{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:09:10Z","timestamp":1790798950240,"version":"4.1.0"},"reference-count":58,"publisher":"Radiation Research Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2023,8,1]]},"DOI":"10.1667\/rade-22-00196.1","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T18:08:51Z","timestamp":1690913331000},"source":"Crossref","is-referenced-by-count":13,"title":["Loss of Cognitive Flexibility Practice Effects in Female Rats Exposed to Simulated Space Radiation"],"prefix":"10.1667","volume":"200","author":[{"given":"Richard A.","family":"Britten","sequence":"first","affiliation":[{"name":"EVMS Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arriyam","family":"Fesshaye","sequence":"additional","affiliation":[{"name":"EVMS Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Tidmore","sequence":"additional","affiliation":[{"name":"EVMS Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiyi","family":"Liu","sequence":"additional","affiliation":[{"name":"EVMS Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley A.","family":"Blackwell","sequence":"additional","affiliation":[{"name":"EVMS Radiation Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"FA Cucinotta, M Alp, FM Sulzman, et al.  \"Life Sci Sp Res.\"  2, \"Space radiation risks to the central nervous system.\" 54 (2014)","DOI":"10.1016\/j.lssr.2014.06.003"},{"key":"30","doi-asserted-by":"crossref","unstructured":"JS Jewell, VD Duncan, A Fesshaye, et al.  \"Radiat Res.\"  190, \"Exposure to \u226415 cGy of 600 MeV\/n 56 Fe particles impairs rule acquisition but not long-term memory in the attentional set-shifting assay.\" 565 (2018)","DOI":"10.1667\/RR15085.1"},{"key":"28","doi-asserted-by":"crossref","unstructured":"MM Hadley, LK Davis, JS Jewell, et al.  \"Radiat Res.\"  185, \"Exposure to mission-relevant doses of 1 GeV\/n 48Ti particles impairs attentional set-shifting performance in retired breeder rats.\" 13 (2016)","DOI":"10.1667\/RR14086.1"},{"key":"31","doi-asserted-by":"crossref","unstructured":"RA Britten, JS Jewell, VD Duncan, et al.  \"Radiat Res.\"  189, \"Impaired attentional set-shifting performance after exposure to 5 cGy of 600 MeV\/n 28Si particles.\" 273 (2018)","DOI":"10.1667\/RR14627.1"},{"key":"14","doi-asserted-by":"crossref","unstructured":"F Kiffer, T Alexander, JE Anderson, et al.  \"Radiat Res.\"  191, \"Late effects of 16 O-particle radiation on female social and cognitive behavior and hippocampal physiology.\" 278 (2019)","DOI":"10.1667\/RR15092.1"},{"key":"10","doi-asserted-by":"crossref","unstructured":"BM Rabin, MG Miller, A Larsen, et al.  \"Life Sci Sp Res.\"  22, \"Effects of exposure to 12C and 4He particles on cognitive performance of intact and ovariectomized female rats.\" 47 (2019)","DOI":"10.1016\/j.lssr.2019.07.005"},{"key":"53","doi-asserted-by":"crossref","unstructured":"K Krukowski, T Jones, M Campbell-Beachler, et al.  \"Radiat Res.\"  190, \"Peripheral T cells as a biomarker for oxygen-ion-radiation-induced social impairments.\" 186 (2018)","DOI":"10.1667\/RR15046.1"},{"key":"8","doi-asserted-by":"crossref","unstructured":"K Krukowski, K Grue, ES Frias, et al.  \"Brain Behav Immun.\"  74, \"Female mice are protected from space radiation-induced maladaptive responses.\" 106 (2018)","DOI":"10.1016\/j.bbi.2018.08.008"},{"key":"29","doi-asserted-by":"crossref","unstructured":"VK Parihar, M Maroso, A Syage, et al.  \"Exp Neurol.\"  305, \"Persistent nature of alterations in cognition and neuronal circuit excitability after exposure to simulated cosmic radiation in mice.