{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:31:53Z","timestamp":1790184713358,"version":"4.1.0"},"reference-count":53,"publisher":"Radiation Research Society","issue":"4","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bioone.org\/page\/resources\/researchers\/rights_and_permissions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2018,7,24]]},"DOI":"10.1667\/rr14976.1","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T10:50:00Z","timestamp":1532429400000},"page":"424","source":"Crossref","is-referenced-by-count":34,"title":["Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure"],"prefix":"10.1667","volume":"190","author":[{"given":"Lin","family":"Shi","sequence":"first","affiliation":[{"name":"epartments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurumi","family":"Fujioka","sequence":"additional","affiliation":[{"name":"Molecular Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nami","family":"Sakurai-Ozato","sequence":"additional","affiliation":[{"name":"epartments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Hiroshima University, Hiroshima 734-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Satoh","sequence":"additional","affiliation":[{"name":"Environmetrics and Biometrics, Research Institute for Radiation Biology Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiying","family":"Sun","sequence":"additional","affiliation":[{"name":"epartments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Awazu","sequence":"additional","affiliation":[{"name":"Department of Mathematics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimio","family":"Tanaka","sequence":"additional","affiliation":[{"name":"epartments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Ishida","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Physiology and Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Nakano","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuki","family":"Kihara","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Nelson","family":"Hayes","sequence":"additional","affiliation":[{"name":"Gastroenterology and Metabolism, Biomedical Sciences, Graduate School of Biomedical and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Aikata","sequence":"additional","affiliation":[{"name":"Gastroenterology and Metabolism, Biomedical Sciences, Graduate School of Biomedical and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[{"name":"Gastroenterology and Metabolism, Biomedical Sciences, Graduate School of Biomedical and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Nagasaki University School of Medicine, Nagasaki 852-8523, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Awai","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Hiroshima University, Hiroshima 734-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Tashiro","sequence":"additional","affiliation":[{"name":"epartments of"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"DL, Preston, Y, Shimizu, DA, Pierce, et al.  \"Radiat Res.\"  160, \"Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950\u20131997\" 381 (2003)","DOI":"10.1667\/RR3049"},{"key":"2","doi-asserted-by":"crossref","unstructured":"DL, Preston, DA, Pierce, Y, Shimizu, et al.  \"Radiat Res.\"  162, \"Effect of recent changes in atomic bomb survivor dosimetry on cancer mortality risk estimates\" 377 (2004)","DOI":"10.1667\/RR3232"},{"key":"3","doi-asserted-by":"crossref","unstructured":"DL, Preston, E, Ron, S, Tokuoka, et al.  \"Radiat Res.\"  168, \"Solid cancer incidence in atomic bomb survivors: 1958\u20131998\" 1 (2007)","DOI":"10.1667\/RR0763.1"},{"key":"4","doi-asserted-by":"crossref","unstructured":"ES. Gilbert,  \"Int J Radiat Biol.\"  85, \"Ionising radiation and cancer risks: what have we learned from epidemiology?\" 467 (2009)","DOI":"10.1080\/09553000902883836"},{"key":"5","doi-asserted-by":"crossref","unstructured":"DA, Pierce  and DL. Preston  \"Radiat Res.\"  154, \"Radiation-related cancer risks at low doses among atomic bomb survivors\" 178 (2000)","DOI":"10.1667\/0033-7587(2000)154[0178:RRCRAL]2.0.CO;2"},{"key":"6","doi-asserted-by":"crossref","unstructured":"L, Mullenders, M, Atkinson, H, Paretzke, et al.  \"Nat Rev Cancer.\"  9, \"Assessing cancer risks of low-dose radiation\" 596 (2009)","DOI":"10.1038\/nrc2677"},{"key":"7","unstructured":"EJ, Hall  and AJ. Giaccia  \"Radiobiology for the radiologist. 7th ed.\"  ,  (2012)"},{"key":"8","doi-asserted-by":"crossref","unstructured":"EI, Piechowiak, JF, Peter, B, Kleb, et al.  \"Radiology.\"  275, \"Intravenous iodinated contrast agents amplify DNA radiation damage at CT\" 692 (2015)","DOI":"10.1148\/radiol.14132478"},{"key":"9","doi-asserted-by":"crossref","unstructured":"DJ, Brenner  and EJ. Hall  \"N Engl J Med.\"  357, \"Computed tomography\u2013an increasing source of radiation exposure\" 2277 (2007)","DOI":"10.1056\/NEJMra072149"},{"key":"10","doi-asserted-by":"crossref","unstructured":"K, Rothkamm, S, Balroop, J, Shekhdar, et al.  \"Radiology.\"  242, \"Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure\" 244 (2007)","DOI":"10.1148\/radiol.2421060171"},{"key":"11","doi-asserted-by":"crossref","unstructured":"MS, Pearce, JA, Salotti, MP, Little, et al.  \"Lancet.\"  380, \"Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study\" 499 (2012)","DOI":"10.1016\/S0140-6736(12)60815-0"},{"key":"12","doi-asserted-by":"crossref","unstructured":"JD, Mathews, AV, Forsythe, Z, Brady, et al.  \"BMJ.\"  346, \"Cancer risk in 680,000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians\" f2360 (2013)","DOI":"10.1136\/bmj.f2360"},{"key":"13","doi-asserted-by":"crossref","unstructured":"WY, Huang, CH, Muo, CY, Lin, et al.  \"Br J Cancer.\"  110, \"Paediatric head CT scan and subsequent risk of malignancy and benign brain tumour: a nation-wide population-based cohort study\" 2354 (2014)","DOI":"10.1038\/bjc.2014.103"},{"key":"14","doi-asserted-by":"crossref","unstructured":"G, Alzen  and G. Benz-Bohm  \"Dtsch Arztebl Int.\"  108, \"Radiation protection in pediatric radiology\" 407 (2011)","DOI":"10.3238\/arztebl.2011.0407"},{"key":"15","unstructured":"et al.  \"Human radiosensitivity: report of the independent advisory group on ionising radiation.\"  ,  (2013)"},{"key":"16","doi-asserted-by":"crossref","unstructured":"M, O'Driscoll, KM, Cerosaletti, PM, Girard, et al.  \"Mol Cell.\"  8, \"DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency\" 1175 (2001)","DOI":"10.1016\/S1097-2765(01)00408-7"},{"key":"17","doi-asserted-by":"crossref","unstructured":"M, Ege, Y, Ma, B, Manfras, et al.  \"Blood.\"  105, \"Omenn syndrome due to ARTEMIS mutations\" 4179 (2005)","DOI":"10.1182\/blood-2004-12-4861"},{"key":"18","doi-asserted-by":"crossref","unstructured":"M, Van der Burg, H, Ijspeert, NS, Verkaik, et al.  \"J Clin Invest.\"  119, \"A DNA-PKcs mutation in a radiosensitive T\u2013B\u2013 SCID patient inhibits Artemis activation and nonhomologous end-joining\" 91 (2009)","DOI":"10.1172\/JCI37141"},{"key":"19","doi-asserted-by":"crossref","unstructured":"TJ, Robnett, M, Machtay, EF, Vines, et al.  \"Int J Radiat Oncol Biol Phys.\"  48, \"Factors predicting severe radiation pneumonitis in patients receiving definitive chemoradiation for lung cancer\" 89 (2000)","DOI":"10.1016\/S0360-3016(00)00648-9"},{"key":"20","doi-asserted-by":"crossref","unstructured":"RS, Pieters, A, Niemierko, BC, Fullerton, et al.  \"Int J Radiat Oncol Biol Phys.\"  64, \"Cauda equina tolerance to high-dose fractionated irradiation\" 251 (2006)","DOI":"10.1016\/j.ijrobp.2005.04.019"},{"key":"21","doi-asserted-by":"crossref","unstructured":"EC, Bourton, PN, Plowman, D, Smith, et al.  \"Int J Cancer.\"  129, \"Prolonged expression of the gamma-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatment\" 2928 (2011)","DOI":"10.1002\/ijc.25953"},{"key":"22","doi-asserted-by":"crossref","unstructured":"CS, Djuzenova, B, Muhl, M, Fehn, et al.  \"Br J Cancer.\"  94, \"Radiosensitivity in breast cancer assessed by the Comet and micronucleus assays\" 1194 (2006)","DOI":"10.1038\/sj.bjc.6603005"},{"key":"23","doi-asserted-by":"crossref","unstructured":"MH, Lankinen, LM, Vilpo, JA. Vilpo,  \"Mutat Res.