{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:57:08Z","timestamp":1791248228721,"version":"4.1.0"},"reference-count":74,"publisher":"Radiation Research Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2024,5,8]]},"abstract":"<jats:p>The increased risk of acute large-scale radiological exposure for the world's population underlines the need for optimal radiation biomarkers. Ionizing radiation triggers a complex response by the genome, proteome, and metabolome, all of which have been reported as suitable indicators of radiation-induced damage in vivo. This study analyzed peripheral blood samples from total-body irradiation (TBI) leukemia patients through mass spectrometry (MS) to identify and quantify differentially regulated proteins in plasma before and after irradiation. In brief, samples were taken from 16 leukemic patients prior to and 24 h after TBI (2 \u00d7 2.0 Gy), processed with Tandem Mass Tag isobaric labelling kit (TMTpro-16-plex), and analyzed by MS. In parallel, label-free relative quantification was performed with a RP-nanoLC-ESI-MS\/MS system in a Q-Exactive mass spectrometer. Protein identification was done in Proteome Discoverer v.2.2 platform (Thermo). Data is available via ProteomeXchange with identifier PXD043516. Using two different methods, we acquired two datasets of up-regulated (ratio \u2265 1.2) or down-regulated (ratio \u2264 0.83) plasmatic proteins 24 h after irradiation, identifying 356 and 346 proteins in the TMT-16plex and 285 and 308 label-free analyses, respectively (P \u2264 0.05). Combining the two datasets yielded 15 candidates with significant relation to gamma-radiation exposure. The majority of these proteins were associated with the inflammatory response and lipid metabolism. Subsequently, from these, five proteins showed the strongest potential as radiation biomarkers in humans (C-reactive protein, Alpha amylase 1A, Mannose-binding protein C, Phospholipid transfer protein, and Complement C5). These candidate biomarkers might have implications for practical biological dosimetry.<\/jats:p>","DOI":"10.1667\/rade-23-00137.1","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T09:31:56Z","timestamp":1707125516000},"page":"418-424","source":"Crossref","is-referenced-by-count":1,"title":["Discovering the Radiation Biomarkers in the Plasma of Total-Body Irradiated Leukemia Patients"],"prefix":"10.1667","volume":"201","author":[{"given":"Rydlova","family":"Gabriela","sequence":"first","affiliation":[{"name":"Department of Radiobiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vozandychova","family":"Vera","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehulka","family":"Pavel","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehulkova","family":"Helena","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirak","family":"Igor","sequence":"additional","affiliation":[{"name":"Department of Oncology and Radiotherapy and 4th Department of Internal Medicine - Haematology, University Hospital, Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davidkova","family":"Marie","sequence":"additional","affiliation":[{"name":"Department of Radiation Dosimetry, Nuclear Physics Institute of the Czech Academy of Sciences, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markova","family":"Marketa","sequence":"additional","affiliation":[{"name":"Department of Haematology and Blood Transfusion, University Hospital Na Bulovce, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myslivcova-Fucikova","family":"Alena","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Natural Sciences, University of Hradec Kr\u00e1lov\u00e9, Czech Republic, Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tichy","family":"Ales","sequence":"additional","affiliation":[{"name":"Department of Radiobiology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"48","doi-asserted-by":"crossref","unstructured":"E Rosen, OO Fatanmi, SY Wise, et al.  \"Sci Rep.\"  12, \"Gamma-tocotrienol, a radiation countermeasure, reverses proteomic changes in serum following total-body gamma irradiation in mice.\" 3387 (2022)","DOI":"10.1038\/s41598-022-07266-5"},{"key":"46","doi-asserted-by":"crossref","unstructured":"L Surace, V Lysenko, AO Fontana, et al.  \"Immunity.\"  42, \"Complement is a central mediator of radiotherapy-induced tumor-specific immunity and clinical response.\" 767 (2015)","DOI":"10.1016\/j.immuni.2015.03.009"},{"key":"11","doi-asserted-by":"crossref","unstructured":"VK Singh, VL Newman, PL Romaine, et al.  \"Expert Rev Mol Diagn.\"  16, \"Use of biomarkers for assessing radiation injury and efficacy of countermeasures.\" 65 (2016)","DOI":"10.1586\/14737159.2016.1121102"},{"key":"5","doi-asserted-by":"crossref","unstructured":"CN Coleman  and JF Koerner  \"Radiat Prot Dosimetry.\"  172, \"Biodosimetry: medicine, science, and systems to support the medical decision-maker following a large scale nuclear or radiation incident.\" 38 (2016)","DOI":"10.1093\/rpd\/ncw155"},{"key":"2","doi-asserted-by":"crossref","unstructured":"MA. 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Gnanasekaran,  \"Radiat Oncol J.\"  39, \"Cytogenetic biological dosimetry assays: recent developments and updates.\" 159 (2021)","DOI":"10.3857\/roj.2021.00339"},{"key":"26","doi-asserted-by":"crossref","unstructured":"M Cengiz, S Akbulut, IL Atahan, et al.  \"Int J Radiat Oncol Biol Phys.\"  49, \"Acute phase response during radiotherapy.\" 1093 (2001)","DOI":"10.1016\/S0360-3016(00)01426-7"},{"key":"27","doi-asserted-by":"crossref","unstructured":"S Nigam  and T Schewe  \"Biochim Biophys Acta.\"  1488, \"Phospholipase A(2)s and lipid peroxidation.\" 167 (2000)","DOI":"10.1016\/S1388-1981(00)00119-0"},{"key":"28","doi-asserted-by":"crossref","unstructured":"S Loganathan, SN Athalye, SR Joshi,  \"Expert Opin Biol Ther.\"  20, \"Itolizumab, an anti-CD6 monoclonal antibody, as a potential treatment for COVID-19 complications.\" 1025 (2020)","DOI":"10.1080\/14712598.2020.1798399"},{"key":"29","doi-asserted-by":"crossref","unstructured":"JW Ryu, IH Jung, EY Park, et al.  \"J Cell Mol Med.\"  26, \"Radiation-induced C-reactive protein triggers apoptosis of vascular smooth muscle cells through ROS interfering with the STAT3\/Ref-1 complex.\" 2104 (2022)","DOI":"10.1111\/jcmm.17233"},{"key":"30","doi-asserted-by":"crossref","unstructured":"JJ Li  and CH Fang  \"Med Hypotheses.\"  62, \"C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases.\" 499 (2004)","DOI":"10.1016\/j.mehy.2003.12.014"},{"key":"31","doi-asserted-by":"crossref","unstructured":"Y Ki, W Kim, J Nam, et al.  \"Int J Radiat Oncol Biol Phys.\"  75, \"C-reactive protein levels and radiation-induced mucositis in patients with head-and-neck cancer.\" 393 (2009)","DOI":"10.1016\/j.ijrobp.2008.11.012"},{"key":"32","doi-asserted-by":"crossref","unstructured":"NI Ossetrova, DJ Sandgren, WF Blakely,  \"Radiation Measurements.\"  46, \"C-reactive protein and serum amyloid A as early-phase and prognostic indicators of acute radiation exposure in nonhuman primate total-body irradiation model.\" 1019 (2011)","DOI":"10.1016\/j.radmeas.2011.05.021"},{"key":"33","doi-asserted-by":"crossref","unstructured":"\u0160 Jane\u010dek, B Svensson, EA MacGregor,  \"Cell Mol Life Sci.\"  71, \"\u03b1-Amylase: an enzyme specificity found in various families of glycoside hydrolases.