{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:37:50Z","timestamp":1791315470576,"version":"4.3.1"},"reference-count":138,"publisher":"Radiation Research Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1667\/rr0380.1","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T18:45:49Z","timestamp":1165430749000},"page":"819-831","source":"Crossref","is-referenced-by-count":59,"title":["Adhesion Molecules in Radiotherapy"],"prefix":"10.1667","volume":"166","author":[{"given":"Roxana G.","family":"Baluna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony Y.","family":"Eng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Charles R.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"i0033-7587-166-6-819-b1","unstructured":"Albelda, S. M. Biology of disease: Role of integrins and other cell adhesion molecules in tumor progression and metastasis. Lab. Invest 68:4\u201317.1993."},{"key":"i0033-7587-166-6-819-b2","doi-asserted-by":"crossref","unstructured":"Juliano, R. L. and J. A. Varner. Adhesion molecules in cancer: The role of integrins. Curr. Opin. Cell Biol 5:812\u2013818.1993.","DOI":"10.1016\/0955-0674(93)90030-T"},{"key":"i0033-7587-166-6-819-b3","unstructured":"Huang, Y., R. Baluna, and E. Vitetta. Adhesion molecules as targets for cancer therapy. Histol. Histopathol 12:467\u2013477.1997."},{"key":"i0033-7587-166-6-819-b4","doi-asserted-by":"crossref","unstructured":"Ruoslahti, E. RGD and other recognition sequences for integrins. Annu. Rev. Cell Dev. Biol 12:697\u2013715.1996.","DOI":"10.1146\/annurev.cellbio.12.1.697"},{"key":"i0033-7587-166-6-819-b5","doi-asserted-by":"crossref","unstructured":"Springer, T. A. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 76:301\u2013314.1994.","DOI":"10.1016\/0092-8674(94)90337-9"},{"key":"i0033-7587-166-6-819-b6","unstructured":"Lisiak, E. and N. Cordes. Integrins and the cellular radiation response. Cancer Ther 2:271\u2013278.2004."},{"key":"i0033-7587-166-6-819-b7","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990730)82:3<385::AID-IJC12>3.0.CO;2-5"},{"key":"i0033-7587-166-6-819-b8","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(99)00066-3"},{"key":"i0033-7587-166-6-819-b9","doi-asserted-by":"crossref","unstructured":"Prabhakarpandian, B., D. J. Goetz, R. A. Swerlick, X. Chen, and M. F. Kiani. Expression and functional significance of adhesion molecules on cultured endothelial cells in response to ionizing radiation. Microcirculation 8:355\u2013364.2001.","DOI":"10.1038\/sj.mn.7800105"},{"key":"i0033-7587-166-6-819-b10","unstructured":"Hallahan, D. E. and S. Virudachalam. Ionizing radiation mediates expression of cell adhesion molecules in distinct histological patterns within the lung. Cancer Res 57:2096\u20132099.1997."},{"key":"i0033-7587-166-6-819-b11","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90138-8"},{"key":"i0033-7587-166-6-819-b12","doi-asserted-by":"crossref","unstructured":"Molla, M., M. Gironella, R. Miquel, V. Tovar, P. Engel, A. Biete, J. M. Pique, and J. Panes. Relative roles of ICAM-1 and VCAM-1 in the pathogenesis of experimental radiation-induced intestinal inflammation. Int. J. Radiat. Oncol. Biol. Phys 57:264\u2013273.2003.","DOI":"10.1016\/S0360-3016(03)00523-6"},{"key":"i0033-7587-166-6-819-b13","doi-asserted-by":"crossref","unstructured":"Patel, K. D., S. L. Cuvelier, and S. Wiehler. Selectins: Critical mediators of leukocyte recruitment. Semin. Immunol 14:73\u201378.2002.","DOI":"10.1006\/smim.2001.0344"},{"key":"i0033-7587-166-6-819-b14","doi-asserted-by":"crossref","unstructured":"Prott, F. J., J. Handschel, O. Micke, C. Sunderkotter, U. Meyer, and J. Piffko. Long-term alterations of oral mucosa in radiotherapy patients. Int. J. Radiat. Oncol. Biol. Phys 54:203\u2013210.2002.","DOI":"10.1016\/S0360-3016(02)02867-5"},{"key":"i0033-7587-166-6-819-b15","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1997.3826"},{"key":"i0033-7587-166-6-819-b16","doi-asserted-by":"crossref","unstructured":"Hallahan, D. E., E. T. Clark, J. Kuchibhotla, B. L. Gewertz, and T. Collins. E-selectin gene induction by ionizing radiation is independent of cytokine induction. Biochem. Biophys. Res. Commun 217:784\u2013795.1995.","DOI":"10.1006\/bbrc.1995.2841"},{"key":"i0033-7587-166-6-819-b17","doi-asserted-by":"publisher","DOI":"10.2307\/3580044"},{"key":"i0033-7587-166-6-819-b18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01513.x"},{"key":"i0033-7587-166-6-819-b19","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00176-X"},{"key":"i0033-7587-166-6-819-b20","doi-asserted-by":"crossref","unstructured":"Hardy, R. G., R. M. Brown, S. J. Miller, C. Tselepis, D. G. Morton, J. A. Jankowski, and