{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:57:42Z","timestamp":1791244662712,"version":"4.1.0"},"reference-count":37,"publisher":"Radiation Research Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2025,1,24]]},"abstract":"<jats:p>Ionizing radiation exposure during perinatal development can produce various biological effects on the developing offspring. These effects are dependent on a number of factors, including total dose, dose rate and the developmental processes occurring at the time of irradiation. The present study conducted an analysis of historical radiobiological archived data involving 60Co-gamma irradiation of beagle dogs at specific periods of prenatal or postnatal development. The original studies were performed at two sites where animals were exposed to a single, acute dose of 0.2 or 1.0 Gy at six different stages of perinatal development or with protracted exposures ranging from 0.004 to 0.35 Gy per day, over multiple days of gestation. A number of outcomes were investigated after perinatal irradiation including changes in sex ratio, survival probability, disease incidence and growth of animals, based on collected size and weight measurements of animals and different tissues. Protracted irradiations with doses up to 0.35 Gy per day did not significantly affect survival in animals when irradiated prenatally, although significant increases in the incidence of neoplasms and diseases related to the cardiovascular and urogenital system were observed at the time of death. Dogs irradiated at a dose rate of 0.10 Gy per day, with the irradiations continuing after birth and resulting in the accumulation of large total doses, were observed to have chronic radiation syndrome symptoms based on pathologies related to the hematopoietic system. Acute irradiation with 0.2 and 1.0 Gy resulted in changes of different body or tissue sizes measured in animals terminally, with changes detected after irradiation at all tested prenatal and postnatal time points, with the exception of irradiation at 365 days after birth. The present analysis provides new information regarding the biological effects of ionizing radiation during perinatal development in offspring in the unique mammalian study model of the beagle dog.<\/jats:p>","DOI":"10.1667\/rade-24-00080.1","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T19:00:47Z","timestamp":1737658847000},"page":"73-82","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Acute and Protracted Gamma Irradiation Effects During Perinatal Development in Beagle Dogs"],"prefix":"10.1667","volume":"203","author":[{"given":"Shayenthiran","family":"Sreetharan","sequence":"first","affiliation":[{"name":"Medical Sciences Division, NOSM University, Sudbury, ON P3E 2C6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Puukila","sequence":"additional","affiliation":[{"name":"Medical Sciences Division, NOSM University, Thunder Bay, ON P7B 5E1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Lalonde","sequence":"additional","affiliation":[{"name":"Medical Sciences Division, NOSM University, Sudbury, ON P3E 2C6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Pirkkanen","sequence":"additional","affiliation":[{"name":"Medical Sciences Division, NOSM University, Sudbury, ON P3E 2C6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayle E.","family":"Woloschak","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Paunesku","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antone L.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Retired Professor, Department of Environmental Science, Washington State University, Richland, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona E.","family":"McNeill","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy, McMaster University, Hamilton, ON L8S 4L8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Thome","sequence":"additional","affiliation":[{"name":"Medical Sciences Division, NOSM University, Sudbury, ON P3E 2C6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"Boreham","sequence":"additional","affiliation":[{"name":"Medical Sciences Division, NOSM University, Sudbury, ON P3E 2C6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Lees","sequence":"additional","affiliation":[{"name":"Medical Sciences Division, NOSM University, Thunder Bay, ON P7B 5E1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujeenthar","family":"Tharmalingam","sequence":"additional","affiliation":[{"name":"Medical Sciences Division, NOSM University, Sudbury, ON P3E 2C6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.C.","family":"Tai","sequence":"additional","affiliation":[{"name":"Medical Sciences Division, NOSM University, Sudbury, ON P3E 2C6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"35","unstructured":"EJ Hall  and AJ Giaccia  \"Radiobiology for the Radiologist.