{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:30:13Z","timestamp":1790609413673,"version":"4.1.0"},"reference-count":58,"publisher":"Radiation Research Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2014,2,25]]},"DOI":"10.1667\/rr13452.1","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T16:32:08Z","timestamp":1393345928000},"page":"324","source":"Crossref","is-referenced-by-count":61,"title":["Radiation-Induced Alterations in Mitochondria of the Rat Heart"],"prefix":"10.1667","volume":"181","author":[{"given":"Vijayalakshmi","family":"Sridharan","sequence":"first","affiliation":[{"name":"University of Arkansas for Medical Sciences, Department of Pharmaceutical Sciences, Division of Radiation Health, Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nukhet","family":"Aykin-Burns","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Department of Pharmaceutical Sciences, Division of Radiation Health, Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Tripathi","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Department of Pharmaceutical Sciences, Division of Radiation Health, Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly J.","family":"Krager","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Department of Pharmaceutical Sciences, Division of Radiation Health, Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Department of Radiation Oncology, Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo G.","family":"Moros","sequence":"additional","affiliation":[{"name":"Moffitt Cancer Center and Research Institute, Department of Radiation Oncology, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Corry","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Department of Radiation Oncology, Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazyna","family":"Nowak","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Department of Pharmaceutical Sciences, Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hauer-Jensen","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Department of Pharmaceutical Sciences, Division of Radiation Health, Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Boerma","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Department of Pharmaceutical Sciences, Division of Radiation Health, Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"i0033-7587-181-3-324-b01","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(01)00227-X"},{"key":"i0033-7587-181-3-324-b02","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.12.026"},{"key":"i0033-7587-181-3-324-b03","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.670588"},{"key":"i0033-7587-181-3-324-b04","doi-asserted-by":"publisher","DOI":"10.1038\/191144a0"},{"key":"i0033-7587-181-3-324-b05","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2004.03.007"},{"key":"i0033-7587-181-3-324-b06","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2004.08.012"},{"key":"i0033-7587-181-3-324-b07","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.268946"},{"key":"i0033-7587-181-3-324-b08","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2008"},{"key":"i0033-7587-181-3-324-b09","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.02.014"},{"key":"i0033-7587-181-3-324-b10","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018060-00002"},{"key":"i0033-7587-181-3-324-b11","doi-asserted-by":"publisher","DOI":"10.1089\/152308603770380098"},{"key":"i0033-7587-181-3-324-b12","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201100178"},{"key":"i0033-7587-181-3-324-b13","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(89)90044-3"},{"key":"i0033-7587-181-3-324-b14","doi-asserted-by":"publisher","DOI":"10.1590\/S0001-37652013005000009"},{"key":"i0033-7587-181-3-324-b15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027811"},{"key":"i0033-7587-181-3-324-b16","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.01.017"},{"key":"i0033-7587-181-3-324-b17","doi-asserted-by":"crossref","unstructured":"Dayal D, Martin SM, Owens KM, Aykin-Burns N, Zhu Y, Boominathan A, et al. Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation. Radiat Res 2009; 172:737\u201345.","DOI":"10.1667\/RR1617.1"},{"key":"i0033-7587-181-3-324-b18","doi-asserted-by":"crossref","unstructured":"Nugent SM, Mothersill CE, Seymour C, McClean B, Lyng FM, Murphy JE. Increased mitochondrial mass in cells with functionally compromised mitochondria after exposure to both direct gamma radiation and bystander factors. Radiat Res 2007; 168:134\u201342.","DOI":"10.1667\/RR0769.1"},{"key":"i0033-7587-181-3-324-b19","doi-asserted-by":"publisher","DOI":"10.1080\/09553000701370878"},{"key":"i0033-7587-181-3-324-b20","doi-asserted-by":"crossref","unstructured":"Sharma S, Moros EG, Boerma M, Sridharan V, Han EY, Clarkson R, et al. A novel technique for image-guided local heart irradiation in the rat. TCRT Express 2013; 