.053"},{"key":"73","doi-asserted-by":"crossref","unstructured":"J Cline, G Dugan, J Bourland, et al.  \"Antioxidants (Basel).\"  7, \"Post-irradiation treatment with a superoxide dismutase mimic, MnTnHex-2-PyP5+, mitigates radiation injury in the lungs of non-human primates after whole-thorax exposure to ionizing radiation.\" 40 (2018)","DOI":"10.3390\/antiox7030040"},{"key":"74","doi-asserted-by":"crossref","unstructured":"M Warner, B Huang, JA Gustafsson,  \"Trends Pharmacol Sci.\"  38, \"Estrogen receptor beta as a pharmaceutical target.\" 92 (2017)","DOI":"10.1016\/j.tips.2016.10.006"},{"key":"75","doi-asserted-by":"crossref","unstructured":"CT Ha, X-H Li, D Fu, et al.  \"Radiat Res.\"  180, \"Genistein nanoparticles protect mouse hematopoietic system and prevent proinflammatory factors after gamma irradiation.\" 316 (2013)","DOI":"10.1667\/RR3326.1"},{"key":"76","doi-asserted-by":"crossref","unstructured":"RM Day, M Barshishat-Kupper, SR Mog, et al.  \"J Radiat Res.\"  49, \"Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation.\" 361 (2008)","DOI":"10.1269\/jrr.07121"},{"key":"78","doi-asserted-by":"crossref","unstructured":"JW Jones, IL Jackson, Z Vujaskovic, et al.  \"Pharm Res.\"  34, \"Targeted metabolomics identifies pharmacodynamic biomarkers for BIO 300 mitigation of radiation-induced lung injury.\" 2698 (2017)","DOI":"10.1007\/s11095-017-2200-9"},{"key":"80","doi-asserted-by":"crossref","unstructured":"LB Marks, M Fan, R Clough, et al.  \"Int J Radiat Biol.\"  76, \"Radiation-induced pulmonary injury: Symptomatic versus subclinical endpoints.\" 469 (2000)","DOI":"10.1080\/095530000138466"},{"key":"82","doi-asserted-by":"crossref","unstructured":"C Booth, GL Tudor, BP Katz, et al.  \"Health Phys.\"  109, \"The delayed effects of acute radiation syndrome: Evidence of long-term functional changes in the clonogenic cells of the small intestine.\" 399 (2015)","DOI":"10.1097\/HP.0000000000000356"},{"key":"83","doi-asserted-by":"crossref","unstructured":"JD Down  and JC Yanch  \"Radiat Res.\"  174, \"Identifying the high radiosensitivity of the lungs of C57L mice in a model of total-body irradiation and bone marrow transplantation.\" 258 (2010)","DOI":"10.1667\/RR2149.1"},{"key":"85","doi-asserted-by":"crossref","unstructured":"P Zhang, W Cui, KG Hankey, et al.  \"Health Phys.\"  109, \"Increased expression of connective tissue growth factor (CTGF) in multiple organs after exposure of non-human primates (NHP) to lethal doses of radiation.\" 374 (2015)","DOI":"10.1097\/HP.0000000000000343"},{"key":"87","doi-asserted-by":"crossref","unstructured":"KO. Leslie,  \"J Clin Pathol.\"  62, \"My approach to interstitial lung disease using clinical, radiological and histopathological patterns.\" 387 (2009)","DOI":"10.1136\/jcp.2008.059782"},{"key":"88","doi-asserted-by":"crossref","unstructured":"WA Wuyts, A Cavazza, G Rossi, et al.  \"Eur Respir Rev.\"  23, \"Differential diagnosis of usual interstitial pneumonia: When is it truly idiopathic?\" 308 (2014)","DOI":"10.1183\/09059180.00004914"},{"key":"89","doi-asserted-by":"crossref","unstructured":"JJ Solomon, AL Olson, A Fischer, et al.  \"Eur Respir Rev.\"  22, \"Scleroderma lung disease.\" 6 (2013)","DOI":"10.1183\/09059180.00005512"},{"key":"90","doi-asserted-by":"crossref","unstructured":"L Wollin, E Wex, A Pautsch, et al.  \"Eur Respir J.\"  45, \"Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis.\" 1434 (2015)","DOI":"10.1183\/09031936.00174914"},{"key":"91","doi-asserted-by":"crossref","unstructured":"Y Takeda, K Tsujino, T Kijima, et al.  \"Patient Prefer Adherence.