D. S. Sanders. Transient P-cadherin expression in radiation proctitis; A model of mucosal injury and repair. J. Pathol 197:194\u2013200.2002.","DOI":"10.1002\/path.1092"},{"key":"i0033-7587-166-6-819-b21","doi-asserted-by":"crossref","unstructured":"Martin, T. A., G. Harrison, R. E. Mansel, and W. G. Jiang. The role of the CD44\/ezrin complex in cancer metastasis. Crit. Rev. Oncol. Hematol 46:165\u2013186.2003.","DOI":"10.1016\/S1040-8428(02)00172-5"},{"key":"i0033-7587-166-6-819-b22","doi-asserted-by":"crossref","unstructured":"Liu, K., M. Kasper, A. Bierhaus, S. Langer, I. Peterson, M. Muller, and K. R. Trott. Differential expression of CD44s and CD44v10 proteins and syndecan in normal and irradiated mouse epidermis. Histochem. Cell Biol 107:159\u2013167.1997.","DOI":"10.1007\/s004180050100"},{"key":"i0033-7587-166-6-819-b23","doi-asserted-by":"publisher","DOI":"10.1080\/095530097143428"},{"key":"i0033-7587-166-6-819-b24","doi-asserted-by":"crossref","unstructured":"Walther, M., W. Kaffenberger, and D. van Beuningen. Influence of clinically used antioxidants on radiation-induced expression of intercellular cell adhesion molecule-1 on HUVEC. Int. J. Radiat. Biol 75:1317\u20131325.1999.","DOI":"10.1080\/095530099139485"},{"key":"i0033-7587-166-6-819-b25","doi-asserted-by":"crossref","unstructured":"Baeuml, H., U. Behrends, R. U. Peter, S. Mueller, C. Kammerbauer, S. W. Caughman, and K. Degitz. Ionizing radiation induces, via generation of reactive oxygen intermediates, intercellular adhesion molecule-1 (ICAM-1) gene transcription and NF-kB-like binding activity in the ICAM-1 transcriptional regulatory region. Free Radic. Res 27:127\u2013142.1997.","DOI":"10.3109\/10715769709097846"},{"key":"i0033-7587-166-6-819-b26","unstructured":"Hallahan, D. E., S. Virudachalam, and J. Kuchibhotla. Nuclear factor kB dominant negative genetic constructs inhibit X-ray induction of cell adhesion molecules in the vascular endothelium. Cancer Res 58:5484\u20135488.1998."},{"key":"i0033-7587-166-6-819-b27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.12.6432"},{"key":"i0033-7587-166-6-819-b28","unstructured":"Hallahan, D. E., J. Kuchibhotla, and C. Wyble. Cell adhesion molecules mediate radiation-induced leukocyte adhesion to the vascular endothelium. Cancer Res 56:5150\u20135155.1996."},{"key":"i0033-7587-166-6-819-b29","doi-asserted-by":"crossref","unstructured":"Eissner, G., H. Lindner, U. Behrends, W. Kolch, A. Hieke, I. Klauke, G. W. Bornkamm, and E. Holler. Influence of bacterial endotoxin on radiation-induced activation of human endothelial cellsin vitroandin vivo: Protective role of IL-10. Transplantation 62:819\u2013827.1996.","DOI":"10.1097\/00007890-199609270-00020"},{"key":"i0033-7587-166-6-819-b30","doi-asserted-by":"crossref","unstructured":"Hildebrandt, G., L. Maggiorella, F. Rodel, V. Rodel, D. Willis, and K. R. Trott. Mononuclear cell adhesion and cell adhesion molecule liberation after X-irradiation of activated endothelial cellsin vitro. Int. J. Radiol. Biol 78:315\u2013325.2002.","DOI":"10.1080\/09553000110106027"},{"key":"i0033-7587-166-6-819-b31","doi-asserted-by":"crossref","unstructured":"Quarmby, S., P. Kumar, J. Wang, J. A. Macro, J. J. Hutchinson, R. D. Hunter, and S. Kumar. Irradiation induces upregulation of CD31 on human endothelial cells. Arterioscler. Thromb. Vasc. Biol 19:588\u2013597.1999.","DOI":"10.1161\/01.ATV.19.3.588"},{"key":"i0033-7587-166-6-819-b32","unstructured":"Quarmby, S., R. D. Hunter, and S. Kumar. Irradiation induced expression of CD31, ICAM-1 and VCAM-1 in human microvascular endothelial cells. Anticancer Res 20:3375\u20133381.2000."},{"key":"i0033-7587-166-6-819-b33","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12398607"},{"key":"i0033-7587-166-6-819-b34","doi-asserted-by":"crossref","unstructured":"Gaugler, M. H., C. Squiban, M. A. Mouthon, P. Gourmelon, and A. van der Meeren. Irradiation enhances the support of haemopoietic cell transmigration, proliferation and differentiation by endothelial cells. Br. J. Haematol 113:940\u2013950.2001.","DOI":"10.1046\/j.1365-2141.2001.02852.x"},{"key":"i0033-7587-166-6-819-b35","doi-asserted-by":"crossref","unstructured":"Kern, P. M., L. Keilholz, C. Forster, R. Hallmann, M. Herrmann, and M. H. Seegenschmiedt. Low-dose radiotherapy selectively reduces adhesion of peripheral blood mononuclear cells to endotheliumin vitro. Radiother. Oncol 54:273\u2013282.2000.","DOI":"10.1016\/S0167-8140(00)00141-9"},{"key":"i0033-7587-166-6-819-b36","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(98)00270-7"},{"key":"i0033-7587-166-6-819-b37","doi-asserted-by":"publisher","DOI":"10.2307\/3579499"},{"key":"i0033-7587-166-6-819-b38","unstructured":"Hallahan, D. E., M. J. Staba-Hogan, S. Virudachalam, and A. Kolchinsky. X-ray-induced P-selectin localization to the lumen of tumor blood vessels. Cancer Res 58:5216\u20135220.1998."