\" 44 (2018)","DOI":"10.1016\/j.expneurol.2018.03.009"},{"key":"4","doi-asserted-by":"crossref","unstructured":"FA Cucinotta  and E Cacao  \"Int J Radiat Biol.\"  95, \"Risks of cognitive detriments after low dose heavy ion and proton exposures.\" 985 (2019)","DOI":"10.1080\/09553002.2019.1623427"},{"key":"24","doi-asserted-by":"crossref","unstructured":"CM Davis, KL DeCicco-Skinner, PG Roma, et al.  \"Radiat Res.\"  181, \"Individual differences in attentional deficits and dopaminergic protein levels following exposure to proton radiation.\" 258 (2014)","DOI":"10.1667\/RR13359.1"},{"key":"25","doi-asserted-by":"crossref","unstructured":"RA Britten, LK Davis, JS Jewell, et al.  \"Radiat Res.\"  182, \"Exposure to mission relevant doses of 1 GeV\/nucleon 56Fe particles leads to impairment of attentional set-shifting performance in socially mature rats.\" 292 (2014)","DOI":"10.1667\/RR3766.1"},{"key":"18","doi-asserted-by":"crossref","unstructured":"RA Britten, VD Duncan, A Fesshaye, et al.  \"Radiat Res.\"  193, \"Altered cognitive flexibility and synaptic plasticity in the rat prefrontal cortex after exposure to low (\u226415 cgy) doses of 28Si radiation.\" 223 (2020)","DOI":"10.1667\/RR15458.1"},{"key":"43","doi-asserted-by":"crossref","unstructured":"VN Marty, R Vlkolinsky, N Minassian, et al.  \"Radiat Res.\"  182, \"Radiation-induced alterations in synaptic neurotransmission of dentate granule cells depend on the dose and species of charged particles.\" 653 (2014)","DOI":"10.1667\/RR13647.1"},{"key":"45","doi-asserted-by":"crossref","unstructured":"JA Bellone, E Rudobeck, RE Hartman, et al.  \"Radiat Res.\"  184, \"A single low dose of proton radiation induces long-term behavioral and electrophysiological changes in mice.\" 193 (2015)","DOI":"10.1667\/RR13903.1"},{"key":"46","doi-asserted-by":"crossref","unstructured":"IV Sokolova, CJ Schneider, M Bezaire, et al.  \"Radiat Res.\"  183, \"Proton radiation alters intrinsic and synaptic properties of CA1 pyramidal neurons of the mouse hippocampus.\" 208 (2015)","DOI":"10.1667\/RR13785.1"},{"key":"56","doi-asserted-by":"crossref","unstructured":"B Mishra, R Ripperdan, L Ortiz, et al.  \"Reproduction.\"  154, \"Very low doses of heavy oxygen ion radiation induce premature ovarian failure.\" 123 (2017)","DOI":"10.1530\/REP-17-0101"},{"key":"34","doi-asserted-by":"crossref","unstructured":"C La Tessa, M Sivertz, IH Chiang, et al.  \"Life Sci Sp Res.\"  11, \"Overview of the NASA space radiation laboratory.\" 18 (2016)","DOI":"10.1016\/j.lssr.2016.10.002"},{"key":"26","doi-asserted-by":"crossref","unstructured":"VK Parihar, B Allen, KK Tran, et al.  \"Sci Adv.\"  1, \"What happens to your brain on the way to Mars.\" (2015)","DOI":"10.1126\/sciadv.1400256"},{"key":"16","doi-asserted-by":"crossref","unstructured":"MM Acharya, JE Baulch, PM Klein, et al.  \"ENeuro.\"  6, \"New concerns for neurocognitive function during deep space exposures to chronic, low dose-rate, neutron radiation.\" (2019)","DOI":"10.1523\/ENEURO.0094-19.2019"},{"key":"27","doi-asserted-by":"crossref","unstructured":"VK Parihar, BD Allen, C Caressi, et al.  \"Sci Rep.\"  6, \"Cosmic radiation exposure and persistent cognitive dysfunction.\" (2016)","DOI":"10.1038\/srep34774"},{"key":"33","doi-asserted-by":"crossref","unstructured":"AS V\u00e9ras-Silva, KC Mattos, NS Gava, et al.  \"Am J Physiol - Hear Circ Physiol.\"  273, \"Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats.\" (1997)","DOI":"10.1152\/ajpheart.1997.273.6.H2627"},{"key":"39","doi-asserted-by":"crossref","unstructured":"J Gl\u00e4scher, R Adolphs, D Tranel,  \"Nat Commun.