{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:58:36Z","timestamp":1791237516412,"version":"4.1.0"},"reference-count":43,"publisher":"Radiation Research Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2026,1,21]]},"abstract":"<jats:p>With the increasing use of radiation in medical and other settings, the potential effects of low-dose radiation on coronary heart disease including myocardial infarction (MI) are of great public health concern. The impact of low-dose radiation on myocardial infarction incidence remains controversial. The purpose of this study was to examine whether atomic bomb radiation exposure (dose &lt; 4 Gy) is associated with the incidence of myocardial infarction. This prospective cohort study included 11,838 Japanese atomic bomb survivors with individually estimated radiation doses from the Adult Health Study cohort who had no history of myocardial infarction or radiotherapy at the first visit. Participants were followed until the earliest of first occurrence of an myocardial infarction, death, or the end of 2015 (57 years maximum). The incidence of myocardial infarctions (non-fatal and fatal), categorized by graded diagnostic accuracy, and the dose-response relationship of atomic bomb radiation were analyzed using Cox proportional hazards models. A total of 515 incident myocardial infarctions were documented, consisting of 188 definite, 30 probable, and 15 possible non-fatal myocardial infarctions, along with 282 fatal myocardial infarctions. For definite and probable non-fatal myocardial infarctions with high diagnostic accuracy, no significant association with radiation was found for both sexes combined [hazard ratio (HR) at 1 Gy = 1.17; 95% confidence interval (CI): 0.91\u20131.51], but sex-stratified analyses indicated a higher HR for females than for males [at 1 Gy, HRfemale = 1.42 (95% CI:1.02\u20131.98), HRmale = 1.02, 95% CI: 0.74\u20131.41], although the difference was not statistically significant (P = 0.13). No statistically significant modification of radiation effect was identified by city, age at exposure, attained age, time since exposure, smoking, or alcohol use. For all myocardial infarctions, including possible non-fatal myocardial infarction and fatal myocardial infarction with low diagnostic accuracy, the HRs at 1 Gy were 1.04 (95% CI: 0.86\u20131.25) for both sexes combined, 1.14 (95% CI: 0.88\u20131.47) for females, and 0.96 (95% CI: 0.75\u20131.22) for males. Findings from this long-term cohort study of atomic bomb survivors suggest an association between exposure to atomic bomb radiation and the incidence of myocardial infarction in females, but not in males. Further studies are necessary to clarify the reasons underlying the sex difference in dose-response relationship for myocardial infarction.<\/jats:p>","DOI":"10.1667\/rade-25-00167.1","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:02:21Z","timestamp":1770836541000},"page":"295-306","source":"Crossref","is-referenced-by-count":0,"title":["Radiation Effects on the Incidence of Myocardial Infarction in Atomic Bomb Survivors, 1958\u20132015"],"prefix":"10.1667","volume":"205","author":[{"given":"Satoshi","family":"Kurisu","sequence":"first","affiliation":[{"name":"Department of Clinical Studies, Hiroshima, RERF, Hiroshima City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munechika","family":"Misumi","sequence":"additional","affiliation":[{"name":"Department of Statistics, RERF, Hiroshima City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Hiroshima, RERF, Hiroshima City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Nakamizo","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Nagasaki, RERF, Nagasaki City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Tatsukawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Hiroshima, RERF, Hiroshima City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Hiroshima, RERF, Hiroshima City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Hiroshima, RERF, Hiroshima City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misa","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Nagasaki, RERF, Nagasaki City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Kadowaki","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, RERF, Hiroshima City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsu","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, RERF, Hiroshima City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Hida","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Nagasaki, RERF, Nagasaki City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Maemura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waka","family":"Ohishi","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Hiroshima, RERF, Hiroshima City, 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(2008)","DOI":"10.1093\/ije\/dyn018"},{"key":"11","doi-asserted-by":"crossref","unstructured":"TV Azizova, ES Grigoryeva, RG Haylock, et al.  \"Br J Radiol.\"  88, \"Ischaemic heart disease incidence and mortality in an extended cohort of Mayak workers first employed in 1948-82.\" 20150169 (2015)","DOI":"10.1259\/bjr.20150169"},{"key":"12","doi-asserted-by":"crossref","unstructured":"P Rajaraman, MM Doody, CL Yu, et al.  \"Occup Environ Med.\"  73, \"Incidence and mortality risks for circulatory diseases in US radiologic technologists who worked with fluoroscopically guided interventional procedures, 1994-2008.\" 21 (2016)","DOI":"10.1136\/oemed-2015-102888"},{"key":"13","doi-asserted-by":"crossref","unstructured":"AB Karpov, YV Semenova, RM Takhauov, et al.  \"Health Phys.\"  103, \"The risk of acute myocardial infarction and arterial hypertension in a cohort of male employees of a Siberian group of chemical enterprises exposed to long-term irradiation.\" 15 (2012)","DOI":"10.1097\/HP.0b013e318249fa59"},{"key":"14","unstructured":"K Kodama, Y Shimizu, H Sawada, et al.  \"Incidence of stroke and coronary heart disease in the Adult Health Study sample, 1958-78.\"  TR 22 (1987)"},{"key":"15","doi-asserted-by":"crossref","unstructured":"M Yamada, FL Wong, S Fujiwara, et al.  \"Radiat Res.\"  161, \"Non-cancer disease incidence in atomic bomb survivors, 1958\u20131998.\" 622 (2004)","DOI":"10.1667\/RR3183"},{"key":"20","doi-asserted-by":"crossref","unstructured":"D Haruta, RD Landes, A Hida, et al.  \"Circ Rep.\"  3, \"Relationship between radiation exposure and incident atrial fibrillation among atomic bomb survivors.\" 381 (2021)","DOI":"10.1253\/circrep.CR-21-0059"},{"key":"21","doi-asserted-by":"crossref","unstructured":"H Tunstall-Pedoe, K Kuulasmaa, P Amouyel, et al.  \"Circulation.\"  90, \"Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents.\" 583 (1994)","DOI":"10.1161\/01.CIR.90.1.583"},{"key":"22","doi-asserted-by":"crossref","unstructured":"L Chambless, U Keil, A Dobson, et al.  \"Circulation.\"  96, \"Population versus clinical view of case fatality from acute coronary heart disease: results from the WHO MONICA Project 1985-1990. Multinational MONItoring of Trends and Determinants in CArdiovascular Disease.\" 3849 (1997)","DOI":"10.1161\/01.CIR.96.11.3849"},{"key":"26","unstructured":"TL Robertson, H Kato, GG Rhoads, et al.  \"Am J Cardiol.\"  39, \"Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. Incidence of myocardial infarction and death from coronary heart disease.\" 239 (1977)"},{"key":"27","doi-asserted-by":"crossref","unstructured":"J Hata, T Ninomiya, Y Hirakawa, et al.  \"Circulation.\"  128, \"Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009).\" 1198 (2013)","DOI":"10.1161\/CIRCULATIONAHA.113.002424"},{"key":"28","unstructured":"RL Carter, E Ron, K Mabuchi,  \"RERF TR 15-91.\"  \"Combining diagnostic categories to improve agreement between death certificate and autopsy classifications of cause of death for atomic bomb survivors, 1950-87.\""},{"key":"29","unstructured":"I Saito, H Aono, T Ikebe, et al.  \"Nihon Koshu Eisei Zasshi.\"  48, \"The validity of revised death certificates (ICD-10) for ischemic heart disease in Oita City, Japan.\" 584 (2001)"},{"key":"32","doi-asserted-by":"crossref","unstructured":"T Nakamizo, J Cologne, K Cordova, et al.  \"Eur J Epidemiol.\"  36, \"Radiation effects on atherosclerosis in atomic bomb survivors: a cross-sectional study using structural equation modeling.\" 401 (2021)","DOI":"10.1007\/s10654-021-00731-x"},{"key":"36","doi-asserted-by":"crossref","unstructured":"M Akahoshi, M Soda, E Nakashima, et al.  \"Circulation.\"  94, \"Effects of menopause on trends of serum cholesterol, blood pressure, and body mass index.\" 61 (1996)","DOI":"10.1161\/01.CIR.94.1.61"},{"key":"37","doi-asserted-by":"crossref","unstructured":"R Sakata, Y Shimizu, M Soda, et al.  \"Radiat Res.\"  176, \"Effect of radiation on age at menopause among atomic bomb survivors.\" 787 (2011)","DOI":"10.1667\/RR2676.1"},{"key":"39","doi-asserted-by":"crossref","unstructured":"U Keil, AD Liese, HW Hense, et al.  \"Eur Heart J.\"  19, \"Classical risk factors and their impact on incident non-fatal and fatal myocardial infarction and all-cause mortality in southern Germany. Results from the MONICA Augsburg cohort study 1984-1992. Monitoring Trends and Determinants in Cardiovascular Diseases.\" 1197 (1998)","DOI":"10.1053\/euhj.1998.1089"},{"key":"40","doi-asserted-by":"crossref","unstructured":"T Hasebe  and N Hasebe  \"Hypertens Res.\"  45, \"Impact of risk factors related to metabolic syndrome on acute myocardial infarction in younger patients.\" 1447 (2022)","DOI":"10.1038\/s41440-022-00951-y"},{"key":"41","doi-asserted-by":"crossref","unstructured":"Z Sedaghat, S Khodakarim, SA Nejadghaderi, et al.  \"BMC Public Health.