},{"key":"i0033-7587-166-6-819-b39","doi-asserted-by":"crossref","unstructured":"Handschel, J., F. J. Prott, C. Sunderkotter, D. Metze, U. Meyer, and U. Joos. Irradiation induces increase of adhesion molecules and accumulation of \u03b22\u2013integrin-expressing cells in humans. Int. J. Radiat. Oncol. Biol. Phys 45:475\u2013481.1999.","DOI":"10.1016\/S0360-3016(99)00202-3"},{"key":"i0033-7587-166-6-819-b40","doi-asserted-by":"crossref","unstructured":"Meineke, V., T. Moede, K. P. Gilbertz, A. Mayerhofer, J. Ring, F. M. Kohn, and D. van Beuningen. Protein kinase inhibitors modulate time-dependent effects of UV and ionizing irradiation on ICAM-1 expression on human hepatoma cells. Int. J. Radiat. Biol 78:577\u2013583.2002.","DOI":"10.1080\/09553000110113056"},{"key":"i0033-7587-166-6-819-b41","doi-asserted-by":"crossref","unstructured":"Santin, A. D., P. L. Hermonat, J. C. Hiserodt, M. Chiriva-Internati, J. Woodliff, J. W. Theus, D. Barclay, S. Pecorelli, and G. P. Parham. Effects of irradiation on the expression of major histocompatibility complex class I antigen and adhesion costimulation molecules ICAM-1 in human cervical cancer. Int. J. Radiat. Oncol. Biol. Phys 39:737\u2013742.1997.","DOI":"10.1016\/S0360-3016(97)00372-6"},{"key":"i0033-7587-166-6-819-b42","doi-asserted-by":"publisher","DOI":"10.1006\/brbi.1997.0506"},{"key":"i0033-7587-166-6-819-b43","unstructured":"McNamara, M. P., K. A. Bjornstad, P. Y. Chang, W. Chou, S. J. Lockett, and E. A. Blakely. Modulation of lens cell adhesion molecules by particle beams. Phys. Med 17:(Suppl.). 247\u2013248.2001."},{"key":"i0033-7587-166-6-819-b44","unstructured":"Tsujino, K., A. Kodama, N. Kanaoka, T. Maruta, and M. Kono. Expression of pulmonary mRNA encoding ICAM-1, VCAM-1, and P-selectin following thoracic irradiation in mice. Radiat. Med 17:283\u2013287.1999."},{"key":"i0033-7587-166-6-819-b45","unstructured":"Epperly, M. W., H. Guo, D. Shields, X. Zhang, and J. S. Greenberger. Correlation of ionizing irradiation-induced late pulmonary fibrosis with long-term bone marrow culture fibroblast progenitor cell biology in mice homozygous deletion recombinant negative for endothelial cell adhesion molecules. In Vivo 18:1\u201314.2004."},{"key":"i0033-7587-166-6-819-b46","doi-asserted-by":"crossref","unstructured":"Molla, M., M. Gironella, A. Salas, R. Miquel, S. Perez-del-Pulgar, C. Conill, P. Engel, A. Biete, J. M. Pique, and J. Panes. Role of P-selectin in radiation-induced intestinal inflammatory damage. Int. J. Cancer 96:99\u2013109.2001.","DOI":"10.1002\/ijc.1009"},{"key":"i0033-7587-166-6-819-b47","doi-asserted-by":"crossref","unstructured":"Ikeda, Y., M. Ito, M. Matsuu, K. Shichijo, E. Fukuda, T. Nakayama, M. Nakashima, S. Naito, and I. Sekine. Expression of ICAM-1 and acute inflammatory cell infiltration in the early phase of radiation colitis in rats. J. Radiat. Res 41:279\u2013291.2000.","DOI":"10.1269\/jrr.41.279"},{"key":"i0033-7587-166-6-819-b48","doi-asserted-by":"crossref","unstructured":"Sharp, C. D., A. Jawahar, A. C. Warren, J. W. Elrod, A. Nanda, and J. S. Alexander. Gamma knife irradiation increases cerebral endothelial expression of intercellular adhesion molecule 1 and E-selectin. Neurosurgery 53:154\u2013161.2003.","DOI":"10.1227\/01.NEU.0000068840.84484.DA"},{"key":"i0033-7587-166-6-819-b49","doi-asserted-by":"crossref","unstructured":"Kyrkanides, S., A. H. Moore, J. A. Olschowka, J. C. Daeschner, J. P. Williams, J. T. Hansen, and M. K. O'Banion. Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury. Brain Res. Mol. Brain Res 104:159\u2013169.2002.","DOI":"10.1016\/S0169-328X(02)00353-4"},{"key":"i0033-7587-166-6-819-b50","unstructured":"Hallahan, D. E., M. J. Staba-Hogan, S. Virudachalam, and A. Kolchinsky. X-ray-induced P-selectin localization to the lumen of tumor blood vessels. Cancer Res 58:5216\u20135220.1998."