1:47\u201357.","DOI":"10.7785\/tcrtexpress.2013.600256"},{"key":"i0033-7587-181-3-324-b21","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-1831"},{"key":"i0033-7587-181-3-324-b22","doi-asserted-by":"publisher","DOI":"10.1118\/1.1374247"},{"key":"i0033-7587-181-3-324-b23","doi-asserted-by":"publisher","DOI":"10.1118\/1.1929253"},{"key":"i0033-7587-181-3-324-b24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.572552"},{"key":"i0033-7587-181-3-324-b25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021746"},{"key":"i0033-7587-181-3-324-b26","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2006"},{"key":"i0033-7587-181-3-324-b27","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000148632.35500.d9"},{"key":"i0033-7587-181-3-324-b28","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.15.1899"},{"key":"i0033-7587-181-3-324-b29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2003.10.016"},{"key":"i0033-7587-181-3-324-b30","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-008-0434-z"},{"key":"i0033-7587-181-3-324-b31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2006.04.011"},{"key":"i0033-7587-181-3-324-b32","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20051654"},{"key":"i0033-7587-181-3-324-b33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400695200"},{"key":"i0033-7587-181-3-324-b34","doi-asserted-by":"publisher","DOI":"10.1038\/20959"},{"key":"i0033-7587-181-3-324-b35","doi-asserted-by":"publisher","DOI":"10.1038\/35019596"},{"key":"i0033-7587-181-3-324-b36","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrs001"},{"key":"i0033-7587-181-3-324-b37","doi-asserted-by":"crossref","unstructured":"Zhang Y, Zhang X, Rabbani ZN, Jackson IL, Vujaskovic Z. Oxidative stress mediates radiation lung injury by inducing apoptosis. Int J Radiat Oncol Biol Phys 2012; 83:740\u20138.","DOI":"10.1016\/j.ijrobp.2011.08.005"},{"key":"i0033-7587-181-3-324-b38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200422218"},{"key":"i0033-7587-181-3-324-b39","doi-asserted-by":"crossref","unstructured":"Lee CL, Moding EJ, Cuneo KC, Li Y, Sullivan JM, Mao L, et al. p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice. Sci Signal 2012; 5:ra52.","DOI":"10.1126\/scisignal.2002918"},{"key":"i0033-7587-181-3-324-b40","doi-asserted-by":"publisher","DOI":"10.1038\/20959"},{"key":"i0033-7587-181-3-324-b41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43171"},{"key":"i0033-7587-181-3-324-b42","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(03)00533-9"},{"key":"i0033-7587-181-3-324-b43","doi-asserted-by":"publisher","DOI":"10.1038\/35048073"},{"key":"i0033-7587-181-3-324-b44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.01.031"},{"key":"i0033-7587-181-3-324-b45","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00024.2007"},{"key":"i0033-7587-181-3-324-b46","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000087542.26971.D4"},{"key":"i0033-7587-181-3-324-b47","doi-asserted-by":"crossref","unstructured":"Hunter DR, Haworth RA, Southard JH. Relationship between configuration, function, and permeability in calcium-treated mitochondria. J Biol Chem 1976; 251:5069\u201377.","DOI":"10.1016\/S0021-9258(17)33220-9"},{"key":"i0033-7587-181-3-324-b48","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0728-7"},{"key":"i0033-7587-181-3-324-b49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.11.036"},{"key":"i0033-7587-181-3-324-b50","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006810523586"},{"key":"i0033-7587-181-3-324-b51","unstructured":"Leach JK, Van TG, Lin PS, Schmidt-Ullrich R, Mikkelsen RB. Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen\/nitrogen. Cancer Res 2001; 61:3894\u201301."},{"key":"i0033-7587-181-3-324-b52","unstructured":"Limoli CL, Giedzinski E, Morgan WF, Swarts SG, Jones GD, Hyun W. Persistent oxidative stress in chromosomally unstable cells. Cancer Res 2003; 63:3107\u201311."},{"key":"i0033-7587-181-3-324-b53","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.138.2.449"},{"key":"i0033-7587-181-3-324-b54","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-7249(02)00045-4"},{"key":"i0033-7587-181-3-324-b55","doi-asserted-by":"publisher","DOI":"10.2307\/3578504"},{"key":"i0033-7587-181-3-324-b56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04704.x"},{"key":"i0033-7587-181-3-324-b57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2013.01.004"},{"key":"i0033-7587-181-3-324-b58","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200793"}],"container-title":["Radiation Research"],"original-title":[],"deposited":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T14:36:43Z","timestamp":1648391803000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-181\/issue-3\/RR13452.1\/Radiation-Induced-Alterations-in-Mitochondria-of-the-Rat-Heart\/10.1667\/RR13452.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,25]]},"references-count":58,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rr13452.1","relation":{},"ISSN":["0033-7587"],"issn-type":[{"value":"0033-7587","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2,25]]}}}