{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:53:10Z","timestamp":1791247990053,"version":"4.1.0"},"reference-count":118,"publisher":"Radiation Research Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2024,10,28]]},"abstract":"<jats:p>The study of One Million U.S. Radiation Workers and Veterans, the Million Person Study (MPS), examines the health consequences, both cancer and non-cancer, of exposure to ionizing radiation received gradually over time. Recently the MPS has focused on mortality patterns from neurological and behavioral conditions, e.g., Parkinson's disease, Alzheimer's disease, dementia, and motor neuron disease such as amyotrophic lateral sclerosis. A fuller picture of radiation-related late effects comes from studying both mortality and the occurrence (incidence) of conditions not leading to death. Accordingly, the MPS is identifying neurocognitive diagnoses from fee-for-service insurance claims from the Centers for Medicare and Medicaid Services (CMS), among Medicare beneficiaries beginning in 1999 (the earliest date claims data are available). Linkages to date have identified \u223c540,000 workers with available health information. Such linkages provide individual information on important co-factor and confounding variables such as smoking, alcohol consumption, blood pressure, obesity, diabetes and many other health and demographic characteristics. The total person-level set of time-dependent variables, outcomes, organ-specific dose measures, co-factors, and demographics will be massive and much too large to be evaluated with standard software. Thus, development of specialized open-source software designed for large datasets (Colossus) is nearly complete. The wealth of information available from CMS claims data, coupled with individual dose reconstructions, will thus greatly enhance the quality and precision of health evaluations for this new field of low-dose radiation and neurocognitive effects.<\/jats:p>","DOI":"10.1667\/rade-23-00186.1","type":"journal-article","created":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T20:00:59Z","timestamp":1730059259000},"page":"847-861","source":"Crossref","is-referenced-by-count":9,"title":["A Million Person Study Innovation: Evaluating Cognitive Impairment and other Morbidity Outcomes from Chronic Radiation Exposure Through Linkages with the Centers for Medicaid and Medicare Services Assessment and Claims Data"],"prefix":"10.1667","volume":"202","author":[{"given":"Lawrence T.","family":"Dauer","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Mumma","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center's International Epidemiology Field Station, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C.","family":"Lima","sequence":"additional","affiliation":[{"name":"Brown University School of Public Health, Providence, Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S.","family":"Cohen","sequence":"additional","affiliation":[{"name":"DLH, LLC, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Andresen","sequence":"additional","affiliation":[{"name":"Kansas State University, Manhattan, Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir A.","family":"Bahadori","sequence":"additional","affiliation":[{"name":"Kansas State University, Manhattan, Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bellamy","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bierman","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Blattnig","sequence":"additional","affiliation":[{"name":"NASA Langley Research Center, Hampton, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"French","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Giunta","sequence":"additional","affiliation":[{"name":"Kansas State University, Manhattan, Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Held","sequence":"additional","affiliation":[{"name":"National Council on Radiation Protection and Measurements, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nolan","family":"Hertel","sequence":"additional","affiliation":[{"name":"Georgia Institute of Technology, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Keohane","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Leggett","sequence":"additional","affiliation":[{"name":"Oak Ridge National Laboratory, Oak Ridge, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren","family":"Lipworth","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen B.","family":"Miller","sequence":"additional","affiliation":[{"name":"National Institute of Aerospace, Hampton, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan B.","family":"Norman","sequence":"additional","affiliation":[{"name":"NASA Langley Research Center, Hampton, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleigh","family":"Samuels","sequence":"additional","affiliation":[{"name":"Oak Ridge National Laboratory, Oak Ridge, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kali S.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Nursing, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei Y.","family":"Tolmachev","sequence":"additional","affiliation":[{"name":"Washington State University, Richland, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Walsh","sequence":"additional","affiliation":[{"name":"University of Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Boice","sequence":"additional","affiliation":[{"name":"National Council on Radiation Protection and Measurements, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"68","unstructured":"\"R: A language and environment for statistical computing.\"  (2021)"},{"key":"110","doi-asserted-by":"crossref","unstructured":"L Walsh  and JC Kaiser  \"Radiat Environ Biophys.\"  50, \"Multi-model inference of adult and childhood leukaemia excess relative risks based on the Japanese A-bomb survivors mortality data (1950-2000).\" 21 (2011)","DOI":"10.1007\/s00411-010-0337-6"},{"key":"91","doi-asserted-by":"crossref","unstructured":"C Zeitlin, DM Hassler, FA 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Hamada,  \"Radiat Res.\"  200, \"Noncancer effects of ionizing radiation exposure on the eye, the circulatory system and beyond: developments made since the 2011 ICRP Statement on tissue reactions.\" 188 (2023)","DOI":"10.1667\/RADE-23-00030.1"},{"key":"28","doi-asserted-by":"crossref","unstructured":"GR Clement, RD Boyle, KA George, et al.  \"J Neurophysiol.\"  123, \"Challenges to the central nervous system during human spaceflight missions to Mars.\" 2037 (2020)","DOI":"10.1152\/jn.00476.2019"},{"key":"31","unstructured":"\"NCRP Commenatry No. 25.\"  \"Potential for central nervous system effects from radiation exposure during space activities.\" (2016)"},{"key":"32","doi-asserted-by":"crossref","unstructured":"E Cekanaviciute, S Rosi, SV Costes,  \"Int J Mol Sci.\"  19, \"Central nervous system responses to simulated galactic cosmic rays.\" 1 (2018)","DOI":"10.3390\/ijms19113669"},{"key":"34","doi-asserted-by":"crossref","unstructured":"SS Cohen, MT Mumma, ED Ellis, et al.  \"Int J Radiat Biol.\"  98, \"Validating the use of census data on education as a measure of socioeconomic status in an occupational cohort.\" 587 (2022)","DOI":"10.1080\/09553002.2018.1549758"},{"key":"35","doi-asserted-by":"crossref","unstructured":"AP Golden, SS Cohen, H Chen, et al.  \"Int J Radiat Biol.\"  98, \"Evaluation of statistical modeling approaches for epidemiologic studies of low-dose radiation health effects.\" 572 (2022)","DOI":"10.1080\/09553002.2018.1554924"},{"key":"36","unstructured":"\"Deriving organ doses and their uncdertainty for epidemiologic studies (with a focus on the One Million U.S. Workers and Veterans Study of Low-Dose Radiation Health Effects). 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