},{"key":"i0033-7587-166-6-819-b51","doi-asserted-by":"crossref","unstructured":"Fushiki, S., K. Matsushita, H. Yoshioka, and W. J. Schull.In uteroexposure to low-doses of ionizing radiation decelerates neuronal migration in the developing rat brain. Int. J. Radiol. Biol 70:53\u201360.1996.","DOI":"10.1080\/095530096145328"},{"key":"i0033-7587-166-6-819-b52","doi-asserted-by":"crossref","unstructured":"Matsushita, K., H. Yoshioka, S. Fushiki, K. Hirai, M. Kihara, N. Kadono, K. Hasegawa, H. Goma, and T. Sawada. Tissue culture study on neuronal migration in the rat cerebral cortex: Effects of low dose radiation. Brain Dev 19:452\u2013458.1997.","DOI":"10.1016\/S0387-7604(97)00057-0"},{"key":"i0033-7587-166-6-819-b53","doi-asserted-by":"crossref","unstructured":"Mouthon, M. A., M. Vandamme, A. van der Meeren, P. Gourmelon, and M. H. Gaugler. Inflammatory response to abdominal irradiation. Int. J. Radiat. Biol 77:95\u2013103.2001.","DOI":"10.1080\/0955300010000782"},{"key":"i0033-7587-166-6-819-b54","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-002-0993-9"},{"key":"i0033-7587-166-6-819-b55","unstructured":"Baluna, R., B. Leal, T. S. Herman, and B. A. Woynarowska. Extracellular matrix proteins modulate the effect of gamma-radiation in brain tumor cells. J. Clin. Oncol 22:(Suppl.). 868\u2013868.2003."},{"key":"i0033-7587-166-6-819-b56","doi-asserted-by":"publisher","DOI":"10.2307\/3579120"},{"key":"i0033-7587-166-6-819-b57","doi-asserted-by":"crossref","unstructured":"Pomp, J., J. Blom, M. Linthorst, A. H. Zwinderman, and C. van Krimpen. The influence of pre-operative radiotherapy on the expression of p53 and adhesion molecules: Correlation with treatment results in patients with squamous cell carcinoma or adenocarcinoma. Oncol. Rep 9:621\u2013625.2002.","DOI":"10.3892\/or.9.3.621"},{"key":"i0033-7587-166-6-819-b58","doi-asserted-by":"crossref","unstructured":"Ebara, T., N. Mitsuhashi, Y. Saito, T. Akimoto, and H. Niibe. Change in E-cadherin expression after X-ray irradiation of a human cancer cell linein vitroandin vivo. Int. J. Radiat. Oncol. Biol. Phys 41:669\u2013674.1998.","DOI":"10.1016\/S0360-3016(98)00096-0"},{"key":"i0033-7587-166-6-819-b59","unstructured":"Takahashi, Y., T. Teshima, N. Kawaguchi, Y. Hamada, S. Mori, A. Madachi, S. Ikeda, H. Mizuno, T. Ogata, and N. Matsuura. Heavy ion irradiation inhibitsin vitroangiogenesis even at sublethal dose. Cancer Res 63:4253\u20134257.2003."},{"key":"i0033-7587-166-6-819-b60","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5131(01)00770-1"},{"key":"i0033-7587-166-6-819-b61","doi-asserted-by":"crossref","unstructured":"Carnevali, S., T. Mio, Y. Adachi, J. R. Spurzem, I. Striz, D. J. Romberger, M. Illig, and S. I. Rennard. Gamma radiation inhibits fibroblast-mediated collagen gel retraction. Tissue Cell 35:459\u2013469.2003.","DOI":"10.1016\/S0040-8166(03)00072-7"},{"key":"i0033-7587-166-6-819-b62","doi-asserted-by":"crossref","unstructured":"Meineke, V., K. Muller, R. Ridi, N. Cordes, F. M. Kohn, A. Mayerhofer, J. Ring, and D. van Beuningen. Development and evaluation of a skin organ model for the analysis of radiation effects. Strahlenther Onkol 180:102\u2013108.2004.","DOI":"10.1007\/s00066-004-1134-4"},{"key":"i0033-7587-166-6-819-b63","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(01)00335-2"},{"key":"i0033-7587-166-6-819-b64","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.07.147"},{"key":"i0033-7587-166-6-819-b65","unstructured":"Wild-Bode, C., M. Weller, A. Rimner, J. Dichgans, and W. Wick. Sublethal irradiation promotes migration and invasiveness of glioma cells: Implications for radiotherapy of human glioblastoma. Cancer Res 61:2744\u20132750.2001."},{"key":"i0033-7587-166-6-819-b66","doi-asserted-by":"crossref","unstructured":"Cordes, N., B. Hansmeier, C. Beinke, V. Meineke, and D. van Beuningen. Irradiation differentially affects substratum-dependent survival, adhesion, and invasion of glioblastoma cell lines. Br. J. Cancer 89:2122\u20132132.2003.","DOI":"10.1038\/sj.bjc.6601429"},{"key":"i0033-7587-166-6-819-b67","doi-asserted-by":"crossref","unstructured":"Hallahan, D. E. Radiation-mediated gene expression in the pathogenesis of the clinical radiation response. Semin. Radiat. Oncol 6:250\u2013267.1996.","DOI":"10.1016\/S1053-4296(96)80021-X"},{"key":"i0033-7587-166-6-819-b68","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00279-8"},{"key":"i0033-7587-166-6-819-b69","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.171"},{"key":"i0033-7587-166-6-819-b70","doi-asserted-by":"publisher","DOI":"10.2307\/3579697"},{"key":"i0033-7587-166-6-819-b71","unstructured":"Kiani, M. F., H. Yuan, X. Chen, L. Smith, M. W. Gaber, and D. J. Goetz. Targeting microparticles to select tissue via radiation-induced upregulation of endothelial cell adhesion molecules. Pharm. Res 19:1317\u20131322.2002."