{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:17:48Z","timestamp":1785845868665,"version":"3.56.0"},"reference-count":55,"publisher":"Radiation Research Society","issue":"5","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bioone.org\/page\/resources\/researchers\/rights_and_permissions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1667\/rr14647.1","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T18:56:12Z","timestamp":1504032972000},"page":"556-570","source":"Crossref","is-referenced-by-count":39,"title":["Combined Therapy of Pegylated G-CSF and Alxn4100TPO Improves Survival and Mitigates Acute Radiation Syndrome after Whole-Body Ionizing Irradiation Alone and Followed by Wound Trauma"],"prefix":"10.1667","volume":"188","author":[{"given":"Juliann G.","family":"Kiang","sequence":"first","affiliation":[{"name":"Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland"},{"name":"Departments of b\u2009Pharmacology and Molecular Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland"},{"name":"College of Letters and Science, University of California, Berkeley, Berkeley, California, 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhai","sequence":"additional","affiliation":[{"name":"Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Bolduc","sequence":"additional","affiliation":[{"name":"Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan T.","family":"Smith","sequence":"additional","affiliation":[{"name":"Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha N.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Ho","sequence":"additional","affiliation":[{"name":"Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland"},{"name":"College of Letters and Science, University of California, Berkeley, Berkeley, California, 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Lin","sequence":"additional","affiliation":[{"name":"Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"i0033-7587-188-5-476-b01","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3701-2-20"},{"key":"i0033-7587-188-5-476-b02","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2053-z"},{"key":"i0033-7587-188-5-476-b03","doi-asserted-by":"crossref","unstructured":"Fukumoto R, Kiang JG. Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat shock protein 90 kDa after ionizing radiation. Radiat Res 2011; 176:333\u201345.","DOI":"10.1667\/RR2534.1"},{"key":"i0033-7587-188-5-476-b04","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058389"},{"key":"i0033-7587-188-5-476-b05","doi-asserted-by":"publisher","DOI":"10.1097\/01.HP.0000348466.09978.77"},{"key":"i0033-7587-188-5-476-b06","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/821541"},{"key":"i0033-7587-188-5-476-b07","doi-asserted-by":"crossref","unstructured":"Kiang JG, Jiao W, Cary LH, Mog SR, Elliott TB, Pellmar TC, et al. Wound trauma increases radiation-induced mortality by increasing iNOS, cytokine concentrations, and bacterial infections. Radiat Res 2010; 173:319\u201332.","DOI":"10.1667\/RR1892.1"},{"key":"i0033-7587-188-5-476-b08","doi-asserted-by":"crossref","unstructured":"Farese AM, Cohen MV, Katz BP, Smith CP, Gibbs A, Cohen DM, et al. Filgrastim improves survival in lethally irradiated nonhuman primates. Radiat Res 2013; 179:89\u2013100.","DOI":"10.1667\/RR3049.1"},{"key":"i0033-7587-188-5-476-b09","doi-asserted-by":"crossref","unstructured":"Hankey KG, Farese AM, Blaauw EC, Gibbs AM, Smith CP, Katz BP, et al. Pegfilgrastim Improves Survival of Lethally Irradiated Nonhuman Primates. Radiat Res 2015; 