{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:50:44Z","timestamp":1791244244514,"version":"4.1.0"},"reference-count":32,"publisher":"Radiation Research Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2025,9,5]]},"abstract":"<jats:p>High radon levels in the environment can lead to adverse biological effects such as DNA damage, thereby increasing cancer risk, especially lung cancer. This study focused on Tande-Tande sub-village in Mamuju, West Sulawesi, Indonesia, an area known for naturally high indoor radon concentrations, where inhabitants have been chronically exposed to radon throughout their lives. Blood samples from 38 subjects in Tande-Tande sub-village and the control area, Topoyo village, were examined. We then evaluated the DNA damage by assessing c-H2AX for double-strand breaks and 8-hydroxydeoxyguanosine (8-OHdG) for oxidative damage. Additionally, we measured key molecules of the thioredoxin (Trx) system, Trx and thioredoxin reductase (TrxR), to gauge antioxidant levels and thus, oxidative stress response status. The C-reactive protein (CRP) to albumin ratio was analyzed to assess inflammatory status. Comparison of 8-OHdG, Trx, TrxR concentrations, and CRP\/Albumin between the exposed and control groups were assessed by unpaired Student's t-test or Mann-Whitney test, depending on the normality of the data distribution. Correlations between concentration of 8-OHdG, Trx, TrxR or CRP\/Albumin and indoor radon concentrations were investigated using either the Pearson or Spearman correlation tests, based on the distribution characteristics of the data. Our analyses of DNA damage markers (c-H2AX and 8-OHdG), Trx, TrxR, and CRP\/albumin ratio showed no significant increase in DNA damage markers in Tande-Tande sub-village residents compared to controls. Levels of 8-OHdG, Trx, and TrxR were significantly lower in Tande-Tande sub-village inhabitants when compared to the control area (P &lt; 0.0001, P = 0.002, and P = 0.003, respectively), whereas CRP\/albumin ratio did not differ significantly between these groups (P = 0.844). The present study did not find significant evidence of increased DNA damage, antioxidant system activity, or inflammatory status in inhabitants exposed to high radon levels. There is a possibility that the excessive ROS production existed in the early life period and subsequently manifested as a radio-adaptive response (RAR) during the adulthood of this population. These findings also support our previous assumptions that the excessive ROS production disrupts redox signaling and leads to a reduction in antioxidant levels.<\/jats:p>","DOI":"10.1667\/rade-24-00114.1","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T03:54:29Z","timestamp":1757562869000},"page":"502-514","source":"Crossref","is-referenced-by-count":0,"title":["DNA Damage Markers, Thioredoxin System, and Inflammation in a Population Exposed to High Indoor Radon Levels"],"prefix":"10.1667","volume":"204","author":[{"given":"Dwi","family":"Ramadhani","sequence":"first","affiliation":[{"name":"Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency, Banten, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofiati","family":"Purnami","sequence":"additional","affiliation":[{"name":"Research Center for Safety, Metrology, and Nuclear Quality Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency, Banten, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiara Andalya","family":"Oktariyani","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science and Technology, Al-Azhar University of Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dira","family":"Syafira","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science and Technology, Al-Azhar University of Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viria Agesti","family":"Suvifan","sequence":"additional","affiliation":[{"name":"Directorate of Strengthening and Partnership of Research and Innovation Infrastructure, Deputy for Research and Innovation Infrastructure, National Research and Innovation Agency, Banten, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iin Kurnia Hasan","family":"Basri","sequence":"additional","affiliation":[{"name":"Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency, Banten, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teja","family":"Kisnanto","sequence":"additional","affiliation":[{"name":"Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency, Banten, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heri","family":"Wibowo","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Hirosaki University, Hirosaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Kashiwakura","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Hirosaki University, Hirosaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomisato","family":"Miura","sequence":"additional","affiliation":[{"name":"Institute of Radiation Emergency Medicine, Hirosaki University, Hirosaki, Aomori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukh","family":"Syaifudin","sequence":"additional","affiliation":[{"name":"Research Center for Radioisotope, Radiopharmaceutical, and Biodosimetry Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency, Banten, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Septelia Inawati","family":"Wanandi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry & Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Retno","family":"Widowati","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology and Agriculture, Universitas Nasional, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"19","doi-asserted-by":"crossref","unstructured":"K Walczak, J Olszewski, P Polita\u0144ski, et al.  \"Chemosphere.\"  247, \"Residential exposure to radon and levels of histone \u03b3H2AX and DNA damage in peripheral blood lymphocytes of residents of Kowary city regions (Poland).\" 125748 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Research"],"original-title":[],"link":[{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-24-00114.1\/3539786\/10.1667_rade-24-00114.1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/meridian.allenpress.com\/radiation-research\/article-pdf\/doi\/10.1667\/RADE-24-00114.1\/3539786\/10.1667_rade-24-00114.1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:52:15Z","timestamp":1791240735000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-204\/issue-5\/RADE-24-00114.1\/DNA-Damage-Markers-Thioredoxin-System-and-Inflammation-in-a-Population\/10.1667\/RADE-24-00114.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,5]]},"references-count":32,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,11,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rade-24-00114.1","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,5]]}}}