\"  (2012)"},{"key":"2","doi-asserted-by":"publisher","unstructured":"RS Groen, JY Bae, KJ Lim,  \"Am J Obst Gyn.\"  206, \"Fear of the unknown: ionizing radiation exposure during pregnancy.\" 456 (2012)","DOI":"10.1016\/j.ajog.2011.12.001"},{"key":"3","doi-asserted-by":"publisher","unstructured":"K Kamiya, K Ozasa, S Akiba,  \"The Lancet.\"  386, \"Long-term effects of radiation exposure on health.\" 469 (2015)","DOI":"10.1016\/S0140-6736(15)61167-9"},{"key":"4","doi-asserted-by":"publisher","unstructured":"S Sreetharan, C Thome, S Tharmalingam,  \"Radiat Res.\"  187, \"Ionizing radiation exposure during pregnancy: Effects on postnatal development and life.\" 647 (2017)","DOI":"10.1667\/RR14657.1"},{"key":"5","doi-asserted-by":"publisher","unstructured":"M Otake  and WJ Schull  \"Int J Radiat Biol.\"  74, \"Review: Radiation-related brain damage and growth retardation among the prenatally exposed atomic bomb survivors.\" 159 (1998)","DOI":"10.1080\/095530098141555"},{"key":"6","doi-asserted-by":"publisher","unstructured":"AC Andersen  and LS Rosenblatt  \"Exp Gerontol.\"  1, \"Survival of beagles under natural and laboratory conditions.\" 193 (1965)","DOI":"10.1016\/0531-5565(65)90003-3"},{"key":"7","doi-asserted-by":"publisher","unstructured":"AC Andersen  and LS Rosenblatt  \"Radiat Res.\"  39, \"The effect of whole-body X-irradiation on the median lifespan of female dogs (beagles).\" 177 (1969)","DOI":"10.2307\/3572640"},{"key":"8","doi-asserted-by":"publisher","unstructured":"B Haley, Q Wang, B Wanzer,  \"Health Phys.\"  100, \"Past and future work on radiobiology mega-studies: a case study at Argonne National Laboratory.\" 613 (2011)","DOI":"10.1097\/HP.0b013e3181febad3"},{"key":"9","doi-asserted-by":"publisher","unstructured":"GJ Spatola, EA Ostrander, TA Mousseau,  \"Biol Rev.\"  96, \"The effects of ionizing radiation on domestic dogs: a review of the atomic bomb testing era.\" 1799 (2021)","DOI":"10.1111\/brv.12723"},{"key":"10","doi-asserted-by":"publisher","unstructured":"S Puukila, C Thome, A Brooks,  \"Cancers.\"  9, \"The role of radiation induced injury on lung cancer.\" 89 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Effect of Total dose and dose rate.\" 125 (1991)","DOI":"10.2307\/3578129"},{"key":"14","doi-asserted-by":"publisher","unstructured":"BA Carnes  and TE Fritz  \"Radiat Res.\"  136, \"Continuous irradiation of beagles with gamma rays.\" 103 (1993)","DOI":"10.2307\/3578646"},{"key":"15","unstructured":"GM Angleton  and GA Lo Presti  \"Health Phys.\"  33, \"A summary of the dosimetrics for exposures to 60Co of the beagles entered into the CRHL long-term study.\" 100 (1977)"},{"key":"16","doi-asserted-by":"publisher","unstructured":"GM. Angleton,  \"Health Phys.\"  35, \"Dose Assignment criteria for beagles exposed bilaterally to 60Co gamma rays.\" 625 (1978)","DOI":"10.1097\/00004032-197811000-00003"},{"key":"17","doi-asserted-by":"publisher","unstructured":"SA Benjamin, AC Lee, GM Angleton,  \"Radiat Res.\"  150, \"Mortality in beagles irradiated during prenatal and postnatal development. II. Contribution of benign and malignant neoplasia.\" 330 (1998)","DOI":"10.2307\/3579982"},{"key":"18","doi-asserted-by":"publisher","unstructured":"SA Benjamin, AC Lee, GM Angleton,  \"Radiat Res.\"  150, \"Mortality in beagles irradiated during prenatal and postnatal development. I. Contribution of non-neoplastic diseases.\" 316 (1998)","DOI":"10.2307\/3579981"},{"key":"19","doi-asserted-by":"publisher","unstructured":"B Frangione, P Hinton, PJ Villeneuve,  \"Arc Occu Env Heal.\"  \"Low-dose ionizing radiation and adverse birth outcomes: a systematic review and meta-analysis.\" (2022)","DOI":"10.1007\/s00420-022-01911-2"},{"key":"20","doi-asserted-by":"publisher","unstructured":"RP Jensh  and RL Brent  \"Exp Biol Med.\"  181, \"Effects of 0.6-Gy Prenatal X irradiation on postnatal neurophysiologic development in the Wistar Rat.\" 611 (1986)","DOI":"10.3181\/00379727-181-42299"},{"key":"21","doi-asserted-by":"publisher","unstructured":"MP Hande, P Uma Devi, GC Jagetia,  \"J Radiat Res.\"  31, \"Effect of \u201cin utero\u201d exposure to low doses of low energy X-rays on the postnatal development of mouse.\" 354 (1990)","DOI":"10.1269\/jrr.31.354"},{"key":"22","doi-asserted-by":"publisher","unstructured":"M Hossain, PU Devi, KS Bisht,  \"Teratology.