\"  352, \"UV- and gamma-irradiation-induced DNA single-strand breaks and their repair in human blood granulocytes and lymphocytes\" 31 (1996)","DOI":"10.1016\/0027-5107(95)00172-7"},{"key":"24","doi-asserted-by":"crossref","unstructured":"MH, Myllyperkio, TR, Koski, LM, Vilpo, et al.  \"Hematol Cell Ther.\"  41, \"Gamma-irradiation-induced DNA single- and double-strand breaks and their repair in chronic lymphocytic leukemia cells of variable radiosensitivity\" 95 (1999)","DOI":"10.1007\/s00282-999-0095-6"},{"key":"25","doi-asserted-by":"crossref","unstructured":"TT, Paull, EP, Rogakou, V, Yamazaki, et al.  \"Curr Biol.\"  10, \"A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage\" 886 (2000)","DOI":"10.1016\/S0960-9822(00)00610-2"},{"key":"26","doi-asserted-by":"crossref","unstructured":"CH, Bassing, KF, Chua, J, Sekiguchi, et al.  \"Proc Natl Acad Sci U S A.\"  99, \"Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX\" 8173 (2002)","DOI":"10.1073\/pnas.122228699"},{"key":"27","doi-asserted-by":"crossref","unstructured":"S, Grudzenski, A, Raths, S, Conrad, et al.  \"Proc Natl Acad Sci U S A.\"  107, \"Inducible response required for repair of low-dose radiation damage in human fibroblasts\" 14205 (2010)","DOI":"10.1073\/pnas.1002213107"},{"key":"28","doi-asserted-by":"crossref","unstructured":"M, Kuhne, E, Riballo, N, Rief, et al.  \"Cancer Res.\"  64, \"A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity\" 500 (2004)","DOI":"10.1158\/0008-5472.CAN-03-2384"},{"key":"29","doi-asserted-by":"crossref","unstructured":"E, Riballo, M, Kuhne, N, Rief, et al.  \"Mol Cell.\"  16, \"A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci\" 715 (2004)","DOI":"10.1016\/j.molcel.2004.10.029"},{"key":"30","doi-asserted-by":"crossref","unstructured":"OA, Sedelnikova, EP, Rogakou, IG, Panyutin, et al.  \"Radiat Res.\"  158, \"Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody\" 486 (2002)","DOI":"10.1667\/0033-7587(2002)158[0486:QDOIID]2.0.CO;2"},{"key":"31","doi-asserted-by":"crossref","unstructured":"M, Lobrich, A, Shibata, A, Beucher, et al.  \"Cell Cycle.\"  9, \"GammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization\" 662 (2010)","DOI":"10.4161\/cc.9.4.10764"},{"key":"32","doi-asserted-by":"crossref","unstructured":"M, Lobrich, N, Rief, M, Kuhne, et al.  \"Proc Natl Acad Sci U S A.\"  102, \"In vivo formation and repair of DNA double-strand breaks after computed tomography examinations\" 8984 (2005)","DOI":"10.1073\/pnas.0501895102"},{"key":"33","doi-asserted-by":"crossref","unstructured":"S, Bonassi, H, Norppa, M, Ceppi, et al.  \"Carcinogenesis.\"  29, \"Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries\" 1178 (2008)","DOI":"10.1093\/carcin\/bgn075"},{"key":"35","doi-asserted-by":"crossref","unstructured":"J. Valentin,  \"Ann ICRP.\"  35, \"Low-dose extrapolation of radiation-related cancer risk\" 1 (2005)","DOI":"10.1016\/j.icrp.2005.01.001"},{"key":"36","doi-asserted-by":"crossref","unstructured":"L, Shi, K, Fujioka, J, Sun, et al.  \"Radiat Res.\"  177, \"A modified system for analyzing ionizing radiation-induced chromosome abnormalities\" 533 (2012)","DOI":"10.1667\/RR2849.1"},{"key":"37","doi-asserted-by":"crossref","unstructured":"GK, Livingston, IK, Khvostunov, E, Gregoire, et al.  \"Radiat Environ Biophys.\"  55, \"Cytogenetic effects of radioiodine therapy: a 20-year follow-up study\" 203 (2016)","DOI":"10.1007\/s00411-016-0647-4"},{"key":"38","doi-asserted-by":"crossref","unstructured":"J, Pohl-Ruling, P, Fischer, O, Haas, et al.  \"Mutat Res.\"  110, \"Effect of low-dose acute X-irradiation on the frequencies of chromosomal aberrations in human peripheral lymphocytes in vitro\" 71 (1983)","DOI":"10.1016\/0027-5107(83)90019-2"},{"key":"39","doi-asserted-by":"crossref","unstructured":"DC, Lloyd, AA, Edwards, A, Leonard, et al.  \"Int J Radiat Biol.\"  61, \"Chromosomal aberrations in human lymphocytes induced in vitro by very low doses of X-rays\" 335 (1992)","DOI":"10.1080\/09553009214551021"},{"key":"40","unstructured":"J, Valentin,  \"Ann ICRP.\"  37, \"Managing patient dose in multi-detector computed tomography (MDCT). ICRP publication 102\" 1 (2007)"},{"key":"41","unstructured":"et al.  \"Doses from computed tomography (CT) examinations in the UK-2003 (NRPB-W67).\"  ,  (2005)"},{"key":"42","doi-asserted-by":"crossref","unstructured":"C, Pathe, K, Eble, D, Schmitz-Beuting, et al.  \"Contrast Media Mol Imaging.\"  6, \"The presence of iodinated contrast agents amplifies DNA radiation damage in computed tomography\" 507 (2011)","DOI":"10.1002\/cmmi.453"},{"key":"43","doi-asserted-by":"crossref","unstructured":"AT, Ramalho, MP, Curado, AT. Natarajan,  \"Mutat Res.\"  331, \"Lifespan of human lymphocytes estimated during a six year cytogenetic follow-up of individuals accidentally exposed in the 1987 radiological accident in Brazil\" 47 (1995)","DOI":"10.1016\/0027-5107(95)00049-O"},{"key":"44","doi-asserted-by":"crossref","unstructured":"MA, Bender, RJ, Preston, RC, Leonard, et al.  \"Mutat Res.\"  212, \"Chromosomal aberration and sister-chromatid exchange frequencies in peripheral blood lymphocytes of a large human population sample. II. Extension of age range\" 149 (1989)","DOI":"10.1016\/0027-5107(89)90065-1"},{"key":"45","doi-asserted-by":"crossref","unstructured":"MV, Bakhmutsky, MC, Joiner, TB, Jones, et al.  \"Radiat Res.\"  181, \"Differences in cytogenetic sensitivity to ionizing radiation in newborns and adults\" 605 (2014)","DOI":"10.1667\/RR13598.1"},{"key":"46","doi-asserted-by":"crossref","unstructured":"MJ, Ramsey, DH. Moore, JF, Briner, et al.  \"Mutat Res.\"  338, \"The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting\" 95 (1995)","DOI":"10.1016\/0921-8734(95)00015-X"},{"key":"47","doi-asserted-by":"crossref","unstructured":"HS, Thomsen  and SK. Morcos  \"Br J Radiol.\"  76, \"Contrast media and the kidney: European Society of Urogenital Radiology (ESUR) guidelines\" 513 (2003)","DOI":"10.1259\/bjr\/26964464"},{"key":"48","doi-asserted-by":"crossref","unstructured":"JA. Brink,  \"J Comput Assist Tomogr.\"  27, \"Contrast optimization and scan timing for single and multidetector-row computed tomography\" S3 (2003)","DOI":"10.1097\/00004728-200305001-00003"},{"key":"49","doi-asserted-by":"crossref","unstructured":"D. Fleischmann,  \"Eur Radiol.\"  13, \"Use of high-concentration contrast media in multiple-detector-row CT: principles and rationale\" 14 (2003)","DOI":"10.1007\/s00330-003-2097-z"},{"key":"50","doi-asserted-by":"crossref","unstructured":"MA. Hill,  \"Radiat Prot Dosimetry.\"  112, \"The variation in biological effectiveness of X-rays and gamma rays with energy\" 471 (2004)","DOI":"10.1093\/rpd\/nch091"},{"key":"51","doi-asserted-by":"crossref","unstructured":"G, Kraft, M, Kramer, M. Scholz,  \"Radiat Environ Biophys.\"  31, \"LET, track structure and models\" 161 (1992)","DOI":"10.1007\/BF01214825"},{"key":"52","doi-asserted-by":"crossref","unstructured":"E, Amato, D, Lizio, N, Settineri, et al.  \"Med Phys.\"  37, \"A method to evaluate the dose increase in CT with iodinated contrast medium\" 4249 (2010)","DOI":"10.1118\/1.3460797"},{"key":"53","doi-asserted-by":"crossref","unstructured":"P, Sahbaee, E, Abadi, WP, Segars, et al.  \"Radiology.\"  283, \"The effect of contrast material on radiation dose at CT: Part II. A systematic evaluation across 58 patient models\" 749 (2017)","DOI":"10.1148\/radiol.2017152852"},{"key":"34","unstructured":"et al.  \"Cytogenetic dosimetry: applications in preparedness for and response to radiation emergencies.\"  ,  (2011)"}],"container-title":["Radiation Research"],"original-title":[],"link":[{"URL":"http:\/\/www.bioone.org\/doi\/full-xml\/10.1667\/RR14976.1","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T15:16:05Z","timestamp":1564586165000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-190\/issue-4\/RR14976.1\/Chromosomal-Abnormalities-in-Human-Lymphocytes-after-Computed-Tomography-Scan-Procedure\/10.1667\/RR14976.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,24]]},"references-count":53,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,10,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rr14976.1","relation":{},"ISSN":["0033-7587"],"issn-type":[{"value":"0033-7587","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7,24]]}}}