{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T06:31:22Z","timestamp":1793428282525,"version":"4.5.0"},"reference-count":36,"publisher":"Radiation Research Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2023,7,7]]},"abstract":"<jats:p>The mesh-type models are superior to voxel models in cellular dose assessment coupled with Monte Carlo codes. The aim of this study was to expand the micron-scale mesh-type models based on the fluorescence tomography of real human cells, and to investigate the feasibility of these models in the application of various irradiation scenarios and Monte Carlo codes. Six different human cell lines, including pulmonary epithelial BEAS-2B, embryonic kidney 293T, hepatocyte L-02, B-lymphoblastoid HMy2.CIR, Gastric mucosal GES-1, and intestine epithelial FHs74Int, were adopted for single mesh-type models reconstruction and optimization based on laser confocal tomography images. Mesh-type models were transformed into the format of polygon mesh and tetrahedral mesh for the GATE and PHITS Monte Carlo codes, respectively. The effect of model reduction was analyzed by dose assessment and geometry consideration. The cytoplasm and nucleus doses were obtained by designating monoenergetic electrons and protons as external irradiation, and S values with different \u201ctarget-source\u201d combinations were calculated by assigning radioisotopes as internal exposure. Four kinds of Monte Carlo codes were employed, i.e., GATE with \u201cLivermore,\u201d \u201cStandard\u201d and \u201cStandard and Geant4-DNA mixed\u201d models for electrons and protons, as well as PHITS with \u201cEGS\u201d mode for electrons and radioisotopes. Multiple mesh-type real human cellular models can be applied to Monte Carlo codes directly without voxelization when combined with certain necessary surface reduction. Relative deviations between different cell types were observed among various irradiation scenarios. The relative deviation of nucleus S value reaches up to 85.65% between L-02 and GES-1 cells by 3H for the \u201cnucleus-nucleus\u201d combination, while that of 293T and FHs74Int nucleus dose for external beams at a 5.12 cm depth of water is 106.99%. Nucleus with smaller volume is far more affected by physical codes. There is a considerable deviation for dose within BEAS-2B at the nanoscale. The multiple mesh-type real cell models were more versatile than voxel models and mathematical models. The present study provided several models which can easily be extended to other cell types and irradiation scenarios for RBE estimations and biological effect predictions, including radiation biological experiments, radiotherapy and radiation protection.<\/jats:p>","DOI":"10.1667\/rade-23-00020.1","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T10:52:22Z","timestamp":1688640742000},"page":"176-187","source":"Crossref","is-referenced-by-count":8,"title":["Multiple Mesh-type Real Human Cell Models for Dosimetric Application Coupled with Monte Carlo Simulations"],"prefix":"10.1667","volume":"200","author":[{"given":"YiDi","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Affiliated Hospital of Jiangnan University, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChuanSheng","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HuiYuan","family":"Xue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiangHui","family":"Kong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenYue","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuChen","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"36","doi-asserted-by":"crossref","unstructured":"H Nikjoo, D Emfietzoglou, T Liamsuwan, et al.  \"Rep Prog Phys.\"  79, \"Radiation track, DNA damage and response-a review.\" 116601 (2016)","DOI":"10.1088\/0034-4885\/79\/11\/116601"},{"key":"24","doi-asserted-by":"crossref","unstructured":"K Niita, T Sato, H Iwase, et al.  \"Radiat Meas.\"  41, \"PHITS\u2014a particle and heavy ion transport code system.\" 1080 (2006)","DOI":"10.1016\/j.radmeas.2006.07.013"},{"key":"1","unstructured":"D Shabzi-Gahrouei  and S Nikzad  \"Iran J Radiat Res.\"  8, \"Determination of organ doses in radioiodine therapy using medical internal radiation dosimetry 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