\" 1149 (2014)","DOI":"10.1007\/s00018-013-1388-z"},{"key":"34","doi-asserted-by":"crossref","unstructured":"A Becciolini, G Giannardi, L Cionini, et al.  \"Acta Radiol Oncol.\"  23, \"Plasma amylase activity as a biochemical indicator of radiation injury to salivary glands.\" 9 (1984)","DOI":"10.3109\/02841868409135978"},{"key":"35","unstructured":"R Hofmann, GA Schreiber, N Willich, et al.  \"Strahlenther Onkol.\"  166, \"Increased serum amylase in patients after radiotherapy as a probable bioindicator for radiation exposure.\" 688 (1990)"},{"key":"36","doi-asserted-by":"crossref","unstructured":"WF Blakely, NI Ossetrova, GL Manglapus, et al.  \"Radiation Measurements.\"  42, \"Amylase and blood cell-count hematological radiation-injury biomarkers in a rhesus monkey radiation model\u2014use of multiparameter and integrated biological dosimetry.\" 1164 (2007)","DOI":"10.1016\/j.radmeas.2007.05.013"},{"key":"37","doi-asserted-by":"crossref","unstructured":"WA. Wirtz Karel,  \"Biochemical Journal.\"  324, \"Phospholipid transfer proteins revisited.\" 353 (1997)","DOI":"10.1042\/bj3240353"},{"key":"38","doi-asserted-by":"crossref","unstructured":"T Parasassi, AM Giusti, E Gratton, et al.  \"International Journal of Radiation Biology.\"  65, \"Evidence for an Increase in Water Concentration in Bilayers after Oxidative Damage of Phospholipids Induced by Ionizing Radiation.\" 329 (1994)","DOI":"10.1080\/09553009414550391"},{"key":"39","doi-asserted-by":"crossref","unstructured":"C Wang, J Yang, J Nie,  \"Biomedical Chromatography.\"  23, \"Plasma phospholipid metabolic profiling and biomarkers of rats following radiation exposure based on liquid chromatography\u2013mass spectrometry technique.\" 1079 (2009)","DOI":"10.1002\/bmc.1226"},{"key":"40","doi-asserted-by":"crossref","unstructured":"MK Pangburn  and N Rawal  \"Biochemical Society Transactions.\"  30, \"Structure and function of complement C5 convertase enzymes.\" 1006 (2002)","DOI":"10.1042\/bst0301006"},{"key":"41","doi-asserted-by":"crossref","unstructured":"MM Jore, S Johnson, D Sheppard, et al.  \"Nat Struct Mol Biol.\"  23, \"Structural basis for therapeutic inhibition of complement C5.\" 378 (2016)","DOI":"10.1038\/nsmb.3196"},{"key":"42","doi-asserted-by":"crossref","unstructured":"N Fausto, JS Campbell, KJ Riehle,  \"Hepatology.\"  43, \"Liver regeneration.\" S45 (2006)","DOI":"10.1002\/hep.20969"},{"key":"43","unstructured":"RL Jirtle, G Michalopoulos, JR McLain, et al.  \"Cancer Research.\"  41, \"Transplantation System for Determining the Clonogenic Survival of Parenchymal Hepatocytes Exposed to Ionizing Radiation1.\" 3512 (1981)"},{"key":"44","doi-asserted-by":"crossref","unstructured":"HL Schieferdecker, G Schlaf, M Koleva, et al.  \"J Immunol.\"  164, \"Induction of functional anaphylatoxin C5a receptors on hepatocytes by in vivo treatment of rats with IL-6.\" 5453 (2000)","DOI":"10.4049\/jimmunol.164.10.5453"},{"key":"45","doi-asserted-by":"crossref","unstructured":"MG Strainic, J Liu, D Huang, et al.  \"Immunity.\"  28, \"Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells.\" 425 (2008)","DOI":"10.1016\/j.immuni.2008.02.001"},{"key":"47","doi-asserted-by":"crossref","unstructured":"CD Collard, MC Montalto, WR Reenstra, et al.  \"The American Journal of Pathology.\"  159, \"Endothelial Oxidative Stress Activates the Lectin Complement Pathway: Role of Cytokeratin 1.\" 1045 (2001)","DOI":"10.1016\/S0002-9440(10)61779-8"},{"key":"49","doi-asserted-by":"crossref","unstructured":"KN Rithidech, L Honikel, R Rieger, et al.  \"International Journal of Radiation Biology.\"  85, \"Protein-expression profiles in mouse blood-plasma following acute whole-body exposure to 137Cs \u03b3 rays.