{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T07:30:05Z","timestamp":1793431805181,"version":"4.5.0"},"reference-count":24,"publisher":"Radiation Research Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2022,12,15]]},"abstract":"<jats:p>Nasopharyngeal carcinoma (NPC) is a rare head and neck tumor that threatens people's health. Radiotherapy is a major treatment for NPC, however, radioresistance of the NPC cells may contribute to treatment failure. LncRNA SNHG16 was upregulated in NPC; however, the function of SNHG16 in radioresistant NPC cells remains unexplored. RT-qPCR was applied for detecting SNHG16, miR-31-5p and SFN levels. MTT assay and colony formation assay were applied to assess the cell viability and proliferation. Dual luciferase was applied for assessing the relation among SNHG16, miR-31-5p and SFN. SFN level in NPC cells was examined by Western blot. The level of SNHG16 and SFN in NPC cells was significantly upregulated by exposure to radiation. In addition, silencing of SNHG16 or miR-31-5p mimics notably attenuated radioresistance of NPC cells. SNHG16 could positively regulate the expression of SFN in NPC cells through binding with miR-31-5p. Furthermore, SNHG16 downregulation obviously attenuated the proliferation and radioresistance of NPC cells by regulation of miR-31-5p\/SFN axis. Knockdown of lncRNA SNHG16 attenuates radioresistance of nasopharyngeal carcinoma cells by miR-31-5p\/SFN axis. Thus, our research data show a novel method for improving the efficacy of radiotherapy for NPC.<\/jats:p>","DOI":"10.1667\/rade-22-00163.1","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T14:11:36Z","timestamp":1671113496000},"page":"124-131","source":"Crossref","is-referenced-by-count":6,"title":["Knockdown of lncRNA SNHG16 Attenuates the Proliferation and Radioresistance of Nasopharyngeal Carcinoma Cells by Mediating miR-31-5p\/SFN Axis"],"prefix":"10.1667","volume":"199","author":[{"given":"Weiwei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oncology, Brain Hospital of Hunan Province, Changsha 410007, Hunan Province, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanyuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan Province, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangqi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, North China University of Science and Technology Affiliated Hospital, Tangshan 063000, Hebei Province, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan Province, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan Province, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangchu","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan Province, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, Hunan Province, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Z Shen, Y Wu, G He,  \"Bioengineered.\"  13, \"Long non-coding RNA PTPRG-AS1\/microRNA-124-3p regulates radiosensitivity of nasopharyngeal carcinoma via the LIM Homeobox 2-dependent Notch pathway through competitive endogenous RNA mechanism.\" 8208 (2022)","DOI":"10.1080\/21655979.2022.2037364"},{"key":"2","doi-asserted-by":"crossref","unstructured":"W Wang, Z Zhang, Y Li, et al.  \"Bioengineered.\"  13, \"Down-regulated long non-coding RNA LHFPL3 antisense RNA 1 inhibits the radiotherapy resistance of nasopharyngeal carcinoma via modulating microRNA-143-5p\/homeobox A6 axis.\" 5421 (2022)","DOI":"10.1080\/21655979.2021.2024386"},{"key":"3","doi-asserted-by":"crossref","unstructured":"M Wu, J Jin, Z Li, et al.  \"PeerJ.\"  10, \"Influence of beamlet width on dynamic IMRT plan quality in nasopharyngeal carcinoma.\" e13748 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