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performance criteria for service laboratories performing biological dosimetry by cytogenetics.\"  ,  (2014)"},{"key":"11","unstructured":"et al.  \"Technical Report Series 430: Commissioning and quality assurance of computerized planning systems for radiation treatment of cancer.\"  ,  (2004)"},{"key":"12","unstructured":"GW.  Dolphin,  \"(Proc Int Symp Vienna Vienna, 1969).\"  , \"Biological dosimetry with particular reference to chromosome aberration analysis. A review of methods. Handling of Radiation Accidents\"  (1969)"},{"key":"13","doi-asserted-by":"crossref","unstructured":"M,  Higueras, P,  Puig, EA,  Ainsbury, et al.  \"Radiat Prot Dosim.\"  168, \"A new Bayesian model applied to cytogenetic partial body irradiation estimation\" 330 (2016)","DOI":"10.1093\/rpd\/ncv356"},{"key":"14","doi-asserted-by":"crossref","unstructured":"E,  Ainsbury  and D.  Lloyd  \"Health Phys.\"  98, \"Dose estimation software for radiation biodosimetry\" 290 (2010)","DOI":"10.1097\/01.HP.0000346305.84577.b4"},{"key":"15","doi-asserted-by":"crossref","unstructured":"DC,  Lloyd, RJ,  Purrott, GW,  Dolphin, et al.  \"Int J Radiat Biol.\"  28, \"The relationship between chromosome aberrations and low LET radiation dose in human lymphocytes\" 75 (1975)","DOI":"10.1080\/09553007514550781"},{"key":"16","doi-asserted-by":"crossref","unstructured":"E,  Pernot, J,  Hall, S,  Baatout, et al.  \"Mut Res.\"  751, \"Ionizing radiation biomarkers for potential use in epidemiological studies\" 258 (2012)","DOI":"10.1016\/j.mrrev.2012.05.003"},{"key":"17","doi-asserted-by":"crossref","unstructured":"NV,  Sotnik, TV,  Azizova, F,  Darroudi, et al.  \"Radiat Environ Biophys.\"  54, \"Verification by the FISH translocation assay of historic doses to Mayak workers from external gamma radiation\" 445 (2015)","DOI":"10.1007\/s00411-015-0614-5"},{"key":"18","doi-asserted-by":"crossref","unstructured":"J,  Hall, P,  Jeggo, C,  West, et al.  \"Mut Res Reviews.\"  771, \"Ionizing radiation biomarkers in epidemiological studies - an update\" 59 (2017)","DOI":"10.1016\/j.mrrev.2017.01.001"},{"key":"19","doi-asserted-by":"crossref","unstructured":"SL,  Kerns, L,  Dorling, L,  Fachal, et al.  \"EBioMedicine.\"  10, \"Meta-analysis of genome wide association studies identifies genetic markers of late toxicity following radiotherapy for prostate cancer\" 150 (2016)","DOI":"10.1016\/j.ebiom.2016.07.022"},{"key":"20","doi-asserted-by":"crossref","unstructured":"CN,  Andreassen, B,  Rosenstei, S,  Kerns, et al.  \"Radiother Oncol.\"  121, \"Individual patient data meta-analysis shows a significant association between ATMrs1801516 SNP and toxicity after radiotherapy in 5,456 breast and prostate cancer patients\" 431 (2016)","DOI":"10.1016\/j.radonc.2016.06.017"},{"key":"21","doi-asserted-by":"crossref","unstructured":"L,  Yang, J,  Taylor, A,  Eustace, et al.  \"Clin Cancer Res.\"  23, \"A gene signature for selecting benefit from hypoxia modification of radiotherapy for high-risk bladder cancer patients\" 4761 (2017)","DOI":"10.1158\/1078-0432.CCR-17-0038"},{"key":"22","doi-asserted-by":"crossref","unstructured":"K,  Borgmann, B,  Roper, RA,  El-Awady, et al.  \"Radiother Oncol.\"  64, \"Indicators of late normal tissue responses after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair and chromosome aberrations\" 141 (2002)","DOI":"10.1016\/S0167-8140(02)00167-6"},{"key":"23","doi-asserted-by":"crossref","unstructured":"ML,  Chua, N,  Somaiah, R,  A'Hern, et al.  \"Radiother Oncol.\"  99, \"Residual DNA and chromosomal damage in ex vivo irradiated blood lymphocytes correlated with normal tissue response to breast radiotherapy\" 362 (2011)","DOI":"10.1016\/j.radonc.2011.05.071"},{"key":"24","doi-asserted-by":"crossref","unstructured":"LA,  Beaton, L,  Marro, S,  Samiee, et al.  \"Int J Radiat Biol.\"  89, \"Investigating chromosome damage using fluorescent in situ hybridization to identify biomarkers of radiosensitivity in prostate cancer patients\" 1087 (2013)","DOI":"10.3109\/09553002.2013.825060"},{"key":"25","doi-asserted-by":"crossref","unstructured":"C,  Badie, S,  Dziwura, C,  Raffy, et al.  \"Br J Cancer.\"  98, \"Aberrant CDKN1A transcriptional response associates with abnormal sensitivity to radiation treatment\" 1845 (2008)","DOI":"10.1038\/sj.bjc.6604381"},{"key":"26","doi-asserted-by":"crossref","unstructured":"C,  Mayer, O,  Popanda, B,  Greve, et al.  \"Cancer Lett.\"  302, \"A radiation-induced gene expression signature as a tool to predict acute radiotherapy-induced adverse side effects\" 20 (2011)","DOI":"10.1016\/j.canlet.2010.12.006"},{"key":"27","doi-asserted-by":"crossref","unstructured":"P,  Finnon, S,  Kabacik, A,  MacKay, et al.  \"Radiother Oncol.\"  105, \"Correlation of in vitro lymphocyte radiosensitivity and gene expression with late normal tissue reactions following curative radiotherapy for breast cancer\" 329 (2012)","DOI":"10.1016\/j.radonc.2012.10.007"},{"key":"28","doi-asserted-by":"crossref","unstructured":"S,  Paul  and SA.  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