},{"key":"i0033-7587-166-6-819-b72","doi-asserted-by":"crossref","unstructured":"Kimura, H., N. Z. Wu, R. Dodge, D. P. Spencer, B. M. Klitzman, T. M. McIntyre, and M. W. Dewhirst. Inhibition of radiation-induced upregulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021. Int. J. Radiat. Oncol. Biol. Phys 33:627\u2013633.1995.","DOI":"10.1016\/0360-3016(95)00205-D"},{"key":"i0033-7587-166-6-819-b73","doi-asserted-by":"crossref","unstructured":"Molla, M., M. Gironella, A. Salas, D. Closa, A. Biete, M. Gimeno, P. Coronel, J. M. Pique, and J. Panes. Protective effect of superoxide dismutase in radiation-induced intestinal inflammation. Int. J. Radiat Oncol. Biol. Phys 61:1159\u20131166.2005.","DOI":"10.1016\/j.ijrobp.2004.11.010"},{"key":"i0033-7587-166-6-819-b74","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00060-9"},{"key":"i0033-7587-166-6-819-b75","doi-asserted-by":"crossref","unstructured":"Vereycken-Holler, V., J. Aigueperse, and M. H. Gaugler. Radiation effects on circulating and endothelial cell interactions studied by quantitative real-time videomicroscopy. Int. J. Radiat. Biol 78:923\u2013930.2002.","DOI":"10.1080\/09553000210152980"},{"key":"i0033-7587-166-6-819-b76","doi-asserted-by":"crossref","unstructured":"Greenberger, J. S., H. Guo, and M. W. Epperly. Role of adhesion molecules in irradiation-induced organizing alveolitis\/fibrosis in C57BL\/6J mice. Int. J. Radiat. Oncol. Biol. Phys 57:(Suppl.). 57\u201358.2003.","DOI":"10.1016\/S0360-3016(03)00933-7"},{"key":"i0033-7587-166-6-819-b77","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.07.206"},{"key":"i0033-7587-166-6-819-b78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.07.729"},{"key":"i0033-7587-166-6-819-b79","doi-asserted-by":"crossref","unstructured":"Hallahan, D. E., L. Geng, and Y. Shyr. Effects of intercellular adhesion molecule 1 (ICAM-1) null mutation on radiation-induced pulmonary fibrosis and respiratory insufficiency in mice. J. Natl. Cancer Inst 94:733\u2013741.2002.","DOI":"10.1093\/jnci\/94.10.733"},{"key":"i0033-7587-166-6-819-b80","doi-asserted-by":"crossref","unstructured":"Kachnic, L. A. and S. N. Powell. Can ICAM modulation prevent lung injury from ionizing radiation? J. Natl. Cancer Inst 94:704\u2013705.2002.","DOI":"10.1093\/jnci\/94.10.704"},{"key":"i0033-7587-166-6-819-b81","doi-asserted-by":"crossref","unstructured":"Yuan, H., M. W. Gaber, T. McColgan, M. D. Naimark, M. F. Kiani, and T. E. Merchant. Radiation-induced permeability and leukocyte adhesion in the rat blood\u2013brain barrier: modulation with anti-ICAM-1 antibodies. Brain Res 96:959\u2013969.2003.","DOI":"10.1016\/S0006-8993(03)02278-9"},{"key":"i0033-7587-166-6-819-b82","doi-asserted-by":"crossref","unstructured":"Molla, M., J. Panes, M. Casadevall, A. Salas, C. Conill, A. Biete, D. C. Anderson, D. N. Granger, and J. M. Pique. Influence of dose-rate on inflammatory damage and adhesion molecule expression after abdominal radiation in the rat. Int. J. Radiat. Oncol. Biol. Phys 45:1011\u20131018.1999.","DOI":"10.1016\/S0360-3016(99)00286-2"},{"key":"i0033-7587-166-6-819-b83","unstructured":"Denham, J. W. Influence of dose-rate on inflammatory damage and adhesion molecule expression after abdominal radiation in the rat. Int. J. Radiat. Oncol. Biol. Phys 47:1460\u20131461.2000."},{"key":"i0033-7587-166-6-819-b84","doi-asserted-by":"publisher","DOI":"10.1080\/0955300031000114738"},{"key":"i0033-7587-166-6-819-b85","doi-asserted-by":"crossref","unstructured":"Rodel, F., F. Kamprad, R. Sauer, and G. Hildebrandt. Functional and molecular aspects of anti-inflammatory effects of low-dose radiotherapyStrahlenther. Onkol 178:1\u20139.2002.","DOI":"10.1007\/s00066-002-0901-3"},{"key":"i0033-7587-166-6-819-b86","doi-asserted-by":"publisher","DOI":"10.1080\/09553000110117340"},{"key":"i0033-7587-166-6-819-b87","doi-asserted-by":"crossref","unstructured":"Cordes, N. and D. van Beuningen. Arrest of human lung fibroblasts in G2phase after irradiation is regulated by converging phosphatidylinositol-3 kinase and \u03b21-integrin signalingin vitro. Int. J. Radiat. Oncol. Biol. Phys 58:453\u2013462.2004.","DOI":"10.1016\/j.ijrobp.2003.09.069"},{"key":"i0033-7587-166-6-819-b88","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600912"},{"key":"i0033-7587-166-6-819-b89","doi-asserted-by":"crossref","unstructured":"Kasahara, T., E. Koguchi, M. Funakoshi, E. Aizu-Yokota, and Y. Sonoda. Antiapoptotic action of focal adhesion kinase (FAK) against ionizing radiation. Antioxid. Redox Signal 