{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:32:16Z","timestamp":1793421136584,"version":"4.5.0"},"reference-count":65,"publisher":"Radiation Research Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2024,4,12]]},"abstract":"<jats:p>This study offers a review of published data on DNA double strand break (DSB) repair kinetics after exposure to ionizing radiation. By compiling a database, which currently includes 285 DNA DSB repair experiments utilizing both photons and ions, we investigate the impact of distinct experimental parameters on the kinetics of DNA DSB repair. Methodological differences and inconsistencies in reporting make the comparison of data generated by different research groups challenging. Nevertheless, by implementing filtering criteria, we can compare repair kinetics obtained with normal and tumor cells derived from human or animal tissues, as well as cells exposed to photons or ions ranging from hydrogen to iron ions. In addition, several repair curves of repair deficient cell lines were included. The study aims to provide researchers with a comprehensive overview of experimental factors that may confound results and emphasize the importance of precise reporting of experimental parameters. Moreover, we identify gaps in the literature that require attention in future studies, aiming to address clinically relevant questions related to radiotherapy. The database can be freely accessed at: https:\/\/github.com\/weradstake\/DRDNA.<\/jats:p>","DOI":"10.1667\/rade-23-00190.1","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T10:41:39Z","timestamp":1708425699000},"page":"604-616","source":"Crossref","is-referenced-by-count":5,"title":["DNA Double-Strand Break Repair Kinetics after Exposure to Photons and Ions: A Systematic Review"],"prefix":"10.1667","volume":"201","author":[{"given":"Wilhelmina E.","family":"Radstake","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Parisi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet M.","family":"Denbeigh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith M.","family":"Furutani","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris J.","family":"Beltran","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"37","doi-asserted-by":"crossref","unstructured":"JC Pinheiro  and DM Bates  \"Mixed-effects models in S and S-Plus.\"  (2000)","DOI":"10.1007\/978-1-4419-0318-1"},{"key":"41","doi-asserted-by":"crossref","unstructured":"A Beucher, J Birraux, L Tchouandong, et al.  \"EMBO J.\"  28, \"ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.\" 3413 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I. Pulsed-Field Gel Electrophoresis Method.\" 133 (1994)","DOI":"10.2307\/3578657"},{"key":"22","doi-asserted-by":"crossref","unstructured":"B Stenerl\u00f6w, E Blomquist, E Grusell, et al.  \"Int J Radiat Biol.\"  70, \"Rejoining of DNA double-strand breaks induced by accelerated nitrogen ions.\" 413 (1996)","DOI":"10.1080\/095530096144888"},{"key":"23","doi-asserted-by":"crossref","unstructured":"M L\u00f6brich, B Rydberg, PK Cooper,  \"Proc Natl Acad Sci U S A.\"  92, \"Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends.\" 12050 (1995)","DOI":"10.1073\/pnas.92.26.12050"},{"key":"24","unstructured":"K Rothkamm, M K\u00fchne, PA Jeggo, et al.  \"Cancer Res.\"  61, \"Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks.\" 3886 (2001)"},{"key":"25","doi-asserted-by":"crossref","unstructured":"IR. 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1129 (1999)","DOI":"10.1080\/095530099139601"},{"key":"29","doi-asserted-by":"crossref","unstructured":"R Okayasu  and C Liu  \"Methods Mol Biol.\"  1984, \"G1 Premature Chromosome Condensation (PCC) Assay.\" 31 (2019)","DOI":"10.1007\/978-1-4939-9432-8_4"},{"key":"30","doi-asserted-by":"crossref","unstructured":"MN Cornforth  and JS Bedford  \"Science.\"  227, \"On the nature of a defect in cells from individuals with ataxia-telangiectasia.\" 1589 (1985)","DOI":"10.1126\/science.3975628"},{"key":"31","doi-asserted-by":"crossref","unstructured":"MN Cornforth  and JS Bedford  \"Science.\"  222, \"X-ray\u2013induced breakage and rejoining of human interphase chromosomes.\" 1141 (1983)","DOI":"10.1126\/science.6648528"},{"key":"34","doi-asserted-by":"crossref","unstructured":"J Korns, S McCauley, M Lehn, et al.  \"Radiat Res.\"  199, \"Varied Photon Radiation Sources Produce Differences in Cellular Response.\" 422 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National Cancer Institute special panel: Characterization of the physical parameters of particle beams for biological research.\" e37 (2019)","DOI":"10.1002\/mp.13324"},{"key":"58","doi-asserted-by":"crossref","unstructured":"A Carlos-Reyes, MA Mu\u00f1iz-Lino, S Romero-Garcia, et al.  \"Front Oncol.\"  11, \"Biological Adaptations of Tumor Cells to Radiation Therapy.\" 718636 (2021)","DOI":"10.3389\/fonc.2021.718636"},{"key":"59","doi-asserted-by":"crossref","unstructured":"J Thoms  and RG Bristow  \"Seminars Rad Oncol.\"  20, \"DNA repair targeting and radiotherapy: a focus on the therapeutic ratio.\" 217 (2010)","DOI":"10.1016\/j.semradonc.2010.06.003"},{"key":"60","doi-asserted-by":"crossref","unstructured":"S Deng, T Vlatkovic, M Li, et al.  \"Cancers.\"  14, \"Targeting the DNA Damage Response and DNA Repair Pathways to Enhance Radiosensitivity in Colorectal Cancer.\" 4874 (2022)","DOI":"10.3390\/cancers14194874"},{"key":"61","doi-asserted-by":"crossref","unstructured":"F Natale, A Rapp, W Yu, et al.  \"Nature Commun.\"  8, \"Identification of the elementary structural units of the DNA damage response.\" 15760 (2017)","DOI":"10.1038\/ncomms15760"},{"key":"62","doi-asserted-by":"crossref","unstructured":"R Lopez Perez, G Best, NH Nicolay, et al.  \"FASEB J.\"  30, \"Superresolution light microscopy shows nanostructure of carbon ion radiation-induced DNA double-strand break repair foci.\" 2767 (2016)","DOI":"10.1096\/fj.201500106R"},{"key":"63","doi-asserted-by":"crossref","unstructured":"RB. Hawkins,  \"Int J Radiat Oncol Biol Phys.\"  63, \"The influence of concentration of DNA on the radiosensitivity of mammalian cells.\" 529 (2005)","DOI":"10.1016\/j.ijrobp.2005.05.055"},{"key":"65","doi-asserted-by":"crossref","unstructured":"X Xu, T Nakano, M Tsuda, et al.  \"Nucleic Acids Res.\"  48, \"Direct observation of damage clustering in irradiated DNA with atomic force microscopy.\" e18 (2019)","DOI":"10.1093\/nar\/gkz1159"},{"key":"36","unstructured":"\"R: A language and environment for statistical computing. R foundation for statistical computing.\"  (2022)"}],"container-title":["Radiation Research"],"original-title":[],"link":[{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-23-00190.1\/3356330\/10.1667_rade-23-00190.1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-23-00190.1\/3356330\/10.1667_rade-23-00190.1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:22:49Z","timestamp":1793420569000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-201\/issue-6\/RADE-23-00190.1\/DNA-Double-Strand-Break-Repair-Kinetics-after-Exposure-to-Photons\/10.1667\/RADE-23-00190.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,12]]},"references-count":65,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rade-23-00190.1","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,12]]}}}