{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:56:39Z","timestamp":1791244599615,"version":"4.1.0"},"reference-count":28,"publisher":"Radiation Research Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2025,2,28]]},"abstract":"<jats:p>Non-small-cell lung cancer (NSCLC) is the leading cause of tumor-related death in humans. Radiotherapy is a crucial strategy for NSCLC treatment, although its effectiveness is limited by the radio-resistance of tumor cells. Our current research finds that the protein arginine methyltransferase 7 (PRMT7) is upregulated in NSCLC and correlates with poor prognosis. Pharmacological inhibition of PRMT7 by SGC3027, a specific small-molecule PRMT7 inhibitor, suppresses the proliferation, migration and invasion of NSCLC. Combining irradiation with SGC3027 strengthens the impact of irradiation on the biological behaviors of NSCLC cells. We also find that SGC3027 specifically activates ATM kinase and its downstream cell cycle checkpoint kinases to enhance radiobiological response in NSCLC. These findings underscore the promising therapeutic potential of PRMT7 inhibitors as well as combining PRMT7 inhibition with irradiation exposure for effective NSCLC therapies.<\/jats:p>","DOI":"10.1667\/rade-24-00242.1","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T19:02:01Z","timestamp":1740682921000},"page":"284-292","source":"Crossref","is-referenced-by-count":0,"title":["PRMT7 Inhibitor SGC3027 Enhances Radiotherapy Efficacy via Activating ATM Kinase in Non-Small Cell Lung Carcinoma"],"prefix":"10.1667","volume":"203","author":[{"given":"Ya","family":"Heng","sequence":"first","affiliation":[{"name":"Institute of Department of Health Sciences and Technology, Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Department of Health Sciences and Technology, Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Department of Health Sciences and Technology, Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zebang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Anhui Medical University, Hefei 230601, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuling","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Department of Health Sciences and Technology, Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"F Drakopanagiotakis,  \"Cancers (Basel).\"  16, \"Lung cancer and interstitial lung diseases.\" (2024)","DOI":"10.3390\/cancers16162837"},{"key":"2","doi-asserted-by":"crossref","unstructured":"D Das, L Xie, J Hong,  \"Rsc Med Chem.\"  \"Next-Generation Egfr Tyrosine Kinase Inhibitors to Overcome C797s Mutation inNon-Small Cell Lung Cancer (2019-2024).\" (2024)","DOI":"10.1039\/D4MD00384E"},{"key":"3","doi-asserted-by":"crossref","unstructured":"V Relli,  \"Trends Mol Med.\"  25, \"Abandoning The Notion of Non-Small Cell Lung Cancer.\" 585 (2019)","DOI":"10.1016\/j.molmed.2019.04.012"},{"key":"4","doi-asserted-by":"crossref","unstructured":"L Geng,  \"Oncogene.\"  43, \"Tkt-Parp1 Axis Induces Radioresistance by Promoting DNA Double-Strand Break Repair in Hepatocellular Carcinoma.\" 682 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