{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T07:30:36Z","timestamp":1793431836458,"version":"4.5.0"},"reference-count":34,"publisher":"Radiation Research Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2022,11,11]]},"abstract":"<jats:p>Thyroid doses from intake of radioiodine isotopes (131I, 132Te+132I, and 133I) and associated uncertainties were revised for the 13,204 Ukrainian-American cohort members exposed in childhood and adolescence to fallout from the Chornobyl nuclear power plant accident. The main changes related to the revision of the 131I thyroid activity measured in cohort members, the use of thyroid-mass values specific to the Ukrainian population, and the revision of the 131I ground deposition densities in Ukraine. Uncertainties in doses were assessed considering shared and unshared errors in the parameters of the dosimetry model. Using a Monte-Carlo simulation procedure, 1,000 individual stochastic thyroid doses were calculated for each cohort member. The arithmetic mean of thyroid doses from intake of 131I, 132Te+132I, and 133I for the entire cohort was 0.60 Gy (median = 0.22 Gy). For 9,474 subjects (71.6% of the total), the thyroid doses were less than 0.5 Gy. Thyroid doses for 42 cohort members (0.3% of the total) exceeded 10 Gy while the highest dose was 35 Gy. Intake of 131I contributed around 95% to internal thyroid exposure from radioiodine isotopes. The geometric standard deviation of individual stochastic thyroid doses varied among cohort members from 1.4 to 4.3 with an arithmetic mean of 1.6 and a median of 1.4. It was shown that the contribution of shared errors to the dose uncertainty was small. The revised thyroid doses resulted, in average, in around 40% decrease for cohort members from Zhytomyr Oblast and an increase of around 24% and 35% for the cohort members from Kyiv and Chernihiv Oblast, respectively. Arithmetic mean of TD20 doses for the cohort was around 8% less than that estimated in TD10, 0.60 Gy vs. 0.65 Gy, respectively; however, global median of TD20 doses somewhat increased compared to TD10: 0.22 Gy vs. 0.19 Gy, respectively. The difference between TD10 and TD20 was mainly due to a revision of the individual 131I thyroid activity measured in the cohort members.<\/jats:p>","DOI":"10.1667\/rade-21-00152.1","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T02:18:06Z","timestamp":1668133086000},"page":"61-73","source":"Crossref","is-referenced-by-count":5,"title":["Exposure to the Thyroid from Intake of Radioiodine Isotopes after the Chornobyl Accident. Report I: Revised Doses and Associated Uncertainties for the Ukrainian-American Cohort"],"prefix":"10.1667","volume":"199","author":[{"given":"Sergii","family":"Masiuk","sequence":"first","affiliation":[{"name":"State Institution \u201cNational Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine\u201d, Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykola","family":"Chepurny","sequence":"additional","affiliation":[{"name":"State Institution \u201cNational Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine\u201d, Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentyna","family":"Buderatska","sequence":"additional","affiliation":[{"name":"State Institution \u201cNational Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine\u201d, Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Ivanova","sequence":"additional","affiliation":[{"name":"State Institution \u201cNational Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine\u201d, Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulfira","family":"Boiko","sequence":"additional","affiliation":[{"name":"State Institution \u201cNational Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine\u201d, Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Zhadan","sequence":"additional","affiliation":[{"name":"State Institution \u201cNational Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine\u201d, Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohiko","family":"Mabuchi","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth K","family":"Cahoon","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P","family":"Little","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kukush","sequence":"additional","affiliation":[{"name":"Taras Shevchenko National University of Kyiv, Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetiana","family":"Bogdanova","sequence":"additional","affiliation":[{"name":"V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Shpak","sequence":"additional","affiliation":[{"name":"V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galyna","family":"Zamotayeva","sequence":"additional","affiliation":[{"name":"V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykola","family":"Tronko","sequence":"additional","affiliation":[{"name":"V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Drozdovitch","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"29","doi-asserted-by":"crossref","unstructured":"V Drozdovitch, V Kryuchkov, E Bakhanova, et al.  \"Health Phys.\"  118, \"Reconstruction of individual thyroid doses for case-control study of thyroid cancer among Ukrainian Chernobyl cleanup workers.\" 18 (2020)","DOI":"10.1097\/HP.0000000000001120"},{"key":"1","doi-asserted-by":"crossref","unstructured":"MD Tronko, GR Howe, TI Bogdanova, et al.  \"J Natl Cancer Inst.\"  98, \"A cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident: thyroid cancer in Ukraine detected during first screening.\" 897 (2006)","DOI":"10.1093\/jnci\/djj244"},{"key":"2","doi-asserted-by":"crossref","unstructured":"I Likhtarev, A Bouville, L Kovgan, et al.  \"Radiat Res.\"  166, \"Questionnaire- and measurement-based individual thyroid doses in Ukraine resulting from the Chernobyl nuclear reactor accident.\" 271 (2006)","DOI":"10.1667\/RR3545.1"},{"key":"3","doi-asserted-by":"crossref","unstructured":"I Likhtarov, L Kovgan, S Masiuk, et al.  \"Health Phys.\"  106, \"Thyroid cancer study among Ukrainian children exposed to radiation after the Chornobyl accident: improved estimates of the thyroid doses to the cohort members.\" 370 (2014)","DOI":"10.1097\/HP.0b013e31829f3096"},{"key":"4","doi-asserted-by":"crossref","unstructured":"AV Brenner, MD Tronko, M Hatch, et al.  \"Environ Health Perspect.\"  119, \"I-131 dose response for incident thyroid cancers in Ukraine related to the Chornobyl accident.\" 933 (2011)","DOI":"10.1289\/ehp.1002674"},{"key":"5","doi-asserted-by":"crossref","unstructured":"MP Little, AG Kukush, SV Masiuk, et al.  \"PLoS ONE.\"  9, \"Impact of uncertainties in exposure assessment on thyroid cancer risk among Ukrainian children and adolescents exposed from the Chornobyl accident.\" e85723 (2014)","DOI":"10.1371\/journal.pone.0085723"},{"key":"6","doi-asserted-by":"crossref","unstructured":"KO Peters, M Tronko, M Hatch, et al.  \"Environ Res.\"  156, \"Factors associated with serum thyroglobulin in a Ukrainian cohort exposed to iodine-131 from the accident at the Chernobyl Nuclear Plant.\" 801 (2017)","DOI":"10.1016\/j.envres.2017.04.014"},{"key":"7","doi-asserted-by":"crossref","unstructured":"M Tronko, A Brenner, T Bogdanova, et al.  \"Int J Cancer.\"  141, \"Thyroid neoplasia risk is increased nearly 30 years after the Chernobyl accident.\" 1585 (2017)","DOI":"10.1002\/ijc.30857"},{"key":"8","doi-asserted-by":"crossref","unstructured":"S Masiuk, M Chepurny, V Buderatska, et al.  \"Radiat Environ Biophys.\"  60, \"Thyroid doses in Ukraine due to 131I intake after the Chornobyl accident. 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