{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:32:57Z","timestamp":1793424777850,"version":"4.5.0"},"reference-count":36,"publisher":"Radiation Research Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2023,11,14]]},"abstract":"<jats:p>This work describes an analysis, using a previously established chelation model, of the bioassay data collected from a worker who received delayed chelation therapy following a plutonium-238 inhalation. The details of the case have already been described in two publications. The individual was treated with Ca-DTPA via multiple intravenous injections and then nebulizations beginning several months after the intake and continuing for four years. The exact date and circumstances of the intake are unknown. However, interviews with the worker suggested that the intake occurred via inhalation of a soluble plutonium compound. The worker provided daily urine and fecal bioassay samples throughout the chelation treatment protocol, including samples collected before, during, and after the administration of Ca-DTPA. Unlike the previous two publications presenting this case, the current analysis explicitly models the combined biokinetics of the plutonium-DTPA chelate. Using the previously established chelation model, it was possible to fit the data through optimizing only the intake (day and magnitude), solubility, and absorbed fraction of nebulized Ca-DTPA. This work supports the hypothesis that the efficacy of the delayed chelation treatment observed in this case results mainly from chelation of cell-internalized plutonium by Ca-DTPA (intracellular chelation). It also demonstrates the validity of the previously established chelation model. As the bioassay data were modified to ensure data anonymization, the calculation of the true committed effective dose was not possible. However, the treatment-induced dose inhibition (in percentage) was calculated.<\/jats:p>","DOI":"10.1667\/rade-23-00135.1","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T19:08:27Z","timestamp":1699902507000},"page":"577-586","source":"Crossref","is-referenced-by-count":1,"title":["Chelation Modeling of a Plutonium-238 Inhalation Incident Treated with Delayed DTPA"],"prefix":"10.1667","volume":"200","author":[{"given":"Sara","family":"Dumit","sequence":"first","affiliation":[{"name":"Los Alamos National Laboratory (LANL), Radiation Protection Division, Los Alamos, New Mexico 87545"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guthrie","family":"Miller","sequence":"additional","affiliation":[{"name":"Unaffiliated (retired from Los Alamos National Laboratory), Santa Fe, New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Gr\u00e9my","sequence":"additional","affiliation":[{"name":"Commissariat \u00e0 l'Energie Atomique et aux Energies Alternatives (CEA), Direction de la Recherche Fondamentale, Institut de Biologie Fran\u00e7ois Jacob, Universit\u00e9 Paris-Saclay, Fontenay-aux-Roses, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepesh","family":"Poudel","sequence":"additional","affiliation":[{"name":"Los Alamos National Laboratory (LANL), Radiation Protection Division, Los Alamos, New Mexico 87545"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz","family":"Bertelli","sequence":"additional","affiliation":[{"name":"L Bertelli and Associates, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Klumpp","sequence":"additional","affiliation":[{"name":"Los Alamos National Laboratory (LANL), Radiation Protection Division, Los Alamos, New Mexico 87545"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"13","doi-asserted-by":"crossref","unstructured":"G Miller, JA Klumpp, D Poudel, et al.  \"Radiat Res.\"  192, \"Americium systemic biokinetic model for rats.\" 75 (2019)","DOI":"10.1667\/RR15256.1"},{"key":"9","doi-asserted-by":"crossref","unstructured":"S Dumit, G Miller, JA Klumpp, et al.  \"Health Phys.\"  119, \"Development of a new chelation model: bioassay data interpretation and dose assessment after plutonium intake via wound and treatment with DTPA.\" 715 (2020)","DOI":"10.1097\/HP.0000000000001282"},{"key":"21","doi-asserted-by":"crossref","unstructured":"RW Leggett, KF Eckerman, VF Khokhryakov, et al.  \"Radiat Res.\"  164, \"Mayak worker study: an improved biokinetic model for reconstructing doses from internally deposited plutonium.\" 111 (2005)","DOI":"10.1667\/RR3371"},{"key":"34","doi-asserted-by":"crossref","unstructured":"O Gr\u00e9my, L Miccoli, F Lelan, et al.  \"Radiat Res.\"  189, \"Delivery of DTPA through liposomes as a good strategy for enhancing plutonium decorporation regardless of treatment regimen.\" 477 (2018)","DOI":"10.1667\/RR14968.1"},{"key":"33","doi-asserted-by":"crossref","unstructured":"O Gr\u00e9my, D Laurent, S Coudert, et al.  \"Radiat Res.\"  185, \"Decorporation of Pu\/Am actinides by chelation therapy: New arguments in favor of an intracellular component of DTPA action.\" 568 (2016)","DOI":"10.1667\/RR14193.1"},{"key":"17","doi-asserted-by":"crossref","unstructured":"G Miller, JA Klumpp, D Melo, et al.  \"Health Phys.\"  113, \"The role of extracellular fluid in biokinetic modeling.\" 519 (2017)","DOI":"10.1097\/HP.0000000000000722"},{"key":"28","doi-asserted-by":"crossref","unstructured":"S Dumit, M Avtandilashvili, DJ Strom, et al.  \"Radiat Res.\"  191, \"Improved modeling of plutonium-DTPA decorporation.\" 201 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Miller,  \"Probabilistic interpretation of data\u2014a physicist's approach.\"  (2017)"},{"key":"31","doi-asserted-by":"crossref","unstructured":"O Gr\u00e9my, N Tsapis, S Bruel, et al.  \"Radiat Res.\"  178, \"Decorporation approach following rat lung contamination with a moderately soluble compound of plutonium using local and systemic Ca-DTPA combined chelation.\" 217 (2012)","DOI":"10.1667\/RR2866.1"},{"key":"32","doi-asserted-by":"crossref","unstructured":"L Miccoli, F M\u00e9n\u00e9trier, P Laroche, et al.  \"Radiat Res.\"  192, \"Chelation treatment by early inhalation of liquid aerosol DTPA for removing plutonium after rat lung contamination.\" 630 (2019)","DOI":"10.1667\/RR15451.1"},{"key":"35","doi-asserted-by":"crossref","unstructured":"O Gr\u00e9my  and L Miccoli  \"Radiat Res.\"  192, \"Comments on \u201cImproved modeling of plutonium-DTPA decorporation\u201d (Radiat Res 2019; 191:201-10).\" 680 (2019)","DOI":"10.1667\/RR00OG.1"},{"key":"36","doi-asserted-by":"crossref","unstructured":"S Dumit, B Breustedt, M Avtandilashvili, et al.  \"Radiat Res.\"  192, \"Response to the letter to the editor by Gr\u00e9my and Miccoli on \u201cImproved modeling of plutonium-DTPA decorporation\" 682 (2019)","DOI":"10.1667\/0033-7587-192.6.682"}],"container-title":["Radiation Research"],"original-title":[],"link":[{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-23-00135.1\/3288134\/10.1667_rade-23-00135.1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-23-00135.1\/3288134\/10.1667_rade-23-00135.1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:08:01Z","timestamp":1793423281000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-200\/issue-6\/RADE-23-00135.1\/Chelation-Modeling-of-a-Plutonium-238-Inhalation-Incident-Treated-with\/10.1667\/RADE-23-00135.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,14]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,12,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rade-23-00135.1","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,14]]}}}