\"  24, \"Association between metabolic syndrome and myocardial infarction among patients with excess body weight: a systematic review and meta-analysis.\" 444 (2024)","DOI":"10.1186\/s12889-024-17707-7"},{"key":"43","doi-asserted-by":"crossref","unstructured":"H Cooper, S Wells, S Mehta,  \"Int J Epidemiol.\"  51, \"Are competing-risk models superior to standard Cox models for predicting cardiovascular risk in older adults? Analysis of a whole-of-country primary prevention cohort aged \u226565 years.\" 604 (2022)","DOI":"10.1093\/ije\/dyab116"},{"key":"25","unstructured":"\"The r project for statistical computing.\""},{"key":"35","doi-asserted-by":"crossref","unstructured":"M Yamada  and S Izumi  \"Soc Psychiatry Psychiatr Epidemiol.\"  37, \"Psychiatric sequelae in atomic bomb survivors in Hiroshima and Nagasaki two decades after the explosions.\" 409 (2002)","DOI":"10.1007\/s00127-002-0572-5"},{"key":"16","doi-asserted-by":"publisher","unstructured":"Y Shimizu, K Kodama, N Nishi, et al.  \"BMJ.\"  340, \"Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003.\" b5349 (2010)","DOI":"10.1136\/bmj.b5349"},{"key":"23","doi-asserted-by":"crossref","unstructured":"E Ron, R Carter, S Jablon, et al.  \"Epidemiology.\"  5, \"Agreement between death certificate and autopsy diagnoses among atomic bomb survivors.\" 48 (1994)","DOI":"10.1097\/00001648-199401000-00009"},{"key":"3","doi-asserted-by":"publisher","unstructured":"SC Darby, M Ewertz, P McGale, et al.  \"N Engl J Med.\"  368, \"Risk of ischemic heart disease in women after radiotherapy for breast cancer.\" 987 (2013)","DOI":"10.1056\/NEJMoa1209825"},{"key":"42","doi-asserted-by":"crossref","unstructured":"K Ozasa, Y Shimizu, A Suyama, et al.  \"Radiat Res.\"  177, \"Studies of the mortality of atomic bomb survivors, Report 14, 1950\u20132003: an overview of cancer and noncancer diseases.\" 229 (2012)","DOI":"10.1667\/RR2629.1"},{"key":"24","doi-asserted-by":"crossref","unstructured":"B French, J Cologne, R Sakata, et al.  \"Eur J Epidemiol.\"  32, \"Selection of reference groups in the Life Span Study of atomic bomb survivors.\" 1055 (2017)","DOI":"10.1007\/s10654-017-0337-9"},{"key":"7","doi-asserted-by":"crossref","unstructured":"M Gillies, DB Richardson, E Cardis, et al.  \"Radiat Res.\"  188, \"Mortality from circulatory diseases and other non-cancer outcomes among nuclear workers in France, the United Kingdom and the United States (INWORKS).\" 276 (2017)","DOI":"10.1667\/RR14608.1"},{"key":"30","doi-asserted-by":"crossref","unstructured":"H Sasaki, FL Wong, M Yamada, et al.  \"J Clin Epidemiol.\"  55, \"The effects of aging and radiation exposure on blood pressure levels of atomic bomb survivors.\" 974 (2002)","DOI":"10.1016\/S0895-4356(02)00439-0"},{"key":"38","doi-asserted-by":"crossref","unstructured":"EJ Grant, A Brenner, H Sugiyama, et al.  \"Radiat Res.\"  187, \"Solid cancer incidence among the Life Span Study of Atomic Bomb Survivors: 1958\u20132009.\" 513 (2017)","DOI":"10.1667\/RR14492.1"},{"key":"17","doi-asserted-by":"crossref","unstructured":"I Takahashi, Y Shimizu, EJ Grant, et al.  \"Radiat Res.\"  187, \"Heart disease mortality in the Life Span Study, 1950\u20132008.\" 319 (2017)","DOI":"10.1667\/RR14347.1"},{"key":"5","doi-asserted-by":"crossref","unstructured":"VK Ivanov, MA Maksioutov, SY Chekin, et al.  \"Health Phys.\"  90, \"The risk of radiation-induced cerebrovascular disease in Chernobyl emergency workers.\" 199 (2006)","DOI":"10.1097\/01.HP.0000175835.31663.ea"},{"key":"8","doi-asserted-by":"crossref","unstructured":"M Vrijheid, E Cardis, P Ashmore, et al.  \"Int J Epidemiol.\"  36, \"Mortality from diseases other than cancer following low doses of ionizing radiation: Results from the 15-Country Study of nuclear industry workers.\" 1126 (2007)","DOI":"10.1093\/ije\/dym138"},{"key":"9","doi-asserted-by":"crossref","unstructured":"O Laurent, C Metz-Flamant, A Rogel, et al.  \"Int Arch Occup Environ Health.\"  83, \"Relationship between occupational exposure to ionizing radiation and mortality at the French electricity company, period 1961\u20132003.\" 935 (2010)","DOI":"10.1007\/s00420-010-0509-3"},{"key":"19","doi-asserted-by":"crossref","unstructured":"K Ozasa, HM Cullings, W Ohishi, et al.  \"Int J Radiat Biol.\"  95, \"Epidemiological studies of atomic bomb 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Takahashi, EJ Grant, et al.  \"Int J Radiat Biol.\"  93, \"Cardiovascular disease among atomic bomb survivors.\" 1145 (2017)","DOI":"10.1080\/09553002.2017.1290849"},{"key":"31","doi-asserted-by":"crossref","unstructured":"FL Wong, M Yamada, H Sasaki, et al.  \"Radiat Res.\"  151, \"Effects of radiation on the longitudinal trends of total serum cholesterol levels in the atomic bomb survivors.\" 736 (1999)","DOI":"10.2307\/3580213"}],"container-title":["Radiation 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