\"  8, \"Efficacy and safety of pirfenidone for idiopathic pulmonary fibrosis.\" 361 (2014)","DOI":"10.2147\/PPA.S37233"},{"key":"92","doi-asserted-by":"crossref","unstructured":"G Raghu, M Remy-Jardin, JL Myers, et al.  \"Am J Respir Crit Care Med.\"  198, \"Diagnosis of idiopathic pulmonary fibrosis. An official ATS\/ERS\/JRS\/ALAT clinical practice guideline.\" e44 (2018)","DOI":"10.1164\/rccm.201807-1255ST"},{"key":"93","doi-asserted-by":"crossref","unstructured":"S Bickelhaupt, C Erbel, C Timke, et al.  \"J Natl Cancer Inst.\"  109, \"Effects of CTGF blockade on attenuation and reversal of radiation-induced pulmonary fibrosis.\" (2017)","DOI":"10.1093\/jnci\/djw339"},{"key":"94","doi-asserted-by":"crossref","unstructured":"E Gorina, L Richeldi, G Raghu, et al.  \"Eur Respir J.\"  50, \"PRAISE, a randomized, placebo-controlled, double-blind phase 2 clinical trial of pamrevlumab (FG-3019) in IPF patients.\" OA3400 (2017)","DOI":"10.1183\/1393003.congress-2017.OA3400"},{"key":"95","doi-asserted-by":"crossref","unstructured":"LS Huang, P Fu, P Patel, et al.  \"Am J Respir Cell Mol Biol.\"  49, \"Lysophosphatidic acid receptor-2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice.\" 912 (2013)","DOI":"10.1165\/rcmb.2013-0070OC"},{"key":"96","doi-asserted-by":"crossref","unstructured":"DN Brindley, MG Benesch, MM Murph,  \"Melanoma\u2013Current clinical management and future therapeutics.\"  \"Autotaxin\u2013an enzymatic augmenter of malignant progression linked to inflammation.\" 297 (2015)","DOI":"10.5772\/59013"},{"key":"97","doi-asserted-by":"crossref","unstructured":"S Zulfikar, S Mulholland, H Adamali, et al.  \"Clin Pharmacol.\"  12, \"Inhibitors of the autotaxin-lysophosphatidic acid axis and their potential in the treatment of interstitial lung disease: Current perspectives.\" 97 (2020)","DOI":"10.2147\/CPAA.S228362"},{"key":"98","doi-asserted-by":"crossref","unstructured":"LA Murray, R Rosada, AP Moreira, et al.  \"PloS One.\"  5, \"Serum amyloid P therapeutically attenuates murine bleomycin-induced pulmonary fibrosis via its effects on macrophages.\" e9683 (2010)","DOI":"10.1371\/journal.pone.0009683"},{"key":"99","doi-asserted-by":"crossref","unstructured":"G Raghu, B van den Blink, MJ Hamblin, et al.  \"JAMA.\"  319, \"Effect of recombinant human pentraxin 2 vs placebo on change in forced vital capacity in patients with idiopathic pulmonary fibrosis: A randomized clinical trial.\" 2299 (2018)","DOI":"10.1001\/jama.2018.6129"},{"key":"100","doi-asserted-by":"crossref","unstructured":"K Grynberg, FY Ma, DJ Nikolic-Paterson,  \"Front Physiol.\"  8, \"The JNK signaling pathway in renal fibrosis.\" 829 (2017)","DOI":"10.3389\/fphys.2017.00829"},{"key":"101","doi-asserted-by":"crossref","unstructured":"E Fouquerel, J Li, A Braganza, et al.  \"Genotoxicity and DNA repair. Methods in pharmacology and toxicology.\"  \"Use of RNA interference to study DNA repair. Genotoxicity and DNA repair.\" (2014)","DOI":"10.1007\/978-1-4939-1068-7_24"},{"key":"102","doi-asserted-by":"crossref","unstructured":"J Wang, L Chen, B Chen, et al.  \"Sci Rep.\"  5, \"Chronic activation of the renin-angiotensin system induces lung fibrosis.\" 15561 (2015)","DOI":"10.1038\/srep15561"},{"key":"103","doi-asserted-by":"crossref","unstructured":"M Couluris, BW Kinder, P Xu, et al.  \"Lung.\"  190, \"Treatment of idiopathic pulmonary fibrosis with losartan: A pilot project.\" 523 (2012)","DOI":"10.1007\/s00408-012-9410-z"},{"key":"104","unstructured":"\"Qualification process for drug development tools guidance for industry and FDA staff. Docket No. FDA-2010-D-0529.