\"  10, \"Model-based lesion mapping of cognitive control using the Wisconsin card sorting test.\" (2019)","DOI":"10.1038\/s41467-018-07912-5"},{"key":"42","doi-asserted-by":"crossref","unstructured":"M Machida, G Lonart, RA Britten,  \"Radiat Res.\"  174, \"Low (60 cGy) doses of 56Fe HZE-particle radiation lead to a persistent reduction in the glutamatergic readily releasable pool in rat hippocampal synaptosomes.\" 618 (2010)","DOI":"10.1667\/RR1988.1"},{"key":"44","doi-asserted-by":"crossref","unstructured":"E Rudobeck, GA Nelson, IV Sokolova, et al.  \"Radiat Res.\"  181, \"28Silicon radiation impairs neuronal output in CA1 neurons of mouse ventral hippocampus without altering dendritic excitability.\" 407 (2014)","DOI":"10.1667\/RR13484.1"},{"key":"7","doi-asserted-by":"crossref","unstructured":"RA Britten, LL Wellman, LD Sanford,  \"Neurosci Biobehav Rev.\"  126, \"Progressive increase in the complexity and translatability of rodent testing to assess space-radiation induced cognitive impairment.\" 159 (2021)","DOI":"10.1016\/j.neubiorev.2021.01.027"},{"key":"19","doi-asserted-by":"crossref","unstructured":"JA Burket, M Matar, A Fesshaye, et al.  \"Radiat Res.\"  196, \"Exposure to low (\u226410 cGy) doses of 4He particles leads to increased social withdrawal and loss of executive function performance.\" 345 (2021)","DOI":"10.1667\/RADE-20-00251.1"},{"key":"11","doi-asserted-by":"crossref","unstructured":"I Soler, S Yun, RP Reynolds, et al.  \"Front Behav Neurosci.\"  15, \"Multi-domain touchscreen-based cognitive assessment of C57BL\/6J female mice shows Whole-body exposure to (56)Fe particle space radiation in maturity improves discrimination learning yet impairs stimulus-response rule-based habit learning.\" 722780 (2021)","DOI":"10.3389\/fnbeh.2021.722780"},{"key":"20","doi-asserted-by":"crossref","unstructured":"RA Britten, A Fesshaye, P Ihle, et al.  \"Radiat Res.\"  197, \"Dissecting differential complex behavioral responses to simulated space radiation exposures.\" 289 (2022)","DOI":"10.1667\/RADE-21-00068.1"},{"key":"17","doi-asserted-by":"crossref","unstructured":"RA Britten, AS Fesshaye, VD Duncan, et al.  \"Radiat Res.\"  194, \"sleep fragmentation exacerbates executive function impairments induced by low doses of Si ions.\" 116 (2020)","DOI":"10.1667\/RADE-20-00080.1"},{"key":"23","doi-asserted-by":"crossref","unstructured":"RA Britten, VD Duncan, AS Fesshaye, et al.  \"Int J Radiat Biol.\"  97, \"Sleep fragmentation exacerbates executive function impairments induced by protracted low dose rate neutron exposure.\" 1077 (2021)","DOI":"10.1080\/09553002.2019.1694190"},{"key":"12","doi-asserted-by":"crossref","unstructured":"K Krukowski, K Grue, M Becker, et al.  \"Sci Adv.\"  7, \"The impact of deep space radiation on cognitive performance: From biological sex to biomarkers to countermeasures.\" eabg6702 (2021)","DOI":"10.1126\/sciadv.abg6702"},{"key":"15","doi-asserted-by":"crossref","unstructured":"EA Schaeffer, AA Blackwell, JRO Oltmanns, et al.  \"Behav Brain Res.\"  416, \"Differential organization of open field behavior in mice following acute or chronic simulated GCR exposure.\" 113577 (2022)","DOI":"10.1016\/j.bbr.2021.113577"},{"key":"2","unstructured":"LC Simonsen, TC Slaba, PM Guida, et al.  \"Proc. Int. Astronaut. Congr. IAC.\"  \"NASA's galactic cosmic ray simulator at Brookhaven National Laboratory: Enabling human exploration missions to the Moon and Mars.\" (2019)"},{"key":"3","doi-asserted-by":"crossref","unstructured":"E Cekanaviciute, S Rosi, SV Costes,  \"Int J Mol Sci.