{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T02:34:13Z","timestamp":1792982053675,"version":"4.5.0"},"reference-count":0,"publisher":"Radiation Research Society","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:p>Immediate early response gene-3 (IER3\/IEX-1) encodes a radiation-inducible stress-response adaptor protein that integrates pro-survival signaling pathways, yet the upstream mechanisms regulating its expression after irradiation remain incompletely understood. Here we investigated whether lysophosphatidic acid receptor (LPAR) signaling regulates IEX-1 expression during the radiation response and examined the radiobiological consequences of IEX-1 deficiency. LPAR activation enhanced IEX-1 expression in irradiated mouse whole blood, bone marrow, intestinal mucosa, and intestinal enteroids. In addition, IEX-1-deficient mice exhibited increased susceptibility to lethal radiation injury after total-body or partial body irradiation, while IEX-1-deficient enteroids displayed delayed growth and altered ERK phosphorylation kinetics. Together, these findings identify IEX-1 as a previously unrecognized downstream target of LPAR signaling after irradiation.<\/jats:p>","DOI":"10.1667\/rade-26-00052.1","type":"journal-article","created":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T02:13:46Z","timestamp":1792980826000},"source":"Crossref","is-referenced-by-count":0,"title":["Lysophosphatidic Acid Receptor Activation Regulates Expression of the Immediate Early Gene IEX-1 in Irradiated Cells and Tissues"],"prefix":"10.1667","author":[{"given":"Derek D.","family":"Norman","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee"},{"name":"Department of Translational Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoojin","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"Bal\u00e1zs","sequence":"additional","affiliation":[{"name":"The Pathology Group, St. Francis Hospital, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erzs\u00e9bet","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Debrecen, Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Beny\u00f3","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue Chin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor J.","family":"Tigyi","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee"},{"name":"Department of Translational Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","container-title":["Radiation Research"],"original-title":[],"link":[{"URL":"https:\/\/radiation-research.kglmeridian.com\/view\/journals\/rare\/aop\/article-10.1667-RADE-26-00052.1\/article-10.1667-RADE-26-00052.1.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/radiation-research.kglmeridian.com\/downloadpdf\/journals\/rare\/aop\/article-10.1667-RADE-26-00052.1\/article-10.1667-RADE-26-00052.1.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T02:13:47Z","timestamp":1792980827000},"score":1,"resource":{"primary":{"URL":"https:\/\/radiation-research.kglmeridian.com\/view\/journals\/rare\/aop\/article-10.1667-RADE-26-00052.1\/article-10.1667-RADE-26-00052.1.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1667\/rade-26-00052.1","relation":{},"ISSN":["1938-5404","0033-7587"],"issn-type":[{"value":"1938-5404","type":"electronic"},{"value":"0033-7587","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,2]]}}}