\"  (2020)"},{"key":"105","doi-asserted-by":"crossref","unstructured":"\"Clin Pharmacol Ther.\"  69, \"Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework.\" 89 (2001)","DOI":"10.1067\/mcp.2001.113989"},{"key":"108","unstructured":"\"Framework for defining evidentiary criteria for biomarker qualification.\"  (2016)"},{"key":"109","unstructured":"\"Biomarker qualification: Evidentiary framework. Docket No. FDA-2018-D-4267.\"  (2018)"},{"key":"110","doi-asserted-by":"crossref","unstructured":"AL Bachman  and K Macken  \"Radiology.\"  72, \"Pleural effusions following supervoltage radiation for breast carcinoma.\" 699 (1959)","DOI":"10.1148\/72.5.699"},{"key":"111","doi-asserted-by":"crossref","unstructured":"N Morrone, VL Gama e Silva Volpe, AM Dourado, et al.  \"Chest.\"  104, \"Bilateral pleural effusion due to mediastinal fibrosis induced by radiotherapy.\" 1276 (1993)","DOI":"10.1378\/chest.104.4.1276"},{"key":"112","doi-asserted-by":"crossref","unstructured":"JL Rodriguez-Garcia, G Fraile, MA Moreno, et al.  \"Chest.\"  100, \"Recurrent massive pleural effusion as a late complication of radiotherapy in Hodgkin's disease.\" 1165 (1991)","DOI":"10.1378\/chest.100.4.1165"},{"key":"113","unstructured":"ME Whitcomb  and MI Schwarz  \"Am Rev Respir Dis.\"  103, \"Pleural effusion complicating intensive mediastinal radiation therapy.\" 100 (1971)"},{"key":"114","doi-asserted-by":"crossref","unstructured":"J Zhao, RM Day, JY Jin, et al.  \"Oncotarget.\"  8, \"Thoracic radiation-induced pleural effusion and risk factors in patients with lung cancer.\" 97623 (2017)","DOI":"10.18632\/oncotarget.18824"},{"key":"115","doi-asserted-by":"crossref","unstructured":"P Horby, WS Lim, JR Emberson, et al.  \"N Engl J Med.\"  384, \"Dexamethasone in hospitalized patients with Covid-19.\" 693 (2021)","DOI":"10.1056\/NEJMoa2021436"},{"key":"116","doi-asserted-by":"crossref","unstructured":"CI Rios, DR Cassatt, BA Hollingsworth, et al.  \"Radiat Res.\"  195, \"Commonalities between COVID-19 and radiation injury.\" 1 (2021)","DOI":"10.1667\/RADE-20-00188.1"},{"key":"79","doi-asserted-by":"crossref","unstructured":"PA Plett, CH Sampson, HL Chua, et al.  \"Health Phys.\"  103, \"Establishing a murine model of the hematopoietic syndrome of the acute radiation syndrome.\" 343 (2012)","DOI":"10.1097\/HP.0b013e3182667309"},{"key":"14","doi-asserted-by":"crossref","unstructured":"BL Fish, F Gao, J Narayanan, et al.  \"Health Phys.\"  111, \"Combined hydration and antibiotics with lisinopril to mitigate acute and delayed high-dose radiation injuries to multiple organs.\" 410 (2016)","DOI":"10.1097\/HP.0000000000000554"},{"key":"106","doi-asserted-by":"crossref","unstructured":"JK Waselenko, TJ MacVittie, WF Blakely, et al.  \"Ann Intern Med.\"  140, \"Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group.\" 1037 (2004)","DOI":"10.7326\/0003-4819-140-12-200406150-00015"},{"key":"38","doi-asserted-by":"crossref","unstructured":"DL Preston, Y Shimizu, DA Pierce, et al.  \"Radiat Res.\"  160, \"Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950\u20131997.\" 381 (2003)","DOI":"10.1667\/RR3049"},{"key":"64","doi-asserted-by":"crossref","unstructured":"EP Cohen, KG Hankey, AW Bennett, et al.  \"Radiat Res.\"  188, \"Acute and chronic kidney injury in a non-human primate model of partial-body irradiation with bone marrow sparing.\" 661 (2017)","DOI":"10.1667\/RR24857.1"},{"key":"9","doi-asserted-by":"crossref","unstructured":"A Baranov, RP Gale, A Guskova, et al.  \"N Engl J Med.\"  321, \"Bone marrow transplantation after the Chernobyl nuclear accident.