{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:59:43Z","timestamp":1791237583351,"version":"4.1.0"},"reference-count":42,"publisher":"Radiation Research Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2026,2,2]]},"abstract":"<jats:p>Radiotherapy may cause acute and late damage to off-target abscopal tissues, and the underlying signaling factors need further exploration. This study aimed to investigate whether local irradiation could induce damage in non-irradiated abscopal lung tissues using a murine model subjected to fractionated irradiation (8 Gy per fraction over three days) targeted to the right lung. It was found that unilateral fractionated thoracic irradiation could induce progressive tissue injury in the contralateral lung. The exclusion of scattered radiation as a contributor to the observed structural injury and acute DNA damage was confirmed. Notably, unilateral fractionated thoracic irradiation increased macrophages with NF-\u03baB activation. Therapeutic inhibition of NF-\u03baB, as well as administration of cimetidine, markedly mitigated radiation-induced pneumonitis and fibrosis in the contralateral lung. These results demonstrate that abscopal lung injury following unilateral irradiation may be driven by increased macrophages, offering novel mechanistic insight and a potential treatment for lung injury associated with thoracic radiotherapy.<\/jats:p>","DOI":"10.1667\/rade-25-00038.1","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:09:51Z","timestamp":1770836991000},"page":"307-317","source":"Crossref","is-referenced-by-count":0,"title":["Unilateral Fractionated Thoracic Irradiation Induces Abscopal Injury in Contralateral Lung through NF-\u03baB Pathway"],"prefix":"10.1667","volume":"205","author":[{"given":"Xinglong","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Radiation Medicine and Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimeng","family":"Song","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songling","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Shanghai Key Laboratory of Craniomaxillofacial; Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Medical College, Fudan University, Shanghai 200001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Bai","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Shao","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"E Daguenet, S Louati, AS Wozny, et al.  \"Br J Cancer.\"  123, \"Radiation-induced bystander and abscopal effects: important lessons from preclinical models.\" 339 (2020)","DOI":"10.1038\/s41416-020-0942-3"},{"key":"3","doi-asserted-by":"crossref","unstructured":"L Zhu, S Hu, Q Chen, et al.  \"Int 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Citrin,  \"N Engl J Med.\"  377, \"Recent developments in radiotherapy.\" 1065 (2017)","DOI":"10.1056\/NEJMra1608986"}],"container-title":["Radiation Research"],"original-title":[],"link":[{"URL":"https:\/\/radiation-research.kglmeridian.com\/view\/journals\/rare\/aop\/article-10.1667-RADE-25-00038.1\/article-10.1667-RADE-25-00038.1.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/radiation-research.kglmeridian.com\/downloadpdf\/journals\/rare\/aop\/article-10.1667-RADE-25-00038.1\/article-10.1667-RADE-25-00038.1.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/radiation-research.kglmeridian.com\/downloadpdf\/journals\/rare\/aop\/article-10.1667-RADE-25-00038.1\/article-10.1667-RADE-25-00038.1.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:23:54Z","timestamp":1791235434000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-205\/issue-3\/RADE-25-00038.1\/Unilateral-Fractionated-Thoracic-Irradiation-Induces-Abscopal-Injury-in-Contralateral-Lung\/10.1667\/RADE-25-00038.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rade-25-00038.1","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]}}}