{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:32:29Z","timestamp":1793424749156,"version":"4.5.0"},"reference-count":30,"publisher":"Radiation Research Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2023,11,28]]},"abstract":"<jats:p>Patients with hepatobiliary tumors who accept radiotherapy are at risk for radiation-induced liver fibrosis. MicroRNAs (miRNAs) have been implicated in the pathogenesis of radiation-induced liver damage and possess potential as novel biomarkers and therapeutic targets. However, the role of miR-146a-5p in radiation-induced liver fibrosis is less well understood. The current study was designed to evaluate the role of miR-146a-5p in radiation-induced liver fibrosis in mice and to investigate the possible mechanisms involved in miR-146a-5p-mediated effects. The experiments were performed on Institute of Cancer Research (ICR) mice which received fractionated radiation (30 Gy in 5 fractions) to the liver. The results show radiation could induce histopathological changes, liver dysfunction and fibrosis accompanied with decreased miR-146a-5p expression. miR-146a-5p agomir treatment resulted in recovery of liver function and reduced the amount of alpha-smooth muscle actin (\u03b1-SMA), collagen 1, protein tyrosine phosphatase receptor type A (PTPRA) and phosphorylated SRC in the livers of irradiated mice. Therefore, our study reveals that miR-146a-5p inhibits the progression of hepatic fibrosis after radiation treatment. And the beneficial role of miR-146a-5p may be relevant to PTPRA-SRC signaling pathway.<\/jats:p>","DOI":"10.1667\/rade-22-00017.1","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T04:48:31Z","timestamp":1701146911000},"page":"531-537","source":"Crossref","is-referenced-by-count":2,"title":["miR-146a-5p Alleviates Radiation-Induced Liver Fibrosis by Regulating PTPRA-SRC Signaling in Mice"],"prefix":"10.1667","volume":"200","author":[{"given":"Bao-ying","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Feng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Mei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen-Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Chong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"3","doi-asserted-by":"crossref","unstructured":"RF Khozouz, SZ Huq, MC Perry,  \"J Clin Oncol.\"  26, \"Radiation-induced liver disease.\" 4844 (2008)","DOI":"10.1200\/JCO.2008.18.2931"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Y He, C Huang, X Sun, et al.  \"Cell Signal.\"  24, \"MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4.\" 1923 (2012)","DOI":"10.1016\/j.cellsig.2012.06.003"},{"key":"18","doi-asserted-by":"crossref","unstructured":"CM Croce  and GA Calin  \"Cell.\"  122, \"miRNAs, cancer, and stem cell division.\" 6 (2005)","DOI":"10.1016\/j.cell.2005.06.036"},{"key":"16","doi-asserted-by":"crossref","unstructured":"J Kim, S Wang, J Hyun, et al.  \"Cell Physiol Biochem.\"  40, \"Hedgehog signaling is associated with liver response to fractionated irradiation in mice.\" 263 (2016)","DOI":"10.1159\/000452543"},{"key":"1","doi-asserted-by":"crossref","unstructured":"CH Rim, J Cheng, WY Huang, et al.  \"Radiother Oncol.\"  148, \"An evaluation of hepatocellular carcinoma practice guidelines from a radiation oncology perspective.\" 73 (2020)","DOI":"10.1016\/j.radonc.2020.03.027"},{"key":"2","doi-asserted-by":"crossref","unstructured":"RF Munden, JJ Erasmus, WR Smythe, et al.  \"AJR Am J Roentgenol.\"  184, \"Radiation injury to the liver after intensity-modulated radiation therapy in patients with mesothelioma: an unusual CT appearance.\" 1091 (2005)","DOI":"10.2214\/ajr.184.4.01841091"},{"key":"4","doi-asserted-by":"crossref","unstructured":"LA Dawson, D Normolle, JM Balter, et al.  \"Int J Radiat Oncol Biol Phys.\"  53, \"Analysis of radiation-induced liver disease using the Lyman NTCP model.\" 810 (2002)","DOI":"10.1016\/S0360-3016(02)02846-8"},{"key":"5","doi-asserted-by":"crossref","unstructured":"LA Dawson  and RK Ten Haken  \"Semin Radiat Oncol.\"  15, \"Partial volume tolerance of the liver to radiation.\" 279 (2005)","DOI":"10.1016\/j.semradonc.2005.04.005"},{"key":"6","doi-asserted-by":"crossref","unstructured":"PN. 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Elson,  \"Int J Biochem Cell Biol.\"  96, \"Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases.\" 135 (2018)","DOI":"10.1016\/j.biocel.2017.09.013"},{"key":"29","doi-asserted-by":"crossref","unstructured":"H Li, C Zhao, Y Tian, et al.  \"Biomed Pharmacother.\"  127, \"Src family kinases and pulmonary fibrosis: A review.\" 110183 (2020)","DOI":"10.1016\/j.biopha.2020.110183"},{"key":"30","doi-asserted-by":"crossref","unstructured":"DH Kim, HI Choi, JS Park, et al.  \"FASEB J.\"  33, \"Src-mediated crosstalk between FXR and YAP protects against renal fibrosis.\" 11109 (2019)","DOI":"10.1096\/fj.201900325R"}],"container-title":["Radiation Research"],"original-title":[],"link":[{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-22-00017.1\/3294643\/10.1667_rade-22-00017.1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-22-00017.1\/3294643\/10.1667_rade-22-00017.1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:04:21Z","timestamp":1793423061000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-200\/issue-6\/RADE-22-00017.1\/miR-146a-5p-Alleviates-Radiation-Induced-Liver-Fibrosis-by-Regulating\/10.1667\/RADE-22-00017.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,28]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,12,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rade-22-00017.1","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,28]]}}}