\" 205 (1989)","DOI":"10.1056\/NEJM198907273210401"},{"key":"18","doi-asserted-by":"crossref","unstructured":"TJ MacVittie, A Bennett, C Booth, et al.  \"Health Phys.\"  103, \"The prolonged gastrointestinal syndrome in rhesus macaques: the relationship between gastrointestinal, hematopoietic, and delayed multi-organ sequelae following acute, potentially lethal, partial-body irradiation.\" 427 (2012)","DOI":"10.1097\/HP.0b013e318266eb4c"},{"key":"84","doi-asserted-by":"crossref","unstructured":"MS. Anscher,  \"Oncologist.\"  15, \"Targeting the TGF-beta1 pathway to prevent normal tissue injury after cancer therapy.\" 350 (2010)","DOI":"10.1634\/theoncologist.2009-S101"},{"key":"57","doi-asserted-by":"crossref","unstructured":"IL Jackson, Z Vujaskovic, JD Down,  \"Radiat Res.\"  173, \"Revisiting strain-related differences in radiation sensitivity of the mouse lung: recognizing and avoiding the confounding effects of pleural effusions.\" 10 (2010)","DOI":"10.1667\/RR1911.1"},{"key":"66","doi-asserted-by":"crossref","unstructured":"C Prado, TJ MacVittie, AW Bennett, et al.  \"Radiat Res.\"  188, \"Organ doses associated with partial-body irradiation with 2.5% bone marrow sparing of the non-human primate: a retrospective study.\" 615 (2017)","DOI":"10.1667\/RR14804.1"},{"key":"49","doi-asserted-by":"crossref","unstructured":"LB Marks, ED Yorke, A Jackson, et al.  \"Int J Radiat Oncol Biol Phys.\"  76, \"Use of normal tissue complication probability models in the clinic.\" S10 (2010)","DOI":"10.1016\/j.ijrobp.2009.07.1754"},{"key":"107","doi-asserted-by":"crossref","unstructured":"IS Vlachos, K Zagganas, MD Paraskevopoulou, et al.  \"Nucleic Acids Res.\"  43, \"DIANA-miRPath v3.0: deciphering microRNA function with experimental support.\" W460 (2015)","DOI":"10.1093\/nar\/gkv403"},{"key":"1","doi-asserted-by":"crossref","unstructured":"L Giuranno, J Ient, D De Ruysscher, et al.  \"Front Oncol.\"  9, \"Radiation-induced lung injury (RILI).\" 877 (2019)","DOI":"10.3389\/fonc.2019.00877"},{"key":"13","doi-asserted-by":"crossref","unstructured":"M Garofalo, A Bennett, AM Farese, et al.  \"Health Phys.\"  106, \"The delayed pulmonary syndrome following acute high-dose irradiation: a rhesus macaque model.\" 56 (2014)","DOI":"10.1097\/HP.0b013e3182a32b3f"},{"key":"52","doi-asserted-by":"crossref","unstructured":"MC Garofalo, AA Ward, AM Farese, et al.  \"Health Phys.\"  106, \"A pilot study in rhesus macaques to assess the treatment efficacy of a small molecular weight catalytic metalloporphyrin antioxidant (AEOL 10150) in mitigating radiation-induced lung damage.\" 73 (2014)","DOI":"10.1097\/HP.0b013e3182a4d967"},{"key":"70","doi-asserted-by":"crossref","unstructured":"TJ MacVittie, A Gibbs, AM Farese, et al.  \"Radiat Res.\"  187, \"AEOL 10150 mitigates radiation-induced lung injury in the nonhuman primate: Morbidity and mortality are administration schedule-dependent.\" 298 (2017)","DOI":"10.1667\/RR4413.1"},{"key":"47","doi-asserted-by":"crossref","unstructured":"KD Thrall, S Mahendra, MK Jackson, et al.  \"Health Phys.\"  116, \"A comparative dose-response relationship between sexes for mortality and morbidity of radiation-induced lung injury in the rhesus macaque.\" 354 (2019)","DOI":"10.1097\/HP.0000000000000925"},{"key":"26","doi-asserted-by":"crossref","unstructured":"IL Jackson, Z Vujaskovic, JD Down,  \"Radiat Res.\"  175, \"A further comparison of pathologies after thoracic irradiation among different mouse strains: finding the best preclinical model for evaluating therapies directed against radiation-induced lung damage.\" 510 (2011)","DOI":"10.1667\/RR2421.1"},{"key":"62","doi-asserted-by":"crossref","unstructured":"M Medhora, F Gao, T Gasperetti, et al.  \"Health Phys.\"  116, \"Delayed effects of acute radiation exposure (Deare) in juvenile and old rats: Mitigation by lisinopril.\" 529 (2019)","DOI":"10.1097\/HP.0000000000000920"},{"key":"16","doi-asserted-by":"crossref","unstructured":"TJ MacVittie, AM Farese, GA Parker, et al.  \"Health Phys.\"  116, \"The time course of radiation-induced lung injury in a nonhuman primate model of partial-body irradiation with minimal bone marrow sparing: clinical and radiographic evidence and the effect of neupogen administration.\" 366 (2019)","DOI":"10.1097\/HP.0000000000000968"},{"key":"77","doi-asserted-by":"crossref","unstructured":"IL Jackson, A Zodda, G Gurung, et al.  \"Br J Pharmacol.\"  174, \"BIO 300, a nanosuspension of genistein, mitigates pneumonitis\/fibrosis following high-dose radiation exposure in the C57L\/J murine model.\" 4738 (2017)","DOI":"10.1111\/bph.14056"},{"key":"86","doi-asserted-by":"crossref","unstructured":"C Rabender, E Mezzaroma, AG Mauro, et al.  \"Radiat Res.\"  186, \"IPW-5371 proves effective as a radiation countermeasure by mitigating radiation-induced late effects.\" 478 (2016)","DOI":"10.1667\/RR14403.2"},{"key":"68","doi-asserted-by":"crossref","unstructured":"F Gao, BL Fish, JE Moulder, et al.  \"Radiat Res.\"  180, \"Enalapril mitigates radiation-induced pneumonitis and pulmonary fibrosis if started 35 days after whole-thorax irradiation.\" 546 (2013)","DOI":"10.1667\/RR13350.1"},{"key":"27","doi-asserted-by":"crossref","unstructured":"B Mathew, Y Huang, JR Jacobson, et al.  \"Am J Respir Cell Mol Biol.\"  44, \"Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression.\" 415 (2011)","DOI":"10.1165\/rcmb.2010-0122OC"},{"key":"60","doi-asserted-by":"crossref","unstructured":"G Ghobadi, S van der Veen, B Bartelds, et al.  \"Int J Radiat Oncol Biol Phys.\"  84, \"Physiological interaction of heart and lung in thoracic irradiation.\" e639 (2012)","DOI":"10.1016\/j.ijrobp.2012.07.2362"},{"key":"25","doi-asserted-by":"crossref","unstructured":"A Koch, J Gulani, G King, et al.  \"PLoS One.\"  11, \"Establishment of early endpoints in mouse total-body irradiation model.\" e0161079 (2016)","DOI":"10.1371\/journal.pone.0161079"},{"key":"81","doi-asserted-by":"crossref","unstructured":"C Booth, G Tudor, N Tonge, et al.  \"Health Phys.\"  103, \"Evidence of delayed gastrointestinal syndrome in high-dose irradiated mice.\" 400 (2012)","DOI":"10.1097\/HP.0b013e31826530e2"},{"key":"117","doi-asserted-by":"crossref","unstructured":"RM Vigneulle, S Rao, A Fasano, et al.  \"Dig Dis Sci.\"  47, \"Structural and functional alterations of the gastrointestinal tract following radiation-induced injury in the rhesus monkey.\" 1480 (2002)","DOI":"10.1023\/A:1015846514471"},{"key":"50","doi-asserted-by":"crossref","unstructured":"FA Stewart, AV Akleyev, M Hauer-Jensen, et al.  \"Ann ICRP.\"  41, \"ICRP publication 118: ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs\u2013threshold doses for tissue reactions in a radiation protection context.\" 1 (2012)","DOI":"10.1016\/j.icrp.2012.02.001"}],"container-title":["Radiation Research"],"original-title":[],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T08:49:00Z","timestamp":1793436540000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-197\/issue-4\/RADE-21-00127.1\/A-Trans-Agency-Workshop-on-the-Pathophysiology-of-Radiation-Induced\/10.1667\/RADE-21-00127.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":117,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rade-21-00127.1","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,3]]}}}