4:491\u2013499.2002.","DOI":"10.1089\/15230860260196290"},{"key":"i0033-7587-166-6-819-b90","doi-asserted-by":"crossref","unstructured":"Beinke, C., D. van Beuningen, and N. Cordes. Ionizing radiation modules of the expression and tyrosine phosphorylation of the focal adhesion-associated proteins focal adhesion kinase (FAK) and its substrates p130cas and paxillin in A549 human lung carcinoma cellsin vitro. Int. J. Radiol. Biol 79:721\u2013731.2003.","DOI":"10.1080\/09553000310001610231"},{"key":"i0033-7587-166-6-819-b91","doi-asserted-by":"crossref","unstructured":"Lewis, J. M., T. N. Truong, and M. A. Schwartz. Integrins regulate the apoptotic response to DNA damage through modulation of p53. Proc. Natl. Acad. Sci. USA 99:3627\u20133632.2002.","DOI":"10.1073\/pnas.062698499"},{"key":"i0033-7587-166-6-819-b92","doi-asserted-by":"crossref","unstructured":"Cordes, N. Overexpression of hyperactive integrin-linked kinase leads to increased cellular radiosensitivity. Cancer Res 64:5683\u20135692.2004.","DOI":"10.1158\/0008-5472.CAN-04-1056"},{"key":"i0033-7587-166-6-819-b93","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.3.1.570"},{"key":"i0033-7587-166-6-819-b94","doi-asserted-by":"crossref","unstructured":"Cordes, N., C. Beinke, L. Plasswilm, and D. van Beuningen. Irradiation and various cytotoxic drugs enhance tyrosine phosphorylation and beta(1)-integrin clustering in human A549 lung cancer cells in a substratum-dependent mannerin vitro. Strahlenther. Onkol 180:157\u2013164.2004.","DOI":"10.1007\/s00066-004-1144-2"},{"key":"i0033-7587-166-6-819-b95","doi-asserted-by":"crossref","unstructured":"Damiano, J. S., L. A. Hazlehurst, and W. S. Dalton. Cell adhesion-mediated drug resistance (CAM-DR) protects the K562 chronic myelogenous leukemia cell line from apoptosis induced by BCR\/ABL inhibition, cytotoxic drugs, and gamma-irradiation. Leukemia 5:1232\u20131239.2001.","DOI":"10.1038\/sj.leu.2402179"},{"key":"i0033-7587-166-6-819-b96","doi-asserted-by":"crossref","unstructured":"Cordes, N., M. A. Blaese, L. Plasswilm, H. P. Rodemann, and D. van Beuningen. Fibronectin and laminin increase resistance to ionizing radiation and the cytotoxic drug Ukrain in human tumor and normal cellsin vitro. Int. J. Radiat. Oncol. Biol. Phys 79:709\u2013720.2003.","DOI":"10.1080\/09553000310001610240"},{"key":"i0033-7587-166-6-819-b97","doi-asserted-by":"crossref","unstructured":"Fuks, Z., I. Vlodavsky, M. Andreeff, M. McLoughlin, and A. Haimovitz-Friedman. Effects of extracellular matrix on the response of endothelial cells to radiationin vitro. Eur. J. Cancer 28:725\u2013731.1992.","DOI":"10.1016\/0959-8049(92)90104-A"},{"key":"i0033-7587-166-6-819-b98","doi-asserted-by":"crossref","unstructured":"Brown, C. K., N. M. Khodarev, J. Yu, C. K. Brown, T. Moo-Young, E. Labay, T. E. Darga, and M. C. Posner. Glioblastoma cells block radiation-induced programmed cell death of endothelial cells. FEBS Lett 565:167\u2013170.2004.","DOI":"10.1016\/j.febslet.2004.03.099"},{"key":"i0033-7587-166-6-819-b99","doi-asserted-by":"crossref","unstructured":"Kaus, A. C., I. Ferber, S. O. Bachmann, H. Specht, A. Wimmel, M. W. Gross, J. Schlegel, G. Suske, and M. Schuermann.In vitrochemo- and radio-resistance in small cell lung cancer correlates with cell adhesion and constitutive activation of AKT and MAP kinase pathways. Oncogene 21:8683\u20138695.2002.","DOI":"10.1038\/sj.onc.1205939"},{"key":"i0033-7587-166-6-819-b100","unstructured":"Maula, S. M., M. Luukkaa, R. Grenman, D. Jackson, S. Jalkanen, and R. Ristamaki. Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region. Cancer Res 63:1920\u20131926.2003."},{"key":"i0033-7587-166-6-819-b101","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)85473-9"},{"key":"i0033-7587-166-6-819-b102","doi-asserted-by":"crossref","unstructured":"Park, C., H. Zhang, M. Peng, and M. J. Bissell. Cell-ECM mediated radiation response in breast cancer: \u03b21 integrin as a potential molecular target. Int. J. Radiat. Oncol. Biol. Phys 57:(Suppl.). 161\u2013161.2003.","DOI":"10.1016\/S0360-3016(03)00939-8"},{"key":"i0033-7587-166-6-819-b103","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600304"},{"key":"i0033-7587-166-6-819-b104","doi-asserted-by":"publisher","DOI":"10.2307\/3578372"},{"key":"i0033-7587-166-6-819-b105","doi-asserted-by":"crossref","unstructured":"Kiani, M. F., B. M. Fenton, L. A. Sporn, and D. W. Siemann. Effect of ionizing radiation on the adhesive interaction of human tumor and endothelial cellsin vitro. Clin. Exp. Metastasis 15:12\u201318.1997.","DOI":"10.1023\/A:1018424021393"},{"key":"i0033-7587-166-6-819-b106","unstructured":"Konemann, S., J. Malath, T. Bolling, A. Kolkmeyer, K. Janke, D. Riesenbeck, S. Hesselmann, T. P. Nguyen, R. Diallo, and A. Schuck. Changed adhesion molecule profile of Ewing tumor cell lines and xenografts under the influence of ionizing radiation. Anticancer Res 24:1637\u20131644.2004."