\"  19, \"Central nervous system responses to simulated galactic cosmic rays.\" (2018)","DOI":"10.3390\/ijms19113669"},{"key":"5","doi-asserted-by":"crossref","unstructured":"CW Whoolery, S Yun, RP Reynolds, et al.  \"Sci Rep.\"  10, \"Multi-domain cognitive assessment of male mice shows space radiation is not harmful to high-level cognition and actually improves pattern separation.\" 2737 (2020)","DOI":"10.1038\/s41598-020-59419-z"},{"key":"6","doi-asserted-by":"crossref","unstructured":"F Kiffer, M Boerma, A Allen,  \"Life Sci Sp Res.\"  21, \"Behavioral effects of space radiation: A comprehensive review of animal studies.\" 1 (2019)","DOI":"10.1016\/j.lssr.2019.02.004"},{"key":"9","doi-asserted-by":"crossref","unstructured":"K Krukowski, X Feng, MS Paladini, et al.  \"Sci Rep.\"  8, \"Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits.\" (2018)","DOI":"10.1038\/s41598-018-26039-7"},{"key":"13","doi-asserted-by":"crossref","unstructured":"VK Parihar, MC Angulo, BD Allen, et al.  \"Front Behav Neurosci.\"  \"Sex-Specific Cognitive Deficits Following Space Radiation Exposure.\" 2020","DOI":"10.3389\/fnbeh.2020.535885"},{"key":"21","doi-asserted-by":"crossref","unstructured":"S Stephenson  and R Britten  \"Aerosp Med Hum Perform.\"  93, \"Simulated Space Radiation Exposure Effects on Switch Task Performance in Rats.\" 673 (2022)","DOI":"10.3357\/AMHP.6017.2022"},{"key":"22","doi-asserted-by":"crossref","unstructured":"RA Britten, A Fesshaye, A Tidmore, et al.  \"Radiat Res.\"  198, \"Similar Loss of Executive Function Performance after Exposure to Low (10 cGy) Doses of Single (4He) Ions and the Multi-Ion GCRSim Beam.\" 375 (2022)","DOI":"10.1667\/RADE-22-00022.1"},{"key":"32","doi-asserted-by":"crossref","unstructured":"NA Andreollo, EF dos Santos, MR de Araujo, et al.  \"Arq Bras Cir Dig.\"  25, \"Rat's age versus human's age: what is the relationship?\" 49 (2012)","DOI":"10.1590\/S0102-67202012000100011"},{"key":"35","doi-asserted-by":"crossref","unstructured":"RJ Jutten, E Grandoit, NS Foldi, et al.  \"Alzheimer's Dement.\"  2020, \"Lower practice effects as a marker of cognitive performance and dementia risk: A literature review.\" e12055","DOI":"10.1002\/dad2.12055"},{"key":"36","doi-asserted-by":"crossref","unstructured":"AL Eagle, M Mazei-Robison, AJ Robison,  \"Bio-Protocol.\"  6, \"Sucrose Preference Test to Measure Stress-induced Anhedonia.\" e1822 (2016)","DOI":"10.21769\/BioProtoc.1822"},{"key":"37","doi-asserted-by":"crossref","unstructured":"M-Y Liu, C-Y Yin, L-J Zhu, et al.  \"Nat Protoc.\"  13, \"Sucrose preference test for measurement of stress-induced anhedonia in mice.\" 1686 (2018)","DOI":"10.1038\/s41596-018-0011-z"},{"key":"38","doi-asserted-by":"crossref","unstructured":"Y Nagahama, T Okina, N Suzuki, et al.  \"J Neurol Neurosurg Psychiatry.\"  76, \"The cerebral correlates of different types of perseveration in the Wisconsin Card Sorting Test.\" 169 (2005)","DOI":"10.1136\/jnnp.2004.039818"},{"key":"40","doi-asserted-by":"crossref","unstructured":"J Raber, A Fuentes Anaya, ERS Torres, et al.  \"Front Physiol.\"  11, \"Effects of Six Sequential Charged Particle Beams on Behavioral and Cognitive Performance in B6D2F1 Female and Male Mice.\" (2020)","DOI":"10.3389\/fphys.2020.00959"},{"key":"41","doi-asserted-by":"crossref","unstructured":"JL Huff, F Poignant, S Rahmanian, et al.  \"Life Sci Sp Res.\"  \"Galactic cosmic ray simulation at the NASA space radiation laboratory \u2013 Progress, challenges and recommendations on mixed-field effects.