183:643\u201355.","DOI":"10.1667\/RR13940.1"},{"key":"i0033-7587-188-5-476-b10","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kql011"},{"key":"i0033-7587-188-5-476-b11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-12-200406150-00015"},{"key":"i0033-7587-188-5-476-b12","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043452613"},{"key":"i0033-7587-188-5-476-b14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-079681"},{"key":"i0033-7587-188-5-476-b15","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10260"},{"key":"i0033-7587-188-5-476-b16","doi-asserted-by":"crossref","unstructured":"Bertho JM, Roy L, Souidi M, Benderitter M, Gueguen Y, Lataillade JJ, et al. New biological indicators to evaluate and monitor radiation-induced damage: an accident case report. Radiat Res 2008; 169:543\u201350.","DOI":"10.1667\/RR1259.1"},{"key":"i0033-7587-188-5-476-b17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.08.003"},{"key":"i0033-7587-188-5-476-b18","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/481392"},{"key":"i0033-7587-188-5-476-b19","doi-asserted-by":"crossref","unstructured":"Farese AM, Cohen MV, Stead RB, Jackson W 3rd, Macvittie TJ. Pegfilgrastim administered in an abbreviated schedule, significantly improved neutrophil recovery after high-dose radiation-induced myelosuppression in rhesus macaques. Radiat Res 2012; 178:403\u201313.","DOI":"10.1667\/RR2900.1"},{"key":"i0033-7587-188-5-476-b20","doi-asserted-by":"publisher","DOI":"10.1080\/09553009014550891"},{"key":"i0033-7587-188-5-476-b21","unstructured":"Neelis KJ, Dubbelman YD, Luo Q, Thomas GR, Eaton DL, Wagemaker G. Simultaneous TPOand G-CSF treatment following cytoreductive treatment of rhesus monkeys prevents thrombocytopenia, accelerates platelet and red cell reconstitution, alleviates neutropenia and promotes the recovery of immature bone marrow cells. Exp Hematol 1997; 25:1084\u201393."},{"key":"i0033-7587-188-5-476-b22","doi-asserted-by":"crossref","unstructured":"Neelis KJ, Hartong SC, Egeland T, Thomas GR, Eaton DL, Wagemaker G. The efficacy of single-dose administration of thrombopoietin with coadministration of either granulocyte\/macrophage or granulocyte colony-stimulating factor in myelosuppressed rhesus monkeys. Blood 199790:2565\u201373.","DOI":"10.1182\/blood.V90.7.2565.2565_2565_2573"},{"key":"i0033-7587-188-5-476-b23","doi-asserted-by":"crossref","unstructured":"Satyamitra M, Lombardini ME, Graves J 3rd, Mullaney C, Ney P, Hunter J, et al. A TPO receptor agonist, ALXN4100TPO, mitigates radiation-induced lethality and stimulates hematopoiesis in CD2F1 mice. Radiat Res 2011; 175:746\u201358.","DOI":"10.1667\/RR2462.1"},{"key":"i0033-7587-188-5-476-b24","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7582079"},{"key":"i0033-7587-188-5-476-b25","doi-asserted-by":"publisher","DOI":"10.3109\/09553002.2015.1054526"},{"key":"i0033-7587-188-5-476-b26","doi-asserted-by":"publisher","DOI":"10.4172\/2157-7013.1000190"},{"key":"i0033-7587-188-5-476-b27","doi-asserted-by":"publisher","DOI":"10.1097\/HP.0000000000000459"},{"key":"i0033-7587-188-5-476-b28","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/215858"},{"key":"i0033-7587-188-5-476-b29","doi-asserted-by":"publisher","DOI":"10.1097\/HP.0000000000000108"},{"key":"i0033-7587-188-5-476-b30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090448"},{"key":"i0033-7587-188-5-476-b31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058389"},{"key":"i0033-7587-188-5-476-b32","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118652"},{"key":"i0033-7587-188-5-476-b33","unstructured":"Montgomery CAOncologic and toxicologic research: Alleviation and control of pain and distress in laboratory animals. Cancer Bull 1990; 42:230\u20137."},{"key":"i0033-7587-188-5-476-b34","unstructured":"Tomasivic SP, Coghlan LG, Gray KN, Mastromarino AJ, Travis EL. IACUC evaluation of experiments requiring death as an end point: A cancer center's recommendations. Lab AnimalJanuary\/February1988:31\u201334."},{"key":"i0033-7587-188-5-476-b35","unstructured":"International Standardization Organization and ASTM International. Standard practice for use of an alanine-EPR dosimetry system, standard 51607:2004(E) (9 pages). Geneva: ISO and West Conshohocken, PA: ASTM International;2004."