},{"key":"i0033-7587-166-6-819-b107","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2464"},{"key":"i0033-7587-166-6-819-b108","unstructured":"Camphausen, K., M. A. Moses, W. D. Beecken, M. K. Khan, J. Folkman, and M. S. O'Reilly. Radiation therapy to a primary tumor accelerates metastatic growth in mice. Cancer Res 61:2207\u20132211.2001."},{"key":"i0033-7587-166-6-819-b109","doi-asserted-by":"publisher","DOI":"10.1007\/BF01756381"},{"key":"i0033-7587-166-6-819-b110","unstructured":"Sonveaux, P., A. Brouet, X. Havaux, V. Gregoire, C. Dessy, J. L. Balligand, and O. Feron. Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: Implications for tumor radiotherapy. Cancer Res 63:1012\u20131019.2003."},{"key":"i0033-7587-166-6-819-b111","unstructured":"Wachsberger, P., R. Burd, and A. P. Dicker. Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: Exploring mechanisms of interaction. Clin. Cancer Res 9:1957\u20131971.2003."},{"key":"i0033-7587-166-6-819-b112","unstructured":"Abdollahi, A., K. E. Lipson, X. Han, R. Krempien, T. Trinh, K. J. Weber, P. Hahnfeldt, L. Hlatky, J. Debus, and P. E. Huber. SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiationin vitro. Cancer Res 63:3755\u20133763.2003."},{"key":"i0033-7587-166-6-819-b113","doi-asserted-by":"crossref","unstructured":"Ogata, T., T. Teshima, K. Kagawa, Y. Hishikawa, Y. Takahashi, A. Kawaguchi, Y. Suzumoto, K. Nojima, Y. Furusawa, and N. Matsuura. Particle irradiation suppresses metastatic potential of cancer cells. Cancer Res 65:113\u2013120.2005.","DOI":"10.1158\/0008-5472.113.65.1"},{"key":"i0033-7587-166-6-819-b114","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1832185100"},{"key":"i0033-7587-166-6-819-b115","doi-asserted-by":"crossref","unstructured":"Barcellos-Hoff, M. H. Integrative radiation carcinogenesis: Interactions between cell and tissue responses to DNA damage. Semin. Cancer Biol 15:138\u2013148.2005.","DOI":"10.1016\/j.semcancer.2004.08.010"},{"key":"i0033-7587-166-6-819-b116","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2004.06.014"},{"key":"i0033-7587-166-6-819-b117","doi-asserted-by":"crossref","unstructured":"Santin, A. D., P. L. Hermonat, A. Ravaggi, M. Chiriva-Internati, J. C. Hiserodt, R. B. Batchu, S. Pecorelli, and G. P. Parham. The effects of irradiation on the expression of a tumour rejection antigen (heat shock protein gp96) in human cervical cancer. Int. J. Radiat. Biol 73:699\u2013704.1998.","DOI":"10.1046\/j.1525-1438.1998.09807.x"},{"key":"i0033-7587-166-6-819-b118","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.0075"},{"key":"i0033-7587-166-6-819-b119","doi-asserted-by":"crossref","unstructured":"Hareyama, M., K. Imai, A. Oouchi, H. Takahashi, Y. Hinoda, M. Tsujisaki, M. Adachi, T. Shonai, K. Sakata, and K. Morita. The effect of radiation on the expression of intercellular adhesion molecule-1 of human adenocarcinoma cells. Int. J. Radiat. Oncol. Biol. Phys 40:691\u2013696.1998.","DOI":"10.1016\/S0360-3016(97)00860-2"},{"key":"i0033-7587-166-6-819-b120","doi-asserted-by":"crossref","unstructured":"Ryschich, E., W. Harms, T. Loeffler, M. Eble, E. Klar, and J. Schmidt. Radiation-induced leukocyte adhesion to endothelium in normal pancreas and in pancreatic carcinoma of the rat. Int. J. Cancer 105:506\u2013511.2003.","DOI":"10.1002\/ijc.11073"},{"key":"i0033-7587-166-6-819-b121","doi-asserted-by":"crossref","unstructured":"Friedman, E. J. Immune modulation by ionizing radiation and its implications for cancer immunotherapy. Curr. Pharm. Des 8:1765\u20131780.2002.","DOI":"10.2174\/1381612023394089"},{"key":"i0033-7587-166-6-819-b122","doi-asserted-by":"crossref","unstructured":"Ishii, Y. and S. Kitamura. Soluble intercellular adhesion molecule-1 as an early detection marker for radiation pneumonitis. Eur. Resp. J 13:733\u2013738.1999.","DOI":"10.1034\/j.1399-3003.1999.13d06.x"},{"key":"i0033-7587-166-6-819-b123","doi-asserted-by":"publisher","DOI":"10.1053\/srao.2002.31360"},{"key":"i0033-7587-166-6-819-b124","doi-asserted-by":"crossref","unstructured":"Baluna, R., C. D. Fuller, T. Y. Eng, and C. R. Thomas Jr. Plasma fibronectin levels in cancer patients undergoing radiation therapy. Int. J. Radiat. Oncol. Biol. Phys 60:(Suppl.). 