{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:23:48Z","timestamp":1784978628857,"version":"3.55.0"},"reference-count":35,"publisher":"Radiation Research Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2014,6,16]]},"DOI":"10.1667\/rr13633.1","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T17:13:49Z","timestamp":1402938829000},"page":"35","source":"Crossref","is-referenced-by-count":27,"title":["Amelioration of Radiation-Induced Oral Cavity Mucositis and Distant Bone Marrow Suppression in Fanconi Anemia Fancd2\u2013\/\u2013 (FVB\/N) Mice by Intraoral GS-Nitroxide JP4-039"],"prefix":"10.1667","volume":"182","author":[{"given":"Hebist","family":"Berhane","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwin","family":"Shinde","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny","family":"Kalash","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Epperly","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Goff","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcy","family":"Franicola","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xichen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Shields","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wipf","sequence":"additional","affiliation":[{"name":"Department of Chemistry, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15260"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel S.","family":"Greenberger","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"i0033-7587-182-1-35-b01","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2010.07.127"},{"key":"i0033-7587-182-1-35-b02","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.27.20130034"},{"key":"i0033-7587-182-1-35-b03","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199610)53:2<99::AID-AJH7>3.0.CO;2-Z"},{"key":"i0033-7587-182-1-35-b04","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0563"},{"key":"i0033-7587-182-1-35-b05","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.05.013"},{"key":"i0033-7587-182-1-35-b06","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00173-3"},{"key":"i0033-7587-182-1-35-b07","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.154"},{"key":"i0033-7587-182-1-35-b08","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-003-1099-8"},{"key":"i0033-7587-182-1-35-b09","doi-asserted-by":"publisher","DOI":"10.1038\/nrc970"},{"key":"i0033-7587-182-1-35-b10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1182372"},{"key":"i0033-7587-182-1-35-b11","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.12.003"},{"key":"i0033-7587-182-1-35-b12","doi-asserted-by":"publisher","DOI":"10.1126\/science.1205805"},{"key":"i0033-7587-182-1-35-b13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-09-427740"},{"key":"i0033-7587-182-1-35-b14","doi-asserted-by":"crossref","unstructured":"Bernard ME, Kim H, Berhane H, Epperly MW, Franicola D, Zhang X, et al. GS-nitroxide (JP4-039)-mediated radioprotection of human Fanconi Anemia cell lines. Radiat Res 2011; 176:603\u201312.","DOI":"10.1667\/RR2624.1"},{"key":"i0033-7587-182-1-35-b15","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1291"},{"key":"i0033-7587-182-1-35-b16","doi-asserted-by":"crossref","unstructured":"Berhane H, Epperly MW, Goff J, Kalash R, Cao S, Franicola D, et al. Radiobiologic differences between bone marrow stromal and hematopoietic progenitor cell lines form Fanconi Anemia (Fancd2\u2013\/\u2013) mice. Radiat Res. 2014; 181: 76\u201389.","DOI":"10.1667\/RR13405.1"},{"key":"i0033-7587-182-1-35-b17","doi-asserted-by":"crossref","unstructured":"Guo H, Seixas-Silva JA, Epperly MW, Gretton JE, Shin DM, Bar-Sagi D, et al. Prevention of radiation-induced oral cavity mucositis by plasmid\/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene. Radiat Res 2003; 159:361\u201370.","DOI":"10.1667\/0033-7587(2003)159[0361:PORIOC]2.0.CO;2"},{"key":"i0033-7587-182-1-35-b18","unstructured":"Epperly MW, Goff JP, Li S, Gao X, Wipf P, Dixon T, et al. Intraesophageal administration of GS-nitroxide (JP4-039) protects against ionizing irradiation-induced esophagitis. In Vivo 2010; 24:811\u201320."},{"key":"i0033-7587-182-1-35-b19","doi-asserted-by":"publisher","DOI":"10.1080\/01926230600964706"},{"key":"i0033-7587-182-1-35-b21","doi-asserted-by":"crossref","unstructured":"Rajagopalan MS, Stone B, Rwigema J-C, Salimi U, Epperly MW, Goff J, et al. Intraesophageal manganese superoxide dismutase-plasmid liposomes ameliorates novel total body and thoracic irradiation sensitivity of homologous deletion recombinant negative nitric oxide synthase-1 (NOS1\u2013\/\u2013) mice. Radiat Res 2010; 174:297\u2013312.","DOI":"10.1667\/RR2019.1"},{"key":"i0033-7587-182-1-35-b22","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1997.2061"},{"key":"i0033-7587-182-1-35-b23","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-849-2_13"},{"key":"i0033-7587-182-1-35-b24","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300502"},{"key":"i0033-7587-182-1-35-b25","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-011-1098-y"},{"key":"i0033-7587-182-1-35-b26","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2011.1.492"},{"key":"i0033-7587-182-1-35-b27","doi-asserted-by":"publisher","DOI":"10.1101\/gad.17020911"},{"key":"i0033-7587-182-1-35-b28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58321"},{"key":"i0033-7587-182-1-35-b29","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.04.016"},{"key":"i0033-7587-182-1-35-b30","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.114769"},{"key":"i0033-7587-182-1-35-b31","unstructured":"Li S, Yan T, Yang JQ, Oberley TD, Oberley LW. The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase. Cancer Res 2000; 60:3927\u201339."},{"key":"i0033-7587-182-1-35-b32","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-381970"},{"key":"i0033-7587-182-1-35-b33","doi-asserted-by":"publisher","DOI":"10.1038\/nature10192"},{"key":"i0033-7587-182-1-35-b34","doi-asserted-by":"publisher","DOI":"10.1038\/nature11368"},{"key":"i0033-7587-182-1-35-b35","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-507962"},{"key":"i0033-7587-182-1-35-b36","unstructured":"Kalash R, Berhane H, Yang Y, Epperly MW, Wang H, Dixon T, et al. Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU\/min SRS beam. In Vivo 2014; 28:1\u201312."}],"container-title":["Radiation Research"],"original-title":[],"deposited":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T19:02:03Z","timestamp":1564599723000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-182\/issue-1\/RR13633.1\/Amelioration-of-Radiation-Induced-Oral-Cavity-Mucositis-and-Distant-Bone\/10.1667\/RR13633.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,16]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,7,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rr13633.1","relation":{},"ISSN":["0033-7587"],"issn-type":[{"value":"0033-7587","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6,16]]}}}