\" (2022)","DOI":"10.1016\/j.lssr.2022.09.001"},{"key":"47","doi-asserted-by":"crossref","unstructured":"R Vlkolinsk\u00fd, T Krucker, GA Nelson, et al.  \"Radiat Res.\"  169, \"56Fe-particle radiation reduces neuronal output and attenuates lipopolysaccharideinduced inhibition of long-term potentiation in the mouse hippocampus.\" 523 (2008)","DOI":"10.1667\/RR1228.1"},{"key":"48","doi-asserted-by":"crossref","unstructured":"J Raber, E Rudobeck, M Campbell-Beachler, et al.  \"Radiat Res.\"  181, \"Silicon radiation-induced enhancement of synaptic plasticity in the hippocampus of na\u00efve and cognitively tested mice.\" 362 (28)","DOI":"10.1667\/RR13347.1"},{"key":"49","doi-asserted-by":"crossref","unstructured":"B Krishnan, C Natarajan, KZ Bourne, et al.  \"Int J Mol Sci.\"  \"Chronic low dose neutron exposure results in altered neurotransmission properties of the hippocampus-prefrontal cortex axis in both mice and rats.\" (2021)","DOI":"10.3390\/ijms22073668"},{"key":"50","doi-asserted-by":"crossref","unstructured":"G Zanni, K Zhou, I Riebe, et al.  \"Dev Neurosci.\"  37, \"Irradiation of the Juvenile Brain Provokes a Shift from Long-Term Potentiation to Long-Term Depression.\" 263 (2015)","DOI":"10.1159\/000430435"},{"key":"51","doi-asserted-by":"crossref","unstructured":"D Zhang, W Zhou, TT Lam, et al.  \"Neuro-Oncology Radiation induces age-dependent deficits in cortical synaptic plasticity.\"  20, 1207 (2018)","DOI":"10.1093\/neuonc\/noy052"},{"key":"52","doi-asserted-by":"crossref","unstructured":"O Miry, X-L Zhang, LR Vose, et al.  \"Sci Rep.\"  11, \"Life-long brain compensatory responses to galactic cosmic radiation exposure.\" 4292 (2021)","DOI":"10.1038\/s41598-021-83447-y"},{"key":"54","doi-asserted-by":"crossref","unstructured":"C Barth, A Villringer, J Sacher,  \"Front Neurosci.\"  9, \"Sex hormones affect neurotransmitters and shape the adult female brain during hormonal transition periods.\" (2015)","DOI":"10.3389\/fnins.2015.00037"},{"key":"55","doi-asserted-by":"crossref","unstructured":"PM Maki,  \"Ann N Y Acad Sci.\"  1052, \"A systematic review of clinical trials of hormone therapy on cognitive function: effects of age at initiation and progestin use.\" 182 (2005)","DOI":"10.1196\/annals.1347.012"},{"key":"57","doi-asserted-by":"crossref","unstructured":"BI Rose,  \"Eur J Obstet Gynecol Reprod Biol.\"  271, \"Female astronauts: Impact of space radiation on menopause.\" 210 (2022)","DOI":"10.1016\/j.ejogrb.2022.02.022"},{"key":"58","doi-asserted-by":"crossref","unstructured":"R Hamel, J-F Lepage, P-M Bernier,  \"Eur J Neurosci.\"  55, \"Anterograde interference emerges along a gradient as a function of task similarity: A behavioural study.\" 49 (2022)","DOI":"10.1111\/ejn.15561"}],"container-title":["Radiation Research"],"original-title":[],"link":[{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-22-00196.1\/3243405\/10.1667_rade-22-00196.1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-22-00196.1\/3243405\/10.1667_rade-22-00196.1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T15:02:14Z","timestamp":1696345334000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-200\/issue-3\/RADE-22-00196.1\/Loss-of-Cognitive-Flexibility-Practice-Effects-in-Female-Rats-Exposed\/10.1667\/RADE-22-00196.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,1]]},"references-count":58,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rade-22-00196.1","relation":{},"ISSN":["0033-7587"],"issn-type":[{"value":"0033-7587","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,1]]}}}