35. 2004.","DOI":"10.1016\/S0360-3016(04)01534-2"},{"key":"i0033-7587-166-6-819-b125","unstructured":"Baluna, R., C. D. Fuller, T. Y. Eng, and C. R. Thomas Jr. Plasma fibronectin levels in lung cancer patients undergoing radiation therapy. Lung Cancer 46:38\u201338.2004."},{"key":"i0033-7587-166-6-819-b126","doi-asserted-by":"crossref","unstructured":"Wang, S. Z., Z. C. Chen, J. P. McNamar, S. Y. Wang, and Q. F. Cheng. The relationship between the protective effect of amifostine and decreased intercellular adhesion molecule 1 expression. Am. J. Otolaryngol 26:118\u2013122.2005.","DOI":"10.1016\/j.amjoto.2004.11.002"},{"key":"i0033-7587-166-6-819-b127","doi-asserted-by":"crossref","unstructured":"Son, E. W., C. K. Cho, D. K. Rhee, and S. Pyo. Inhibition of gamma-irradiation induced adhesion molecules and NO production by alginate in human endothelial cells. Arch. Pharm. Res 24:466\u2013471.2001.","DOI":"10.1007\/BF02975195"},{"key":"i0033-7587-166-6-819-b128","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2001.1182"},{"key":"i0033-7587-166-6-819-b129","doi-asserted-by":"crossref","unstructured":"Landau-Levin, M. and C. K. Chao. Extracellular matrix (ECM)-integrin receptors predict invasive\/metastatic propensities in cervical neoplasm. Int. J. Radiat. Oncol. Biol. Phys 36:324\u2013324.1996.","DOI":"10.1016\/S0360-3016(97)85672-6"},{"key":"i0033-7587-166-6-819-b130","doi-asserted-by":"crossref","unstructured":"Kawano, T., Y. Nakamura, S. Yanoma, A. Kubota, M. Furukawa, Y. Miyagi, and M. Tsukuda. Expression of E-cadherin, and CD44s and CD44v6 and its association with prognosis in head and neck cancer. Auris. Nasus. Larynx 31:35\u201341.2004.","DOI":"10.1016\/j.anl.2003.09.005"},{"key":"i0033-7587-166-6-819-b131","doi-asserted-by":"crossref","unstructured":"Yu, Y., W. Dong, X. Zhou, and S. Li. The significance of serum soluble intercellular adhesion molecule 1 and transforming growth factor alpha in patients with nasopharyngeal carcinoma. Arch. Otolaryngol. Head Neck Surg 130:1205\u20131208.2004.","DOI":"10.1001\/archotol.130.10.1205"},{"key":"i0033-7587-166-6-819-b132","doi-asserted-by":"crossref","unstructured":"Hallahan, D. E., L. Geng, S. Qu, C. Scarfone, T. Giorgio, E. Donnelly, X. Gao, and J. Clanton. Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels. Cancer Cell 3:63\u201374.2003.","DOI":"10.1016\/S1535-6108(02)00238-6"},{"key":"i0033-7587-166-6-819-b133","unstructured":"Hallahan, D. E., A. Y. Chen, M. Teng, and A. J. Cmelak. Drug-radiation interactions in tumor blood vessels. Oncology (Huntington) 13:(Suppl.). 71\u201377.1999."},{"key":"i0033-7587-166-6-819-b134","doi-asserted-by":"crossref","unstructured":"Hallahan, D. E., S. Qu, L. Geng, A. Cmelak, A. Chakravarthy, W. Martin, C. Scarfone, and T. Giorgio. Radiation-mediated control of drug delivery. Am. J. Clin. Oncol 24:473\u2013480.2001.","DOI":"10.1097\/00000421-200110000-00012"},{"key":"i0033-7587-166-6-819-b135","doi-asserted-by":"crossref","unstructured":"Geng, L., K. Osusky, S. Konjeti, A. Fu, and D. E. Hallahan. Radiation-guided drug delivery to tumor blood vessels results in improved tumor growth delay. J. Controlled Release 99:369\u2013381.2004.","DOI":"10.1016\/j.jconrel.2004.07.024"},{"key":"i0033-7587-166-6-819-b136","doi-asserted-by":"crossref","unstructured":"Stacy, D. R., B. Lu, and D. E. Hallahan. Radiation-guided drug delivery systems. Expert Rev. Anticancer Ther 4:283\u2013288.2004.","DOI":"10.1586\/14737140.4.2.283"},{"key":"i0033-7587-166-6-819-b137","doi-asserted-by":"crossref","unstructured":"Abdollahi, A. H., A. Zieher, D. Roth, A. Poerschke, J. Debus, K. Lipson, and P. E. Huber. Enhancing radiation-induced inhibition of angiogenesis and tumor growth by an alpha-V-beta-3 integrin receptor antagonist. Int. J. Radiat. Oncol. Biol. Phys 57:(Suppl.). 319\u2013320.2003.","DOI":"10.1016\/S0360-3016(03)01195-7"},{"key":"i0033-7587-166-6-819-b138","unstructured":"Burke, P. A., S. J. DeNardo, L. A. Miers, K. P. Lamborn, S. Matzku, and G. L. DeNardo. Cilengitide targeting of alpha(v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts. Cancer Res 62:4263\u20134272.2002."}],"container-title":["Radiation Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T22:07:30Z","timestamp":1683670050000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.bioone.org\/doi\/10.1667\/RR0380.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":138,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1667\/RR0380.1"],"URL":"https:\/\/doi.org\/10.1667\/rr0380.1","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}