},{"key":"i0033-7587-188-5-476-b36","unstructured":"Lord BI, Woolford LB, Molineux G. Kinetics of neutrophil production in normal and neutropenic animals during the response to filgrastim (r-metHu G-CSF) or filgrastim SD\/01 (PEG-r-metHu G-CSF ). Clin Cancer Res 2001; 7:2085\u201390."},{"key":"i0033-7587-188-5-476-b37","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1999.0670"},{"key":"i0033-7587-188-5-476-b38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139271"},{"key":"i0033-7587-188-5-476-b39","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1970.01340280030009"},{"key":"i0033-7587-188-5-476-b40","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195407000-00013"},{"key":"i0033-7587-188-5-476-b41","doi-asserted-by":"publisher","DOI":"10.2307\/3571550"},{"key":"i0033-7587-188-5-476-b42","unstructured":"Korlof B. Infection of burns, I. A bacteriological and clinical study of 99 cases. II. Animal experiments: burns and total body x-irradiation. Acta Chir Scand Suppl 1956; 209:1\u2013144."},{"key":"i0033-7587-188-5-476-b43","doi-asserted-by":"crossref","unstructured":"Brooks JW, Evans EI, Ham WT Jr, Reid JDThe influence of external body radiation on mortality from thermal burns. Ann Surg 1952; 136:533\u201345.","DOI":"10.1097\/00000658-195210000-00018"},{"key":"i0033-7587-188-5-476-b44","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-195312000-00007"},{"key":"i0033-7587-188-5-476-b46","doi-asserted-by":"publisher","DOI":"10.3109\/02841868109130187"},{"key":"i0033-7587-188-5-476-b47","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e31820aafa9"},{"key":"i0033-7587-188-5-476-b48","doi-asserted-by":"crossref","unstructured":"Jacob A, Shah KG, Wu R, Wang P. Ghrelin as a novel therapy for radiation combined injury. Mol Med 2010; 16:137\u2013243.","DOI":"10.2119\/molmed.2009.00154"},{"key":"i0033-7587-188-5-476-b49","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/167.suppl_1.64"},{"key":"i0033-7587-188-5-476-b50","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrs060"},{"key":"i0033-7587-188-5-476-b51","doi-asserted-by":"crossref","unstructured":"Islam A, Bolduc DL, Zhai M, Kiang JG, Swift JM. Captopril increases survival after whole-body ionizing irradiation but decreases survival when combined with skin-burn trauma in mice. Radiat Res 2015; 184:273\u20139.","DOI":"10.1667\/RR14113.1"},{"key":"i0033-7587-188-5-476-b53","doi-asserted-by":"publisher","DOI":"10.1097\/01.HP.0000173143.69659.5b"},{"key":"i0033-7587-188-5-476-b54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.03.011"},{"key":"i0033-7587-188-5-476-b55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2009.00638.x"},{"key":"i0033-7587-188-5-476-b56","doi-asserted-by":"crossref","unstructured":"MacVittie TJ, Farese AM, Smith WG, Baum CM, Burton E, McKearn JP. Myelopoietin, an engineered chimeric IL-3 and G-CSF receptor agonist, stimulates multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression. Blood 2000; 95:837\u201345.","DOI":"10.1182\/blood.V95.3.837.003k08_837_845"},{"key":"i0033-7587-188-5-476-b57","doi-asserted-by":"publisher","DOI":"10.1159\/000252823"},{"key":"i0033-7587-188-5-476-b58","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2006.10.002"}],"container-title":["Radiation Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.bioone.org\/doi\/full-xml\/10.1667\/RR14647.1","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T14:59:01Z","timestamp":1602860341000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.bioone.org\/doi\/10.1667\/RR14647.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1667\/RR14647.1"],"URL":"https:\/\/doi.org\/10.1667\/rr14647.1","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]}}}