\" 432 (2009)","DOI":"10.1080\/09553000902820390"},{"key":"50","doi-asserted-by":"crossref","unstructured":"A Taferner, L Micutkova, M Hermann, et al.  \"J Cell Commun Signal.\"  5, \"Purification and characterization of native human insulin-like growth factor binding protein-6.\" 277 (2011)","DOI":"10.1007\/s12079-011-0126-2"},{"key":"51","doi-asserted-by":"crossref","unstructured":"PG Mylonas, PT Matsouka, EV Papandoniou, et al.  \"Molecular and Cellular Endocrinology.\"  160, \"Growth hormone and insulin-like growth factor I protect intestinal cells from radiation induced apoptosis.\" 115 (2000)","DOI":"10.1016\/S0303-7207(99)00215-4"},{"key":"52","doi-asserted-by":"crossref","unstructured":"S Zinati-Saeed, E Shakiba, Z Rahimi, et al.  \"Iran J Pathol.\"  15, \"The Insulin-like Growth Factor-1 (G>A) and 5,10-methylenetetrahydrofolate Reductase (C677T) Gene Variants and the Serum Levels of Insulin-like Growth Factor-1, Insulin, and Homeostasis Model Assessment in Patients with Acne Vulgaris.\" 23 (2020)","DOI":"10.30699\/ijp.2019.105695.2098"},{"key":"53","doi-asserted-by":"crossref","unstructured":"JP Segrest, DW Garber, CG Brouillette, et al.  \"Advances in Protein Chemistry [Internet].\"  \"The Amphipathic \u03b1 Helix: A Multifunctional Structural Motif in Plasma Apolipoproteins.\" 303 (1994)","DOI":"10.1016\/S0065-3233(08)60643-9"},{"key":"54","doi-asserted-by":"crossref","unstructured":"SG. 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Jack,  \"CD14 in the Inflammatory Response.\"  191 (2000)","DOI":"10.1159\/isbn.978-3-318-00463-2"},{"key":"60","doi-asserted-by":"crossref","unstructured":"J Chalubinska-Fendler, W Fendler, M Spych, et al.  \"Biomed Rep.\"  5, \"Lipopolysaccharide-binding protein is efficient in biodosimetry during radiotherapy of lung cancer.\" 450 (2016)","DOI":"10.3892\/br.2016.739"},{"key":"61","doi-asserted-by":"crossref","unstructured":"J Chalubinska-Fendler, L Graczyk, G Piotrowski, et al.  \"International Journal of Radiation Oncology*Biology*Physics.\"  104, \"Lipopolysaccharide-Binding Protein Is an Early Biomarker of Cardiac Function After Radiation Therapy for Breast Cancer.\" 1074 (2019)","DOI":"10.1016\/j.ijrobp.2019.04.002"},{"key":"62","doi-asserted-by":"crossref","unstructured":"S. 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Ridker,  \"Circulation.\"  107, \"Clinical application of C-reactive protein for cardiovascular disease detection and prevention.\" 363 (2003)","DOI":"10.1161\/01.CIR.0000053730.47739.3C"},{"key":"73","doi-asserted-by":"crossref","unstructured":"KJ McKelvey, AL Hudson, M Back, et al.  \"Mamm Genome.\"  29, \"Radiation, inflammation and the immune response in cancer.\" 843 (2018)","DOI":"10.1007\/s00335-018-9777-0"},{"key":"74","doi-asserted-by":"crossref","unstructured":"JF Regal, KJ Dornfeld, SD Fleming,  \"Ann Transl Med.\"  4, \"Radiotherapy: killing with complement.\" 94 (2016)","DOI":"10.21037\/atm.2015.12.46"}],"container-title":["Radiation Research"],"original-title":[],"link":[{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-23-00137.1\/3324880\/10.1667_rade-23-00137.1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-23-00137.1\/3324880\/10.1667_rade-23-00137.1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:42:08Z","timestamp":1791247328000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-201\/issue-5\/RADE-23-00137.1\/Discovering-the-Radiation-Biomarkers-in-the-Plasma-of-Total-Body\/10.1667\/RADE-23-00137.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,8]]},"references-count":74,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rade-23-00137.1","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,8]]}}}