{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:30:25Z","timestamp":1793424625171,"version":"4.5.0"},"reference-count":101,"publisher":"Radiation Research Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2024,3,8]]},"abstract":"<jats:p>The U.S. Government is committed to maintaining a robust research program that supports a portfolio of scientific experts who are investigating the biological effects of radiation exposure. On August 17 and 18, 2023, the Radiation and Nuclear Countermeasures Program, within the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), partnered with the National Cancer Institute, NIH, the National Aeronautics and Space Administration, and the Radiation Injury Treatment Network to convene a workshop titled, Advanced Technologies in Radiation Research (ATRR), which focused on the use of advanced technologies under development or in current use to accelerate radiation research. This meeting report provides a comprehensive overview of the research presented at the workshop, which included an assembly of subject matter experts from government, industry, and academia. Topics discussed during the workshop included assessments of acute and delayed effects of radiation exposure using modalities such as clustered regularly interspaced short palindromic repeats (CRISPR) \u2013 based gene editing, tissue chips, advanced computing, artificial intelligence, and immersive imaging techniques. These approaches are being applied to develop products to diagnose and treat radiation injury to the bone marrow, skin, lung, and gastrointestinal tract, among other tissues. The overarching goal of the workshop was to provide an opportunity for the radiation research community to come together to assess the technological landscape through sharing of data, methodologies, and challenges, followed by a guided discussion with all participants. Ultimately, the organizers hope that the radiation research community will benefit from the workshop and seek solutions to scientific questions that remain unaddressed. Understanding existing research gaps and harnessing new or re-imagined tools and methods will allow for the design of studies to advance medical products along the critical path to U.S. Food and Drug Administration approval.<\/jats:p>","DOI":"10.1667\/rade-24-00003.1","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T22:13:05Z","timestamp":1709849585000},"page":"338-365","source":"Crossref","is-referenced-by-count":8,"title":["Advanced Technologies in Radiation Research"],"prefix":"10.1667","volume":"201","author":[{"given":"Carmen I.","family":"Rios","sequence":"first","affiliation":[{"name":"Radiation and Nuclear Countermeasures Program\/Division of Allergy, Immunology, and Transplantation\/National Institute of Allergy and Infectious Diseases\/National Institutes of Health (NIH), Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"DiCarlo","sequence":"additional","affiliation":[{"name":"Radiation and Nuclear Countermeasures Program\/Division of Allergy, Immunology, and Transplantation\/National Institute of Allergy and Infectious Diseases\/National Institutes of Health (NIH), Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Harrison","sequence":"additional","affiliation":[{"name":"Division of Biological and Physical Sciences\/National Aeronautics and Space Administration, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pataje G. S.","family":"Prasanna","sequence":"additional","affiliation":[{"name":"Division of Cancer Treatment and Diagnosis\/National Cancer Institute\/NIH, Gaithersburg, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Buchsbaum","sequence":"additional","affiliation":[{"name":"Division of Cancer Treatment and Diagnosis\/National Cancer Institute\/NIH, Gaithersburg, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Rudokas","sequence":"additional","affiliation":[{"name":"Radiation and Nuclear Countermeasures Program\/Division of Allergy, Immunology, and Transplantation\/National Institute of Allergy and Infectious Diseases\/National Institutes of Health (NIH), Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Radiation and Nuclear Countermeasures Program\/Division of Allergy, Immunology, and Transplantation\/National Institute of Allergy and Infectious Diseases\/National Institutes of Health (NIH), Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Winters","sequence":"additional","affiliation":[{"name":"Radiation and Nuclear Countermeasures Program\/Division of Allergy, Immunology, and Transplantation\/National Institute of Allergy and Infectious Diseases\/National Institutes of Health (NIH), Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"16","doi-asserted-by":"crossref","unstructured":"SA Ghandhi, L Smilenov, I Shuryak, et al.  \"Sci Rep.\"  9, \"Discordant gene responses to radiation in humans and mice and the role of hematopoietically humanized mice in the search for radiation biomarkers.\" 19434 (2019)","DOI":"10.1038\/s41598-019-55982-2"},{"key":"74","doi-asserted-by":"crossref","unstructured":"NC Yeo, A Chavez, A Lance-Byrne, et al.  \"Nat Methods.\"  15, \"An enhanced CRISPR repressor for targeted mammalian gene regulation.\" 611 (2018)","DOI":"10.1038\/s41592-018-0048-5"},{"key":"35","doi-asserted-by":"crossref","unstructured":"JM May, M Bylicky, S Chopra, et al.  \"Transl Res.\"  233, \"Long and short non-coding RNA and radiation response: a review.\" 162 (2021)","DOI":"10.1016\/j.trsl.2021.02.005"},{"key":"68","doi-asserted-by":"crossref","unstructured":"CJ Rogers, EM Kyubwa, AI Lukaszewicz, et al.  \"Radiat Res.\"  196, \"Observation of Unique Circulating miRNA Signatures in Non-Human Primates Exposed to Total-Body vs. Whole Thorax Lung Irradiation.\" 547 (2021)","DOI":"10.1667\/RADE-21-00043.1"},{"key":"55","doi-asserted-by":"crossref","unstructured":"CJ Iddins, AL DiCarlo, MD Ervin, et al.  \"J Radiol Prot.\"  42, \"Cutaneous and local radiation injuries.\" (2022)","DOI":"10.1088\/1361-6498\/ac241a"},{"key":"19","doi-asserted-by":"crossref","unstructured":"GA. 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mouse model of internal exposure to 137Cs. Part 1: Global transcriptomic responses in blood.\" 478 (2020)","DOI":"10.1667\/RADE-20-00041"},{"key":"66","doi-asserted-by":"crossref","unstructured":"WA da Silveira, H Fazelinia, SB Rosenthal, et al.  \"Cell.\"  183, \"Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact.\" 1185 (2020)","DOI":"10.1016\/j.cell.2020.11.002"}],"container-title":["Radiation Research"],"original-title":[],"link":[{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-24-00003.1\/3340786\/10.1667_rade-24-00003.1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-24-00003.1\/3340786\/10.1667_rade-24-00003.1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:33:39Z","timestamp":1793421219000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-201\/issue-4\/RADE-24-00003.1\/Advanced-Technologies-in-Radiation-Research\/10.1667\/RADE-24-00003.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,8]]},"references-count":101,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rade-24-00003.1","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,8]]}}}