\"  59, \"Effect of prenatal gamma irradiation during the late fetal period on the postnatal development of the mouse.\" 133 (1999)","DOI":"10.1002\/(SICI)1096-9926(199903)59:3<133::AID-TERA4>3.0.CO; 2-T"},{"key":"23","doi-asserted-by":"publisher","unstructured":"GM Angleton, SA Benjamin, AC Lee,  \"Radiat Res.\"  115, \"Health effects of low-level irradiation during development: experimental design and prenatal and early neonatal mortality in beagles exposed to 60 Co g rays.\" 70 (1988)","DOI":"10.2307\/3577056"},{"key":"24","doi-asserted-by":"publisher","unstructured":"LB Russell  and WL Russell  \"J Cell Comp Phys.\"  43, \"An analysis of the changing radiation response of the developing mouse embryo.\" 103 (1954)","DOI":"10.1002\/jcp.1030430407"},{"key":"25","doi-asserted-by":"publisher","unstructured":"EJ Kwon  and YJ Kim  \"Obst Gyn Sci.\"  60, \"What is fetal programming?: a lifetime health is under the control of in utero health.\" 506 (2017)","DOI":"10.5468\/ogs.2017.60.6.506"},{"key":"26","doi-asserted-by":"publisher","unstructured":"M De Santis, E Di Gianantonio, G Straface,  \"Reprod Toxicol.\"  20, \"Ionizing radiations in pregnancy and teratogenesisA review of literature.\" 323 (2005)","DOI":"10.1016\/j.reprotox.2005.04.004"},{"key":"27","doi-asserted-by":"publisher","unstructured":"BF Hamilton, SA Benjamin, GM Angleton,  \"Radiat Res.\"  119, \"The effect of perinatal 60 Cs g Radiation on brain weight in beagles.\" 366 (1989)","DOI":"10.2307\/3577627"},{"key":"28","doi-asserted-by":"publisher","unstructured":"P Uma Devi, R Baskar, MP Hande,  \"Radiat Res.\"  138, \"Effect of Exposure to low-dose gamma radiation during late organogenesis in the mouse fetus.\" 133 (1994)","DOI":"10.2307\/3578857"},{"key":"29","doi-asserted-by":"publisher","unstructured":"T Jaylet, R Quintens, MA Benotmane,  \"Int J Radiat Biol.\"  \"Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning.\" 1 (2022)","DOI":"10.1080\/09553002.2022.2110312"},{"key":"30","doi-asserted-by":"crossref","unstructured":"H Laser  and MJ Thornley  \"Proceedings of the Royal Society of London Series B - Biological Sciences.\"  150, \"Stimulation by X-radiation of enzyme induction and growth in Escherichia coli.\" 539 (1959)","DOI":"10.1098\/rspb.1959.0041"},{"key":"31","doi-asserted-by":"publisher","unstructured":"AM Kuzin, ME Vagabova, MM Vilenchik,  \"Environmental and Experimental Botany.\"  26, \"Stimulation of plant growth by exposure to low level \u03b3-radiation and magnetic field, and their possible mechanism of action.\" 163 (1986)","DOI":"10.1016\/0098-8472(86)90011-0"},{"key":"32","doi-asserted-by":"publisher","unstructured":"A Conter, D Dupouy, H Planel,  \"Radiat Res.\"  99, \"Influence of growth phase on radiation stimulation of proliferation in Synechococcus lividus in culture.\" 651 (1984)","DOI":"10.2307\/3576338"},{"key":"33","doi-asserted-by":"publisher","unstructured":"C Thome, C Mitz, EN Hulley,  \"Radiat Res.\"  188, \"Initial Characterization of the growth stimulation and heat-shock-induced adaptive response in developing Lake Whitefish embryos after Ionizing radiation exposure.\" 475 (2017)","DOI":"10.1667\/RR14574.1"},{"key":"34","doi-asserted-by":"publisher","unstructured":"RD Phemister, RW Thomassen, RW Norrdin,  \"Radiat Res.\"  55, \"Renal failure in perinatally irradiated beagles.\" 399 (1973)","DOI":"10.2307\/3573845"},{"key":"36","doi-asserted-by":"publisher","unstructured":"RJ Garner, RD Phemister, GM Angleton,  \"Radiat Res.\"  58, \"Effect of Age on the acute lethal response of the beagle to Cobalt-60 gamma radiation.\" 190 (1974)","DOI":"10.2307\/3573931"},{"key":"37","doi-asserted-by":"crossref","unstructured":"AV. 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Brent,  \"Health Phys.\"  108, \"Protection of the gametes embryo\/fetus from prenatal radiation exposure.\" 242 (2015)","DOI":"10.1097\/HP.0000000000000235"}],"container-title":["Radiation Research"],"original-title":[],"link":[{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-24-00080.1\/3480401\/10.1667_rade-24-00080.1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-24-00080.1\/3480401\/10.1667_rade-24-00080.1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:39:28Z","timestamp":1791243568000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-203\/issue-2\/RADE-24-00080.1\/Comparison-of-Acute-and-Protracted-Gamma-Irradiation-Effects-During-Perinatal\/10.1667\/RADE-24-00080.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rade-24-00080.1","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]}}}